Role of germinal centers for the induction of broadly-reactive memory B cells.

Journal Article (Review)

Virus-specific memory B cells (Bmem) play a crucial role in protecting against variant viruses. The ability to recognize these variant viruses, defined as antibody breadth, is achieved in Bmem populations by two very different pathways, germline-encoded cross-reactivity and affinity-driven, somatic evolution in germinal centers (GCs) for conserved viral epitopes. The latter class of broadly-reactive Bmem cells are not cross-reactive per se, but bind epitopes crucial for viral fitness. Although these conserved epitopes are often weakly immunogenic, the GC reaction is surprisingly permissive for the continued survival/proliferation of B cells that bind with low affinity or react to cryptic epitopes, increasing their chance of memory recruitment. In this review, we discuss the adaptive strategies of B-cell memory to viral antigenic variations.

Full Text

Duke Authors

Cited Authors

  • Takahashi, Y; Kelsoe, G

Published Date

  • April 2017

Published In

Volume / Issue

  • 45 /

Start / End Page

  • 119 - 125

PubMed ID

  • 28355576

Electronic International Standard Serial Number (EISSN)

  • 1879-0372

International Standard Serial Number (ISSN)

  • 0952-7915

Digital Object Identifier (DOI)

  • 10.1016/j.coi.2017.03.002

Language

  • eng