Joseph Geradts | Scholars@Duke

Joseph Geradts
Adjunct Professor in the Department of Pathology

Dr. Geradts' primary research focus is on the molecular pathology of breast cancer. His laboratory uses genomic profiling strategies to identify novel candidate breast cancer genes. Dr. Geradts is also interested in biomarker development. He directs the Tissue Core of Duke's Breast Cancer SPORE and collaborates on numerous breast cancer related research projects with other investigators at Duke and elsewhere.

Current Appointments & Affiliations

Adjunct Professor in the Department of Pathology, Pathology, Clinical Science Departments 2015

Contact Information

Duke Box 3712, Durham, NC 27710
Rm 3108 Meyer Ward, Department Of Pathology, Durham, NC 27710
joseph.geradts@duke.edu (919) 684-2452

Background
Education, Training, & Certifications
- Attending Pathologist, Pathology, State University of New York at Buffalo 2001 - 2005
- Attending Surgical Pathologist, Pathology, University of North Carolina at Chapel Hill 1992 - 1993
- Fellowship/Research, National Cancer Institute, National Institutes of Health 1990 - 1991
- Fellow, Pathology, Stanford University 1989 - 1990
- Resident, Pathology, University of California, San Francisco, School of Medicine 1987 - 1989
- M.D., University of Chicago 1987
- M.A., University of California at Berkeley 1984
Duke Appointment History
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2005 - 2015
- Professor of Pathology, Pathology, Clinical Science Departments 2006 - 2014
- Instructor, Temporary in the Department of Pathology, Pathology, Clinical Science Departments 2005
Recognition
In the News
- DEC 2, 2013 The News & Observer
  
