Scholars@Duke
Stuart Dean Russell

Stuart Dean Russell

Professor of Medicine
Medicine, Cardiology
stuart.russell@duke.edu
Box 3126 Med Ctr, Durham, NC 27710
DUMC Box 3126, Durham, NC 27710
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Selected Publications

Exercise and weight loss with a left ventricular assist device: A case report and review of the literature.

Journal Article Current problems in cardiology · October 2024 With changes in the heart transplant allocation system in the United States, the use of left ventricular device therapy (LVAD) as a bridge to transplant has decreased. Currently, one of the primary reasons to implant a device is for patient support until t ... Full text Cite

Appropriate and inappropriate ICD shocks in patients with LVADs: Prevalence, associated factors, and etiologies.

Journal Article Heart Rhythm · July 23, 2024 BACKGROUND: Implantable cardioverter-defibrillator (ICD) shocks are a common complication after left ventricular assist device (LVAD) implantation; however, data on their frequency and causes are limited. OBJECTIVE: The purpose of this study was to define ... Full text Link to item Cite

Value of nutritional indices in predicting survival free from pump replacement and driveline infections in centrifugal left ventricular assist devices

Journal Article JTCVS Open · June 1, 2024 Objective: There is a paucity of data assessing the impact of nutritional status on outcomes in patients supported with the HeartMate 3 (HM3) left ventricular assist device (LVAD). Methods: Patients ≥18 years of age who underwent HM3 LVAD implantation betw ... Full text Cite

Surgical Treatment of Tricuspid Valve Regurgitation in Patients Undergoing Left Ventricular Assist Device Implantation: Interim analysis of the TVVAD trial.

Journal Article J Thorac Cardiovasc Surg · May 2024 OBJECTIVES: Right heart failure remains a serious complication of left ventricular assist device therapy. Many patients presenting for left ventricular assist device implantation have significant tricuspid regurgitation. It remains unknown whether concurre ... Full text Link to item Cite

Metabolomic Association and Risk Prediction With Heart Failure in Older Adults.

Journal Article Circ Heart Fail · March 2024 BACKGROUND: Older adults have markedly increased risks of heart failure (HF), specifically HF with preserved ejection fraction (HFpEF). Identifying novel biomarkers can help in understanding HF pathogenesis and improve at-risk population identification. Th ... Full text Link to item Cite

Long-term predictors of morbidity and mortality in patients following LVAD replacement.

Journal Article Artif Organs · February 2024 BACKGROUND: As heart transplant guidelines evolve, the clinical indication for 73% of durable left ventricular assist device (LVAD) implants is now destination therapy. Although completely magnetically levitated LVAD devices have demonstrated improved dura ... Full text Link to item Cite

Beyond Stage C: Considerations in the Management of Patients With Heart Failure Progression and Gaps in Evidence.

Journal Article J Card Fail · May 2023 Despite treatment with contemporary medical therapies for chronic heart failure (HF), there has been an increase in the prevalence of patients progressing to more advanced disease. Patients progressing to and living at the interface of severe stage C and s ... Full text Link to item Cite

Acute Diuretic-Sparing Effects of Sacubitril-Valsartan: Staying in the Loop.

Journal Article J Pharm Pract · December 2022 BACKGROUND: Previous literature has suggested a potential diuretic sparing effect as early as 6 months following sacubitril-valsartan initiation in patients with heart failure with reduced ejection fraction (HFrEF); however, whether this effect manifests e ... Full text Link to item Cite

Atrial fibrillation is an independent risk factor for heart failure hospitalization in heart failure with preserved ejection fraction.

Journal Article ESC Heart Fail · October 2022 AIMS: Atrial fibrillation (AF) is a common comorbid condition in heart failure with preserved ejection fraction (HFpEF). The effect of AF on heart failure (HF) exacerbation in HFpEF has not been well described. This study investigated how AF modifies the c ... Full text Link to item Cite

Cardiovascular Disease Risk Among Cancer Survivors: The Atherosclerosis Risk In Communities (ARIC) Study.

