https://orcid.org/0000-0001-7197-4054
Current Duke Appointments & Affiliations
Associate Professor of Biochemistry
·
2025 - Present
Biochemistry,
Basic Science Departments
Assistant Professor of Cell Biology
·
2022 - Present
Cell Biology,
Basic Science Departments
Associate Professor in Neurobiology
·
2025 - Present
Neurobiology,
Basic Science Departments
Recent Scholarly Works
Transcript architecture sets the m 6 A landscape: CSTF2 and CSTF2T reshape m 6 A through cleavage-dependent and -independent mechanisms.
Journal article bioRxiv · June 8, 2026 Alternative RNA processing generates extensive transcript diversity, yet how transcript architecture influences selective m 6 A deposition is incompletely understood. Exon-junction-based models explain where m 6 A is excluded, but a positive determinant of ... Full text Link to item CiteM6A-driven control of T cell fitness via lrpprc defines a novel regulatory axis to enhance adoptive cell therapy
Conference Blood · November 3, 2025 AbstractAdoptive cellular therapies (ACT) including chimeric antigen receptor (CAR)-T cells have transformed the treatment landscape for pa ... Full text CiteThe catalytic efficiency of METTL16 affects cellular processes by governing the intracellular S-adenosylmethionine setpoint.
Journal article Cell Rep · July 22, 2025 The methyl donor S-adenosylmethionine (SAM) regulates many cellular processes. The N6-methyladenosine (m6A) methyltransferase METTL16 regulates the expression of the SAM synthetase MAT2A, but the consequences of this regulation are not well documented. Her ... Full text Link to item CiteRecent Grants
Cell and Molecular Biology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 2026 - 2031Cell Type-Specific Epitranscriptomic Regulation in the Brain in Aging and Alzheimer's Disease
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2026 - 2030Epitranscriptomic Regulation of Microglia in Alzheimer's Disease
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2025 - 2030View All Grants
Education
Northwestern University ·
2010
Ph.D.