  Duke study: Many breast cancers may be linked with cholesterol byproduct
Expertise
Global Scholarship
- Research
  - Belarus (Country)
Research
Selected Grants
- Developing a HER3 Vaccine to Prevent Resistance to Endocrine Therapy awarded by Department of Defense 2012 - 2021
- Genomic Diversity and the Microenvironment as Drivers of Progression in DCIS awarded by Department of Defense 2014 - 2020
- Oncogenic Signaling Networks awarded by Department of Defense 2012 - 2020
- A Molecular Framework for Understanding DCIS awarded by Department of Defense 2014 - 2019
- CaMKK2: a druggable target that regulates macrophage function in breast cancer awarded by Susan G. Komen Breast Cancer Foundation 2013 - 2017
- Targeting nuclear FGF receptor to improve chemotherapy response in triple-negative breast cancer awarded by Department of Defense 2013 - 2016
- Atlantic Breast and Gynecologic Clinical Validation Center awarded by National Institutes of Health 1999 - 2016
- KCNK9 Imprinting in Breast Cancer Progression and Metastasis awarded by National Institutes of Health 2011 - 2015
- Heat and Radiation Effects on Tumor Microcirculation awarded by National Institutes of Health 1985 - 2015
- Harnessing the power of light to see and treat breast cancer awarded by United States Army Medical Research and Materiel Command 2009 - 2015
- TCGA - Breast Cancer awarded by National Institutes of Health 2010 - 2015
- A Fluorescence Histology System for In Vivo Breast Tumor Margin Assessment awarded by National Institutes of Health 2011 - 2013
- Nuclear Snail-1 in the progression of Estrogen Receptor(-) invasive breast cancer awarded by National Institutes of Health 2011 - 2013
- Can Optical Spectroscopy Predict Early Treatment Response in Solid Tumors awarded by National Institutes of Health 2010 - 2012
- Somatic Genetic Changes in Early Breast Cancer awarded by National Institutes of Health 2005 - 2007
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Williams, LA, Hoadley, KA, Nichols, HB, Geradts, J, Perou, CM, Love, MI, Olshan, AF, and Troester, MA. "Differences in race, molecular and tumor characteristics among women diagnosed with invasive ductal and lobular breast carcinomas." Cancer Causes & Control : Ccc (January 8, 2019). Full Text
  - Paoletti, C, Schiavon, G, Dolce, EM, Darga, EP, Carr, TH, Geradts, J, Hoch, M, Klinowska, T, Lindemann, J, Marshall, G, Morgan, S, Patel, P, Rowlands, V, Sathiyayogan, N, Aung, K, Hamilton, E, Patel, M, Armstrong, A, Jhaveri, K, Im, S-A, Iqbal, N, Butt, F, Dive, C, Harrington, EA, Barrett, JC, Baird, R, and Hayes, DF. "Circulating Biomarkers and Resistance to Endocrine Therapy in Metastatic Breast Cancers: Correlative Results from AZD9496 Oral SERD Phase I Trial." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research (August 6, 2018). Full Text
  - Jiang, L, Zhang, X, Xiang, C, Geradts, J, Wei, Q, Liang, Y, Huang, H, and Xu, J-F. "Differential cellular localization of CELSR2 and ING4 and correlations with hormone receptor status in breast cancer." Histology and Histopathology 33, no. 8 (August 2018): 835-842. Full Text
  - Xiao, T, Li, W, Wang, X, Xu, H, Yang, J, Wu, Q, Huang, Y, Geradts, J, Jiang, P, Fei, T, Chi, D, Zang, C, Liao, Q, Rennhack, J, Andrechek, E, Li, N, Detre, S, Dowsett, M, Jeselsohn, RM, Liu, XS, and Brown, M. "Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy." Proceedings of the National Academy of Sciences of the United States of America 115, no. 31 (July 9, 2018): 7869-7878. Full Text
  - Evans, MK, Brown, MC, Geradts, J, Bao, X, Robinson, TJ, Jolly, MK, Vermeulen, PB, Palmer, GM, Gromeier, M, Levine, H, Morse, MA, Van Laere, SJ, and Devi, GR. "XIAP Regulation by MNK Links MAPK and NFκB Signaling to Determine an Aggressive Breast Cancer Phenotype." Cancer Research 78, no. 7 (April 2018): 1726-1738. Full Text
  - Allott, EH, Geradts, J, Cohen, SM, Khoury, T, Zirpoli, GR, Bshara, W, Davis, W, Omilian, A, Nair, P, Ondracek, RP, Cheng, T-YD, Miller, CR, Hwang, H, Thorne, LB, O'Connor, S, Bethea, TN, Bell, ME, Hu, Z, Li, Y, Kirk, EL, Sun, X, Ruiz-Narvaez, EA, Perou, CM, Palmer, JR, Olshan, AF, Ambrosone, CB, and Troester, MA. "Frequency of breast cancer subtypes among African American women in the AMBER consortium." Breast Cancer Research : Bcr 20, no. 1 (February 6, 2018): 12-null. Full Text
  - Troester, MA, Sun, X, Allott, EH, Geradts, J, Cohen, SM, Tse, C-K, Kirk, EL, Thorne, LB, Mathews, M, Li, Y, Hu, Z, Robinson, WR, Hoadley, KA, Olopade, OI, Reeder-Hayes, KE, Earp, HS, Olshan, AF, Carey, LA, and Perou, CM. "Racial Differences in PAM50 Subtypes in the Carolina Breast Cancer Study." Journal of the National Cancer Institute 110, no. 2 (February 2018). Full Text
  - Butler, EN, Bensen, JT, Chen, M, Conway, K, Richardson, DB, Sun, X, Geradts, J, Olshan, AF, and Troester, MA. "Prediagnostic Smoking Is Associated with Binary and Quantitative Measures of ER Protein and ESR1 mRNA Expression in Breast Tumors." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 27, no. 1 (January 2018): 67-74. Full Text
  - Couture, HD, Williams, LA, Geradts, J, Nyante, SJ, Butler, EN, Marron, JS, Perou, CM, Troester, MA, and Niethammer, M. "Image analysis with deep learning to predict breast cancer grade, ER status, histologic subtype, and intrinsic subtype." Npj Breast Cancer 4 (January 2018): 30-null. Full Text
  - Williams, LA, Butler, EN, Sun, X, Allott, EH, Cohen, SM, Fuller, AM, Hoadley, KA, Perou, CM, Geradts, J, Olshan, AF, and Troester, MA. "TP53 protein levels, RNA-based pathway assessment, and race among invasive breast cancer cases." Npj Breast Cancer 4 (January 2018): 13-null. Full Text
  - Williams, LA, Nichols, HB, Hoadley, KA, Tse, CK, Geradts, J, Bell, ME, Perou, CM, Love, MI, Olshan, AF, and Troester, MA. "Reproductive risk factor associations with lobular and ductal carcinoma in the Carolina Breast Cancer Study." Cancer causes & control : CCC 29, no. 1 (January 2018): 25-32. Full Text
  - Khoury, T, Zirpoli, G, Cohen, SM, Geradts, J, Omilian, A, Davis, W, Bshara, W, Miller, R, Mathews, MM, Troester, M, Palmer, JR, and Ambrosone, CB. "Ki-67 Expression in Breast Cancer Tissue Microarrays: Assessing Tumor Heterogeneity, Concordance With Full Section, and Scoring Methods." American Journal of Clinical Pathology 148, no. 2 (August 2017): 108-118. Full Text
  - Sood, AK, Geradts, J, and Young, J. "Prostate-derived Ets factor, an oncogenic driver in breast cancer." Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine 39, no. 5 (May 2017): 1010428317691688-null. (Review) Full Text
  - Alfaqih, MA, Nelson, ER, Liu, W, Safi, R, Jasper, JS, Macias, E, Geradts, J, Thompson, JW, Dubois, LG, Freeman, MR, Chang, C-Y, Chi, J-T, McDonnell, DP, and Freedland, SJ. "CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer." Cancer Research 77, no. 7 (April 2017): 1662-1673. Full Text
  - Nichols, BS, Llopis, A, Palmer, GM, McCachren, SS, Senlik, O, Miller, D, Brooke, MA, Jokerst, NM, Geradts, J, Greenup, R, and Ramanujam, N. "Miniature spectral imaging device for wide-field quantitative functional imaging of the morphological landscape of breast tumor margins." Journal of Biomedical Optics 22, no. 2 (February 2017): 26007-null. Full Text
  - Mueller, JL, Gallagher, JE, Chitalia, R, Krieger, M, Erkanli, A, Willett, RM, Geradts, J, and Ramanujam, N. "Rapid staining and imaging of subnuclear features to differentiate between malignant and benign breast tissues at a point-of-care setting." Journal of Cancer Research and Clinical Oncology 142, no. 7 (July 2016): 1475-1486. Full Text
