Serotonergic Modulation Enables Pathway-Specific Plasticity in a Developing Sensory Circuit in Drosophila.

Journal Article (Journal Article)

How experiences during development cause long-lasting changes in sensory circuits and affect behavior in mature animals are poorly understood. Here we establish a novel system for mechanistic analysis of the plasticity of developing neural circuits by showing that sensory experience during development alters nociceptive behavior and circuit physiology in Drosophila larvae. Despite the convergence of nociceptive and mechanosensory inputs on common second-order neurons (SONs), developmental noxious input modifies transmission from nociceptors to their SONs, but not from mechanosensors to the same SONs, which suggests striking sensory pathway specificity. These SONs activate serotonergic neurons to inhibit nociceptor-to-SON transmission; stimulation of nociceptors during development sensitizes nociceptor presynapses to this feedback inhibition. Our results demonstrate that, unlike associative learning, which involves inputs from two sensory pathways, sensory pathway-specific plasticity in the Drosophila nociceptive circuit is in part established through feedback modulation. This study elucidates a novel mechanism that enables pathway-specific plasticity in sensory systems. VIDEO ABSTRACT.

Full Text

Duke Authors

Cited Authors

  • Kaneko, T; Macara, AM; Li, R; Hu, Y; Iwasaki, K; Dunnings, Z; Firestone, E; Horvatic, S; Guntur, A; Shafer, OT; Yang, C-H; Zhou, J; Ye, B

Published Date

  • August 2, 2017

Published In

Volume / Issue

  • 95 / 3

Start / End Page

  • 623 - 638.e4

PubMed ID

  • 28712652

Pubmed Central ID

  • PMC5555049

Electronic International Standard Serial Number (EISSN)

  • 1097-4199

Digital Object Identifier (DOI)

  • 10.1016/j.neuron.2017.06.034


  • eng

Conference Location

  • United States