Journal Article J Am Coll Cardiol · July 5, 2022 BACKGROUND: More than 80% of adult patients diagnosed with cancer survive long term. Long-term complications of cancer and its therapies may increase the risk of cardiovascular disease (CVD), but prospective studies using adjudicated cancer and CVD events ... Full text Link to item Cite

Nonplatelet thromboxane generation is associated with impaired cardiovascular performance and mortality in heart failure.

Journal Article Am J Physiol Heart Circ Physiol · July 1, 2022 Nonplatelet thromboxane generation, stimulated largely by oxidative stress, is a novel mortality risk factor in individuals with coronary artery disease. Though inversely associated with left ventricular ejection fraction (LVEF), a potential role in the pa ... Full text Link to item Cite

Progression of aortic valve insufficiency during centrifugal versus axial flow left ventricular assist device support.

Journal Article Eur J Cardiothorac Surg · May 2, 2022 OBJECTIVES: Long-term left ventricular assist device (LVAD) support can cause accelerated progression of aortic insufficiency (AI). The MOMENTUM trial has led to increased use of the HeartMate 3 (HM3) LVAD, due to greater hemocompatibility. However, the di ... Full text Link to item Cite

Race- and Gender-Based Differences in Cardiac Structure and Function and Risk of Heart Failure.

Journal Article J Am Coll Cardiol · February 1, 2022 BACKGROUND: Although heart failure (HF) risk and cardiac structure/function reportedly differ according to race and gender, limited data exist in late life when risk of HF is highest. OBJECTIVES: The goal of this study was to evaluate race/gender-based dif ... Full text Link to item Cite

Pericardial Adipose Tissue Volume and Left Ventricular Assist Device-Associated Outcomes.

Journal Article J Card Fail · January 2022 BACKGROUND: Pericardial adipose tissue (PAT) is associated with adverse cardiovascular outcomes in those with and without established heart failure (HF). However, it is not known whether PAT is associated with adverse outcomes in patients with end-stage HF ... Full text Link to item Cite

Trends in Substance Use in Patients Requiring Advanced Heart Failure Therapies

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2022 Cite

Exercise and weight loss with a left ventricular assist device: A case report and review of the literature.

Journal Article Current problems in cardiology · October 2024 With changes in the heart transplant allocation system in the United States, the use of left ventricular device therapy (LVAD) as a bridge to transplant has decreased. Currently, one of the primary reasons to implant a device is for patient support until t ... Full text Cite

Appropriate and inappropriate ICD shocks in patients with LVADs: Prevalence, associated factors, and etiologies.

Journal Article Heart Rhythm · July 23, 2024 BACKGROUND: Implantable cardioverter-defibrillator (ICD) shocks are a common complication after left ventricular assist device (LVAD) implantation; however, data on their frequency and causes are limited. OBJECTIVE: The purpose of this study was to define ... Full text Link to item Cite

Value of nutritional indices in predicting survival free from pump replacement and driveline infections in centrifugal left ventricular assist devices

Journal Article JTCVS Open · June 1, 2024 Objective: There is a paucity of data assessing the impact of nutritional status on outcomes in patients supported with the HeartMate 3 (HM3) left ventricular assist device (LVAD). Methods: Patients ≥18 years of age who underwent HM3 LVAD implantation betw ... Full text Cite

Surgical Treatment of Tricuspid Valve Regurgitation in Patients Undergoing Left Ventricular Assist Device Implantation: Interim analysis of the TVVAD trial.

Journal Article J Thorac Cardiovasc Surg · May 2024 OBJECTIVES: Right heart failure remains a serious complication of left ventricular assist device therapy. Many patients presenting for left ventricular assist device implantation have significant tricuspid regurgitation. It remains unknown whether concurre ... Full text Link to item Cite

Metabolomic Association and Risk Prediction With Heart Failure in Older Adults.

Journal Article Circ Heart Fail · March 2024 BACKGROUND: Older adults have markedly increased risks of heart failure (HF), specifically HF with preserved ejection fraction (HFpEF). Identifying novel biomarkers can help in understanding HF pathogenesis and improve at-risk population identification. Th ... Full text Link to item Cite

Long-term predictors of morbidity and mortality in patients following LVAD replacement.

