Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Clinical Neurophysiology Fellowship, Pediatrics, Duke University School of Medicine 2017 - 2018
  • Pediatric Neurology Fellowship, Pediatrics, Duke University School of Medicine 2014 - 2017
  • Residency, Pediatrics, Duke University School of Medicine 2012 - 2014
  • M.D., Eastern Virginia Medical School 2012
• 

  Previous Appointments & Affiliations

  • Assistant Professor of Pediatrics, Pediatrics, Neurology, Pediatrics 2018 - 2021
  • Assistant Professor in the Department of Neurology, Neurology, Clinical Science Departments 2018 - 2021
• 

  Leadership & Clinical Positions at Duke

  • Medical Director, Duke Center for Ketogenic Therapy
• Expertise
• 

  Subject Headings

  • Bioinformatics
  • Electroencephalography
  • Epilepsy
  • Machine learning
  • Pediatric neurology
  • Status Epilepticus
  • Zika virus infection
• 

  Global Scholarship

  • Research

    • Brazil (Country) 
• Research
• 

  Selected Grants

  • Consequences of prolonged febrile seizures in childhood awarded by Albert Einstein College of Medicine 2017 - 2022
  • The relationship between maternal ZIKV-specific and ADE antibodies and fetal outcome awarded by National Institutes of Health 2018 - 2021
  • A Learning Healthcare System for Pediatric Epilepsy awarded by Cornell University 2019 - 2020
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Sooy, Meredith, Rachel L. Randell, Dmitry Tchapyjnikov, Klaus Werner, and Kristina Nazareth-Pidgeon. “Painful, reappearing eruption in a medically complex 4-year-old.” Bmj Case Rep 14, no. 2 (February 18, 2021). https://doi.org/10.1136/bcr-2020-239310.
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    • Vasquez, Alejandra, Marina Gaínza-Lein, Nicholas S. Abend, Marta Amengual-Gual, Anne Anderson, Ravindra Arya, J Nicholas Brenton, et al. “First-line medication dosing in pediatric refractory status epilepticus.” Neurology 95, no. 19 (November 10, 2020): e2683–96. https://doi.org/10.1212/WNL.0000000000010828.
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    • Trau, Steven P., Emily C. Sterrett, Lydia Feinstein, Linh Tran, William B. Gallentine, and Dmitry Tchapyjnikov. “Institutional Pediatric Convulsive Status Epilepticus Protocol Decreases Time to First and Second Line Anti-Seizure Medication Administration.” Seizure 81 (October 2020): 263–68. https://doi.org/10.1016/j.seizure.2020.08.011.
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    • Sánchez Fernández, Iván, Nicholas S. Abend, Marta Amengual-Gual, Anne Anderson, Ravindra Arya, Cristina Barcia Aguilar, James Nicholas Brenton, et al. “Association of guideline publication and delays to treatment in pediatric status epilepticus.” Neurology 95, no. 9 (September 1, 2020): e1222–35. https://doi.org/10.1212/WNL.0000000000010174.
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    • Isaev, Dmitry Yu, Dmitry Tchapyjnikov, C Michael Cotten, David Tanaka, Natalia Martinez, Martin Bertran, Guillermo Sapiro, and David Carlson. “Attention-Based Network for Weak Labels in Neonatal Seizure Detection.” Proc Mach Learn Res 126 (August 2020): 479–507.
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    • Sansevere, Arnold J., Ravindra Arya, Iván Sánchez Fernández, William D. Gaillard, Robert C. Tasker, Yi-Chen Lai, Anne E. Anderson, et al. “Electroencephalographic Reporting for Refractory Status Epilepticus.” J Clin Neurophysiol 36, no. 5 (September 2019): 365–70. https://doi.org/10.1097/WNP.0000000000000595.
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    • Sánchez Fernández, Iván, Marina Gaínza-Lein, Nicholas S. Abend, Marta Amengual-Gual, Anne Anderson, Ravindra Arya, J Nicholas Brenton, et al. “The onset of pediatric refractory status epilepticus is not distributed uniformly during the day.” Seizure 70 (August 2019): 90–96. https://doi.org/10.1016/j.seizure.2019.06.017.
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    • Tchapyjnikov, Dmitry, and Matthew W. Luedke. “Cefepime-Induced Encephalopathy and Nonconvulsive Status Epilepticus: Dispelling an Artificial Dichotomy.” Neurohospitalist 9, no. 2 (April 2019): 100–104. https://doi.org/10.1177/1941874418803225.
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    • Slone, Jesse, Yanyan Peng, Adam Chamberlin, Belinda Harris, Julie Kaylor, Marie T. McDonald, Monica Lemmon, et al. “Biallelic mutations in FDXR cause neurodegeneration associated with inflammation.” J Hum Genet 63, no. 12 (December 2018): 1211–22. https://doi.org/10.1038/s10038-018-0515-y.
