Joseph Geradts

Dr. Geradts' primary research focus is on the molecular pathology of breast cancer. His laboratory uses genomic profiling strategies to identify novel candidate breast cancer genes. Dr. Geradts is also interested in biomarker development. He directs the Tissue Core of Duke's Breast Cancer SPORE and collaborates on numerous breast cancer related research projects with other investigators at Duke and elsewhere.

Current Appointments & Affiliations

Adjunct Professor in the Department of Pathology · 2015 - Present Pathology, Clinical Science Departments

In the News

Published December 2, 2013

Duke study: Many breast cancers may be linked with cholesterol byproduct

View All News

Recent Publications

Computational Pathology Detection of Hypoxia-Induced Morphologic Changes in Breast Cancer.

Journal Article Am J Pathol · April 2025 Understanding the tumor hypoxic microenvironment is crucial for grasping tumor biology, clinical progression, and treatment responses. This study presents a novel application of artificial intelligence in computational histopathology to evaluate hypoxia in ... Full text Link to item Cite

XIAP overexpressing inflammatory breast cancer patients have high infiltration of immunosuppressive subsets and increased TNFR1 signaling targetable with Birinapant.

Journal Article Transl Oncol · May 2024 OBJECTIVE: To assess the expression pattern of X-linked inhibitor of apoptosis protein (XIAP), a cellular stress sensor, and delineate the associated changes in the tumor immune microenvironment (TiME) for prognostic value and new therapeutic targets in in ... Full text Link to item Cite

Androgen deprivation induces double-null prostate cancer via aberrant nuclear export and ribosomal biogenesis through HGF and Wnt activation.

Journal Article Nat Commun · February 9, 2024 Androgen deprivation therapy (ADT) targeting androgen/androgen receptor (AR)- signaling pathways is the main therapy for advanced prostate cancer (PCa). However, ADT eventually fails in most patients who consequently develop castration-resistant prostate c ... Full text Link to item Cite

View All Publications

Recent Grants

Detection and Elimination of Oncogenic Signaling Networks in Pre-malignant and Malignant Cells with Magnetic Resonance Imaging

ResearchCo Investigator · Awarded by Department of Defense · 2012 - 2022

Developing a HER3 Vaccine to Prevent Resistance to Endocrine Therapy

ResearchCollaborator · Awarded by Department of Defense · 2012 - 2022

A Molecular Framework for Understanding DCIS

ResearchCo Investigator · Awarded by Department of Defense · 2014 - 2022

View All Grants

Education, Training & Certifications

The University of Chicago · 1987 M.D.

University of California, Berkeley · 1984 M.A.