Journal Article Artif Organs · February 2024 BACKGROUND: As heart transplant guidelines evolve, the clinical indication for 73% of durable left ventricular assist device (LVAD) implants is now destination therapy. Although completely magnetically levitated LVAD devices have demonstrated improved dura ... Full text Link to item Cite

Beyond Stage C: Considerations in the Management of Patients With Heart Failure Progression and Gaps in Evidence.

Journal Article J Card Fail · May 2023 Despite treatment with contemporary medical therapies for chronic heart failure (HF), there has been an increase in the prevalence of patients progressing to more advanced disease. Patients progressing to and living at the interface of severe stage C and s ... Full text Link to item Cite

Acute Diuretic-Sparing Effects of Sacubitril-Valsartan: Staying in the Loop.

Journal Article J Pharm Pract · December 2022 BACKGROUND: Previous literature has suggested a potential diuretic sparing effect as early as 6 months following sacubitril-valsartan initiation in patients with heart failure with reduced ejection fraction (HFrEF); however, whether this effect manifests e ... Full text Link to item Cite

Atrial fibrillation is an independent risk factor for heart failure hospitalization in heart failure with preserved ejection fraction.

Journal Article ESC Heart Fail · October 2022 AIMS: Atrial fibrillation (AF) is a common comorbid condition in heart failure with preserved ejection fraction (HFpEF). The effect of AF on heart failure (HF) exacerbation in HFpEF has not been well described. This study investigated how AF modifies the c ... Full text Link to item Cite

Cardiovascular Disease Risk Among Cancer Survivors: The Atherosclerosis Risk In Communities (ARIC) Study.

Journal Article J Am Coll Cardiol · July 5, 2022 BACKGROUND: More than 80% of adult patients diagnosed with cancer survive long term. Long-term complications of cancer and its therapies may increase the risk of cardiovascular disease (CVD), but prospective studies using adjudicated cancer and CVD events ... Full text Link to item Cite

Nonplatelet thromboxane generation is associated with impaired cardiovascular performance and mortality in heart failure.

Journal Article Am J Physiol Heart Circ Physiol · July 1, 2022 Nonplatelet thromboxane generation, stimulated largely by oxidative stress, is a novel mortality risk factor in individuals with coronary artery disease. Though inversely associated with left ventricular ejection fraction (LVEF), a potential role in the pa ... Full text Link to item Cite

Progression of aortic valve insufficiency during centrifugal versus axial flow left ventricular assist device support.

Journal Article Eur J Cardiothorac Surg · May 2, 2022 OBJECTIVES: Long-term left ventricular assist device (LVAD) support can cause accelerated progression of aortic insufficiency (AI). The MOMENTUM trial has led to increased use of the HeartMate 3 (HM3) LVAD, due to greater hemocompatibility. However, the di ... Full text Link to item Cite

Race- and Gender-Based Differences in Cardiac Structure and Function and Risk of Heart Failure.

Journal Article J Am Coll Cardiol · February 1, 2022 BACKGROUND: Although heart failure (HF) risk and cardiac structure/function reportedly differ according to race and gender, limited data exist in late life when risk of HF is highest. OBJECTIVES: The goal of this study was to evaluate race/gender-based dif ... Full text Link to item Cite

Pericardial Adipose Tissue Volume and Left Ventricular Assist Device-Associated Outcomes.

Journal Article J Card Fail · January 2022 BACKGROUND: Pericardial adipose tissue (PAT) is associated with adverse cardiovascular outcomes in those with and without established heart failure (HF). However, it is not known whether PAT is associated with adverse outcomes in patients with end-stage HF ... Full text Link to item Cite

Trends in Substance Use in Patients Requiring Advanced Heart Failure Therapies

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2022 Cite

Guidance for Timely and Appropriate Referral of Patients With Advanced Heart Failure: A Scientific Statement From the American Heart Association.

Journal Article Circulation · October 12, 2021 Among the estimated 6.2 million Americans living with heart failure (HF), ≈5%/y may progress to advanced, or stage D, disease. Advanced HF has a high morbidity and mortality, such that early recognition of this condition is important to optimize care. Dela ... Full text Link to item Cite

Prognostic Value of Peak Oxygen Uptake in Patients Supported With Left Ventricular Assist Devices (PRO-VAD).

