A Systematic Review of Metastatic Hepatocellular Carcinoma to the Spine.

Journal Article (Journal Article;Review;Systematic Review)

BACKGROUND: Hepatocellular carcinoma (HCC) frequently metastasizes to the spine. The impact of medical and/or surgical intervention on overall survival has been examined in a limited number of clinical studies, and herein we systematically review these data. METHODS: We performed a literature review using PubMed, Embase, CINAHL, and Web of Science to identify articles that reported survival, clinical outcomes, and/or prognostic factors associated with patients diagnosed with spinal metastases. The methodologic quality of each review was assessed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses tool. RESULTS: There were 26 articles (152 patients) that met the inclusion criteria and were treated with either surgery, radiotherapy, chemotherapy, and/or observation. There were 3 retrospective cohort studies, 17 case reports, 5 case series, and 1 longitudinal observational study. Of the patients with known overall survival after diagnosis of spinal metastasis, survival at 3 months, 6 months, 1 year, 2 years, and 5 years was 95.2%, 83.0%, 28.6%, 2.0%, and 1.4%, respectively. The median survival after diagnosis of the metastasis was 0.7 months in the patients who received no treatment, 7 months in the patients treated with surgical intervention alone, 6 months for patients who received chemotherapy and/or radiation, and 13.5 months in the patients treated with a combination of surgery and medical management. All other clinical or prognostic parameters were of low or insufficient strength. CONCLUSIONS: Patients diagnosed with HCC spinal metastasis have a 10.6-month overall survival. Further analysis of patients in prospective controlled trials will be essential to the development of treatment algorithms for these patients in the future.

Full Text

Duke Authors

Cited Authors

  • Goodwin, CR; Yanamadala, V; Ruiz-Valls, A; Abu-Bonsrah, N; Shankar, G; Sankey, EW; Boone, C; Clarke, MJ; Bilsky, M; Laufer, I; Fisher, C; Shin, JH; Sciubba, DM

Published Date

  • July 2016

Published In

Volume / Issue

  • 91 /

Start / End Page

  • 510 - 517.e4

PubMed ID

  • 27090971

Pubmed Central ID

  • PMC5586495

Electronic International Standard Serial Number (EISSN)

  • 1878-8769

Digital Object Identifier (DOI)

  • 10.1016/j.wneu.2016.04.026


  • eng

Conference Location

  • United States