Optimal visual perception and detection of oral cavity neoplasia.

Journal Article (Journal Article)

The most common way to detect disease is by visual inspection of the suspect tissue. However, the human eye is not optimized for this task because the perceived spectrum of light is divided into three channels, all of which have overlapping spectral sensitivity curves. Here, we present new methods to optimize visually perceived contrast based on spectral differences between normal and abnormal tissue. We apply these methods to the perception of fluorescence emission from the oral cavity. Abnormalities in the oral cavity are optimally perceived when the excitation is between nm. To optimally visualize fluorescence at 340-nm excitation, the emission should be observed through a blue bandpass filter transmitting light at 430 nm.

Full Text

Duke Authors

Cited Authors

  • Utzinger, U; Bueeler, M; Oh, S; Heintzelman, DL; Svistun, ES; Abd-El-Barr, M; Gillenwater, A; Richards-Kortum, R

Published Date

  • March 2003

Published In

Volume / Issue

  • 50 / 3

Start / End Page

  • 396 - 399

PubMed ID

  • 12669997

International Standard Serial Number (ISSN)

  • 0018-9294

Digital Object Identifier (DOI)

  • 10.1109/TBME.2003.808832


  • eng

Conference Location

  • United States