Journal Article JACC Heart Fail · October 2021 OBJECTIVES: The purpose of this study was to examine whether peak oxygen uptake (pVO2) and other cardiopulmonary exercise test (CPET)-derived variables could predict intermediate-term mortality in stable continuous flow LVAD recipients. BACKGROUND: pVO2 is ... Full text Link to item Cite

Endothelial Stromal PD-L1 (Programmed Death Ligand 1) Modulates CD8+ T-Cell Infiltration After Heart Transplantation.

Journal Article Circ Heart Fail · October 2021 BACKGROUND: The role of checkpoint axes in transplantation has been partially addressed in animal models but not in humans. Occurrence of fulminant myocarditis with allorejection-like immunologic features in patients under anti-PD1 (programmed death cell p ... Full text Link to item Cite

Caregiver Health-Related Quality of Life, Burden, and Patient Outcomes in Ambulatory Advanced Heart Failure: A Report From REVIVAL.

Journal Article J Am Heart Assoc · July 20, 2021 Background Heart failure (HF) imposes significant burden on patients and caregivers. Longitudinal data on caregiver health-related quality of life (HRQOL) and burden in ambulatory advanced HF are limited. Methods and Results Ambulatory patients with advanc ... Full text Link to item Cite

Racial Differences and Temporal Obesity Trends in Heart Failure with Preserved Ejection Fraction.

Journal Article J Am Geriatr Soc · May 2021 BACKGROUND/OBJECTIVES: Obesity increases with age, is disproportionately prevalent in black populations, and is associated with heart failure with preserved ejection fraction (HFpEF). An "obesity paradox," or improved survival with obesity, has been report ... Full text Link to item Cite

Acute cardiovascular hospitalizations and illness severity before and during the COVID-19 pandemic.

Journal Article Clin Cardiol · May 2021 BACKGROUND: Cardiovascular disease (CVD) hospitalizations declined worldwide during the COVID-19 pandemic. It is unclear how shelter-in-place orders affected acute CVD hospitalizations, illness severity, and outcomes. HYPOTHESIS: COVID-19 pandemic was asso ... Full text Link to item Cite

Cell-Free DNA to Detect Heart Allograft Acute Rejection.

Journal Article Circulation · March 23, 2021 BACKGROUND: After heart transplantation, endomyocardial biopsy (EMBx) is used to monitor for acute rejection (AR). Unfortunately, EMBx is invasive, and its conventional histological interpretation has limitations. This is a validation study to assess the p ... Full text Link to item Cite

Management of heart failure in cardiac amyloidosis using an ambulatory diuresis clinic.

Journal Article Am Heart J · March 2021 BACKGROUND: Recurrent congestion in cardiac amyloidosis (CA) remains a management challenge, often requiring high dose diuretics and frequent hospitalizations. Innovative outpatient strategies are needed to effectively manage heart failure (HF) in patients ... Full text Link to item Cite

Association between Pulmonary Hypertension and Outcomes in Heart-Kidney Transplantation

Conference JOURNAL OF HEART AND LUNG TRANSPLANTATION · 2021 Cite

Ambulatory management of worsening heart failure: Current strategies and future directions

Journal Article Heart International · January 1, 2021 Heart failure (HF) is a highly prevalent and morbid disease in the USA. The chronic, progressive course of HF is defined by periodic exacerbations of symptoms, described as ‘worsening heart failure’ (WHF). Previously, episodes of WHF have required hospital ... Full text Cite

Predictors of Mortality by Sex and Race in Heart Failure With Preserved Ejection Fraction: ARIC Community Surveillance Study.

Journal Article J Am Heart Assoc · October 20, 2020 Background Heart failure with preserved ejection fraction (HFpEF) accounts for half of heart failure hospitalizations, with limited data on predictors of mortality by sex and race. We evaluated for differences in predictors of all-cause mortality by sex an ... Full text Link to item Cite

Report from the 2018 consensus conference on immunomodulating agents in thoracic transplantation: Access, formulations, generics, therapeutic drug monitoring, and special populations.

