Kathryn Meyer
Assistant Professor of Biochemistry
Current Research Interests
Research in the Meyer laboratory focuses on RNA and epitranscriptomic regulatory mechanisms that control gene expression and cellular function. We have a particular interest in understanding how RNA methylation (m6A) controls RNA processing and RNA function in diverse cell types as well as in the nervous system. Our laboratory also develops novel methods for interrogating m6A and for better understanding RNA:protein interactions in cells.
Current Appointments & Affiliations
- Assistant Professor of Biochemistry, Biochemistry, Basic Science Departments 2016
- Assistant Professor in Neurobiology, Neurobiology, Basic Science Departments 2017
- Assistant Professor of Cell Biology, Cell Biology, Basic Science Departments 2022
Contact Information
- Background
-
Education, Training, & Certifications
- Ph.D., Northwestern University 2010
-
Leadership & Clinical Positions at Duke
- Co-Director, Duke Center for RNA Biology
- Recognition
-
In the News
-
OCT 15, 2019 GenomeWeb -
OCT 10, 2016
-
-
Awards & Honors
- Expertise
-
Subject Headings
- Research
-
Selected Grants
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Neurobiology Training Program awarded by National Institutes of Health 2019 - 2024
- Mechanistic Insights into m6A-Mediated Regulation of Brain Development awarded by National Institutes of Health 2018 - 2023
- Rita Allen Foundation Scholars Award awarded by Rita Allen Foundation 2017 - 2023
- Center for Genomic Information Encoded by RNA Nucleotide Modifications awarded by Weill Cornell Medicine 2022 - 2023
- Decoding RNA-Protein Interactions in Trypanosoma Telomerase awarded by University of North Carolina - Charlotte 2022 - 2023
- Epitranscriptomic Regulation of Synaptic Responses to Drugs of Abuse awarded by National Institutes of Health 2018 - 2023
- Epitranscriptomic Control of Local Gene Expression in Neural Stem Cells awarded by National Institutes of Health 2019 - 2021
- Epitranscriptomic Control of Local Translation in Neurons awarded by Kinship Foundation 2018 - 2021
- RNA Methylation-Mediated Regulation of Brain Development awarded by Esther A. & Joseph Klingenstein Fund 2017 - 2021
- mRNA Methylation: A Novel Regulatory Mechanism in the Neuronal Transcriptome awarded by National Institutes of Health 2014 - 2019
-
External Relationships
- University Hospital Heidelberg
- University of Hong Kong
- University of Trento
- Weill Cornell Medical College
- Publications & Artistic Works
-
Selected Publications
-
Academic Articles
-
Tegowski M, Meyer KD. Detection of m6A in single cultured cells using scDART-seq. Star Protoc. 2022 Sep 16;3(3):101646.Full Text Link to Item
-
Flamand MN, Ke K, Tamming R, Meyer KD. Single-molecule identification of the target RNAs of different RNA binding proteins simultaneously in cells. Genes Dev. 2022 Sep 1;36(17–18):1002–1015.Full Text Link to Item
-
Choi SH, Flamand MN, Liu B, Zhu H, Hu M, Wang M, Sewell J, Holley CL, Al-Hashimi HM, Meyer KD. RBM45 is an m6A-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs. Cell Rep. 2022 Aug 30;40(9):111293.Full Text Link to Item
-
Meyer KD. How m6A makes its mark. Nat Rev Mol Cell Biol. 2022 Aug;23(8):519.Full Text Link to Item
-
Flamand MN, Meyer KD. m6A and YTHDF proteins contribute to the localization of select neuronal mRNAs. Nucleic Acids Res. 2022 May 6;50(8):4464–4483.Full Text Link to Item
-
Tegowski M, Flamand MN, Meyer KD. scDART-seq reveals distinct m6A signatures and mRNA methylation heterogeneity in single cells. Mol Cell. 2022 Feb 17;82(4):868-878.e10.Full Text Link to Item
-
Zhu H, Yin X, Holley CL, Meyer KD. Improved Methods for Deamination-Based m6A Detection. Front Cell Dev Biol. 2022;10:888279.Full Text Link to Item
-
Cotter KA, Gallon J, Uebersax N, Rubin P, Meyer KD, Piscuoglio S, Jaffrey SR, Rubin MA. Mapping of m6A and Its Regulatory Targets in Prostate Cancer Reveals a METTL3-Low Induction of Therapy Resistance. Mol Cancer Res. 2021 Aug;19(8):1398–1411.Full Text Link to Item
-
Madugalle SU, Meyer K, Wang DO, Bredy TW. RNA N6-Methyladenosine and the Regulation of RNA Localization and Function in the Brain. Trends Neurosci. 2020 Dec;43(12):1011–1023.Full Text Link to Item
-
Flamand MN, Meyer KD. The epitranscriptome and synaptic plasticity. Curr Opin Neurobiol. 2019 Dec;59:41–48.Full Text Link to Item
