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Regulator of G-protein signaling (RGS) proteins in cancer biology.

Publication ,  Journal Article
Hurst, JH; Hooks, SB
Published in: Biochem Pharmacol
November 15, 2009

The regulator of G-protein signaling (RGS) family is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). In recent years, GPCRs have been linked to the initiation and progression of multiple cancers; thus, regulators of GPCR signaling are also likely to be important to the pathophysiology of cancer. This review highlights recent studies detailing changes in RGS transcript expression during oncogenesis, single nucleotide polymorphisms in RGS proteins linked to lung and bladder cancers, and specific roles for RGS proteins in multiple cancer types.

Duke Scholars

Published In

Biochem Pharmacol

DOI

EISSN

1873-2968

Publication Date

November 15, 2009

Volume

78

Issue

10

Start / End Page

1289 / 1297

Location

England

Related Subject Headings

  • Signal Transduction
  • Rho Guanine Nucleotide Exchange Factors
  • Receptors, G-Protein-Coupled
  • RGS Proteins
  • Polymorphism, Single Nucleotide
  • Pharmacology & Pharmacy
  • Neoplasms
  • Humans
  • Guanine Nucleotide Exchange Factors
  • Animals
 

Citation

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Hurst, J. H., & Hooks, S. B. (2009). Regulator of G-protein signaling (RGS) proteins in cancer biology. Biochem Pharmacol, 78(10), 1289–1297. https://doi.org/10.1016/j.bcp.2009.06.028
Hurst, Jillian H., and Shelley B. Hooks. “Regulator of G-protein signaling (RGS) proteins in cancer biology.Biochem Pharmacol 78, no. 10 (November 15, 2009): 1289–97. https://doi.org/10.1016/j.bcp.2009.06.028.
Hurst JH, Hooks SB. Regulator of G-protein signaling (RGS) proteins in cancer biology. Biochem Pharmacol. 2009 Nov 15;78(10):1289–97.
Hurst, Jillian H., and Shelley B. Hooks. “Regulator of G-protein signaling (RGS) proteins in cancer biology.Biochem Pharmacol, vol. 78, no. 10, Nov. 2009, pp. 1289–97. Pubmed, doi:10.1016/j.bcp.2009.06.028.
Hurst JH, Hooks SB. Regulator of G-protein signaling (RGS) proteins in cancer biology. Biochem Pharmacol. 2009 Nov 15;78(10):1289–1297.
Journal cover image

Published In

Biochem Pharmacol

DOI

EISSN

1873-2968

Publication Date

November 15, 2009

Volume

78

Issue

10

Start / End Page

1289 / 1297

Location

England

Related Subject Headings

  • Signal Transduction
  • Rho Guanine Nucleotide Exchange Factors
  • Receptors, G-Protein-Coupled
  • RGS Proteins
  • Polymorphism, Single Nucleotide
  • Pharmacology & Pharmacy
  • Neoplasms
  • Humans
  • Guanine Nucleotide Exchange Factors
  • Animals