KIT mutations and CD117 overexpression are markers of better progression-free survival in vulvar melanomas.

Journal Article (Journal Article;Multicenter Study)

BACKGROUND: Few studies have addressed prognostic markers and none has correlated molecular status and prognosis in vulvar melanomas. OBJECTIVES: To evaluate the clinicopathological features of 95 cases of vulvar melanoma. METHODS: p53, CD117, Ki-67, neurofibromin, brafv600e and nrasq61r immunostains, and molecular analyses by either targeted next-generation or direct sequencing, were performed on available archival materials. RESULTS: Molecular testing detected mutations in KIT (44%), BRAF (25%), NF1 (22%), TP53 (17%), NRAS (9%) and TERT promoter (9%). Co-mutation of KIT and NF1 and of KIT and NRAS were identified in two and one cases, respectively. KIT mutations were significantly associated with better progression-free survival in univariate analyses. In multivariate analyses CD117 expression was significantly associated with better progression-free survival. Tumour thickness was significantly associated with worse progression-free and overall survival, and perineural invasion significantly correlated with reduced melanoma-specific survival and reduced overall survival. Cases were from multiple centres and only a subset of samples was available for molecular testing. CONCLUSIONS: KIT mutations and CD117 overexpression are markers of better progression-free survival. In addition to its prognostic value, molecular testing may identify cases that might respond to targeted agents or immunotherapeutic approaches.

Full Text

Duke Authors

Cited Authors

  • Dias-Santagata, D; Selim, MA; Su, Y; Peng, Y; Vollmer, R; Chłopik, A; Tell-Marti, G; Paral, KM; Shalin, SC; Shea, CR; Puig, S; Fernandez-Figueras, MT; Biernat, W; Ryś, J; Marszalek, A; Hoang, MP

Published Date

  • November 2017

Published In

Volume / Issue

  • 177 / 5

Start / End Page

  • 1376 - 1384

PubMed ID

  • 28734009

Electronic International Standard Serial Number (EISSN)

  • 1365-2133

Digital Object Identifier (DOI)

  • 10.1111/bjd.15836


  • eng

Conference Location

  • England