Regulator of G-protein signaling (RGS) proteins in cancer biology.

Published

Journal Article (Review)

The regulator of G-protein signaling (RGS) family is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). In recent years, GPCRs have been linked to the initiation and progression of multiple cancers; thus, regulators of GPCR signaling are also likely to be important to the pathophysiology of cancer. This review highlights recent studies detailing changes in RGS transcript expression during oncogenesis, single nucleotide polymorphisms in RGS proteins linked to lung and bladder cancers, and specific roles for RGS proteins in multiple cancer types.

Full Text

Duke Authors

Cited Authors

  • Hurst, JH; Hooks, SB

Published Date

  • November 2009

Published In

Volume / Issue

  • 78 / 10

Start / End Page

  • 1289 - 1297

PubMed ID

  • 19559677

Pubmed Central ID

  • 19559677

Electronic International Standard Serial Number (EISSN)

  • 1873-2968

International Standard Serial Number (ISSN)

  • 0006-2952

Digital Object Identifier (DOI)

  • 10.1016/j.bcp.2009.06.028

Language

  • eng