Skip to main content

Dmitry Tchapyjnikov

Adjunct Assistant Professor in the Department of Pediatrics
Pediatrics, Neurology
Box 90780, Durham, NC 27708-0780
T0913 Children's Health Center, DUMC Box 3936, Durham, NC 27710

Selected Publications


Pediatric status epilepticus management by Emergency Medical Services (the pSERG cohort).

Journal Article Seizure · October 2023 PURPOSE: Delayed treatment in status epilepticus (SE) is independently associated with increased treatment resistance, morbidity, and mortality. We describe the prehospital management pathway and Emergency Medical Services (EMS) timeliness in children who ... Full text Link to item Cite

Early Clinical Variables Associated With Refractory Convulsive Status Epilepticus in Children.

Journal Article Neurology · August 1, 2023 BACKGROUND AND OBJECTIVES: The objective of this study was to determine patient-specific factors known proximate to the presentation to emergency care associated with the development of refractory convulsive status epilepticus (RSE) in children. METHODS: A ... Full text Link to item Cite

Painful, reappearing eruption in a medically complex 4-year-old.

Journal Article BMJ Case Rep · February 18, 2021 A 4-year-old boy with atypical, complete DiGeorge and CHARGE (coloboma, heart defects, atresia choanae, growth retardation, genital abnormalities and ear abnormalities) syndromes presented with frequent episodes of a painful, markedly erythematous eruption ... Full text Link to item Cite

First-line medication dosing in pediatric refractory status epilepticus.

Journal Article Neurology · November 10, 2020 OBJECTIVE: To identify factors associated with low benzodiazepine (BZD) dosing in patients with refractory status epilepticus (RSE) and to assess the impact of BZD treatment variability on seizure cessation. METHODS: This was a retrospective study with pro ... Full text Link to item Cite

Institutional Pediatric Convulsive Status Epilepticus Protocol Decreases Time to First and Second Line Anti-Seizure Medication Administration.

Journal Article Seizure · October 2020 PURPOSE: Convulsive status epilepticus (CSE) is a medical emergency associated with high rates of morbidity and mortality. Although guidelines for CSE management recommend rapid treatment of seizures, prior studies show that compliance with these guideline ... Full text Link to item Cite

Association of guideline publication and delays to treatment in pediatric status epilepticus.

Journal Article Neurology · September 1, 2020 OBJECTIVE: To determine whether publication of evidence on delays in time to treatment shortens time to treatment in pediatric refractory convulsive status epilepticus (rSE), we compared time to treatment before (2011-2014) and after (2015-2019) publicatio ... Full text Link to item Cite

Attention-Based Network for Weak Labels in Neonatal Seizure Detection.

Journal Article Proc Mach Learn Res · August 2020 Seizures are a common emergency in the neonatal intesive care unit (NICU) among newborns receiving therapeutic hypothermia for hypoxic ischemic encephalopathy. The high incidence of seizures in this patient population necessitates continuous electroencepha ... Link to item Cite

Electroencephalographic Reporting for Refractory Status Epilepticus.

Journal Article J Clin Neurophysiol · September 2019 PURPOSE: We aimed to determine whether clinical EEG reports obtained from children in the intensive care unit with refractory status epilepticus could provide data for comparative effectiveness research studies. METHODS: We conducted a retrospective descri ... Full text Link to item Cite

The onset of pediatric refractory status epilepticus is not distributed uniformly during the day.

Journal Article Seizure · August 2019 PURPOSE: To evaluate whether the onset of pediatric refractory status epilepticus (rSE) is related to time of day. METHOD: We analyzed the time of day for the onset of rSE in this prospective observational study performed from June 2011 to May 2019 in pedi ... Full text Link to item Cite

Cefepime-Induced Encephalopathy and Nonconvulsive Status Epilepticus: Dispelling an Artificial Dichotomy.

Journal Article Neurohospitalist · April 2019 Cefepime is a fourth-generation cephalosporin antibiotic known to have neurotoxic side effects. Recent reports have described patients on cefepime presenting with altered mentation and concurrent triphasic wave discharges on electroencephalogram (EEG). Som ... Full text Link to item Cite

Biallelic mutations in FDXR cause neurodegeneration associated with inflammation.

Journal Article J Hum Genet · December 2018 Mitochondrial dysfunction lies behind many neurodegenerative disorders, owing largely to the intense energy requirements of most neurons. Such mitochondrial dysfunction may work through a variety of mechanisms, from direct disruption of the electron transp ... Full text Link to item Cite

Hospital Emergency Treatment of Convulsive Status Epilepticus: Comparison of Pathways From Ten Pediatric Research Centers.