Journal Article J Heart Lung Transplant · October 2020 In 2009, the International Society for Heart and Lung Transplantation recognized the importance and challenges surrounding generic drug immunosuppression. As experience with generics has expanded and comfort has increased, substantial issues have arisen si ... Full text Link to item Cite

Endomyocardial Biopsy Characterization of Heart Failure With Preserved Ejection Fraction and Prevalence of Cardiac Amyloidosis.

Journal Article JACC Heart Fail · September 2020 OBJECTIVES: This study prospectively evaluated endomyocardial biopsies in patients with heart failure with preserved ejection fraction (HFpEF) to identify histopathologic phenotypes and their association with clinical characteristics. BACKGROUND: Myocardia ... Full text Link to item Cite

Reducing ECG Artifact From Left Ventricular Assist Device Electromagnetic Interference.

Journal Article J Am Heart Assoc · August 18, 2020 Background Left ventricular assist devices (LVADs) generate electromagnetic interference that causes high-frequency noise artifacts on 12-lead ECGs. We describe the causes of this interference and potential solutions to aid ECG interpretation in patients w ... Full text Link to item Cite

Highest Obesity Category Associated With Largest Decrease in N-Terminal Pro-B-Type Natriuretic Peptide in Patients Hospitalized With Heart Failure With Preserved Ejection Fraction.

Journal Article J Am Heart Assoc · August 4, 2020 Background Heart failure with preserved ejection fraction (HFpEF) constitutes half of hospitalized heart failure cases and is commonly associated with obesity. The role of natriuretic peptide levels in hospitalized obese patients with HFpEF, however, is no ... Full text Link to item Cite

SSRI/SNRI Therapy is Associated With a Higher Risk of Gastrointestinal Bleeding in LVAD Patients.

Journal Article Heart Lung Circ · August 2020 BACKGROUND: Gastrointestinal bleeding (GIB) is common in left ventricular assist device (LVAD) patients. Serotonin release from platelets promotes platelet aggregation, and selective serotonin reuptake inhibitor/serotonin-norepinephrine reuptake inhibitor ... Full text Link to item Cite

Temporal Trends in Prevalence and Prognostic Implications of Comorbidities Among Patients With Acute Decompensated Heart Failure: The ARIC Study Community Surveillance.

Journal Article Circulation · July 2020 BackgroundPatients with heart failure (HF) have multiple coexisting comorbidities. The temporal trends in the burden of comorbidities and associated risk of mortality among patients with HF with preserved ejection fraction (HFpEF) and HF with redu ... Full text Cite

Biomarkers in Advanced Heart Failure: Implications for Managing Patients With Mechanical Circulatory Support and Cardiac Transplantation.

Journal Article Circ Heart Fail · July 2020 Biomarkers have a well-defined role in the diagnosis and management of chronic heart failure, but their role in patients with left ventricular assist devices and cardiac transplant is uncertain. In this review, we summarize the available literature in this ... Full text Link to item Cite

Physical Activity and Incident Heart Failure in High-Risk Subgroups: The ARIC Study.

Journal Article J Am Heart Assoc · May 18, 2020 Background Greater physical activity (PA) is associated with lower heart failure (HF) risk. However, it is unclear whether this inverse association exists across all subgroups at high risk for HF, particularly among those with preexisting atherosclerotic c ... Full text Link to item Cite

Impact of Continuous Flow Left Ventricular Assist Device Therapy on Chronic Kidney Disease: A Longitudinal Multicenter Study.

