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Role of germinal centers for the induction of broadly-reactive memory B cells.

Publication ,  Journal Article
Takahashi, Y; Kelsoe, G
Published in: Curr Opin Immunol
April 2017

Virus-specific memory B cells (Bmem) play a crucial role in protecting against variant viruses. The ability to recognize these variant viruses, defined as antibody breadth, is achieved in Bmem populations by two very different pathways, germline-encoded cross-reactivity and affinity-driven, somatic evolution in germinal centers (GCs) for conserved viral epitopes. The latter class of broadly-reactive Bmem cells are not cross-reactive per se, but bind epitopes crucial for viral fitness. Although these conserved epitopes are often weakly immunogenic, the GC reaction is surprisingly permissive for the continued survival/proliferation of B cells that bind with low affinity or react to cryptic epitopes, increasing their chance of memory recruitment. In this review, we discuss the adaptive strategies of B-cell memory to viral antigenic variations.

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Published In

Curr Opin Immunol

DOI

EISSN

1879-0372

Publication Date

April 2017

Volume

45

Start / End Page

119 / 125

Location

England

Related Subject Headings

  • Viruses
  • Immunology
  • Immunologic Memory
  • Humans
  • Germinal Center
  • Epitopes
  • Cell Survival
  • Cell Proliferation
  • B-Lymphocytes
  • Antigens, Viral
 

Citation

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ICMJE
MLA
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Takahashi, Y., & Kelsoe, G. (2017). Role of germinal centers for the induction of broadly-reactive memory B cells. Curr Opin Immunol, 45, 119–125. https://doi.org/10.1016/j.coi.2017.03.002
Takahashi, Yoshimasa, and Garnett Kelsoe. “Role of germinal centers for the induction of broadly-reactive memory B cells.Curr Opin Immunol 45 (April 2017): 119–25. https://doi.org/10.1016/j.coi.2017.03.002.
Takahashi Y, Kelsoe G. Role of germinal centers for the induction of broadly-reactive memory B cells. Curr Opin Immunol. 2017 Apr;45:119–25.
Takahashi, Yoshimasa, and Garnett Kelsoe. “Role of germinal centers for the induction of broadly-reactive memory B cells.Curr Opin Immunol, vol. 45, Apr. 2017, pp. 119–25. Pubmed, doi:10.1016/j.coi.2017.03.002.
Takahashi Y, Kelsoe G. Role of germinal centers for the induction of broadly-reactive memory B cells. Curr Opin Immunol. 2017 Apr;45:119–125.
Journal cover image

Published In

Curr Opin Immunol

DOI

EISSN

1879-0372

Publication Date

April 2017

Volume

45

Start / End Page

119 / 125

Location

England

Related Subject Headings

  • Viruses
  • Immunology
  • Immunologic Memory
  • Humans
  • Germinal Center
  • Epitopes
  • Cell Survival
  • Cell Proliferation
  • B-Lymphocytes
  • Antigens, Viral