Healthcare workers suffer musculoskeletal disorders at rates that exceed most other industries. Despite this, many healthcare facilities do not follow best practices that are proven to reduce risk of injury. This discussion panel will explore the reasons for why the healthcare industry struggles to prevent injuries and will outline successful strategies for protecting workers. The panelists are leaders and advisors for large medical systems and their specialties include ergonomics, safe patient handling, and patient safety. The panelists relate the critical challenges faced when preventing caregiver injuries. Such challenges include underreporting of staff injuries, lack of funding or administrative support, and inability to sell the connections among caregiver safety, caregiver productivity, and patient safety. The panelists also share success stories of when they have achieved positive change and explain the strategies that were effective. Practitioners should gain new insights for implementing successful change, and researchers will be exposed to new and important research questions.