  - Taylor, NJ, Nikolaishvili-Feinberg, N, Midkiff, BR, Conway, K, Millikan, RC, and Geradts, J. "Rational Manual and Automated Scoring Thresholds for the Immunohistochemical Detection of TP53 Missense Mutations in Human Breast Carcinomas." Applied Immunohistochemistry & Molecular Morphology : Aimm 24, no. 6 (July 2016): 398-404. Full Text
  - Allott, EH, Geradts, J, Sun, X, Cohen, SM, Zirpoli, GR, Khoury, T, Bshara, W, Chen, M, Sherman, ME, Palmer, JR, Ambrosone, CB, Olshan, AF, and Troester, MA. "Intratumoral heterogeneity as a source of discordance in breast cancer biomarker classification." Breast Cancer Research : Bcr 18, no. 1 (June 28, 2016): 68-null. Full Text
  - Geradts, J, Groth, J, Wu, Y, and Jin, G. "Validation of an oligo-gene signature for the prognostic stratification of ductal carcinoma in situ (DCIS)." Breast Cancer Research and Treatment 157, no. 3 (June 2016): 447-459. Full Text
  - Kennedy, S, Caldwell, M, Bydlon, T, Mulvey, C, Mueller, J, Wilke, L, Barry, W, Ramanujam, N, and Geradts, J. "Correlation of breast tissue histology and optical signatures to improve margin assessment techniques." Journal of Biomedical Optics 21, no. 6 (June 2016): 66014-null. Full Text
  - Allott, EH, Cohen, SM, Geradts, J, Sun, X, Khoury, T, Bshara, W, Zirpoli, GR, Miller, CR, Hwang, H, Thorne, LB, O'Connor, S, Tse, C-K, Bell, MB, Hu, Z, Li, Y, Kirk, EL, Bethea, TN, Perou, CM, Palmer, JR, Ambrosone, CB, Olshan, AF, and Troester, MA. "Performance of Three-Biomarker Immunohistochemistry for Intrinsic Breast Cancer Subtyping in the AMBER Consortium." Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 25, no. 3 (March 2016): 470-478. Full Text
  - Canfield, K, Wells, W, Geradts, J, Kinlaw, WB, Cheng, C, and Kurokawa, M. "Inverse association between MDM2 and HUWE1 protein expression levels in human breast cancer and liposarcoma." International journal of clinical and experimental pathology 9, no. 6 (January 2016): 6342-6349.
  - Horton, JK, Siamakpour-Reihani, S, Lee, C-T, Zhou, Y, Chen, W, Geradts, J, Fels, DR, Hoang, P, Ashcraft, KA, Groth, J, Kung, H-N, Dewhirst, MW, and Chi, J-TA. "FAS Death Receptor: A Breast Cancer Subtype-Specific Radiation Response Biomarker and Potential Therapeutic Target." Radiation research 184, no. 5 (November 2015): 456-469. Full Text
  - Mueller, JL, Fu, HL, Mito, JK, Whitley, MJ, Chitalia, R, Erkanli, A, Dodd, L, Cardona, DM, Geradts, J, Willett, RM, Kirsch, DG, and Ramanujam, N. "A quantitative microscopic approach to predict local recurrence based on in vivo intraoperative imaging of sarcoma tumor margins." International journal of cancer 137, no. 10 (November 2015): 2403-2412. Full Text
  - Thress, K, Leeson, J, Geradts, J, Schuler, M, Ahn, M-J, Wolf, J, Gold, KA, Yang, JC-H, Blackhall, F, Su, W-C, Jacobs, V, Smith, NR, Angell, H, Brown, K, Vishwanathan, K, Barrett, JC, Cantarini, M, and Jaenne, PA. "Design, Execution, and Preliminary Biomarker Results from Paired Tumor Biopsy Cohorts of the AZD9291 AURA Trial." JOURNAL OF THORACIC ONCOLOGY 10, no. 9 (September 2015): S320-S320. Link to Item
  - Sutton, LM, Geradts, J, Hamilton, EP, Havlin, KA, Kimmick, GG, Marcom, PK, Spector, NL, Watson, M, Rabin, DU, Bruno, TO, Noe, A, Miller, S, Subramaniam, C, Layton, S, and Grichnik, K. "CHAMBER: A Regional Performance Improvement CME Initiative for Breast Cancer Health Care Providers." Journal of the National Comprehensive Cancer Network : Jnccn 13, no. 8 (August 2015): 1005-1011. Full Text
  - Li, S, Payne, S, Wang, F, Claus, P, Su, Z, Groth, J, Geradts, J, de Ridder, G, Alvarez, R, Marcom, PK, Pizzo, SV, and Bachelder, RE. "Nuclear basic fibroblast growth factor regulates triple-negative breast cancer chemo-resistance." Breast cancer research : BCR 17 (July 4, 2015): 91-. Full Text
  - Horton, JK, Blitzblau, RC, Yoo, S, Geradts, J, Chang, Z, Baker, JA, Georgiade, GS, Chen, W, Siamakpour-Reihani, S, Wang, C, Broadwater, G, Groth, J, Palta, M, Dewhirst, M, Barry, WT, Duffy, EA, Chi, J-TA, and Hwang, ES. "Preoperative Single-Fraction Partial Breast Radiation Therapy: A Novel Phase 1, Dose-Escalation Protocol With Radiation Response Biomarkers." International journal of radiation oncology, biology, physics 92, no. 4 (July 2015): 846-855. Full Text
  - Li, S, Payne, S, Wang, F, Claus, P, Su, Z, Groth, J, Geradts, J, Ridder, GD, Alvarez, R, Marcom, PK, Pizzo, SV, and Bachelder, RE. "Nuclear basic fibroblast growth factor regulates triple-negative breast cancer chemo-resistance." Breast Cancer Research (2015). Full Text
  - Nichols, BS, Schindler, CE, Brown, JQ, Wilke, LG, Mulvey, CS, Krieger, MS, Gallagher, J, Geradts, J, Greenup, RA, Von Windheim, JA, and Ramanujam, N. "A Quantitative Diffuse Reflectance Imaging (QDRI) System for Comprehensive Surveillance of the Morphological Landscape in Breast Tumor Margins." PloS one 10, no. 6 (January 2015): e0127525-. Full Text
  - Drendall, CI, Barry, W, Ramos, C, Tolbert, N, Geradts, J, Petricoin, E, and Seewaldt, V. "Abstract C16: Feasibility study: Protein profiling of primary breast cancers from premenopausal women." Cancer Epidemiology Biomarkers & Prevention 23, no. 11 Supplement (November 2014): C16-C16. Full Text
  - Conway, K, Edmiston, SN, May, R, Kuan, PF, Chu, H, Bryant, C, Tse, C-K, Swift-Scanlan, T, Geradts, J, Troester, MA, and Millikan, RC. "DNA methylation profiling in the Carolina Breast Cancer Study defines cancer subclasses differing in clinicopathologic characteristics and survival." Breast Cancer Research : Bcr 16, no. 5 (October 7, 2014): 450-null. Full Text
  - Horton, JK, Dewhirst, MW, Siamakpour-Reihani, S, Zhou, Y, Geradts, J, Chi, J-TA, and Chen, W. "Changes in Gene Expression After Radiation in Human Breast Cancers: A Guide to Predicting and Modulating Radiation Response." JOURNAL OF WOMENS HEALTH 23, no. 10 (October 1, 2014): 861-861. Link to Item
  - Cheng, Q, Chang, JT, Gwin, WR, Zhu, J, Ambs, S, Geradts, J, and Lyerly, HK. "A signature of epithelial-mesenchymal plasticity and stromal activation in primary tumor modulates late recurrence in breast cancer independent of disease subtype." Breast Cancer Research : Bcr 16, no. 4 (July 25, 2014): 407-null. Full Text
  - Hamilton, E, Blackwell, K, Geradts, J, Ewend, M, Carey, L, Shusta, EV, Anders, CK, and Cryns, VL. "αb-crystallin: A novel regulator of breast cancer metastasis to the Brain." Clinical Cancer Research 20, no. 1 (January 1, 2014): 1-12. Full Text
  - Malin, D, Strekalova, E, Petrovic, V, Deal, AM, Ahmad, AA, Adamo, B, Miller, CR, Ugolkov, A, Livasy, C, Fritchie, K, Hamilton, E, Blackwell, K, Geradts, J, Ewend, M, Carey, L, Shusta, EV, Anders, CK, and Cryns, VL. "αB-crystallin: a novel regulator of breast cancer metastasis to the brain." Clinical cancer research : an official journal of the American Association for Cancer Research 20, no. 1 (2014): 56-67. Full Text
  - Malin, D, Strekalova, E, Petrovic, V, Deal, AM, Al Ahmad, A, Adamo, B, Miller, CR, Ugolkov, A, Livasy, C, Fritchie, K, Hamilton, E, Blackwell, K, Geradts, J, Ewend, M, Carey, L, Shusta, EV, Anders, CK, and Cryns, VL. "αB-crystallin: a novel regulator of breast cancer metastasis to the brain." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 20, no. 1 (January 2014): 56-67. Full Text
  - Nelson, ER, Wardell, SE, Jasper, JS, Park, S, Suchindran, S, Howe, MK, Carver, NJ, Pillai, RV, Sullivan, PM, Sondhi, V, Umetani, M, Geradts, J, and McDonnell, DP. "27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology." Science (New York, N.Y.) 342, no. 6162 (November 2013): 1094-1098. Full Text
  - Horton, JK, Chi, J-TA, Groth, J, Zhou, Y, Lee, C-T, and Geradts, J. "Up-regulation of Fas Expression in Human Breast Carcinomas Treated With Preoperative Radiation." JOURNAL OF WOMENS HEALTH 22, no. 10 (October 1, 2013): 890-890. Link to Item
