Toward a Neurocentric View of Learning.

Published

Journal Article (Review)

Synaptic plasticity (e.g., long-term potentiation [LTP]) is considered the cellular correlate of learning. Recent optogenetic studies on memory engram formation assign a critical role in learning to suprathreshold activation of neurons and their integration into active engrams ("engram cells"). Here we review evidence that ensemble integration may result from LTP but also from cell-autonomous changes in membrane excitability. We propose that synaptic plasticity determines synaptic connectivity maps, whereas intrinsic plasticity-possibly separated in time-amplifies neuronal responsiveness and acutely drives engram integration. Our proposal marks a move away from an exclusively synaptocentric toward a non-exclusive, neurocentric view of learning.

Full Text

Duke Authors

Cited Authors

  • Titley, HK; Brunel, N; Hansel, C

Published Date

  • July 5, 2017

Published In

Volume / Issue

  • 95 / 1

Start / End Page

  • 19 - 32

PubMed ID

  • 28683265

Pubmed Central ID

  • 28683265

Electronic International Standard Serial Number (EISSN)

  • 1097-4199

Digital Object Identifier (DOI)

  • 10.1016/j.neuron.2017.05.021

Language

  • eng

Conference Location

  • United States