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    • Vasquez, Alejandra, Marina Gaínza-Lein, Iván Sánchez Fernández, Nicholas S. Abend, Anne Anderson, J Nicholas Brenton, Jessica L. Carpenter, et al. “Hospital Emergency Treatment of Convulsive Status Epilepticus: Comparison of Pathways From Ten Pediatric Research Centers.” Pediatr Neurol 86 (September 2018): 33–41. https://doi.org/10.1016/j.pediatrneurol.2018.06.004.
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    • Arya, Ravindra, Katrina Peariso, Marina Gaínza-Lein, Jessica Harvey, Ann Bergin, J Nicholas Brenton, Brian T. Burrows, et al. “Efficacy and safety of ketogenic diet for treatment of pediatric convulsive refractory status epilepticus.” Epilepsy Res 144 (August 2018): 1–6. https://doi.org/10.1016/j.eplepsyres.2018.04.012.
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    • Sánchez Fernández, I., M. Gaínza-Lein, N. S. Abend, A. E. Anderson, R. Arya, J. N. Brenton, J. L. Carpenter, et al. “Factors associated with treatment delays in pediatric refractory convulsive status epilepticus.” Neurology 90, no. 19 (May 8, 2018): e1692–1701. https://doi.org/10.1212/WNL.0000000000005488.
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    • Borst, Alexandra J., and Dmitry Tchapyjnikov. “B6 and Bleeding: A Case Report of a Novel Vitamin Toxicity.” Pediatrics 141, no. Suppl 5 (April 2018): S430–33. https://doi.org/10.1542/peds.2017-2039.
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    • Gaínza-Lein, Marina, Iván Sánchez Fernández, Michele Jackson, Nicholas S. Abend, Ravindra Arya, J Nicholas Brenton, Jessica L. Carpenter, et al. “Association of Time to Treatment With Short-term Outcomes for Pediatric Patients With Refractory Convulsive Status Epilepticus.” Jama Neurol 75, no. 4 (April 1, 2018): 410–18. https://doi.org/10.1001/jamaneurol.2017.4382.
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    • Tchapyjnikov, Dmitry, and Mohamad A. Mikati. “Acetazolamide-responsive Episodic Ataxia Without Baseline Deficits or Seizures Secondary to GLUT1 Deficiency: A Case Report and Review of the Literature.” Neurologist 23, no. 1 (January 2018): 17–18. https://doi.org/10.1097/NRL.0000000000000168.
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    • Sachdev, Monisha, Marina Gaínza-Lein, Dmitry Tchapyjnikov, Yong-Hui Jiang, Tobias Loddenkemper, and Mohamad A. Mikati. “Novel clinical manifestations in patients with KCNA2 mutations.” Seizure 51 (October 2017): 74–76. https://doi.org/10.1016/j.seizure.2017.07.018.
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    • Tchapyjnikov, Dmitry, and Alexandra J. Borst. “Immune-related Neurological Symptoms in an Adolescent Patient Receiving the Checkpoint Inhibitor Nivolumab.” J Immunother 40, no. 7 (September 2017): 286–88. https://doi.org/10.1097/CJI.0000000000000177.
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    • Fainberg, Nina, Amy Harper, Dmitry Tchapyjnikov, and Mohamad A. Mikati. “Response to immunotherapy in a patient with Landau-Kleffner syndrome and GRIN2A mutation.” Epileptic Disord 18, no. 1 (March 2016): 97–100. https://doi.org/10.1684/epd.2016.0791.
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    • Tchapyjnikov, Dmitry, Yuedan Li, Trairak Pisitkun, Jason D. Hoffert, Ming-Jiun Yu, and Mark A. Knepper. “Proteomic profiling of nuclei from native renal inner medullary collecting duct cells using LC-MS/MS.” Physiol Genomics 40, no. 3 (February 4, 2010): 167–83. https://doi.org/10.1152/physiolgenomics.00148.2009.
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    • Hoffert, Jason D., Robert A. Fenton, Hanne B. Moeller, Brigitte Simons, Dmitry Tchapyjnikov, Bradley W. McDill, Ming-Jiun Yu, Trairak Pisitkun, Feng Chen, and Mark A. Knepper. “Vasopressin-stimulated increase in phosphorylation at Ser269 potentiates plasma membrane retention of aquaporin-2.” J Biol Chem 283, no. 36 (September 5, 2008): 24617–27. https://doi.org/10.1074/jbc.M803074200.
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    • Yu, Ming-Jiun, Trairak Pisitkun, Guanghui Wang, Juan F. Aranda, Patricia A. Gonzales, Dmitry Tchapyjnikov, Rong-Fong Shen, Miguel A. Alonso, and Mark A. Knepper. “Large-scale quantitative LC-MS/MS analysis of detergent-resistant membrane proteins from rat renal collecting duct.” Am J Physiol Cell Physiol 295, no. 3 (September 2008): C661–78. https://doi.org/10.1152/ajpcell.90650.2007.
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    • Pisitkun, Trairak, Jared Bieniek, Dmitry Tchapyjnikov, Guanghui Wang, Wells W. Wu, Rong-Fong Shen, and Mark A. Knepper. “High-throughput identification of IMCD proteins using LC-MS/MS.” Physiol Genomics 25, no. 2 (April 13, 2006): 263–76. https://doi.org/10.1152/physiolgenomics.00214.2005.
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  • Conference Papers

