Overview
The focus of my research is on the care of patients with advanced heart failure. We are involved in single and multicenter clinical trials evaluating new drug therapies for patients with advanced heart failure. Additionally, we are working to understand the exercise limitations and how to improve them in this patient population. We are trying to understand some of the basic pathophysiologic consequences of heart failure such as the origin of the symptoms of dyspnea and fatigue.
We have established an invasive cardiopulmonary exercise lab in which we carry out the majority of our research. We have the ability to monitor hemodynamics and gas exchange during exercise. Additionally, we have been the exercise core lab for various trials involving exercise as an endpoint in the evaluation of new therapies for heart failure.
Key words include: Advanced heart failure, Exercise physiology, and Cardiac transplantation.
We have established an invasive cardiopulmonary exercise lab in which we carry out the majority of our research. We have the ability to monitor hemodynamics and gas exchange during exercise. Additionally, we have been the exercise core lab for various trials involving exercise as an endpoint in the evaluation of new therapies for heart failure.
Key words include: Advanced heart failure, Exercise physiology, and Cardiac transplantation.
Current Appointments & Affiliations
Professor of Medicine
·
2021 - Present
Medicine, Cardiology,
Medicine
Recent Publications
Impact of HeartMate 3 left ventricular assist device infection on outcomes following heart transplant.
Journal Article J Heart Lung Transplant · April 2026 BACKGROUND: Infectious complications are common in patients implanted with HeartMate 3 (HM3) left ventricular assist devices (LVAD). Despite these issues, some patients with LVAD-specific infection are ultimately considered for heart transplant (HT). The i ... Full text Link to item CiteAcute HeartMate3 Malfunction Requiring Exchange Due to Intrapump Obstruction: Inflow Cannula Obstruction Can Cause HM3 Failure.
Journal Article ASAIO J · March 11, 2026 HeartMate III (HM3) pump failure due to intrapump obstruction from biodebris or thrombosis is an uncommon but life-threatening condition. Here, we describe a case of HM3 failure from biodebris occluding the inflow cannula and pump interior 11 months after ... Full text Link to item CitePressure points: Hemodynamics and waitlist risk before heart transplant.
Journal Article J Heart Lung Transplant · March 2026 Full text Link to item CiteRecent Grants
The Atherosclerosis Risk in Communities (ARIC) Study-Field Center
ResearchPrincipal Investigator · Awarded by Johns Hopkins University · 2017 - 2026Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catherization Effectiveness (ESCAPE), RFP NHLBI-HV-98-24
Clinical TrialPrincipal Investigator · Awarded by National Heart, Lung, and Blood Institute · 1999 - 2002View All Grants
Education
University of Washington, School of Medicine ·
1991
M.D.