  - Kurokawa, M, Kim, J, Geradts, J, Matsuura, K, Liu, L, Ran, X, Xia, W, Ribar, TJ, Henao, R, Dewhirst, MW, Kim, W-J, Lucas, JE, Wang, S, Spector, NL, and Kornbluth, S. "A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53." Science Signaling 6, no. 274 (May 7, 2013): ra32-null. Full Text Open Access Copy
  - Lyman, GH, Baker, J, Geradts, J, Horton, J, Kimmick, G, Peppercorn, J, Pruitt, S, Scheri, RP, and Hwang, ES. "Multidisciplinary care of patients with early-stage breast cancer." Surg Oncol Clin N Am 22, no. 2 (April 2013): 299-317. (Review) Full Text Link to Item
  - Mueller, JL, Harmany, ZT, Mito, JK, Kennedy, SA, Kim, Y, Dodd, L, Geradts, J, Kirsch, DG, Willett, RM, Brown, JQ, and Ramanujam, N. "Quantitative segmentation of fluorescence microscopy images of heterogeneous tissue: Approach for tuning algorithm parameters." Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues Xi (February 22, 2013). Full Text
  - Brown, JQ, Bydlon, TM, Kennedy, SA, Caldwell, ML, Gallagher, JE, Junker, M, Wilke, LG, Barry, WT, Geradts, J, and Ramanujam, N. "Optical spectral surveillance of breast tissue landscapes for detection of residual disease in breast tumor margins. (Published online)" PLoS One 8, no. 7 (2013): e69906-. Full Text Link to Item
  - Mueller, JL, Harmany, ZT, Mito, JK, Kennedy, SA, Kim, Y, Dodd, L, Geradts, J, Kirsch, DG, Willett, RM, Brown, JQ, and Ramanujam, N. "Quantitative Segmentation of Fluorescence Microscopy Images of Heterogeneous Tissue: Application to the Detection of Residual Disease in Tumor Margins. (Published online)" PLoS One 8, no. 6 (2013): e66198-. Full Text Link to Item
  - "Optical spectral imaging for breast margin assessment: A comprehensive assessment of sources of contrast." Biomedical Optics, Biomed 2012 (December 1, 2012).
  - Liao, S, Desouki, MM, Gaile, DP, Shepherd, L, Nowak, NJ, Conroy, J, Barry, WT, and Geradts, J. "Differential copy number aberrations in novel candidate genes associated with progression from in situ to invasive ductal carcinoma of the breast." Genes Chromosomes Cancer 51, no. 12 (December 2012): 1067-1078. Full Text Link to Item
  - Geradts, J, de Herreros, AG, Su, Z, Burchette, J, Broadwater, G, and Bachelder, RE. "Erratum to: Nuclear Snail1 and nuclear ZEB1 protein expression in invasive and intraductal human breast carcinomas [Human Pathology 2011;42:1125–1131]." Human Pathology 43, no. 10 (October 2012): 1787-1787. Full Text
  - Sood, AK, Kim, H, and Geradts, J. "PDEF in prostate cancer." The Prostate 72, no. 6 (May 2012): 592-596. (Review) Full Text
  - Cheng, Q, Chang, JT, Geradts, J, Neckers, LM, Haystead, T, Spector, NL, and Lyerly, HK. "Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer. (Published online)" Breast Cancer Res 14, no. 2 (April 17, 2012): R62-. Full Text Link to Item
  - Bydlon, TM, Barry, WT, Kennedy, SA, Brown, JQ, Gallagher, JE, Wilke, LG, Geradts, J, and Ramanujam, N. "Advancing optical imaging for breast margin assessment: an analysis of excisional time, cautery, and patent blue dye on underlying sources of contrast." Plos One 7, no. 12 (January 2012): e51418-null. Full Text
  - Cao, X, Geradts, J, Dewhirst, MW, and Lo, H-W. "Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells." Oncogene 31, no. 1 (January 2012): 104-115. Full Text
  - Sekijima, Y, Uchiyama, S, Tojo, K, Sano, K, Shimizu, Y, Imaeda, T, Hoshii, Y, Kato, H, and Ikeda, S-I. "High prevalence of wild-type transthyretin deposition in patients with idiopathic carpal tunnel syndrome: a common cause of carpal tunnel syndrome in the elderly." Human Pathology 42, no. 11 (November 2011): 1785-1791. Full Text
  - West, D, Geradts, J, Wahidi, M, and Roggli, V. "Endobronchial metastatic breast cancer with pagetoid histology mimicking bronchial pagetoid squamous cell carcinoma in situ." Hum Pathol 42, no. 11 (November 2011): 1819-1822. Full Text Link to Item
  - Geradts, J, de Herreros, AG, Su, Z, Burchette, J, Broadwater, G, and Bachelder, RE. "Nuclear Snail1 and nuclear ZEB1 protein expression in invasive and intraductal human breast carcinomas." Hum Pathol 42, no. 8 (August 2011): 1125-1131. Full Text Link to Item
  - Hutchinson, CB, and Geradts, J. "Histiocytoid carcinoma of the male breast." Ann Diagn Pathol 15, no. 3 (June 2011): 190-193. Full Text Link to Item
  - Desouki, MM, Liao, S, Conroy, J, Nowak, NJ, Shepherd, L, Gaile, DP, and Geradts, J. "The genomic relationship between primary breast carcinomas and their nodal metastases." Cancer Investigation 29, no. 4 (May 2011): 300-307. Full Text
  - Desouki, MM, Liao, S, Huang, H, Conroy, J, Nowak, NJ, Shepherd, L, Gaile, DP, and Geradts, J. "Identification of metastasis-associated breast cancer genes using a high-resolution whole genome profiling approach." J Cancer Res Clin Oncol 137, no. 5 (May 2011): 795-809. Full Text Link to Item
  - Pilie, PG, Ibarra-Drendall, C, Troch, MM, Broadwater, G, Barry, WT, Petricoin, EF, Wulfkuhle, JD, Liotta, LA, Lem, S, Baker, JC, Stouder, A, Ford, AC, Wilke, LG, Zalles, CM, Mehta, P, Williams, J, Shivraj, M, Su, Z, Geradts, J, Yu, D, and Seewaldt, VL. "Protein microarray analysis of mammary epithelial cells from obese and nonobese women at high risk for breast cancer: feasibility data." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 20, no. 3 (March 2011): 476-482. Full Text
  - Adamo, B, Deal, AM, Burrows, E, Geradts, J, Hamilton, E, Blackwell, KL, Livasy, C, Fritchie, K, Prat, A, Harrell, JC, Ewend, MG, Carey, LA, Miller, CR, and Anders, CK. "Phosphatidylinositol 3-kinase pathway activation in breast cancer brain metastases." Breast Cancer Research : Bcr 13, no. 6 (January 2011): R125-null. Full Text
  - O'Brien, KM, Cole, SR, Tse, C-K, Perou, CM, Carey, LA, Foulkes, WD, Dressler, LG, Geradts, J, and Millikan, RC. "Intrinsic breast tumor subtypes, race, and long-term survival in the Carolina Breast Cancer Study." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 16, no. 24 (December 2010): 6100-6110. Full Text
  - Geradts, J, Bean, SM, Bentley, RC, and Barry, WT. "The oncotype DX recurrence score is correlated with a composite index including routinely reported pathobiologic features." Cancer Invest 28, no. 9 (November 2010): 969-977. Full Text Link to Item
  - Barry, WT, Kernagis, DN, Dressman, HK, Griffis, RJ, Hunter, JD, Olson, JA, Marks, JR, Ginsburg, GS, Marcom, PK, Nevins, JR, Geradts, J, and Datto, MB. "Intratumor heterogeneity and precision of microarray-based predictors of breast cancer biology and clinical outcome." Journal of Clinical Oncology 28, no. 13 (May 2010): 2198-2206. Full Text
  - Bydlon, TM, Kennedy, SA, Richards, LM, Brown, JQ, Yu, B, Junker, MK, Gallagher, J, Geradts, J, Wilke, LG, and Ramanujam, N. "Performance metrics of an optical spectral imaging system for intra-operative assessment of breast tumor margins." Optics Express 18, no. 8 (April 2010): 8058-8076. Full Text
  - Brown, JQ, Bydlon, TM, Richards, LM, Yu, B, Kennedy, SA, Geradts, J, Wilke, LG, Junker, M, Gallagher, J, Barry, W, and Ramanujam, N. "Optical assessment of tumor resection margins in the breast." Ieee Journal of Selected Topics in Quantum Electronics : a Publication of the Ieee Lasers and Electro Optics Society 16, no. 3 (March 2010): 530-544. Full Text
  - Brown, JQ, Bydlon, TM, Kennedy, SA, Geradts, J, Wilke, LG, Barry, W, Richards, LM, Junker, MK, Gallagher, J, and Ramanujam, N. "Assessment of breast tumor margins via quantitative diffuse reflectance imaging." Biomedical Applications of Light Scattering Iv (February 11, 2010). Full Text