Journal Article Pediatr Neurol · September 2018 OBJECTIVE: We aimed to evaluate and compare the status epilepticus treatment pathways used by pediatric status epilepticus research group (pSERG) hospitals in the United States and the American Epilepsy Society (AES) status epilepticus guideline. METHODS: ... Full text Link to item Cite

Efficacy and safety of ketogenic diet for treatment of pediatric convulsive refractory status epilepticus.

Journal Article Epilepsy Res · August 2018 PURPOSE: To describe the efficacy and safety of ketogenic diet (KD) for convulsive refractory status epilepticus (RSE). METHODS: RSE patients treated with KD at the 6/11 participating institutions of the pediatric Status Epilepticus Research Group from Jan ... Full text Link to item Cite

Factors associated with treatment delays in pediatric refractory convulsive status epilepticus.

Journal Article Neurology · May 8, 2018 OBJECTIVE: To identify factors associated with treatment delays in pediatric patients with convulsive refractory status epilepticus (rSE). METHODS: This prospective, observational study was performed from June 2011 to March 2017 on pediatric patients (1 mo ... Full text Link to item Cite

Association of Time to Treatment With Short-term Outcomes for Pediatric Patients With Refractory Convulsive Status Epilepticus.

Journal Article JAMA Neurol · April 1, 2018 IMPORTANCE: Treatment delay for seizures can lead to longer seizure duration. Whether treatment delay is associated with major adverse outcomes, such as death, remains unknown. OBJECTIVE: To evaluate whether untimely first-line benzodiazepine treatment is ... Full text Link to item Cite

B6 and Bleeding: A Case Report of a Novel Vitamin Toxicity.

Journal Article Pediatrics · April 2018 Pyridox(am)ine-5-phosphate oxidase deficiency is an inborn error of vitamin B6 metabolism that is characterized by neonatal seizures, requiring lifelong therapy with pyridoxal-5-phosphate. We present the first case of a patient with pyridox(am)ine-5-phosph ... Full text Link to item Cite

Acetazolamide-responsive Episodic Ataxia Without Baseline Deficits or Seizures Secondary to GLUT1 Deficiency: A Case Report and Review of the Literature.

Journal Article Neurologist · January 2018 INTRODUCTION: Glucose transporter type 1 deficiency syndrome (GLUT1 DS) is caused by impaired glucose transport across the blood-brain barrier and commonly presents as severe early onset epilepsy, developmental delay, and movement abnormalities. In rare in ... Full text Link to item Cite

Novel clinical manifestations in patients with KCNA2 mutations.

Journal Article Seizure · October 2017 PURPOSE: To report novel clinical manifestations of KCNA2 mutation related epileptic encephalopathy. METHODS: Blood samples were sent for whole exome and Sanger sequencing. Seizure types were characterized by clinical criteria and EEG recording. RESULTS: K ... Full text Link to item Cite

Pediatric status epilepticus management by Emergency Medical Services (the pSERG cohort).

Journal Article Seizure · October 2023 PURPOSE: Delayed treatment in status epilepticus (SE) is independently associated with increased treatment resistance, morbidity, and mortality. We describe the prehospital management pathway and Emergency Medical Services (EMS) timeliness in children who ... Full text Link to item Cite

Early Clinical Variables Associated With Refractory Convulsive Status Epilepticus in Children.

Journal Article Neurology · August 1, 2023 BACKGROUND AND OBJECTIVES: The objective of this study was to determine patient-specific factors known proximate to the presentation to emergency care associated with the development of refractory convulsive status epilepticus (RSE) in children. METHODS: A ... Full text Link to item Cite

Painful, reappearing eruption in a medically complex 4-year-old.

Journal Article BMJ Case Rep · February 18, 2021 A 4-year-old boy with atypical, complete DiGeorge and CHARGE (coloboma, heart defects, atresia choanae, growth retardation, genital abnormalities and ear abnormalities) syndromes presented with frequent episodes of a painful, markedly erythematous eruption ... Full text Link to item Cite

First-line medication dosing in pediatric refractory status epilepticus.

Journal Article Neurology · November 10, 2020 OBJECTIVE: To identify factors associated with low benzodiazepine (BZD) dosing in patients with refractory status epilepticus (RSE) and to assess the impact of BZD treatment variability on seizure cessation. METHODS: This was a retrospective study with pro ... Full text Link to item Cite

Institutional Pediatric Convulsive Status Epilepticus Protocol Decreases Time to First and Second Line Anti-Seizure Medication Administration.