Journal Article J Card Fail · April 2020 BACKGROUND: Many patients undergoing durable left ventricular assist device (LVAD) implantation suffer from chronic kidney disease (CKD). Therefore, we investigated the effect of LVAD support on CKD. METHODS: A retrospective multicenter cohort study, inclu ... Full text Link to item Cite

Predictors and Outcomes of Hemodynamic and Functional LVAD Non-Responders: An Analysis of the INTERMACS Registry

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Despite recent advancements in left ventricular assist device (LVAD) technology, there remains a population of patients who experience ongoing signs and symptoms of heart failure during LVAD support. We sought to describe risk factors and outcomes ... Full text Cite

Use of Low Dose Dopamine in Heart Failure with Preserved Ejection Fraction Patients with Right Ventricular Dysfunction

Conference The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: Right ventricular dysfunction (RVD) is associated with poor outcomes in heart failure with preserved ejection fraction (HFpEF) and serves as an important therapeutic target. Though treatment with low-dose dopamine (DA) has not shown benefit decomp ... Full text Cite

Usefulness of Noninvasively Measured Pulse Amplitude Changes During the Valsalva Maneuver to Identify Hospitalized Heart Failure Patients at Risk of 30-Day Heart Failure Events (from the PRESSURE-HF Study).

Journal Article Am J Cardiol · March 15, 2020 The pulse amplitude ratio (PAR), the ratio of pulse pressure at the end of the Valsalva maneuver to before the onset, correlates with cardiac filling pressure. We have developed a handheld device that uses finger photoplethysmography to measure PAR and est ... Full text Link to item Cite

Abstract P319: Racial Differences and Temporal Trends in Obesity Among Patients Hospitalized With Acute Decompensated Heart Failure With Preserved Ejection Fraction: The ARIC Study Community Surveillance

Conference Circulation · March 3, 2020 Introduction: Obesity is disproportionately prevalent in black populations and strongly associated with heart failure with preserved ejection fraction (HFpEF). An “obesity paradox” or lower mortality ... Full text Cite

Abstract P320: Temporal Trends In Prevalence & Prognostic Implications Of Cardiac And Non-cardiac Comorbidities Among Patients With Acute Decompensated Heart Failure: Aric Study Community Surveillance

Conference Circulation · March 3, 2020 Introduction: Patients with HF have multiple co-existing CV and non-CV comorbidities. The temporal trends in the burden of co-morbidities and associated risk of mortality among patients with acute dec ... Full text Cite

Safety and Utility of Cardiopulmonary Exercise Testing in Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia.

Journal Article J Am Heart Assoc · February 4, 2020 Background Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is characterized by high arrhythmic burden and progressive heart failure, which can prompt referral for heart transplantation. Cardiopulmonary exercise testing (CPET) has an esta ... Full text Link to item Cite

Effect of Heart Rate Reserve on Exercise Capacity in Patients Treated with a Continuous Left Ventricular Assist Device.

Journal Article ASAIO J · February 2020 We hypothesized that an inadequate increase in heart rate (HR) during exercise was associated with low peak oxygen uptake (VO2 peak) seen in left ventricular assist device (LVAD) recipients and aimed to analyze the potential relation between HR and VO2 pea ... Full text Link to item Cite

Impact of the New Pulmonary Hypertension Definition on Heart Transplant Outcomes: Expanding the Hemodynamic Risk Profile.

Journal Article Chest · January 2020 BACKGROUND: At the recent 6th World Symposium on Pulmonary Hypertension (PH), the definition of PH was redefined to include lower pulmonary artery pressures in the setting of elevated pulmonary vascular resistance (PVR). However, the relevance of this chan ... Full text Link to item Cite

Quality of life and treatment preference for ventricular assist device therapy in ambulatory advanced heart failure: A report from the REVIVAL study.

Journal Article J Heart Lung Transplant · January 2020 BACKGROUND: The Registry Evaluation of Vital Information for Ventricular Assist Devices (VADs) in Ambulatory Life study is a prospective multicenter cohort of 400 ambulatory patients with advanced chronic systolic heart failure (HF). The aim of the study i ... Full text Link to item Cite

Cancer Survivorship and Subclinical Myocardial Damage.

Journal Article Am J Epidemiol · December 31, 2019 Cancer survivors might have an excess risk of cardiovascular disease (CVD) resulting from toxicities of cancer therapies and a high burden of CVD risk factors. We sought to evaluate the association of cancer survivorship with subclinical myocardial damage, ... Full text Link to item Cite

In-Hospital and Postdischarge Mortality Among Patients With Acute Decompensated Heart Failure Hospitalizations Ending on the Weekend Versus Weekday: The ARIC Study Community Surveillance.

