Age-specific association of reduced estimated glomerular filtration rate and albuminuria with all-cause mortality.

Published

Journal Article

It has been suggested that reduced estimated GFR (eGFR) among older adults does not necessarily reflect a pathologic phenomenon.We examined the association between eGFR and albumin-to-creatinine ratio (ACR) and all-cause mortality stratified by age (45 to 59.9, 60 to 69.9, 70 to 79.9, and ≥80 years) among 24,350 U.S. adults in the population-based REasons for Geographic and Racial Differences in Stroke (REGARDS) study. A spot urine sample was used to calculate ACR, and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation was used to calculate eGFR. All-cause mortality was assessed over a median follow-up of 4.5 years.Among participants ≥80 years of age (n = 1669), the age, race, gender, and geographic region of residence adjusted hazard ratios (95% confidence intervals) for mortality associated with eGFR levels of 45 to 59.9 and <45 ml/min per 1.73 m(2), versus ≥60 ml/min per 1.73 m(2), were 1.6 (1.3 - 2.1) and 2.2 (1.7 - 2.9), respectively. Also, among participants ≥80 years of age, the hazard ratios for mortality associated with ACR levels of 10 to 29.9, 30 to 299.9, and ≥300 mg/g, versus <10 mg/g, were 1.7 (1.3 - 2.1), 2.5 (1.9 - 3.3), and 5.1 (3.6 - 7.4), respectively. These associations were present after further multivariable adjustment and within the younger age groupings studied.These data suggest that reduced eGFR and albuminuria confer an increased risk for mortality in all age groups, including adults ≥80 years of age.

Full Text

Duke Authors

Cited Authors

  • Muntner, P; Bowling, CB; Gao, L; Rizk, D; Judd, S; Tanner, RM; McClellan, W; Warnock, DG

Published Date

  • September 2011

Published In

Volume / Issue

  • 6 / 9

Start / End Page

  • 2200 - 2207

PubMed ID

  • 21737849

Pubmed Central ID

  • 21737849

Electronic International Standard Serial Number (EISSN)

  • 1555-905X

International Standard Serial Number (ISSN)

  • 1555-9041

Digital Object Identifier (DOI)

  • 10.2215/CJN.02030311

Language

  • eng