Journal Article Seizure · October 2020 PURPOSE: Convulsive status epilepticus (CSE) is a medical emergency associated with high rates of morbidity and mortality. Although guidelines for CSE management recommend rapid treatment of seizures, prior studies show that compliance with these guideline ... Full text Link to item Cite

Association of guideline publication and delays to treatment in pediatric status epilepticus.

Journal Article Neurology · September 1, 2020 OBJECTIVE: To determine whether publication of evidence on delays in time to treatment shortens time to treatment in pediatric refractory convulsive status epilepticus (rSE), we compared time to treatment before (2011-2014) and after (2015-2019) publicatio ... Full text Link to item Cite

Attention-Based Network for Weak Labels in Neonatal Seizure Detection.

Journal Article Proc Mach Learn Res · August 2020 Seizures are a common emergency in the neonatal intesive care unit (NICU) among newborns receiving therapeutic hypothermia for hypoxic ischemic encephalopathy. The high incidence of seizures in this patient population necessitates continuous electroencepha ... Link to item Cite

Electroencephalographic Reporting for Refractory Status Epilepticus.

Journal Article J Clin Neurophysiol · September 2019 PURPOSE: We aimed to determine whether clinical EEG reports obtained from children in the intensive care unit with refractory status epilepticus could provide data for comparative effectiveness research studies. METHODS: We conducted a retrospective descri ... Full text Link to item Cite

The onset of pediatric refractory status epilepticus is not distributed uniformly during the day.

Journal Article Seizure · August 2019 PURPOSE: To evaluate whether the onset of pediatric refractory status epilepticus (rSE) is related to time of day. METHOD: We analyzed the time of day for the onset of rSE in this prospective observational study performed from June 2011 to May 2019 in pedi ... Full text Link to item Cite

Cefepime-Induced Encephalopathy and Nonconvulsive Status Epilepticus: Dispelling an Artificial Dichotomy.

Journal Article Neurohospitalist · April 2019 Cefepime is a fourth-generation cephalosporin antibiotic known to have neurotoxic side effects. Recent reports have described patients on cefepime presenting with altered mentation and concurrent triphasic wave discharges on electroencephalogram (EEG). Som ... Full text Link to item Cite

Biallelic mutations in FDXR cause neurodegeneration associated with inflammation.

Journal Article J Hum Genet · December 2018 Mitochondrial dysfunction lies behind many neurodegenerative disorders, owing largely to the intense energy requirements of most neurons. Such mitochondrial dysfunction may work through a variety of mechanisms, from direct disruption of the electron transp ... Full text Link to item Cite

Hospital Emergency Treatment of Convulsive Status Epilepticus: Comparison of Pathways From Ten Pediatric Research Centers.

Journal Article Pediatr Neurol · September 2018 OBJECTIVE: We aimed to evaluate and compare the status epilepticus treatment pathways used by pediatric status epilepticus research group (pSERG) hospitals in the United States and the American Epilepsy Society (AES) status epilepticus guideline. METHODS: ... Full text Link to item Cite

Efficacy and safety of ketogenic diet for treatment of pediatric convulsive refractory status epilepticus.

Journal Article Epilepsy Res · August 2018 PURPOSE: To describe the efficacy and safety of ketogenic diet (KD) for convulsive refractory status epilepticus (RSE). METHODS: RSE patients treated with KD at the 6/11 participating institutions of the pediatric Status Epilepticus Research Group from Jan ... Full text Link to item Cite

Factors associated with treatment delays in pediatric refractory convulsive status epilepticus.

Journal Article Neurology · May 8, 2018 OBJECTIVE: To identify factors associated with treatment delays in pediatric patients with convulsive refractory status epilepticus (rSE). METHODS: This prospective, observational study was performed from June 2011 to March 2017 on pediatric patients (1 mo ... Full text Link to item Cite

Association of Time to Treatment With Short-term Outcomes for Pediatric Patients With Refractory Convulsive Status Epilepticus.

Journal Article JAMA Neurol · April 1, 2018 IMPORTANCE: Treatment delay for seizures can lead to longer seizure duration. Whether treatment delay is associated with major adverse outcomes, such as death, remains unknown. OBJECTIVE: To evaluate whether untimely first-line benzodiazepine treatment is ... Full text Link to item Cite

B6 and Bleeding: A Case Report of a Novel Vitamin Toxicity.

