The association between Self-Reported Medication Adherence scores and systolic blood pressure control: a SPRINT baseline data study.

Journal Article (Journal Article;Multicenter Study)

We examined baseline data from the Systolic Blood Pressure Intervention Trial (SPRINT) to investigate whether medication adherence, measured by the 8-item Morisky Medication Adherence Scale (MMAS-8), was associated with systolic blood pressure (SBP) and whether MMAS-8 score and number of antihypertensive medications interacted in influencing SBP. A total of 8435 SPRINT participants were included: 21.2% had low adherence (MMAS-8: <6); 40.0% had medium adherence (6 to <8); and 38.8% had high adherence (8). SBP was <140 mm Hg in 54.6%; 140-160 mm Hg in 36.6%; and >160 mm Hg in 8.8%. In multivariable regression, medium vs. low adherence weakly associated with lower SBP (odds ratio: 1.17; confidence interval: 1.04, 1.31). SPRINT eligibility criteria should be considered when interpreting results. Efforts to understand and enhance adherence are crucial to improve population health, and using self-report instruments might be considered for predicting treatment adherence and response in future efficacy trials and for identifying patients for adherence support in clinical practice.

Full Text

Duke Authors

Cited Authors

  • Haley, WE; Gilbert, ON; Riley, RF; Newman, JC; Roumie, CL; Whittle, J; Kronish, IM; Tamariz, L; Wiggers, A; Morisky, DE; Conroy, MB; Kovalik, E; Kressin, NR; Muntner, P; Goff, DC; SPRINT Study Research Group,

Published Date

  • November 2016

Published In

Volume / Issue

  • 10 / 11

Start / End Page

  • 857 - 864.e2

PubMed ID

  • 27697447

Pubmed Central ID

  • PMC5107135

Electronic International Standard Serial Number (EISSN)

  • 1878-7436

Digital Object Identifier (DOI)

  • 10.1016/j.jash.2016.08.009


  • eng

Conference Location

  • United States