Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Northwestern University 2010
• Recognition
• 

  In the News

  • OCT 10, 2016

    RNA Researcher Regional Award Finalist
• Expertise
• 

  Subject Headings

  • Epigenetics
  • Messenger RNA
  • Molecular neurobiology
  • Muser Mentor
  • Neurobiology
  • Non-coding RNA
  • RNA
  • RNA Editing
  • RNA-protein interactions
• Research
• 

  Selected Grants

  • Oxidative stress mechanisms regulating gamma-globin gene transcription in sickle cell disease awarded by National Institutes of Health 2022 - 2026
  • Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
  • The Role of RBC Reactive Oxygen Species in Regulating Thrombotic Events During Aging awarded by National Institutes of Health 2021 - 2026
  • Neurobiology Training Program awarded by National Institutes of Health 2019 - 2024
  • Mechanistic Insights into m6A-Mediated Regulation of Brain Development awarded by National Institutes of Health 2018 - 2023
  • Rita Allen Foundation Scholars Award awarded by Rita Allen Foundation 2017 - 2023
  • Epitranscriptomic Regulation of Synaptic Responses to Drugs of Abuse awarded by National Institutes of Health 2018 - 2023
  • Center for Genomic Information Encoded by RNA Nucleotide Modifications awarded by Weill Cornell Medicine 2021 - 2022
  • Epitranscriptomic Control of Local Gene Expression in Neural Stem Cells awarded by National Institutes of Health 2019 - 2021
  • Epitranscriptomic Control of Local Translation in Neurons awarded by Kinship Foundation 2018 - 2021
  • RNA Methylation-Mediated Regulation of Brain Development awarded by Esther A. & Joseph Klingenstein Fund 2017 - 2021
  • Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
  • mRNA Methylation: A Novel Regulatory Mechanism in the Neuronal Transcriptome awarded by National Institutes of Health 2014 - 2019
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  External Relationships

  • University Hospital Heidelberg
  • University of Hong Kong
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Flamand, Mathieu N., and Kate D. Meyer. “m6A and YTHDF proteins contribute to the localization of select neuronal mRNAs.” Nucleic Acids Res 50, no. 8 (May 6, 2022): 4464–83. https://doi.org/10.1093/nar/gkac251.
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    • Meyer, Kate D. “How m6A makes its mark.” Nat Rev Mol Cell Biol, May 4, 2022. https://doi.org/10.1038/s41580-022-00492-9.
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    • Tegowski, Matthew, Mathieu N. Flamand, and Kate D. Meyer. “scDART-seq reveals distinct m6A signatures and mRNA methylation heterogeneity in single cells.” Mol Cell 82, no. 4 (February 17, 2022): 868-878.e10. https://doi.org/10.1016/j.molcel.2021.12.038.
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    • Zhu, Huanyu, Xinhe Yin, Christopher L. Holley, and Kate D. Meyer. “Improved Methods for Deamination-Based m6A Detection.” Front Cell Dev Biol 10 (2022): 888279. https://doi.org/10.3389/fcell.2022.888279.
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    • Cotter, Kellie A., John Gallon, Nadine Uebersax, Philip Rubin, Kate D. Meyer, Salvatore Piscuoglio, Samie R. Jaffrey, and Mark A. Rubin. “Mapping of m6A and Its Regulatory Targets in Prostate Cancer Reveals a METTL3-Low Induction of Therapy Resistance.” Mol Cancer Res 19, no. 8 (August 2021): 1398–1411. https://doi.org/10.1158/1541-7786.MCR-21-0014.
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    • Madugalle, Sachithrani U., Kate Meyer, Dan Ohtan Wang, and Timothy W. Bredy. “RNA N6-Methyladenosine and the Regulation of RNA Localization and Function in the Brain.” Trends Neurosci 43, no. 12 (December 2020): 1011–23. https://doi.org/10.1016/j.tins.2020.09.005.
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    • Flamand, Mathieu N., and Kate D. Meyer. “The epitranscriptome and synaptic plasticity.” Curr Opin Neurobiol 59 (December 2019): 41–48. https://doi.org/10.1016/j.conb.2019.04.007.
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    • Meyer, Kate D. “DART-seq: an antibody-free method for global m6A detection.” Nat Methods 16, no. 12 (December 2019): 1275–80. https://doi.org/10.1038/s41592-019-0570-0.
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    • Meyer, Kate D. “m6A-mediated translation regulation.” Biochim Biophys Acta Gene Regul Mech 1862, no. 3 (March 2019): 301–9. https://doi.org/10.1016/j.bbagrm.2018.10.006.
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    • Choi, Seung H., and Kate D. Meyer. “Acetylation takes aim at mRNA.” Nat Struct Mol Biol 25, no. 12 (December 2018): 1067–68. https://doi.org/10.1038/s41594-018-0159-9.
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    • Liu, Bei, Dawn K. Merriman, Seung H. Choi, Maria A. Schumacher, Raphael Plangger, Christoph Kreutz, Stacy M. Horner, Kate D. Meyer, and Hashim M. Al-Hashimi. “A potentially abundant junctional RNA motif stabilized by m6A and Mg2.” Nat Commun 9, no. 1 (July 17, 2018): 2761. https://doi.org/10.1038/s41467-018-05243-z.
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    • Meyer, Kate D., and Samie R. Jaffrey. “Rethinking m6A Readers, Writers, and Erasers.” Annu Rev Cell Dev Biol 33 (October 6, 2017): 319–42. https://doi.org/10.1146/annurev-cellbio-100616-060758.
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    • Meyer, Kate D., and Samie R. Jaffrey. “Expanding the diversity of DNA base modifications with N⁶-methyldeoxyadenosine.” Genome Biol 17 (January 13, 2016): 5. https://doi.org/10.1186/s13059-016-0874-7.
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    • Meyer, Kate D., Deepak P. Patil, Jun Zhou, Alexandra Zinoviev, Maxim A. Skabkin, Olivier Elemento, Tatyana V. Pestova, Shu-Bing Qian, and Samie R. Jaffrey. “5' UTR m(6)A Promotes Cap-Independent Translation.” Cell 163, no. 4 (November 5, 2015): 999–1010. https://doi.org/10.1016/j.cell.2015.10.012.
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    • Satterlee, John S., Maria Basanta-Sanchez, Sandra Blanco, Jin Billy Li, Kate Meyer, Jonathan Pollock, Ghazaleh Sadri-Vakili, and Agnieszka Rybak-Wolf. “Novel RNA modifications in the nervous system: form and function.” J Neurosci 34, no. 46 (November 12, 2014): 15170–77. https://doi.org/10.1523/JNEUROSCI.3236-14.2014.
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    • Meyer, Kate D., and Samie R. Jaffrey. “The dynamic epitranscriptome: N6-methyladenosine and gene expression control.” Nat Rev Mol Cell Biol 15, no. 5 (May 2014): 313–26. https://doi.org/10.1038/nrm3785.
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    • Hess, Martin E., Simon Hess, Kate D. Meyer, Linda A. W. Verhagen, Linda Koch, Hella S. Brönneke, Marcelo O. Dietrich, et al. “The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry.” Nat Neurosci 16, no. 8 (August 2013): 1042–48. https://doi.org/10.1038/nn.3449.
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    • Saletore, Yogesh, Kate Meyer, Jonas Korlach, Igor D. Vilfan, Samie Jaffrey, and Christopher E. Mason. “The birth of the Epitranscriptome: deciphering the function of RNA modifications.” Genome Biol 13, no. 10 (October 31, 2012): 175. https://doi.org/10.1186/gb-2012-13-10-175.
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    • Meyer, Kate D., Yogesh Saletore, Paul Zumbo, Olivier Elemento, Christopher E. Mason, and Samie R. Jaffrey. “Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons.” Cell 149, no. 7 (June 22, 2012): 1635–46. https://doi.org/10.1016/j.cell.2012.05.003.
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    • Meyer, Kate D., and Jill A. Morris. “Disc1 regulates granule cell migration in the developing hippocampus.” Hum Mol Genet 18, no. 17 (September 1, 2009): 3286–97. https://doi.org/10.1093/hmg/ddp266.
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    • Meyer, Kate D., and Jill A. Morris. “Immunohistochemical analysis of Disc1 expression in the developing and adult hippocampus.” Gene Expr Patterns 8, no. 7–8 (September 2008): 494–501. https://doi.org/10.1016/j.gep.2008.06.005.
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  • Book Sections

