Targeting protein localization for anti-infective therapy.

Journal Article

Invasive fungal infections are devastating complications of immunocompromised patients. These infections are notoriously difficult to treat given the surprising degree of physiological similarity between fungi and the infected mammalian host. To explore novel targets for antifungal therapy, investigators have studied enzymes involved in the post-translational modification of highly conserved signaling proteins such as the Ras-like GTPases. These modifications are often required for protein localization and function. In a recent manuscript, investigators used microbial genetics to establish the role of protein farnesyltransferase in the growth and virulence of the opportunistic fungal pathogen Aspergillus fumigatus. This enzyme catalyzes the lipidation and membrane association of many proteins including Ras. The relevance of farnesyltransferase activity for fungal pathogenesis suggests new paradigms for developing therapies against eukaryotic microbial pathogens.

Full Text

Duke Authors

Cited Authors

  • Alspaugh, JA

Published Date

  • June 28, 2017

Published In

Start / End Page

  • 0 -

PubMed ID

  • 28658594

Electronic International Standard Serial Number (EISSN)

  • 2150-5608

International Standard Serial Number (ISSN)

  • 2150-5594

Digital Object Identifier (DOI)

  • 10.1080/21505594.2017.1342921


  • eng