Journal Article J Am Heart Assoc · August 6, 2019 Background Hospital staffing is usually reduced on weekends, potentially impacting inpatient care and postdischarge coordination of care for patients with acute decompensated heart failure (ADHF). However, investigations of in-hospital mortality on the wee ... Full text Link to item Cite

Cardiac Events Within the 30-Day Postoperative Period Is Associated With Increased 1-Year Mortality Among Deceased-Donor Liver Transplant Recipients.

Journal Article Exp Clin Transplant · June 2019 OBJECTIVES: Each year in the United States, approximately 40000 patients with a liver disorder will progress to end-stage liver disease and about 30000 of those patients will subsequently die from this condition. Liver transplant remains the definitive tre ... Full text Link to item Cite

Splanchnic nerve blockade in chronic heart failure (Splanchnic HF-2)

Conference EUROPEAN JOURNAL OF HEART FAILURE · May 1, 2019 Link to item Cite

Abstract P4-16-09: Effect of simvastatin on cardiac strain in breast cancer patients receiving anthracycline therapy

Conference Cancer Research · February 15, 2019 AbstractBackground: Cardiac toxicity (CT) is a rare late effect of anthracycline therapy for breast cancer (BC). Statins may attenuate the CT of anthracyclines. Myocardial strain can detect subclinical CT be ... Full text Cite

Metastatic amelanotic melanoma with cardiac involvement: A case report.

Journal Article J Cardiol Cases · February 2019 Metastatic melanoma has a high rate of cardiac involvement and often presents with non-specific symptoms, including heart failure. We report a case of a 41-year-old woman with a remote history of resected flank melanoma, who presented with heart failure pr ... Full text Link to item Cite

Effects of oral sildenafil on exercise capacity in children with pulmonary arterial hypertension: a randomised trial.

Journal Article Open Heart · 2019 OBJECTIVE: The 16-week, randomised, double-blind Sildenafil in Treatment-Naïve Children, Aged1-17 years, with Pulmonary Arterial Hypertension (STARTS-1) study assessed the effect of sildenafil on cardiopulmonary exercise testing (CPET) in treatment-naïve p ... Full text Link to item Cite

Clinical trial results in mechanical circulatory support

Chapter · January 1, 2019 Clinical trials of mechanical circulatory support devices evolved from simple studies evaluating the efficacy of the device in a few patients to large-scale clinical trials with composite endpoints including quality of life, improvements in functional capa ... Full text Cite

Randomized Evaluation of Heart Failure With Preserved Ejection Fraction Patients With Acute Heart Failure and Dopamine: The ROPA-DOP Trial.

Journal Article JACC Heart Fail · October 2018 OBJECTIVES: This study sought to compare a continuous infusion diuretic strategy versus an intermittent bolus diuretic strategy, with the addition of low-dose dopamine (3 μg/kg/min) in the treatment of hospitalized patients with heart failure with preserve ... Full text Link to item Cite

Analysis of carfilzomib cardiovascular safety profile across relapsed and/or refractory multiple myeloma clinical trials.

Journal Article Blood Adv · July 10, 2018 Carfilzomib is a selective proteasome inhibitor approved for the treatment of relapsed and/or refractory multiple myeloma (RRMM). It has significantly improved outcomes, including overall survival (OS), and shown superiority vs standard treatment with lena ... Full text Link to item Cite

Trends in Hospitalizations and Survival of Acute Decompensated Heart Failure in Four US Communities (2005-2014): ARIC Study Community Surveillance.

Journal Article Circulation · July 3, 2018 BACKGROUND: Community trends of acute decompensated heart failure (ADHF) in diverse populations may differ by race and sex. METHODS: The ARIC study (Atherosclerosis Risk in Communities) sampled heart failure-related hospitalizations (≥55 years of age) in 4 ... Full text Link to item Cite

A Contemporary Analysis of Heart Transplantation and Bridge-to-Transplant Mechanical Circulatory Support Outcomes in Cardiac Sarcoidosis.