    • Tegowski, Matthew, Huanyu Zhu, and Kate D. Meyer. “Detecting m6A with In Vitro DART-Seq.,” 2404:363–74, 2022. https://doi.org/10.1007/978-1-0716-1851-6_20.
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  • Conference Papers

    • Meyer, K. “Covalent Modifications to mRNA, or the "Epitranscriptome".” In Environmental and Molecular Mutagenesis, 58:S41–S41. WILEY, 2017.
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• Teaching & Mentoring
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  Recent Courses

  • BIOCHEM 393: Research Independent Study 2022
  • BIOCHEM 593: Research Independent Study 2022
  • BIOCHEM 668: RNA Biology: Co-Transcriptional and Post-Transcriptional Control of Gene Expression 2022
  • CELLBIO 668: RNA Biology: Co-Transcriptional and Post-Transcriptional Control of Gene Expression 2022
  • UPGEN 668: RNA Biology: Co-Transcriptional and Post-Transcriptional Control of Gene Expression 2022
  • BIOCHEM 393: Research Independent Study 2021
  • BIOCHEM 593: Research Independent Study 2021
  • BIOCHEM 668: RNA Biology: Co-Transcriptional and Post-Transcriptional Control of Gene Expression 2021
  • CELLBIO 668: RNA Biology: Co-Transcriptional and Post-Transcriptional Control of Gene Expression 2021
  • NEUROBIO 393: Research Independent Study 2021
  • NEUROBIO 793: Research in Neurobiology 2021
  • UPGEN 668: RNA Biology: Co-Transcriptional and Post-Transcriptional Control of Gene Expression 2021
  • BIOCHEM 393: Research Independent Study 2020
  • BIOCHEM 593: Research Independent Study 2020
  • BIOCHEM 668: RNA Biology: Co-Transcriptional and Post-Transcriptional Control of Gene Expression 2020
  • CELLBIO 668: RNA Biology: Co-Transcriptional and Post-Transcriptional Control of Gene Expression 2020
  • UPGEN 668: RNA Biology: Co-Transcriptional and Post-Transcriptional Control of Gene Expression 2020

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