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Immune-related Neurological Symptoms in an Adolescent Patient Receiving the Checkpoint Inhibitor Nivolumab.

Publication ,  Journal Article
Tchapyjnikov, D; Borst, AJ
Published in: J Immunother
September 2017

Immune checkpoint inhibitors are a novel group of immunotherapeutic agents for the treatment of cancer. Immune-related adverse events, including neurological symptoms, have been associated with these agents. We present the case of an adolescent with refractory Hodgkin lymphoma treated with nivolumab, a PD1 inhibitor, who developed Hashimoto thyroiditis, posterior reversible encephalopathy syndrome causing seizures, as well as urinary retention, truncal/appendicular spasticity, dysphagia, and a progressive encephalopathy that was clinically consistent with a diagnosis of progressive encephalopathy with rigidity and myoclonus, a stiff-person-syndrome spectrum disorder. He showed response and ultimately full recovery to a combination of intravenous steroids, intravenous immunoglobulin, and plasma exchange. To our knowledge, this is the first documented report of an immune-related neurological reaction to nivolumab in an adolescent patient and expands the spectrum of known nivolumab-associated toxicities.

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Published In

J Immunother

DOI

EISSN

1537-4513

Publication Date

September 2017

Volume

40

Issue

7

Start / End Page

286 / 288

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Symptom Assessment
  • Plasmapheresis
  • Nivolumab
  • Nervous System Diseases
  • Male
  • Magnetic Resonance Imaging
  • Immunosuppressive Agents
  • Immunology
  • Immunoglobulins, Intravenous
 

Citation

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Tchapyjnikov, D., & Borst, A. J. (2017). Immune-related Neurological Symptoms in an Adolescent Patient Receiving the Checkpoint Inhibitor Nivolumab. J Immunother, 40(7), 286–288. https://doi.org/10.1097/CJI.0000000000000177
Tchapyjnikov, Dmitry, and Alexandra J. Borst. “Immune-related Neurological Symptoms in an Adolescent Patient Receiving the Checkpoint Inhibitor Nivolumab.J Immunother 40, no. 7 (September 2017): 286–88. https://doi.org/10.1097/CJI.0000000000000177.
Tchapyjnikov, Dmitry, and Alexandra J. Borst. “Immune-related Neurological Symptoms in an Adolescent Patient Receiving the Checkpoint Inhibitor Nivolumab.J Immunother, vol. 40, no. 7, Sept. 2017, pp. 286–88. Pubmed, doi:10.1097/CJI.0000000000000177.

Published In

J Immunother

DOI

EISSN

1537-4513

Publication Date

September 2017

Volume

40

Issue

7

Start / End Page

286 / 288

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Symptom Assessment
  • Plasmapheresis
  • Nivolumab
  • Nervous System Diseases
  • Male
  • Magnetic Resonance Imaging
  • Immunosuppressive Agents
  • Immunology
  • Immunoglobulins, Intravenous