Current Appointments & Affiliations
Associate Professor of Biochemistry
·
2025 - Present
Biochemistry,
Basic Science Departments
Assistant Professor of Cell Biology
·
2022 - Present
Cell Biology,
Basic Science Departments
Associate Professor in Neurobiology
·
2025 - Present
Neurobiology,
Basic Science Departments
Recent Publications
The catalytic efficiency of METTL16 affects cellular processes by governing the intracellular S-adenosylmethionine setpoint.
Journal Article Cell Rep · July 22, 2025 The methyl donor S-adenosylmethionine (SAM) regulates many cellular processes. The N6-methyladenosine (m6A) methyltransferase METTL16 regulates the expression of the SAM synthetase MAT2A, but the consequences of this regulation are not well documented. Her ... Full text Link to item CiteLoss of age-associated increase in m6A-modified RNA contributes to GABAergic dysregulation in Alzheimer's disease.
Journal Article bioRxiv · May 7, 2025 Dysregulated RNA metabolism is a significant feature of Alzheimer's disease (AD), yet how post-transcriptional RNA modifications like N 6-methyladenosine (m6A) are altered in AD is unknown. Here, we performed deamination adjacent to RNA modification target ... Full text Link to item CiteSingle-cell m6A profiling in the mouse brain uncovers cell type-specific RNA methylomes and age-dependent differential methylation.
Journal Article Nat Neurosci · December 2024 N6-methyladenosine (m6A) is an abundant mRNA modification in the brain that has important roles in neurodevelopment and brain function. However, because of technical limitations, global profiling of m6A sites within the individual cell types that make up t ... Full text Link to item CiteRecent Grants
Cell Type-Specific Epitranscriptomic Regulation in the Brain in Aging and Alzheimer's Disease
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2026 - 2030Epitranscriptomic Regulation of Microglia in Alzheimer's Disease
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2025 - 2030Neurobiology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institute of Neurological Disorders and Stroke · 2024 - 2029View All Grants
Education, Training & Certifications
Northwestern University ·
2010
Ph.D.