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Rethinking m6A Readers, Writers, and Erasers.

Publication ,  Journal Article
Meyer, KD; Jaffrey, SR
Published in: Annu Rev Cell Dev Biol
October 6, 2017

In recent years, m6A has emerged as an abundant and dynamically regulated modification throughout the transcriptome. Recent technological advances have enabled the transcriptome-wide identification of m6A residues, which in turn has provided important insights into the biology and regulation of this pervasive regulatory mark. Also central to our current understanding of m6A are the discovery and characterization of m6A readers, writers, and erasers. Over the last few years, studies into the function of these proteins have led to important discoveries about the regulation and function of m6A. However, during this time our understanding of these proteins has also evolved considerably, sometimes leading to the reversal of early concepts regarding the reading, writing and erasing of m6A. In this review, we summarize recent advances in m6A research, and we highlight how these new findings have reshaped our understanding of how m6A is regulated in the transcriptome.

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Published In

Annu Rev Cell Dev Biol

DOI

EISSN

1530-8995

Publication Date

October 6, 2017

Volume

33

Start / End Page

319 / 342

Location

United States

Related Subject Headings

  • RNA
  • Humans
  • Developmental Biology
  • DNA Methylation
  • Animals
  • Adenosine
  • 3101 Biochemistry and cell biology
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
 

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Meyer, K. D., & Jaffrey, S. R. (2017). Rethinking m6A Readers, Writers, and Erasers. Annu Rev Cell Dev Biol, 33, 319–342. https://doi.org/10.1146/annurev-cellbio-100616-060758
Meyer, Kate D., and Samie R. Jaffrey. “Rethinking m6A Readers, Writers, and Erasers.Annu Rev Cell Dev Biol 33 (October 6, 2017): 319–42. https://doi.org/10.1146/annurev-cellbio-100616-060758.
Meyer KD, Jaffrey SR. Rethinking m6A Readers, Writers, and Erasers. Annu Rev Cell Dev Biol. 2017 Oct 6;33:319–42.
Meyer, Kate D., and Samie R. Jaffrey. “Rethinking m6A Readers, Writers, and Erasers.Annu Rev Cell Dev Biol, vol. 33, Oct. 2017, pp. 319–42. Pubmed, doi:10.1146/annurev-cellbio-100616-060758.
Meyer KD, Jaffrey SR. Rethinking m6A Readers, Writers, and Erasers. Annu Rev Cell Dev Biol. 2017 Oct 6;33:319–342.

Published In

Annu Rev Cell Dev Biol

DOI

EISSN

1530-8995

Publication Date

October 6, 2017

Volume

33

Start / End Page

319 / 342

Location

United States

Related Subject Headings

  • RNA
  • Humans
  • Developmental Biology
  • DNA Methylation
  • Animals
  • Adenosine
  • 3101 Biochemistry and cell biology
  • 11 Medical and Health Sciences
  • 06 Biological Sciences