    • Chamberlain, L., C. Giuberti, R. Dietze, T. Abraham, H. Webster, T. Singh, G. Corey, S. Permar, and D. Tchapyjnikov. “Neurodevelopmental Outcomes in Infants with Congenital Zika Virus Exposure: Data from a Prospective Cohort in Vitoria, Brazil.” In Annals of Neurology, 86:S102–3, 2019.
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    • Tchapyjnikov, D., L. Feinstein, L. Morgan, N. Abend, A. Anderson, R. Arya, N. Brenton, et al. “Delayed Time to EEG Placement is Associated with Longer Seizure Duration in Refractory Pediatric Status Epilepticus (the pSERG Cohort).” In Annals of Neurology, 86:S32–33, 2019.
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    • Sachdev, Monisha, Marina Gainza-Lein, Dmitry Tchapyjnikov, Tobias Loddenkemper, and Mohamad A. Mikati. “Novel Clinical Presentations and Characteristics in Patients with KCNA2 Mutations.” In Neurology, Vol. 88, 2017.
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    • Tchapyjnikov, Dmitry, and Mohamed Mikati. “A Case of GLUT1 Deficiency Associated Episodic Ataxia Without Epilepsy.” In Neurology, Vol. 88, 2017.
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    • Tchapyjnikov, Dmitry, and William Gallentine. “Quality Improvement for the Management of Pediatric Patients with Status Epilepticus.” In Neurology, Vol. 88, 2017.
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    • Khositseth, Sookkasem, M. -. J. Yu, T. Pisitkun, D. Tchapyjnikov, and M. A. Knepper. “Quantitative proteomic analysis of long-term vasopressin actions in mpkCCD cells using SILAC and MRM.” In Faseb Journal, Vol. 23, 2009.
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    • Tchapyjnikov, Dmitry, Yuedan Li, Trairak Pisitkun, and Mark A. Knepper. “Nuclear Proteomics of the Inner Medullary Collecting Duct (IMCD).” In Faseb Journal, Vol. 22, 2008.
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