-
Meyer KD. DART-seq: an antibody-free method for global m6A detection. Nat Methods. 2019 Dec;16(12):1275–1280.Full Text Link to Item
-
Meyer KD. Transcriptome-wide m6A detection with DART-Seq. 2019 Sep 23;Full Text
-
Meyer KD. m6A-mediated translation regulation. Biochim Biophys Acta Gene Regul Mech. 2019 Mar;1862(3):301–309.Full Text Link to Item
-
Choi SH, Meyer KD. Acetylation takes aim at mRNA. Nat Struct Mol Biol. 2018 Dec;25(12):1067–1068.Full Text Link to Item
-
Liu B, Merriman DK, Choi SH, Schumacher MA, Plangger R, Kreutz C, Horner SM, Meyer KD, Al-Hashimi HM. A potentially abundant junctional RNA motif stabilized by m6A and Mg2. Nat Commun. 2018 Jul 17;9(1):2761.Full Text Link to Item
-
Meyer KD, Jaffrey SR. Rethinking m6A Readers, Writers, and Erasers. Annu Rev Cell Dev Biol. 2017 Oct 6;33:319–342.Full Text Link to Item
-
Meyer KD, Jaffrey SR. Expanding the diversity of DNA base modifications with N⁶-methyldeoxyadenosine. Genome Biol. 2016 Jan 13;17:5.Full Text Link to Item
-
Meyer KD, Patil DP, Zhou J, Zinoviev A, Skabkin MA, Elemento O, Pestova TV, Qian S-B, Jaffrey SR. 5' UTR m(6)A Promotes Cap-Independent Translation. Cell. 2015 Nov 5;163(4):999–1010.Full Text Link to Item
-
Satterlee JS, Basanta-Sanchez M, Blanco S, Li JB, Meyer K, Pollock J, Sadri-Vakili G, Rybak-Wolf A. Novel RNA modifications in the nervous system: form and function. J Neurosci. 2014 Nov 12;34(46):15170–15177.Full Text Link to Item
-
Meyer KD, Jaffrey SR. The dynamic epitranscriptome: N6-methyladenosine and gene expression control. Nat Rev Mol Cell Biol. 2014 May;15(5):313–326.Full Text Link to Item
-
Hess ME, Hess S, Meyer KD, Verhagen LAW, Koch L, Brönneke HS, Dietrich MO, Jordan SD, Saletore Y, Elemento O, Belgardt BF, Franz T, Horvath TL, Rüther U, Jaffrey SR, Kloppenburg P, Brüning JC. The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Nat Neurosci. 2013 Aug;16(8):1042–1048.Full Text Link to Item
-
Saletore Y, Meyer K, Korlach J, Vilfan ID, Jaffrey S, Mason CE. The birth of the Epitranscriptome: deciphering the function of RNA modifications. Genome Biol. 2012 Oct 31;13(10):175.Full Text Link to Item
-
Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR. Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell. 2012 Jun 22;149(7):1635–1646.Full Text Link to Item
-
Meyer KD, Morris JA. Disc1 regulates granule cell migration in the developing hippocampus. Hum Mol Genet. 2009 Sep 1;18(17):3286–3297.Full Text Link to Item
-
Meyer KD, Morris JA. Immunohistochemical analysis of Disc1 expression in the developing and adult hippocampus. Gene Expr Patterns. 2008 Sep;8(7–8):494–501.Full Text Link to Item
-
-
Book Sections
-
Tegowski M, Zhu H, Meyer KD. Detecting m6A with In Vitro DART-Seq. 2022. p. 363–374.Full Text Link to Item
-
-
Conference Papers
-
Meyer K. Covalent Modifications to mRNA, or the "Epitranscriptome". Environmental and Molecular Mutagenesis. WILEY; 2017. p. S41–S41.Link to Item
-
-
- Teaching & Mentoring
-
Recent Courses
- BIOCHEM 393: Research Independent Study 2023
- BIOCHEM 668: RNA Biology: Co-Transcriptional and Post-Transcriptional Control of Gene Expression 2023
- CELLBIO 668: RNA Biology: Co-Transcriptional and Post-Transcriptional Control of Gene Expression 2023
- UPGEN 668: RNA Biology: Co-Transcriptional and Post-Transcriptional Control of Gene Expression 2023
- BIOCHEM 393: Research Independent Study 2022
- BIOCHEM 593: Research Independent Study 2022
- BIOCHEM 668: RNA Biology: Co-Transcriptional and Post-Transcriptional Control of Gene Expression 2022
- CELLBIO 668: RNA Biology: Co-Transcriptional and Post-Transcriptional Control of Gene Expression 2022
- UPGEN 668: RNA Biology: Co-Transcriptional and Post-Transcriptional Control of Gene Expression 2022
- BIOCHEM 393: Research Independent Study 2021
- BIOCHEM 593: Research Independent Study 2021
- BIOCHEM 668: RNA Biology: Co-Transcriptional and Post-Transcriptional Control of Gene Expression 2021
- CELLBIO 668: RNA Biology: Co-Transcriptional and Post-Transcriptional Control of Gene Expression 2021
- NEUROBIO 393: Research Independent Study 2021
- NEUROBIO 793: Research in Neurobiology 2021
- UPGEN 668: RNA Biology: Co-Transcriptional and Post-Transcriptional Control of Gene Expression 2021
Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.