  - Kennedy, S, Geradts, J, Bydlon, T, Brown, JQ, Gallagher, J, Junker, M, Barry, W, Ramanujam, N, and Wilke, L. "Optical breast cancer margin assessment: an observational study of the effects of tissue heterogeneity on optical contrast." Breast Cancer Res 12, no. 6 (2010): R91-. Full Text Link to Item
  - Ramanujam, N, Brown, J, Bydlon, TM, Kennedy, SA, Richards, LM, Junker, MK, Gallagher, J, Barry, WT, Wilke, LG, and Geradts, J. "Quantitative spectral reflectance imaging device for intraoperative breast tumor margin assessment." Conference proceedings : .. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference (December 1, 2009): 6554-6556.
  - Wilke, LG, Brown, JQ, Bydlon, TM, Kennedy, SA, Richards, LM, Junker, MK, Gallagher, J, Barry, WT, Geradts, J, and Ramanujam, N. "Rapid noninvasive optical imaging of tissue composition in breast tumor margins." American Journal of Surgery 198, no. 4 (October 2009): 566-574. Full Text
  - Sood, AK, Wang, J, Mhawech-Fauceglia, P, Jana, B, Liang, P, and Geradts, J. "Sam-pointed domain containing Ets transcription factor in luminal breast cancer pathogenesis." Cancer Epidemiol Biomarkers Prev 18, no. 6 (June 2009): 1899-1903. Full Text Link to Item
  - Geradts, J. "Re: KAI1/CD82 is a novel target of estrogen receptor-mediated gene repression and downregulated in primary human breast cancer (Int J Cancer 123: 2239-2246, 2008)." Int J Cancer 124, no. 9 (May 1, 2009): 2243-2244. (Letter) Full Text Link to Item
  - Sood, A, Wang, J, Janarthanan, B, Liang, P, Kim, H, and Geradts, J. "Prostate derived Ets factor (PDEF), an emerging biomarker in cancer." CANCER RESEARCH 69 (May 1, 2009). Link to Item
  - Brown, JQ, Wilke, LG, Geradts, J, Kennedy, SA, Palmer, GM, and Ramanujam, N. "Quantitative optical spectroscopy: a robust tool for direct measurement of breast cancer vascular oxygenation and total hemoglobin content in vivo." Cancer Research 69, no. 7 (April 2009): 2919-2926. Full Text
  - Harvey, S, Kohga, S, Sait, SNJ, Markus, G, Hurd, TC, Martinick, M, Geradts, J, Saxena, R, and Gibbs, JF. "Co-expression of urokinase with haptoglobin in human carcinomas." J Surg Res 152, no. 2 (April 2009): 189-197. Full Text Link to Item
  - Ramanujam, N, Brown, J, Bydlon, TM, Kennedy, SA, Richards, LM, Junker, MK, Gallagher, J, Barry, WT, Wilke, LG, and Geradts, J. "Quantitative spectral reflectance imaging device for intraoperative breast tumor margin assessment." Conf Proc IEEE Eng Med Biol Soc 2009 (2009): 6554-6556. Full Text Link to Item
  - Ramanujam, N, Brown, J, Bydlon, TM, Kennedy, SA, Richards, LM, Junker, MK, Gallagher, J, Barry, WT, Wilke, LG, and Geradts, J. "Quantitative spectral reflectance imaging device for intraoperative breast tumor margin assessment." Conference proceedings : .. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2009 (2009): 6554-6556. Full Text
  - Millikan, RC, Newman, B, Tse, C-K, Moorman, PG, Conway, K, Dressler, LG, Smith, LV, Labbok, MH, Geradts, J, Bensen, JT, Jackson, S, Nyante, S, Livasy, C, Carey, L, Earp, HS, and Perou, CM. "Epidemiology of basal-like breast cancer." Breast Cancer Res Treat 109, no. 1 (May 2008): 123-139. Full Text Link to Item
  - Millikan, RC, Newman, B, Tse, C-K, Moorman, PG, Conway, K, Dressler, LG, Smith, LV, Labbok, MH, Geradts, J, Bensen, JT, Jackson, S, Nyante, S, Livasy, C, Carey, L, Earp, HS, and Perou, CM. "Epidemiology of basal-like breast cancer." Breast Cancer Research and Treatment 109, no. 1 (May 2008): 141-141. Full Text
  - Sood, AK, Saxena, R, Groth, J, Desouki, MM, Cheewakriangkrai, C, Rodabaugh, KJ, Kasyapa, CS, and Geradts, J. "Expression characteristics of prostate-derived Ets factor support a role in breast and prostate cancer progression." Human Pathology 38, no. 11 (November 2007): 1628-1638. Full Text
  - Huang, H, Sossey-Alaoui, K, Beachy, SH, and Geradts, J. "The tetraspanin superfamily member NET-6 is a new tumor suppressor gene." Journal of Cancer Research and Clinical Oncology 133, no. 10 (October 2007): 761-769. Full Text
  - Heller, G, Geradts, J, Ziegler, B, Newsham, I, Filipits, M, Markis-Ritzinger, E-M, Kandioler, D, Berger, W, Stiglbauer, W, Depisch, D, Pirker, R, Zielinski, CC, and Zöchbauer-Müller, S. "Downregulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer." Breast Cancer Research and Treatment 103, no. 3 (July 2007): 283-291. Full Text
  - Desouki, MM, Geradts, J, Milon, B, Franklin, RB, and Costello, LC. "hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands." Molecular Cancer 6 (June 5, 2007): 37-null. Full Text
  - "Corrigendum." Journal of Gastroenterology and Hepatology 22, no. 1 (January 2007): 145-145. Full Text
  - Javle, MM, Yu, J, Khoury, T, Chadha, KS, Iyer, RV, Foster, J, Kuvshinoff, BW, Gibbs, JF, Geradts, J, Black, JD, and Brattain, MG. "Akt expression may predict favorable prognosis in cholangiocarcinoma." Journal of Gastroenterology and Hepatology 21, no. 11 (November 2006): 1744-1751. Full Text
  - Yang, J, Ramnath, N, Moysich, KB, Asch, HL, Swede, H, Alrawi, SJ, Huberman, J, Geradts, J, Brooks, JSJ, and Tan, D. "Prognostic significance of MCM2, Ki-67 and gelsolin in non-small cell lung cancer." Bmc Cancer 6 (August 2006): 203-null. Full Text
  - Carey, LA, Perou, CM, Livasy, CA, Dressler, LG, Cowan, D, Conway, K, Karaca, G, Troester, MA, Tse, CK, Edmiston, S, Deming, SL, Geradts, J, Cheang, MCU, Nielsen, TO, Moorman, PG, Earp, HS, and Millikan, RC. "Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study." Jama 295, no. 21 (June 7, 2006): 2492-2502. Full Text Link to Item
  - Watwe, V, Javle, M, Lawrence, D, Groth, J, Iyer, R, El-Hajjar, D, and Geradts, J. "Cyclooxygenase-2 (COX-2) levels before and after chemotherapy: a study in rectal cancer." American Journal of Clinical Oncology 28, no. 6 (December 2005): 560-564. Full Text
  - Bush, E, Geradts, J, and O'Connor, T. "An unusual cause of cholecystitis?." Am J Clin Oncol 28, no. 5 (October 2005): 529-530. Link to Item
  - Lark, AL, Livasy, CA, Dressler, L, Moore, DT, Millikan, RC, Geradts, J, Iacocca, M, Cowan, D, Little, D, Craven, RJ, and Cance, W. "High focal adhesion kinase expression in invasive breast carcinomas is associated with an aggressive phenotype." Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc 18, no. 10 (October 2005): 1289-1294. Full Text
  - Varma, G, Varma, R, Huang, H, Pryshchepava, A, Groth, J, Fleming, D, Nowak, NJ, McQuaid, D, Conroy, J, Mahoney, M, Moysich, K, Falkner, KL, and Geradts, J. "Array comparative genomic hybridisation (aCGH) analysis of premenopausal breast cancers from a nuclear fallout area and matched cases from Western New York." Br J Cancer 93, no. 6 (September 19, 2005): 699-708. Full Text Link to Item
  - Zöchbauer-Müller, S, Fong, KM, Geradts, J, Xu, X, Seidl, S, End-Pfützenreuter, A, Lang, G, Heller, G, Zielinski, CC, Gazdar, AF, and Minna, JD. "Expression of the candidate tumor suppressor gene hSRBC is frequently lost in primary lung cancers with and without DNA methylation." Oncogene 24, no. 41 (September 2005): 6249-6255. Full Text
  - Singh, KK, Kulawiec, M, Still, I, Desouki, MM, Geradts, J, and Matsui, S-I. "Inter-genomic cross talk between mitochondria and the nucleus plays an important role in tumorigenesis." Gene 354 (July 18, 2005): 140-146. Full Text Link to Item
  - Huang, H, Groth, J, Sossey-Alaoui, K, Hawthorn, L, Beall, S, and Geradts, J. "Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 11, no. 12 (June 2005): 4357-4364. Full Text
  - Geradts, J. "Molecular prediction of recurrence of breast cancer." N Engl J Med 352, no. 15 (April 14, 2005): 1605-1607. (Letter) Full Text Link to Item
