Rethinking m6A Readers, Writers, and Erasers.

Published

Journal Article (Review)

In recent years, m6A has emerged as an abundant and dynamically regulated modification throughout the transcriptome. Recent technological advances have enabled the transcriptome-wide identification of m6A residues, which in turn has provided important insights into the biology and regulation of this pervasive regulatory mark. Also central to our current understanding of m6A are the discovery and characterization of m6A readers, writers, and erasers. Over the last few years, studies into the function of these proteins have led to important discoveries about the regulation and function of m6A. However, during this time our understanding of these proteins has also evolved considerably, sometimes leading to the reversal of early concepts regarding the reading, writing and erasing of m6A. In this review, we summarize recent advances in m6A research, and we highlight how these new findings have reshaped our understanding of how m6A is regulated in the transcriptome.

Full Text

Duke Authors

Cited Authors

  • Meyer, KD; Jaffrey, SR

Published Date

  • October 2017

Published In

Volume / Issue

  • 33 /

Start / End Page

  • 319 - 342

PubMed ID

  • 28759256

Pubmed Central ID

  • 28759256

Electronic International Standard Serial Number (EISSN)

  • 1530-8995

International Standard Serial Number (ISSN)

  • 1081-0706

Digital Object Identifier (DOI)

  • 10.1146/annurev-cellbio-100616-060758

Language

  • eng