
Toward a Neurocentric View of Learning.
Synaptic plasticity (e.g., long-term potentiation [LTP]) is considered the cellular correlate of learning. Recent optogenetic studies on memory engram formation assign a critical role in learning to suprathreshold activation of neurons and their integration into active engrams ("engram cells"). Here we review evidence that ensemble integration may result from LTP but also from cell-autonomous changes in membrane excitability. We propose that synaptic plasticity determines synaptic connectivity maps, whereas intrinsic plasticity-possibly separated in time-amplifies neuronal responsiveness and acutely drives engram integration. Our proposal marks a move away from an exclusively synaptocentric toward a non-exclusive, neurocentric view of learning.
Duke Scholars
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Related Subject Headings
- Synaptic Transmission
- Pyramidal Cells
- Neurons
- Neuronal Plasticity
- Neurology & Neurosurgery
- Membrane Potentials
- Long-Term Potentiation
- Learning
- Hippocampus
- Cerebral Cortex
Citation

Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Synaptic Transmission
- Pyramidal Cells
- Neurons
- Neuronal Plasticity
- Neurology & Neurosurgery
- Membrane Potentials
- Long-Term Potentiation
- Learning
- Hippocampus
- Cerebral Cortex