Kathryn Meyer | Scholars@Duke

Kathryn Meyer
Assistant Professor of Biochemistry

Current Research Interests

Research in the Meyer laboratory focuses on RNA regulatory pathways in the nervous system. We have a particular interest in understanding how RNA methylation (m6A) controls gene expression programs in the brain to contribute to human health and disease.

Current Appointments & Affiliations

Assistant Professor of Biochemistry, Biochemistry, Basic Science Departments 2016
Assistant Professor in Neurobiology, Neurobiology, Basic Science Departments 2017

Contact Information

Background
Education, Training, & Certifications
- Ph.D., Northwestern University 2010
Recognition
In the News
- OCT 10, 2016
  
  RNA Researcher Regional Award Finalist
Expertise
Subject Headings
Research
Selected Grants
- Neurobiology Training Program awarded by National Institutes of Health 2019 - 2024
- Mechanistic Insights into m6A-Mediated Regulation of Brain Development awarded by National Institutes of Health 2018 - 2023
- Epitranscriptomic Regulation of Synaptic Responses to Drugs of Abuse awarded by National Institutes of Health 2018 - 2023
- Rita Allen Foundation Scholars Award awarded by Rita Allen Foundation 2017 - 2022
- Epitranscriptomic Control of Local Gene Expression in Neural Stem Cells awarded by National Institutes of Health 2019 - 2021
- Epitranscriptomic Control of Local Translation in Neurons awarded by Kinship Foundation 2018 - 2021
- RNA Methylation-Mediated Regulation of Brain Development awarded by Esther A. & Joseph Klingenstein Fund 2017 - 2021
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- mRNA Methylation: A Novel Regulatory Mechanism in the Neuronal Transcriptome awarded by National Institutes of Health 2014 - 2019
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Madugalle, Sachithrani U., Kate Meyer, Dan Ohtan Wang, and Timothy W. Bredy. “RNA N6-Methyladenosine and the Regulation of RNA Localization and Function in the Brain.” Trends Neurosci 43, no. 12 (December 2020): 1011–23. https://doi.org/10.1016/j.tins.2020.09.005.
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  - Flamand, Mathieu N., and Kate D. Meyer. “The epitranscriptome and synaptic plasticity.” Curr Opin Neurobiol 59 (December 2019): 41–48. https://doi.org/10.1016/j.conb.2019.04.007.
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  - Meyer, Kate D. “DART-seq: an antibody-free method for global m6A detection.” Nat Methods 16, no. 12 (December 2019): 1275–80. https://doi.org/10.1038/s41592-019-0570-0.
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  - Meyer, Kate D. “m6A-mediated translation regulation.” Biochim Biophys Acta Gene Regul Mech 1862, no. 3 (March 2019): 301–9. https://doi.org/10.1016/j.bbagrm.2018.10.006.
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  - Choi, Seung H., and Kate D. Meyer. “Acetylation takes aim at mRNA.” Nat Struct Mol Biol 25, no. 12 (December 2018): 1067–68. https://doi.org/10.1038/s41594-018-0159-9.
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  - Liu, Bei, Dawn K. Merriman, Seung H. Choi, Maria A. Schumacher, Raphael Plangger, Christoph Kreutz, Stacy M. Horner, Kate D. Meyer, and Hashim M. Al-Hashimi. “A potentially abundant junctional RNA motif stabilized by m6A and Mg2.” Nat Commun 9, no. 1 (July 17, 2018): 2761. https://doi.org/10.1038/s41467-018-05243-z.
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  - Meyer, Kate D., and Samie R. Jaffrey. “Rethinking m6A Readers, Writers, and Erasers.” Annu Rev Cell Dev Biol 33 (October 6, 2017): 319–42. https://doi.org/10.1146/annurev-cellbio-100616-060758.
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  - Meyer, Kate D., and Samie R. Jaffrey. “Expanding the diversity of DNA base modifications with N⁶-methyldeoxyadenosine.” Genome Biol 17 (January 13, 2016): 5. https://doi.org/10.1186/s13059-016-0874-7.
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  - Meyer, Kate D., Deepak P. Patil, Jun Zhou, Alexandra Zinoviev, Maxim A. Skabkin, Olivier Elemento, Tatyana V. Pestova, Shu-Bing Qian, and Samie R. Jaffrey. “5' UTR m(6)A Promotes Cap-Independent Translation.” Cell 163, no. 4 (November 5, 2015): 999–1010. https://doi.org/10.1016/j.cell.2015.10.012.
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  - Satterlee, John S., Maria Basanta-Sanchez, Sandra Blanco, Jin Billy Li, Kate Meyer, Jonathan Pollock, Ghazaleh Sadri-Vakili, and Agnieszka Rybak-Wolf. “Novel RNA modifications in the nervous system: form and function.” J Neurosci 34, no. 46 (November 12, 2014): 15170–77. https://doi.org/10.1523/JNEUROSCI.3236-14.2014.
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  - Meyer, Kate D., and Samie R. Jaffrey. “The dynamic epitranscriptome: N6-methyladenosine and gene expression control.” Nat Rev Mol Cell Biol 15, no. 5 (May 2014): 313–26. https://doi.org/10.1038/nrm3785.
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  - Hess, Martin E., Simon Hess, Kate D. Meyer, Linda A. W. Verhagen, Linda Koch, Hella S. Brönneke, Marcelo O. Dietrich, et al. “The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry.” Nat Neurosci 16, no. 8 (August 2013): 1042–48. https://doi.org/10.1038/nn.3449.
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  - Saletore, Yogesh, Kate Meyer, Jonas Korlach, Igor D. Vilfan, Samie Jaffrey, and Christopher E. Mason. “The birth of the Epitranscriptome: deciphering the function of RNA modifications.” Genome Biol 13, no. 10 (October 31, 2012): 175. https://doi.org/10.1186/gb-2012-13-10-175.
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  - Meyer, Kate D., Yogesh Saletore, Paul Zumbo, Olivier Elemento, Christopher E. Mason, and Samie R. Jaffrey. “Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons.” Cell 149, no. 7 (June 22, 2012): 1635–46. https://doi.org/10.1016/j.cell.2012.05.003.
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  - Meyer, Kate D., and Jill A. Morris. “Disc1 regulates granule cell migration in the developing hippocampus.” Hum Mol Genet 18, no. 17 (September 1, 2009): 3286–97. https://doi.org/10.1093/hmg/ddp266.
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  - Meyer, Kate D., and Jill A. Morris. “Immunohistochemical analysis of Disc1 expression in the developing and adult hippocampus.” Gene Expr Patterns 8, no. 7–8 (September 2008): 494–501. https://doi.org/10.1016/j.gep.2008.06.005.
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- Conference Papers
  - Meyer, K. “Covalent Modifications to mRNA, or the "Epitranscriptome".” In Environmental and Molecular Mutagenesis, 58:S41–S41. WILEY, 2017.
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Teaching & Mentoring
Recent Courses

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Education, Training, & Certifications

In the News

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Conference Papers

Recent Courses