Photoacoustic imaging using genetically encoded reporters: a review.

Journal Article (Review;Journal Article)

Genetically encoded contrast in photoacoustic imaging (PAI) is complementary to the intrinsic contrast provided by endogenous absorbing chromophores such as hemoglobin. The use of reporter genes expressing absorbing proteins opens the possibility of visualizing dynamic cellular and molecular processes. This is an enticing prospect but brings with it challenges and limitations associated with generating and detecting different types of reporters. The purpose of this review is to compare existing PAI reporters and signal detection strategies, thereby offering a practical guide, particularly for the nonbiologist, to choosing the most appropriate reporter for maximum sensitivity in the biological and technological system of interest.

Full Text

Duke Authors

Cited Authors

  • Brunker, J; Yao, J; Laufer, J; Bohndiek, SE

Published Date

  • July 2017

Published In

Volume / Issue

  • 22 / 7

PubMed ID

  • 28717818

Electronic International Standard Serial Number (EISSN)

  • 1560-2281

International Standard Serial Number (ISSN)

  • 1083-3668

Digital Object Identifier (DOI)

  • 10.1117/1.jbo.22.7.070901


  • eng