Vibrio vulnificus induces mTOR activation and inflammatory responses in macrophages.

Published online

Journal Article

Vibrio vulnificus (V. vulnificus), a Gram-negative marine bacterium, can cause life-threatening primary septicemia, especially in patients with liver diseases. How V. vulnificus affects the liver and how it acts on macrophages are not well understood. In this report, we demonstrated that V. vulnificus infection causes a strong inflammatory response, marked expansion of liver-resident macrophages, and liver damage in mice. We demonstrated further that V. vulnificus activates mTOR in macrophages and inhibition of mTOR differentially regulates V. vulnificus induced inflammatory responses, suggesting the possibility of targeting mTOR as a strategy to modulate V. vulnificus induced inflammatory responses.

Full Text

Duke Authors

Cited Authors

  • Xie, D-L; Zheng, M-M; Zheng, Y; Gao, H; Zhang, J; Zhang, T; Guo, J-C; Yang, XF; Zhong, X-P; Lou, Y-L

Published Date

  • 2017

Published In

Volume / Issue

  • 12 / 7

Start / End Page

  • e0181454 -

PubMed ID

  • 28719654

Pubmed Central ID

  • 28719654

Electronic International Standard Serial Number (EISSN)

  • 1932-6203

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0181454

Language

  • eng

Conference Location

  • United States