Overview
1. Lymphocyte development and antigen-driven diversification of immunoglobulin and T cell antigen receptor genes.
2. The germinal center reaction and mechanisms for clonal selection and self - tolerance. The origins of autoimmunity.
3. Interaction of innate- and adaptive immunity and the role of inflammation in lymphoid organogenesis.
4. The role of secondary V(D)J gene rearrangment in lymphocyte development and malignancies.
5. Mathematical modeling of immune responses, DNA motifs, collaborations in bioinformatics.
6. Humoral immunity to influenza and HIV-1.
2. The germinal center reaction and mechanisms for clonal selection and self - tolerance. The origins of autoimmunity.
3. Interaction of innate- and adaptive immunity and the role of inflammation in lymphoid organogenesis.
4. The role of secondary V(D)J gene rearrangment in lymphocyte development and malignancies.
5. Mathematical modeling of immune responses, DNA motifs, collaborations in bioinformatics.
6. Humoral immunity to influenza and HIV-1.
Current Appointments & Affiliations
James B. Duke Distinguished Professor of Immunology
·
2001 - Present
Integrative Immunobiology,
Basic Science Departments
Professor of Integrative Immunobiology
·
1998 - Present
Integrative Immunobiology,
Basic Science Departments
Associate Professor in the Department of Surgery
·
2020 - Present
Surgery, Surgical Sciences,
Surgery
Member of the Duke Cancer Institute
·
1998 - Present
Duke Cancer Institute,
Institutes and Centers
Member of the Duke Human Vaccine Institute
·
2006 - Present
Duke Human Vaccine Institute,
Institutes and Centers
Education, Training & Certifications
Harvard University ·
1979
D.Sc.