  - Conway, K, Parrish, E, Edmiston, SN, Tolbert, D, Tse, C-K, Geradts, J, Livasy, CA, Singh, H, Newman, B, and Millikan, RC. "The estrogen receptor-alpha A908G (K303R) mutation occurs at a low frequency in invasive breast tumors: results from a population-based study." Breast Cancer Res 7, no. 6 (2005): R871-R880. Full Text Link to Item
  - Geradts, J, III, WHG, Tang, CG, Lin, AY, Tanvetyanon, T, Paik, S, Wolmark, N, Shak, S, Jr, RCB, and Hortobagyi, GN. "Molecular prediction of recurrence of breast cancer [2] (multiple letters)." New England Journal of Medicine 352, no. 15 (2005): 1605-1607. Full Text
  - Watwe, V, Javle, M, Lawrence, D, Groth, J, Iyer, R, El-Hajjar, D, and Geradts, J. "Cyclooxyqenase-2 (COX-2) levels before and after chemotherapy: A study in rectal cancer." American Journal of Clinical Oncology: Cancer Clinical Trials 28, no. 6 (2005): 560-564. Full Text
  - Yang, J, Tan, D, Asch, HL, Swede, H, Bepler, G, Geradts, J, and Moysich, KB. "Prognostic significance of gelsolin expression level and variability in non-small cell lung cancer." Lung Cancer 46, no. 1 (October 2004): 29-42. Full Text Link to Item
  - Wilkinson, NW, Black, JD, Roukhadze, E, Driscoll, D, Smiley, S, Hoshi, H, Geradts, J, Javle, M, and Brattain, M. "Epidermal growth factor receptor expression correlates with histologic grade in resected esophageal adenocarcinoma." Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract 8, no. 4 (May 2004): 448-453. Full Text
  - Winston, JS, Geradts, J, Liu, DF, and Stomper, PC. "Microtome shaving radiography: demonstration of loss of mammographic microcalcifications during histologic sectioning." Breast J 10, no. 3 (May 2004): 200-203. Full Text Link to Item
  - Hawthorne, LA, House, MG, and Yeo, CJ. "Global Expression Analysis of Well-Differentiated Pancreatic Endocrine Neoplasms Using Oligonucleotide Microarrays." Clinical Cancer Research 9, no. 16 I (December 1, 2003): 5988-5995.
  - Maitra, A, Hansel, DE, Argani, P, Ashfaq, R, Rahman, A, Naji, A, Deng, S, Geradts, J, Hawthorne, L, House, MG, and Yeo, CJ. "Global expression analysis of well-differentiated pancreatic endocrine neoplasms using oligonucleotide microarrays." Clin Cancer Res 9, no. 16 Pt 1 (December 1, 2003): 5988-5995. Link to Item
  - Rosty, C, Geradts, J, Sato, N, Wilentz, RE, Roberts, H, Sohn, T, Cameron, JL, Yeo, CJ, Hruban, RH, and Goggins, M. "p16 Inactivation in pancreatic intraepithelial neoplasias (PanINs) arising in patients with chronic pancreatitis." The American Journal of Surgical Pathology 27, no. 12 (December 2003): 1495-1501. Full Text
  - Stomper, PC, Geradts, J, Edge, SB, and Levine, EG. "Mammographic predictors of the presence and size of invasive carcinomas associated with malignant microcalcification lesions without a mass." Ajr. American Journal of Roentgenology 181, no. 6 (December 2003): 1679-1684. Full Text
  - Furberg, H, Millikan, RC, Geradts, J, Gammon, MD, Dressler, LG, Ambrosone, CB, and Newman, B. "Reproductive factors in relation to breast cancer characterized by p53 protein expression (United States)." Cancer Causes Control 14, no. 7 (September 2003): 609-618. Link to Item
  - Hansel, DE, Rahman, A, Hidalgo, M, Thuluvath, PJ, Lillemoe, KD, Schulick, R, Ku, J-L, Park, J-G, Miyazaki, K, Ashfaq, R, Wistuba, II, Varma, R, Hawthorne, L, Geradts, J, Argani, P, and Maitra, A. "Identification of novel cellular targets in biliary tract cancers using global gene expression technology." The American Journal of Pathology 163, no. 1 (July 2003): 217-229. Full Text
  - Millikan, R, Eaton, A, Worley, K, Biscocho, L, Hodgson, E, Huang, W-Y, Geradts, J, Iacocca, M, Cowan, D, Conway, K, and Dressler, L. "HER2 codon 655 polymorphism and risk of breast cancer in African Americans and whites." Breast Cancer Research and Treatment 79, no. 3 (June 2003): 355-364. Full Text
  - Parwani, AV, Geradts, J, Caspers, E, Offerhaus, GJ, Yeo, CJ, Cameron, JL, Klimstra, DS, Maitra, A, Hruban, RH, and Argani, P. "Immunohistochemical and genetic analysis of non-small cell and small cell gallbladder carcinoma and their precursor lesions." Mod Pathol 16, no. 4 (April 2003): 299-308. Full Text Link to Item
  - Bhagat, V, Javle, M, and Geradts, J. "Carcinoma of the esophagus with mixed basaloid squamous and glandular differentiation: a distinct histological presentation." Int J Gastrointest Cancer 34, no. 2-3 (2003): 139-142. Full Text Link to Item
  - Geradts, J. "Abrogation of the RB-p16 tumor suppressor pathway in human lung cancer." Methods Mol Med 74 (2003): 89-99. Link to Item
  - Vo, QN, Geradts, J, Boudreau, DA, Bravo, JC, and Schneider, BG. "CDKN2A promoter methylation in gastric adenocarcinomas: clinical variables." Hum Pathol 33, no. 12 (December 2002): 1200-1204. Full Text Link to Item
  - Vestey, S, and Winters, Z. "Correspondence re: Geradts J, Wilentz RE, Roberts H. Immunohistochemical detection of the alternate ink4a-encoded tumor suppressor protein p14(arf) in archival human cancers and cell lines using commercial antibodies: correlation with p16(ink4a) expression. Mod pathol 2001;14:1162-68." Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc 15, no. 10 (October 2002): 1106-null. (Letter) Full Text
  - Wilson, KS, Roberts, H, Leek, R, Harris, AL, and Geradts, J. "Differential gene expression patterns in HER2/neu-positive and -negative breast cancer cell lines and tissues." The American Journal of Pathology 161, no. 4 (October 2002): 1171-1185. Full Text
  - Furberg, H, Millikan, RC, Geradts, J, Gammon, MD, Dressler, LG, Ambrosone, CB, and Newman, B. "Environmental factors in relation to breast cancer characterized by p53 protein expression." Cancer Epidemiol Biomarkers Prev 11, no. 9 (September 2002): 829-835. Link to Item
  - Vo, QN, Geradts, J, Gulley, ML, Boudreau, DA, Bravo, JC, and Schneider, BG. "Epstein-Barr virus in gastric adenocarcinomas: association with ethnicity and CDKN2A promoter methylation." J Clin Pathol 55, no. 9 (September 2002): 669-675. Link to Item
  - Conway, K, Edmiston, SN, Cui, L, Drouin, SS, Pang, J, He, M, Tse, C-K, Geradts, J, Dressler, L, Liu, ET, Millikan, R, and Newman, B. "Prevalence and spectrum of p53 mutations associated with smoking in breast cancer." Cancer Res 62, no. 7 (April 1, 2002): 1987-1995. Link to Item
  - "Erratum: Immunohistochemical detection of the alternate INK4a-encoded tumor suppressor protein p14ARF in archival human cancers and cell lines using commercial antibodies: Correlation with p16INK4a expression (Modern pathology (2001) 14:11 (1162-1168))." Modern Pathology 15, no. 1 (January 1, 2002): 76-null.
  - Boecker, W, Buerger, H, Schmitz, K, Ellis, IA, van Diest, PJ, Sinn, HP, Geradts, J, Diallo, R, Poremba, C, and Herbst, H. "Ductal epithelial proliferations of the breast: a biological continuum? Comparative genomic hybridization and high-molecular-weight cytokeratin expression patterns." J Pathol 195, no. 4 (November 2001): 415-421. Full Text Link to Item
  - Geradts, J, Wilentz, RE, and Roberts, H. "Immunohistochemical [corrected] detection of the alternate INK4a-encoded tumor suppressor protein p14(ARF) in archival human cancers and cell lines using commercial antibodies: correlation with p16(INK4a) expression." Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc 14, no. 11 (November 2001): 1162-1168. Full Text
  - Maitra, A, Roberts, H, Weinberg, AG, and Geradts, J. "Aberrant expression of tumor suppressor proteins in the Ewing family of tumors." Archives of Pathology & Laboratory Medicine 125, no. 9 (September 2001): 1207-1212. Full Text
