Overview
1. Lymphocyte development and antigen-driven diversification of immunoglobulin and T cell antigen receptor genes.
2. The germinal center reaction and mechanisms for clonal selection and self - tolerance. The origins of autoimmunity.
3. Interaction of innate- and adaptive immunity and the role of inflammation in lymphoid organogenesis.
4. The role of secondary V(D)J gene rearrangment in lymphocyte development and malignancies.
5. Mathematical modeling of immune responses, DNA motifs, collaborations in bioinformatics.
6. Humoral immunity to influenza and HIV-1.
2. The germinal center reaction and mechanisms for clonal selection and self - tolerance. The origins of autoimmunity.
3. Interaction of innate- and adaptive immunity and the role of inflammation in lymphoid organogenesis.
4. The role of secondary V(D)J gene rearrangment in lymphocyte development and malignancies.
5. Mathematical modeling of immune responses, DNA motifs, collaborations in bioinformatics.
6. Humoral immunity to influenza and HIV-1.
Current Appointments & Affiliations
James B. Duke Distinguished Professor of Immunology
·
2001 - Present
Integrative Immunobiology,
Basic Science Departments
Professor of Integrative Immunobiology
·
1998 - Present
Integrative Immunobiology,
Basic Science Departments
Associate Professor in the Department of Surgery
·
2020 - Present
Surgery, Surgical Sciences,
Surgery
Member of the Duke Cancer Institute
·
1998 - Present
Duke Cancer Institute,
Institutes and Centers
Member of the Duke Human Vaccine Institute
·
2006 - Present
Duke Human Vaccine Institute,
Institutes and Centers
Recent Publications
Functional Convergence of Genetically Diverse B-Cell Receptors in Simian-HIV Infected Rhesus Macaques
Preprint · January 12, 2026 Full text CiteA roadmap for defining "extrafollicular" B cell responses.
Journal Article Immunity · November 11, 2025 In the twenty years since extrafollicular B cell responses were originally described, much has been learned about B cell biology. With this progress, the term "extrafollicular" has expanded beyond its initial use to describe a variety of B cell processes, ... Full text Link to item CiteA protective and broadly binding antibody class engages the influenza virus hemagglutinin head at its stem interface.
Journal Article mBio · June 11, 2025 UNLABELLED: Influenza infection and vaccination impart strain-specific immunity that protects against neither seasonal antigenic variants nor the next pandemic. However, antibodies directed to conserved sites can confer broad protection. Here, we identify ... Full text Link to item CiteRecent Grants
Characterizing olfactory plasma cell dynamics and survival niche within the upper airway
ResearchCollaborator · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2029Genetic and Structural Basis for Virus Neutralization
ResearchPrincipal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2029Stimulating Access to Research in Residency (StARR) - NIAID
Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of Allergy and Infectious Diseases · 2018 - 2029View All Grants
Education, Training & Certifications
Harvard University ·
1979
D.Sc.
Harvard University ·
1975
M.S.