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Dynamic contrast enhanced-MRI in head and neck cancer patients: Variability of the precontrast longitudinal relaxation time (T10).

Publication ,  Journal Article
Craciunescu, O; Brizel, D; Cleland, E; Yoo, D; Muradyan, N; Carroll, M; Barboriak, D; MacFall, J
Published in: Med Phys
June 2010

PURPOSE: Calculation of the precontrast longitudinal relaxation times (T10) is an integral part of the Tofts-based pharmacokinetic (PK) analysis of dynamic contrast enhanced-magnetic resonance images. The purpose of this study was to investigate the interpatient and over time variability of T10 in head and neck primary tumors and involved nodes and to determine the median T10 for primary and nodes (T10p,n). The authors also looked at the implication of using voxel-based T10 values versus region of interest (ROI)-based T10 on the calculated values for vascular permeability (Ktrans) and extracellular volume fraction (ve). METHODS: Twenty head and neck cancer patients receiving concurrent chemoradiation and molecularly targeted agents on a prospective trial comprised the study population. Voxel-based T10's were generated using a gradient echo sequence on a 1.5 T MR scanner using the variable flip angle method with two flip angles [J. A. Brookes et al., "Measurement of spin-lattice relaxation times with FLASH for dynamic MRI of the breast," Br. J. Radiol. 69, 206-214 (1996)]. The voxel-based T10, Ktrans, and ve were calculated using iCAD's(®) (Nashua, NH) software. The mean T10's in muscle and fat ROIs were calculated (T10m,f). To assess reliability of ROI drawing, T10p,n values from ROIs delineated by 2 users (A and B) were calculated as the average of the T10's for 14 patients. For a subset of three patients, the T10 variability from baseline to end of treatment was also investigated. The Ktrans and ve from primary and node ROIs were calculated using voxel-based T10 values and T10p,n and differences reported. RESULTS: The calculated T10 values for fat and muscle are within the range of values reported in literature for 1.5 T, i.e., T10m=0.958s and T10f=0.303s. The average over 14 patients of the T10's based on drawings by users A and B were T10pA=0.804s, T10nA=0.760s, T10pB=0.849s, and T10nB=0.810s. The absolute percentage difference between Ktrans and ve calculated with voxel-based T10 versus T10p,n ranged from 6% to 81% and from 2% to 24%, respectively. CONCLUSIONS: There is a certain amount of variability in the median T10 values between patients, but the differences are not significant. There were also no statistically significant differences between the T10 values for primary and nodes at baseline and the subsequent time points (p=0.94 Friedman test). Voxel-based T10 calculations are essential when quantitative Tofts-based PK analysis in heterogeneous tumors is needed. In the absence of T10 mapping capability, when a relative, qualitative analysis is deemed sufficient, a value of T10p,n=0.800s can be used as an estimate for T10 for both the primary tumor and the affected nodes in head and neck cancers at all the time points considered.

Duke Scholars

Published In

Med Phys

DOI

EISSN

2473-4209

Publication Date

June 2010

Volume

37

Issue

6Part1

Start / End Page

2683 / 2692

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Prognosis
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Longitudinal Studies
  • Image Enhancement
  • Humans
  • Head and Neck Neoplasms
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Craciunescu, O., Brizel, D., Cleland, E., Yoo, D., Muradyan, N., Carroll, M., … MacFall, J. (2010). Dynamic contrast enhanced-MRI in head and neck cancer patients: Variability of the precontrast longitudinal relaxation time (T10). Med Phys, 37(6Part1), 2683–2692. https://doi.org/10.1118/1.3427487
Craciunescu, Oana, David Brizel, Esi Cleland, David Yoo, Naira Muradyan, Madeline Carroll, Daniel Barboriak, and James MacFall. “Dynamic contrast enhanced-MRI in head and neck cancer patients: Variability of the precontrast longitudinal relaxation time (T10).Med Phys 37, no. 6Part1 (June 2010): 2683–92. https://doi.org/10.1118/1.3427487.
Craciunescu O, Brizel D, Cleland E, Yoo D, Muradyan N, Carroll M, et al. Dynamic contrast enhanced-MRI in head and neck cancer patients: Variability of the precontrast longitudinal relaxation time (T10). Med Phys. 2010 Jun;37(6Part1):2683–92.
Craciunescu, Oana, et al. “Dynamic contrast enhanced-MRI in head and neck cancer patients: Variability of the precontrast longitudinal relaxation time (T10).Med Phys, vol. 37, no. 6Part1, June 2010, pp. 2683–92. Pubmed, doi:10.1118/1.3427487.
Craciunescu O, Brizel D, Cleland E, Yoo D, Muradyan N, Carroll M, Barboriak D, MacFall J. Dynamic contrast enhanced-MRI in head and neck cancer patients: Variability of the precontrast longitudinal relaxation time (T10). Med Phys. 2010 Jun;37(6Part1):2683–2692.

Published In

Med Phys

DOI

EISSN

2473-4209

Publication Date

June 2010

Volume

37

Issue

6Part1

Start / End Page

2683 / 2692

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Prognosis
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Longitudinal Studies
  • Image Enhancement
  • Humans
  • Head and Neck Neoplasms