  - Furberg, H, Millikan, R, Dressler, L, Newman, B, and Geradts, J. "Tumor characteristics in African American and white women." Breast Cancer Res Treat 68, no. 1 (July 2001): 33-43. Link to Item
  - Zöchbauer-Müller, S, Fong, KM, Maitra, A, Lam, S, Geradts, J, Ashfaq, R, Virmani, AK, Milchgrub, S, Gazdar, AF, and Minna, JD. "5' CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer." Cancer Research 61, no. 9 (May 2001): 3581-3585.
  - "Gene amplification of HER-2/neu is inversely correlated with loss of expression of the tetraspanin metastasis suppressor gene, KAI1/CD82, in breast cancer samples and cell lines." Breast Cancer Research and Treatment 69, no. 3 (January 1, 2001): 316-null.
  - Creager, AJ, Cohen, JA, and Geradts, J. "Aberrant expression of cell-cycle regulatory proteins in human mesenchymal neoplasia." Cancer Detect Prev 25, no. 2 (2001): 123-131. Link to Item
  - Geradts, J, Wilentz, RE, and Roberts, H. "utImmunohistochemical detection of the alternate INK4a-encoded tumor suppressor protein p14^ARF in archival human cancers and cell lines using commercial antibodies: Correlation with p16^INK4a expression." Modern Pathology 14, no. 11 (2001): 1162-1168. Full Text
  - Maitra, A, Roberts, H, Weinberg, AG, and Geradts, J. "Loss of p16(INK4a) expression correlates with decreased survival in pediatric osteosarcomas." International Journal of Cancer 95, no. 1 (January 2001): 34-38. Full Text
  - Maitra, A, Roberts, H, Weinberg, AG, and Geradts, J. "Lymphatic microvessel density as a novel prognostic factor in early-stage invasive cervical cancer." International Journal of Cancer 95, no. 1 (2001): 29-33. Full Text
  - Wilson, KS. "Differential gene expression patterns in HER2/neu-positive and -negative breast cancer cells." Breast Cancer Research and Treatment 69, no. 3 (January 1, 2001): 233-null.
  - Zöchbauer-Müller, S, Fong, KM, Virmani, AK, Geradts, J, Gazdar, AF, and Minna, JD. "Aberrant promoter methylation of multiple genes in non-small cell lung cancers." Cancer Research 61, no. 1 (January 2001): 249-255.
  - A. Belchis, Christopher D. Gocke, and J, D. "ALTERATIONS IN THE RB, p16, AND CYCLIN D1 CELL CYCLE CONTROL PATHWAY IN OSTEOSARCOMAS." Pediatric Pathology & Molecular Medicine 19, no. 5 (September 1, 2000): 377-389. Full Text
  - Geradts, J, and Ingram, CD. "Abnormal expression of cell cycle regulatory proteins in ductal and lobular carcinomas of the breast." Mod Pathol 13, no. 9 (September 2000): 945-953. Full Text Link to Item
  - Wistuba, II, Tomlinson, GE, Behrens, C, Virmani, A, Geradts, J, Blum, JL, Minna, JD, and Gazdar, AF. "Two identical triplet sisters carrying a germline BRCA1 gene mutation acquire very similar breast cancer somatic mutations at multiple other sites throughout the genome." Genes, Chromosomes & Cancer 28, no. 4 (August 2000): 359-369. Full Text
  - Schmitz, MJ, Hendricks, DT, Farley, J, Taylor, RR, Geradts, J, Rose, GS, and Birrer, MJ. "p27 and cyclin D1 abnormalities in uterine papillary serous carcinoma." Gynecol Oncol 77, no. 3 (June 2000): 439-445. Full Text Link to Item
  - Geradts, J, Fong, KM, Zimmerman, PV, and Minna, JD. "Loss of Fhit expression in non-small-cell lung cancer: correlation with molecular genetic abnormalities and clinicopathological features." British Journal of Cancer 82, no. 6 (March 2000): 1191-1197. Full Text
  - Geradts, J, Hruban, RH, Schutte, M, Kern, SE, and Maynard, R. "Immunohistochemical p16INK4a analysis of archival tumors with deletion, hypermethylation, or mutation of the CDKN2/MTS1 gene. A comparison of four commercial antibodies." Appl Immunohistochem Mol Morphol 8, no. 1 (March 2000): 71-79. Link to Item
  - Hilgers, W, Groot Koerkamp, B, Geradts, J, Tang, DJ, Yeo, CJ, Hruban, RH, and Kern, SE. "Genomic FHIT analysis in RER+ and RER- adenocarcinomas of the pancreas." Genes Chromosomes Cancer 27, no. 3 (March 2000): 239-243. Link to Item
  - Pisano, ED, Johnston, RE, Chapman, D, Geradts, J, Iacocca, MV, Livasy, CA, Washburn, DB, Sayers, DE, Zhong, Z, Kiss, MZ, and Thomlinson, WC. "Human breast cancer specimens: diffraction-enhanced imaging with histologic correlation--improved conspicuity of lesion detail compared with digital radiography." Radiology 214, no. 3 (March 2000): 895-901. Full Text Link to Item
  - Hilgers, W, Koerkamp, BG, Geradts, J, Tang, DJ, Yeo, CJ, Hruban, RH, and Kern, SE. "Genomic FHIT analysis in RER⁺ and RER^- adenocarcinomas of the pancreas." Genes Chromosomes and Cancer 27, no. 3 (2000): 239-243. Full Text
  - Schneider, BG, Gulley, ML, Eagan, P, Bravo, JC, Mera, R, and Geradts, J. "Loss of p16/CDKN2A tumor suppressor protein in gastric adenocarcinoma is associated with Epstein-Barr virus and anatomic location in the body of the stomach." Hum Pathol 31, no. 1 (January 2000): 45-50. Link to Item
  - "Fhit expression in non-small cell lung cancer (NSCLC)." Respirology 4, no. SUPPL. 1 (December 1, 1999).
  - Lombardi, DP, Geradts, J, Foley, JF, Chiao, C, Lamb, PW, and Barrett, JC. "Loss of KAI1 expression in the progression of colorectal cancer." Cancer Res 59, no. 22 (November 15, 1999): 5724-5731. Link to Item
  - Dressler, LG, Geradts, J, Burroughs, M, Cowan, D, Millikan, RC, and Newman, B. "Policy guidelines for the utilization of formalin-fixed, paraffin-embedded tissue sections: the UNC SPORE experience. University of North Carolina Specialized Program of Research Excellence." Breast Cancer Res Treat 58, no. 1 (November 1999): 31-39. Link to Item
  - Dressler, LG, Geradts, J, Burroughs, M, Cowan, D, Millikan, RC, and Newman, B. "Policy guidelines for the utilization of formalin-fixed, paraffin-embedded tissue sections: the UNC SPORE experience." Breast Cancer Research and Treatment 58, no. 1 (November 1999): 31-39. Full Text
  - Gehrig, PA, Van Le, L, Olatidoye, B, and Geradts, J. "Estrogen receptor status, determined by immunohistochemistry, as a predictor of the recurrence of stage I endometrial carcinoma." Cancer 86, no. 10 (November 1999): 2083-2089. Full Text
  - Birrer, MJ, Hendricks, D, Farley, J, Sundborg, MJ, Bonome, T, Walts, MJ, and Geradts, J. "Abnormal Fhit expression in malignant and premalignant lesions of the cervix." Cancer Res 59, no. 20 (October 15, 1999): 5270-5274. Link to Item
  - Chen, WD, Geradts, J, Keane, MM, Lipkowitz, S, Zajac-Kaye, M, and Kaye, FJ. "The 100-kDa proteolytic fragment of RB is retained predominantly within the nuclear compartment of apoptotic cells." Mol Cell Biol Res Commun 1, no. 3 (June 1999): 216-220. Full Text Link to Item
  - Geradts, J, Maynard, R, Birrer, MJ, Hendricks, D, Abbondanzo, SL, Fong, KM, Barrett, JC, and Lombardi, DP. "Frequent loss of KAI1 expression in squamous and lymphoid neoplasms. An immunohistochemical study of archival tissues." The American Journal of Pathology 154, no. 6 (June 1999): 1665-1671. Full Text
  - Niehans, GA, Kratzke, RA, Froberg, MK, Aeppli, DM, Nguyen, PL, and Geradts, J. "G1 checkpoint protein and p53 abnormalities occur in most invasive transitional cell carcinomas of the urinary bladder." British Journal of Cancer 80, no. 8 (June 1999): 1175-1184. Full Text
  - Geradts, J, Fong, KM, Zimmerman, PV, Maynard, R, and Minna, JD. "Correlation of abnormal RB, p16ink4a, and p53 expression with 3p loss of heterozygosity, other genetic abnormalities, and clinical features in 103 primary non-small cell lung cancers." Clin Cancer Res 5, no. 4 (April 1999): 791-800. Link to Item
  - Wilentz, RE, Geradts, J, Maynard, R, Offerhaus, GJ, Kang, M, Goggins, M, Yeo, CJ, Kern, SE, and Hruban, RH. "Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: loss of intranuclear expression." Cancer Res 58, no. 20 (October 15, 1998): 4740-4744. Link to Item
