Toward a Neurocentric View of Learning.
Published
Journal Article (Review)
Synaptic plasticity (e.g., long-term potentiation [LTP]) is considered the cellular correlate of learning. Recent optogenetic studies on memory engram formation assign a critical role in learning to suprathreshold activation of neurons and their integration into active engrams ("engram cells"). Here we review evidence that ensemble integration may result from LTP but also from cell-autonomous changes in membrane excitability. We propose that synaptic plasticity determines synaptic connectivity maps, whereas intrinsic plasticity-possibly separated in time-amplifies neuronal responsiveness and acutely drives engram integration. Our proposal marks a move away from an exclusively synaptocentric toward a non-exclusive, neurocentric view of learning.
Full Text
Duke Authors
Cited Authors
- Titley, HK; Brunel, N; Hansel, C
Published Date
- July 5, 2017
Published In
Volume / Issue
- 95 / 1
Start / End Page
- 19 - 32
PubMed ID
- 28683265
Pubmed Central ID
- 28683265
Electronic International Standard Serial Number (EISSN)
- 1097-4199
Digital Object Identifier (DOI)
- 10.1016/j.neuron.2017.05.021
Language
- eng
Conference Location
- United States