Journal Article Pediatrics · April 2018 Pyridox(am)ine-5-phosphate oxidase deficiency is an inborn error of vitamin B6 metabolism that is characterized by neonatal seizures, requiring lifelong therapy with pyridoxal-5-phosphate. We present the first case of a patient with pyridox(am)ine-5-phosph ... Full text Link to item Cite

Acetazolamide-responsive Episodic Ataxia Without Baseline Deficits or Seizures Secondary to GLUT1 Deficiency: A Case Report and Review of the Literature.

Journal Article Neurologist · January 2018 INTRODUCTION: Glucose transporter type 1 deficiency syndrome (GLUT1 DS) is caused by impaired glucose transport across the blood-brain barrier and commonly presents as severe early onset epilepsy, developmental delay, and movement abnormalities. In rare in ... Full text Link to item Cite

Novel clinical manifestations in patients with KCNA2 mutations.

Journal Article Seizure · October 2017 PURPOSE: To report novel clinical manifestations of KCNA2 mutation related epileptic encephalopathy. METHODS: Blood samples were sent for whole exome and Sanger sequencing. Seizure types were characterized by clinical criteria and EEG recording. RESULTS: K ... Full text Link to item Cite

Immune-related Neurological Symptoms in an Adolescent Patient Receiving the Checkpoint Inhibitor Nivolumab.

Journal Article J Immunother · September 2017 Immune checkpoint inhibitors are a novel group of immunotherapeutic agents for the treatment of cancer. Immune-related adverse events, including neurological symptoms, have been associated with these agents. We present the case of an adolescent with refrac ... Full text Link to item Cite

Response to immunotherapy in a patient with Landau-Kleffner syndrome and GRIN2A mutation.

Journal Article Epileptic Disord · March 2016 Landau-Kleffner syndrome (LKS) has been demonstrated in the past to respond to immunotherapy. Recently, some cases of LKS have been shown to be secondary to glutamate receptor (GRIN2A) mutations. Whether such cases respond to immunotherapy is not known. He ... Full text Link to item Cite

Proteomic profiling of nuclei from native renal inner medullary collecting duct cells using LC-MS/MS.

Journal Article Physiol Genomics · February 4, 2010 Vasopressin is a peptide hormone that regulates renal water excretion in part through its actions on the collecting duct. The regulation occurs in part via control of transcription of genes coding for the water channels aquaporin-2 (Aqp2) and aquaporin-3 ( ... Full text Link to item Cite

Large-scale proteomics and phosphoproteomics of urinary exosomes.

Journal Article J Am Soc Nephrol · February 2009 Normal human urine contains large numbers of exosomes, which are 40- to 100-nm vesicles that originate as the internal vesicles in multivesicular bodies from every renal epithelial cell type facing the urinary space. Here, we used LC-MS/MS to profile the p ... Full text Link to item Cite

Vasopressin-stimulated increase in phosphorylation at Ser269 potentiates plasma membrane retention of aquaporin-2.

Journal Article J Biol Chem · September 5, 2008 Vasopressin controls water excretion through regulation of aquaporin-2 (AQP2) trafficking in renal collecting duct cells. Using mass spectrometry, we previously demonstrated four phosphorylated serines (Ser256, Ser261, Ser264, and Ser269) in the carboxyl-t ... Full text Link to item Cite

Large-scale quantitative LC-MS/MS analysis of detergent-resistant membrane proteins from rat renal collecting duct.

Journal Article Am J Physiol Cell Physiol · September 2008 In the renal collecting duct, vasopressin controls transport of water and solutes via regulation of membrane transporters such as aquaporin-2 (AQP2) and the epithelial urea transporter UT-A. To discover proteins potentially involved in vasopressin action i ... Full text Link to item Cite

Forskolin stimulates phosphorylation and membrane accumulation of UT-A3.

Journal Article Am J Physiol Renal Physiol · October 2007 UT-A1 is regulated by vasopressin and is localized to the apical membrane and intracellular compartment of inner medullary collecting duct (IMCD) cells. UT-A3 is also expressed in the IMCD and is regulated by forskolin in heterologous systems. The goal of ... Full text Link to item Cite

High-throughput identification of IMCD proteins using LC-MS/MS.

Journal Article Physiol Genomics · April 13, 2006 The inner medullary collecting duct (IMCD) is an important site of vasopressin-regulated water and urea transport. Here we have used protein mass spectrometry to investigate the proteome of the IMCD cell and how it is altered in response to long-term vasop ... Full text Link to item Cite