Prostate-derived Ets factor, an oncogenic driver in breast cancer.

Published

Journal Article (Review)

Prostate-derived Ets factor (PDEF), a member of the Ets family of transcription factors, differs from other family members in its restricted expression in normal tissues and its unique DNA-binding motif. These interesting attributes coupled with its aberrant expression in cancer have rendered PDEF a focus of increasing interest by tumor biologists. This review provides a current understanding of the characteristics of PDEF expression and its role in breast cancer. The bulk of the evidence is consistent with PDEF overexpression in most breast tumors and an oncogenic role for this transcription factor in breast cancer. In addition, high PDEF expression in estrogen receptor-positive breast tumors showed significant correlation with poor overall survival in several independent cohorts of breast cancer patients. Together, these findings demonstrate PDEF to be an oncogenic driver of breast cancer and a biomarker of poor prognosis in this cancer. Based on this understanding and the limited expression of PDEF in normal human tissues, the development of PDEF-based therapeutics for prevention and treatment of breast cancer is also discussed.

Full Text

Duke Authors

Cited Authors

  • Sood, AK; Geradts, J; Young, J

Published Date

  • May 2017

Published In

Volume / Issue

  • 39 / 5

Start / End Page

  • 1010428317691688 -

PubMed ID

  • 28468594

Pubmed Central ID

  • 28468594

Electronic International Standard Serial Number (EISSN)

  • 1423-0380

International Standard Serial Number (ISSN)

  • 1010-4283

Digital Object Identifier (DOI)

  • 10.1177/1010428317691688

Language

  • eng