Skip to main content

Effect of Temporal Changes in Therapeutic Exposure on Self-reported Health Status in Childhood Cancer Survivors.

Publication ,  Journal Article
Ness, KK; Hudson, MM; Jones, KE; Leisenring, W; Yasui, Y; Chen, Y; Stovall, M; Gibson, TM; Green, DM; Neglia, JP; Henderson, TO; Casillas, J ...
Published in: Ann Intern Med
January 17, 2017

BACKGROUND: The effect of temporal changes in cancer therapy on health status among childhood cancer survivors has not been evaluated. OBJECTIVE: To compare proportions of self-reported adverse health status outcomes among childhood cancer survivors across 3 decades. DESIGN: Cross-sectional. (ClinicalTrials.gov: NCT01120353). SETTING: 27 North American institutions. PARTICIPANTS: 14 566 adults, who survived for 5 or more years after initial diagnosis (median age, 27 years; range, 18 to 48 years), treated from 1970 to 1999. MEASUREMENTS: Patient report of poor general or mental health, functional impairment, activity limitation, or cancer-related anxiety or pain was evaluated as a function of treatment decade, cancer treatment exposure, chronic health conditions, demographic characteristics, and health habits. RESULTS: Despite reductions in late mortality and the proportions of survivors with severe, disabling, or life-threatening chronic health conditions (33.4% among those treated from 1970 to 1979 and 21.0% among those treated from 1990 to 1999), those reporting adverse health status did not decrease by treatment decade. Compared with survivors diagnosed in 1970 to 1979, those diagnosed in 1990 to 1999 were more likely to report poor general health (11.2% vs. 13.7%; P < 0.001) and cancer-related anxiety (13.3% vs. 15.0%; P < 0.001). From 1970 to 1979 and 1990 to 1999, the proportions of survivors reporting adverse outcomes were higher (P < 0.001) among those with leukemia (poor general health, 9.5% and 13.9%) and osteosarcoma (pain, 23.9% and 36.6%). Temporal changes in treatment exposures were not associated with changes in the proportions of survivors reporting adverse health status. Smoking, not meeting physical activity guidelines, and being either underweight or obese were associated with poor health status. LIMITATION: Considerable improvement in survival among children diagnosed with cancer in the 1990s compared with those diagnosed in the 1970s makes it difficult to definitively determine the effect of risk factors on later self-reported health status without considering their effect on mortality. CONCLUSION: Because survival rates after a diagnosis of childhood cancer have improved substantially over the past 30 years, the population of survivors now includes those who would have died in earlier decades. Self-reported health status among survivors has not improved despite evolution of treatment designed to reduce toxicities. PRIMARY FUNDING SOURCE: The National Cancer Institute.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Ann Intern Med

DOI

EISSN

1539-3704

Publication Date

January 17, 2017

Volume

166

Issue

2

Start / End Page

89 / 98

Location

United States

Related Subject Headings

  • Time Factors
  • Survivors
  • Self Report
  • Neoplasms
  • Male
  • Humans
  • Health Status
  • Health Behavior
  • General & Internal Medicine
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ness, K. K., Hudson, M. M., Jones, K. E., Leisenring, W., Yasui, Y., Chen, Y., … Nathan, P. C. (2017). Effect of Temporal Changes in Therapeutic Exposure on Self-reported Health Status in Childhood Cancer Survivors. Ann Intern Med, 166(2), 89–98. https://doi.org/10.7326/M16-0742
Ness, Kirsten K., Melissa M. Hudson, Kendra E. Jones, Wendy Leisenring, Yutaka Yasui, Yan Chen, Marilyn Stovall, et al. “Effect of Temporal Changes in Therapeutic Exposure on Self-reported Health Status in Childhood Cancer Survivors.Ann Intern Med 166, no. 2 (January 17, 2017): 89–98. https://doi.org/10.7326/M16-0742.
Ness KK, Hudson MM, Jones KE, Leisenring W, Yasui Y, Chen Y, et al. Effect of Temporal Changes in Therapeutic Exposure on Self-reported Health Status in Childhood Cancer Survivors. Ann Intern Med. 2017 Jan 17;166(2):89–98.
Ness, Kirsten K., et al. “Effect of Temporal Changes in Therapeutic Exposure on Self-reported Health Status in Childhood Cancer Survivors.Ann Intern Med, vol. 166, no. 2, Jan. 2017, pp. 89–98. Pubmed, doi:10.7326/M16-0742.
Ness KK, Hudson MM, Jones KE, Leisenring W, Yasui Y, Chen Y, Stovall M, Gibson TM, Green DM, Neglia JP, Henderson TO, Casillas J, Ford JS, Effinger KE, Krull KR, Armstrong GT, Robison LL, Oeffinger KC, Nathan PC. Effect of Temporal Changes in Therapeutic Exposure on Self-reported Health Status in Childhood Cancer Survivors. Ann Intern Med. 2017 Jan 17;166(2):89–98.

Published In

Ann Intern Med

DOI

EISSN

1539-3704

Publication Date

January 17, 2017

Volume

166

Issue

2

Start / End Page

89 / 98

Location

United States

Related Subject Headings

  • Time Factors
  • Survivors
  • Self Report
  • Neoplasms
  • Male
  • Humans
  • Health Status
  • Health Behavior
  • General & Internal Medicine
  • Female