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A Systematic Review of Metastatic Hepatocellular Carcinoma to the Spine.

Publication ,  Journal Article
Goodwin, CR; Yanamadala, V; Ruiz-Valls, A; Abu-Bonsrah, N; Shankar, G; Sankey, EW; Boone, C; Clarke, MJ; Bilsky, M; Laufer, I; Fisher, C ...
Published in: World Neurosurg
July 2016

BACKGROUND: Hepatocellular carcinoma (HCC) frequently metastasizes to the spine. The impact of medical and/or surgical intervention on overall survival has been examined in a limited number of clinical studies, and herein we systematically review these data. METHODS: We performed a literature review using PubMed, Embase, CINAHL, and Web of Science to identify articles that reported survival, clinical outcomes, and/or prognostic factors associated with patients diagnosed with spinal metastases. The methodologic quality of each review was assessed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses tool. RESULTS: There were 26 articles (152 patients) that met the inclusion criteria and were treated with either surgery, radiotherapy, chemotherapy, and/or observation. There were 3 retrospective cohort studies, 17 case reports, 5 case series, and 1 longitudinal observational study. Of the patients with known overall survival after diagnosis of spinal metastasis, survival at 3 months, 6 months, 1 year, 2 years, and 5 years was 95.2%, 83.0%, 28.6%, 2.0%, and 1.4%, respectively. The median survival after diagnosis of the metastasis was 0.7 months in the patients who received no treatment, 7 months in the patients treated with surgical intervention alone, 6 months for patients who received chemotherapy and/or radiation, and 13.5 months in the patients treated with a combination of surgery and medical management. All other clinical or prognostic parameters were of low or insufficient strength. CONCLUSIONS: Patients diagnosed with HCC spinal metastasis have a 10.6-month overall survival. Further analysis of patients in prospective controlled trials will be essential to the development of treatment algorithms for these patients in the future.

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Published In

World Neurosurg

DOI

EISSN

1878-8769

Publication Date

July 2016

Volume

91

Start / End Page

510 / 517.e4

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Survival Analysis
  • Spinal Neoplasms
  • Middle Aged
  • Male
  • Liver Neoplasms
  • Humans
  • Female
  • Carcinoma, Hepatocellular
  • 3209 Neurosciences
 

Citation

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Goodwin, C. R., Yanamadala, V., Ruiz-Valls, A., Abu-Bonsrah, N., Shankar, G., Sankey, E. W., … Sciubba, D. M. (2016). A Systematic Review of Metastatic Hepatocellular Carcinoma to the Spine. World Neurosurg, 91, 510-517.e4. https://doi.org/10.1016/j.wneu.2016.04.026
Goodwin, C Rory, Vijay Yanamadala, Alejandro Ruiz-Valls, Nancy Abu-Bonsrah, Ganesh Shankar, Eric W. Sankey, Christine Boone, et al. “A Systematic Review of Metastatic Hepatocellular Carcinoma to the Spine.World Neurosurg 91 (July 2016): 510-517.e4. https://doi.org/10.1016/j.wneu.2016.04.026.
Goodwin CR, Yanamadala V, Ruiz-Valls A, Abu-Bonsrah N, Shankar G, Sankey EW, et al. A Systematic Review of Metastatic Hepatocellular Carcinoma to the Spine. World Neurosurg. 2016 Jul;91:510-517.e4.
Goodwin, C. Rory, et al. “A Systematic Review of Metastatic Hepatocellular Carcinoma to the Spine.World Neurosurg, vol. 91, July 2016, pp. 510-517.e4. Pubmed, doi:10.1016/j.wneu.2016.04.026.
Goodwin CR, Yanamadala V, Ruiz-Valls A, Abu-Bonsrah N, Shankar G, Sankey EW, Boone C, Clarke MJ, Bilsky M, Laufer I, Fisher C, Shin JH, Sciubba DM. A Systematic Review of Metastatic Hepatocellular Carcinoma to the Spine. World Neurosurg. 2016 Jul;91:510-517.e4.

Published In

World Neurosurg

DOI

EISSN

1878-8769

Publication Date

July 2016

Volume

91

Start / End Page

510 / 517.e4

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Survival Analysis
  • Spinal Neoplasms
  • Middle Aged
  • Male
  • Liver Neoplasms
  • Humans
  • Female
  • Carcinoma, Hepatocellular
  • 3209 Neurosciences