  - Coxon, AB, Ward, JM, Geradts, J, Otterson, GA, Zajac-Kaye, M, and Kaye, FJ. "RET cooperates with RB/p53 inactivation in a somatic multi-step model for murine thyroid cancer." Oncogene 17, no. 12 (September 24, 1998): 1625-1628. Full Text Link to Item
  - Frizelle, SP, Grim, J, Zhou, J, Gupta, P, Curiel, DT, Geradts, J, and Kratzke, RA. "Re-expression of p16INK4a in mesothelioma cells results in cell cycle arrest, cell death, tumor suppression and tumor regression." Oncogene 16, no. 24 (June 18, 1998): 3087-3095. Full Text Link to Item
  - Geradts, J, Andriko, JW, and Abbondanzo, SL. "Loss of tumor suppressor gene expression in high-grade but not low-grade non-Hodgkin's lymphomas." Am J Clin Pathol 109, no. 6 (June 1998): 669-674. Link to Item
  - Gulley, ML, Nicholls, JM, Schneider, BG, Amin, MB, Ro, JY, and Geradts, J. "Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product." Am J Pathol 152, no. 4 (April 1998): 865-869. Link to Item
  - Otterson, GA, Xiao, GH, Geradts, J, Jin, F, Chen, WD, Niklinska, W, Kaye, FJ, and Yeung, RS. "Protein expression and functional analysis of the FHIT gene in human tumor cells." Journal of the National Cancer Institute 90, no. 6 (March 1998): 426-432. Full Text
  - Cohen, JA, and Geradts, J. "Loss of RB and MTS1/CDKN2 (p16) expression in human sarcomas." Hum Pathol 28, no. 8 (August 1997): 893-898. Link to Item
  - Schutte, M, Hruban, RH, Geradts, J, Maynard, R, Hilgers, W, Rabindran, SK, Moskaluk, CA, Hahn, SA, Schwarte-Waldhoff, I, Schmiegel, W, Baylin, SB, Kern, SE, and Herman, JG. "Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas." Cancer Res 57, no. 15 (August 1, 1997): 3126-3130. Link to Item
  - Parker, MF, Arroyo, GF, Geradts, J, Sabichi, AL, Park, RC, Taylor, RR, and Birrer, MJ. "Molecular characterization of adenocarcinoma of the cervix." Gynecol Oncol 64, no. 2 (February 1997): 242-251. Full Text Link to Item
  - Kratzke, RA, Greatens, TM, Rubins, JB, Maddaus, MA, Niewoehner, DE, Niehans, GA, and Geradts, J. "Rb and p16INK4a expression in resected non-small cell lung tumors." Cancer Res 56, no. 15 (August 1, 1996): 3415-3420. Link to Item
  - Geradts, J, and Wilson, PA. "High frequency of aberrant p16(INK4A) expression in human breast cancer." Am J Pathol 149, no. 1 (July 1996): 15-20. Link to Item
  - Geradts, J, Kratzke, RA, Crush-Stanton, S, Wen, SF, and Lincoln, CE. "Wild-type and mutant retinoblastoma protein in paraffin sections." Mod Pathol 9, no. 3 (March 1996): 339-347. Link to Item
  - Huang, L, Lang, D, Geradts, J, Obara, T, Klein-Szanto, AJ, Lynch, HT, and Ruggeri, BA. "Molecular and immunochemical analyses of RB1 and cyclin D1 in human ductal pancreatic carcinomas and cell lines." Molecular Carcinogenesis 15, no. 2 (February 1996): 85-95. Full Text
  - Kratzke, RA, Otterson, GA, Lincoln, CE, Ewing, S, Oie, H, Geradts, J, and Kaye, FJ. "Immunohistochemical analysis of the p16INK4 cyclin-dependent kinase inhibitor in malignant mesothelioma." J Natl Cancer Inst 87, no. 24 (December 20, 1995): 1870-1875. Link to Item
  - Geradts, J, Kratzke, RA, Niehans, GA, and Lincoln, CE. "Immunohistochemical detection of the cyclin-dependent kinase inhibitor 2/multiple tumor suppressor gene 1 (CDKN2/MTS1) product p16INK4A in archival human solid tumors: correlation with retinoblastoma protein expression." Cancer Res 55, no. 24 (December 15, 1995): 6006-6011. Link to Item
  - Millikan, R, Dressler, L, Geradts, J, and Graham, M. "The need for epidemiologic studies of in-situ carcinoma of the breast." Breast Cancer Res Treat 35, no. 1 (July 1995): 65-77. (Review) Link to Item
  - Newman, B, Moorman, PG, Millikan, R, Qaqish, BF, Geradts, J, Aldrich, TE, and Liu, ET. "The Carolina Breast Cancer Study: integrating population-based epidemiology and molecular biology." Breast Cancer Res Treat 35, no. 1 (July 1995): 51-60. Link to Item
  - Geradts, J, Hu, SX, Lincoln, CE, Benedict, WF, and Xu, HJ. "Aberrant RB gene expression in routinely processed, archival tumor tissues determined by three different anti-RB antibodies." Int J Cancer 58, no. 2 (July 15, 1994): 161-167. Link to Item
  - Geradts, J, and McLendon, WW. "Pathology and laboratory medicine." JAMA 271, no. 21 (June 1, 1994): 1700-1701. Link to Item
  - Geradts, J. "Pathology and Laboratory Medicine." Jama: the Journal of the American Medical Association 271, no. 21 (June 1, 1994): 1700-1700. Full Text
  - Kratzke, RA, Otterson, GA, Hogg, A, Coxon, AB, Geradts, J, Cowell, JK, and Kaye, FJ. "Partial inactivation of the RB product in a family with incomplete penetrance of familial retinoblastoma and benign retinal tumors." Oncogene 9, no. 5 (May 1994): 1321-1326. Link to Item
  - Wen, SF, Nodelman, M, Nared-Hood, K, Duncan, J, Geradts, J, and Shepard, HM. "Retinoblastoma protein monoclonal antibodies with novel characteristics." J Immunol Methods 169, no. 2 (March 10, 1994): 231-240. Link to Item
  - Geradts, J, Chen, JY, Russell, EK, Yankaskas, JR, Nieves, L, and Minna, JD. "Human lung cancer cell lines exhibit resistance to retinoic acid treatment." Cell Growth Differ 4, no. 10 (October 1993): 799-809. Link to Item
  - Kratzke, RA, Shimizu, E, Geradts, J, Gerster, JL, Segal, S, Otterson, GA, and Kaye, FJ. "RB-mediated tumor suppression of a lung cancer cell line is abrogated by an extract enriched in extracellular matrix." Cell Growth Differ 4, no. 8 (August 1993): 629-635. Link to Item
  - Geradts, J, Warnock, M, and Yen, TS. "Use of the polymerase chain reaction in the diagnosis of unsuspected herpes simplex viral pneumonia: report of a case." Human Pathology 21, no. 1 (January 1990): 118-121. Full Text
  - Montag, AG, Geradts, J, Hui, PK, and Franklin, WA. "Chapter 10 Limited expression of myeloid antigens by neuroendocrine tumours of lung." Lung Cancer 4, no. 1-2 (May 1988): 55-57. Full Text
  - Ceriani, RL, Geradts, J, and Peterson, JA. "Second international workshop on monoclonal antibodies and breast cancer. San Francisco, November 20-21, 1986." Breast Cancer Res Treat 10, no. 1 (October 1987): 55-63. Link to Item
  - Geradts, J, Richards, J, Edery, M, Pang, K, Larson, L, and Nandi, S. "Heterogeneity in the hormonal responsiveness of clones derived from the 13762NF rat mammary tumor." Cancer Research 46, no. 4 Pt 2 (April 1986): 1920-1927.
  - "Heterogeneity in the hormonal responsiveness of clones derived from the 13762nf rat mammary tumor." Cancer Research 46 (January 1, 1986): 1920-1927.
  - Geradts, J, Richards, J, and Edery, M. "Heterogeneity in the hormonal responsiveness of clones from the 13762NF rat mammary tumor." Proceedings of the American Association for Cancer Research VOL. 26 (1985): No.-2.
- Conference Papers
  - Khoury, T, Zirpoli, G, Cohen, SM, Merzianu, M, Troester, M, Geradts, J, Worral, A, Bshara, W, and Ambrosone, C. "Comprehensive Evaluation of Ki67 in Luminal/HER2-Negative Breast Cancer in the AMBER Consortium." February 2016. Link to Item
  - Evans, MK, Sauer, SJ, Aldrich, AJ, Geradts, J, Vermeulen, P, Dirix, L, Van Laere, S, and Devi, GR. "Abstract P6-14-05: A novel link between anti-apoptotic signaling, NFκB, and SMAD7 in IBC pathobiology." : American Association for Cancer Research (AACR), May 1, 2015. Full Text
  - Khoury, T, Zirpoli, G, Cohen, S, Geradts, J, Troester, M, and Ambrosone, C. "Correlation of Manual and Image Anlysis Ki-67 Scores in Breast Cancer Tissue Microarrays and Comparison With PAM50 Data." February 2015. Link to Item

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Duke Appointment History

In the News

Global Scholarship

Research

Selected Grants

Selected Publications

Academic Articles

Conference Papers