Overview
1. Lymphocyte development and antigen-driven diversification of immunoglobulin and T cell antigen receptor genes.
2. The germinal center reaction and mechanisms for clonal selection and self - tolerance. The origins of autoimmunity.
3. Interaction of innate- and adaptive immunity and the role of inflammation in lymphoid organogenesis.
4. The role of secondary V(D)J gene rearrangment in lymphocyte development and malignancies.
5. Mathematical modeling of immune responses, DNA motifs, collaborations in bioinformatics.
6. Humoral immunity to influenza and HIV-1.
2. The germinal center reaction and mechanisms for clonal selection and self - tolerance. The origins of autoimmunity.
3. Interaction of innate- and adaptive immunity and the role of inflammation in lymphoid organogenesis.
4. The role of secondary V(D)J gene rearrangment in lymphocyte development and malignancies.
5. Mathematical modeling of immune responses, DNA motifs, collaborations in bioinformatics.
6. Humoral immunity to influenza and HIV-1.
Current Appointments & Affiliations
James B. Duke Distinguished Professor of Immunology
·
2001 - Present
Integrative Immunobiology,
Basic Science Departments
Professor of Integrative Immunobiology
·
1998 - Present
Integrative Immunobiology,
Basic Science Departments
Associate Professor in the Department of Surgery
·
2020 - Present
Surgery, Surgical Sciences,
Surgery
Member of the Duke Cancer Institute
·
1998 - Present
Duke Cancer Institute,
Institutes and Centers
Member of the Duke Human Vaccine Institute
·
2006 - Present
Duke Human Vaccine Institute,
Institutes and Centers
Recent Publications
Fluorescence-barcoded cell lines stably expressing membrane-anchored influenza neuraminidases.
Preprint · January 2, 2025 Full text Link to item CiteProtective human antibodies against a conserved epitope in pre- and postfusion influenza hemagglutinin.
Journal Article Proc Natl Acad Sci U S A · January 2, 2024 Phylogenetically and antigenically distinct influenza A and B viruses (IAV and IBV) circulate in human populations, causing widespread morbidity. Antibodies (Abs) that bind epitopes conserved in both IAV and IBV hemagglutinins (HAs) could protect against d ... Full text Link to item CiteA new class of antibodies that overcomes a steric barrier to cross-group neutralization of influenza viruses.
Journal Article PLoS Biol · December 2023 Antibody titers that inhibit the influenza virus hemagglutinin (HA) from engaging its receptor are the accepted correlate of protection from infection. Many potent antibodies with broad, intra-subtype specificity bind HA at the receptor binding site (RBS). ... Full text Link to item CiteRecent Grants
Characterizing olfactory plasma cell dynamics and survival niche within the upper airway
ResearchCollaborator · Awarded by National Institutes of Health · 2024 - 2029Innovations in Functional B Cell Epitope Discovery
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2029Stimulating Access to Research in Residency (StARR) - NIAID
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2018 - 2029View All Grants
Education, Training & Certifications
Harvard University ·
1979
D.Sc.
Harvard University ·
1975
M.S.