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Pump speed modulations and sub-maximal exercise tolerance in left ventricular assist device recipients: A double-blind, randomized trial.

Publication ,  Journal Article
Jung, MH; Houston, B; Russell, SD; Gustafsson, F
Published in: J Heart Lung Transplant
January 2017

BACKGROUND: The effect of pump speed increase on sub-maximal exercise tolerance, corresponding to activities of daily living (ADLs), is unknown. The aim of this study was to determine the effects of increasing pump speed during exercise at a sub-maximal level below anaerobic threshold (AT). METHODS: Patients each completed 3 exercise sessions on an ergometer cycle. On Day 1 workload at AT was defined. On Day 2 of the study, 2 sub-maximal tests at a workload below AT were undertaken: one at fixed baseline pump speed (Speedbase) and the other with baseline pump speed + 800 rpm (Speedinc). The sequence of the 2 sub-maximal tests was determined by randomization. Both patient and physician were blinded to the sequence. Exercise duration, oxygen consumption (VO2) and rate of perceived exertion (RPE), using the Borg scale (score 6 to 20), were recorded. RESULTS: Nineteen patients (all with a HeartMate II ventricular assist device) completed 57 exercise tests. Baseline pump speed was 9,326 ± 378 rpm. At AT, workload was 63 ± 26 W (25 to 115 W) and VO2 was 79 ± 14% of maximum. Exercise duration improved by 106 ± 217 seconds (~13%) in Speedinc compared with Speedbase (837 ± 358 vs 942 ± 359 seconds; p = 0.048). The RPE was 13.2 ± 2.5 in Speedbase vs 12.7 ± 2.4 in Speedinc (p = 0.2). CONCLUSION: Increasing pump speed by 800 rpm during sustained, low-intensity physical activity is safe and prolongs exercise duration in patients supported with a HeartMate II device. Automated pump speed increase during light exercise may contribute to improved quality of life by facilitating ADLs.

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Published In

J Heart Lung Transplant

DOI

EISSN

1557-3117

Publication Date

January 2017

Volume

36

Issue

1

Start / End Page

36 / 41

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Treatment Outcome
  • Surgery
  • Retrospective Studies
  • Quality of Life
  • Oxygen Consumption
  • Outpatients
  • Middle Aged
  • Male
  • Humans
 

Citation

APA
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ICMJE
MLA
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Jung, M. H., Houston, B., Russell, S. D., & Gustafsson, F. (2017). Pump speed modulations and sub-maximal exercise tolerance in left ventricular assist device recipients: A double-blind, randomized trial. J Heart Lung Transplant, 36(1), 36–41. https://doi.org/10.1016/j.healun.2016.06.020
Jung, Mette Holme, Brian Houston, Stuart D. Russell, and Finn Gustafsson. “Pump speed modulations and sub-maximal exercise tolerance in left ventricular assist device recipients: A double-blind, randomized trial.J Heart Lung Transplant 36, no. 1 (January 2017): 36–41. https://doi.org/10.1016/j.healun.2016.06.020.
Jung MH, Houston B, Russell SD, Gustafsson F. Pump speed modulations and sub-maximal exercise tolerance in left ventricular assist device recipients: A double-blind, randomized trial. J Heart Lung Transplant. 2017 Jan;36(1):36–41.
Jung, Mette Holme, et al. “Pump speed modulations and sub-maximal exercise tolerance in left ventricular assist device recipients: A double-blind, randomized trial.J Heart Lung Transplant, vol. 36, no. 1, Jan. 2017, pp. 36–41. Pubmed, doi:10.1016/j.healun.2016.06.020.
Jung MH, Houston B, Russell SD, Gustafsson F. Pump speed modulations and sub-maximal exercise tolerance in left ventricular assist device recipients: A double-blind, randomized trial. J Heart Lung Transplant. 2017 Jan;36(1):36–41.
Journal cover image

Published In

J Heart Lung Transplant

DOI

EISSN

1557-3117

Publication Date

January 2017

Volume

36

Issue

1

Start / End Page

36 / 41

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Treatment Outcome
  • Surgery
  • Retrospective Studies
  • Quality of Life
  • Oxygen Consumption
  • Outpatients
  • Middle Aged
  • Male
  • Humans