Journal Article J Card Fail · June 2018 BACKGROUND: Patients with end-stage cardiomyopathy due to cardiac sarcoidosis (CS) may be referred for mechanical circulatory support (MCS) and heart transplantation (HT). We describe outcomes of patients with CS undergoing HT, focusing on the use of MCS a ... Full text Link to item Cite

Predictors of intra-aortic balloon pump hemodynamic failure in non-acute myocardial infarction cardiogenic shock.

Journal Article Am Heart J · May 2018 OBJECTIVES: To characterize patient profile and hemodynamic profile of those undergoing intra-aortic balloon pump (IABP) for cardiogenic shock and define predictors of hemodynamic failure of IABP support. BACKGROUND: Clinical characteristics of IABP suppor ... Full text Link to item Cite

Racial disparities in the rate of cardiotoxicity of HER2-targeted therapies among women with early breast cancer.

Journal Article Cancer · May 1, 2018 BACKGROUND: Human epidermal growth factor receptor 2 (HER2)-targeted therapies are highly effective at preventing breast cancer recurrence but are associated with cardiotoxicity in some patients, and minimal data are available regarding racial disparities ... Full text Link to item Cite

Ventricular Fibrosis and Other Factors Influencing Exercise Tolerance in LVAD Patients

Conference The Journal of Heart and Lung Transplantation · April 2018 Full text Cite

Preoperative Echocardiographic Differences and Transplant Outcomes Among Patients Receiving Simultaneous Liver-Kidney Versus Liver Transplant Alone.

Journal Article Exp Clin Transplant · March 2018 OBJECTIVES: Liver transplant and simultaneous liver-kidney transplant are major surgeries performed on high-risk individuals with end-stage liver disease and end-stage renal disease. We sought to examine the relationship between pretransplant echocardiogra ... Full text Link to item Cite

Sympathectomy for Stabilization of Heart Failure Due to Drug-Refractory Ventricular Tachycardia.

Journal Article Ann Thorac Surg · February 2018 We describe the novel use of bilateral cardiac sympathectomy in a woman with end-stage heart failure caused by ventricular tachycardia refractory to standard medical therapy who was under consideration for heart transplantation. Postoperatively, our patien ... Full text Link to item Cite

Challenges with Percent Predicted Maximal V˙O2 in Patients with Heart Failure.

Journal Article Med Sci Sports Exerc · February 2018 PURPOSE: This study aimed to describe the influence of different equations to predict maximal oxygen uptake (MV˙O2) on the percent predicted MV˙O2 (ppMV˙O2) and the resultant categorization of patients with heart failure with reduced ejection fraction into ... Full text Link to item Cite

Pre-operative proteinuria in left ventricular assist devices and clinical outcome.

Journal Article J Heart Lung Transplant · January 2018 BACKGROUND: This study evaluated the association of pre-operative proteinuria before continuous flow left ventricular assist device (CF-LVAD) implantation in relation to mortality and the need for renal replacement therapy (RRT) during the first year of fo ... Full text Link to item Cite

Acute kidney injury and 1-year mortality after left ventricular assist device implantation.

Journal Article J Heart Lung Transplant · January 2018 BACKGROUND: Data on the consequences of acute kidney injury (AKI) after continuous-flow left ventricle assist device (LVAD) implantation are scarce and inconsistent. In this study, we evaluated the incidence, predictors and the impact of AKI on mortality a ... Full text Link to item Cite

A Comprehensive Risk Score to Predict Prolonged Hospital Length of Stay After Heart Transplantation.

Journal Article Ann Thorac Surg · January 2018 BACKGROUND: Prolonged hospital length of stay (PLOS) after heart transplantation increases cost and morbidity. To better inform care, we developed a risk score to identify patients at risk for PLOS after heart transplantation. METHODS: We queried the Unite ... Full text Link to item Cite

Efficacy of Intravenous Furosemide Versus a Novel, pH-Neutral Furosemide Formulation Administered Subcutaneously in Outpatients With Worsening Heart Failure.

Journal Article JACC Heart Fail · January 2018 OBJECTIVES: This study sought to determine the efficacy and safety of a novel, pH-neutral formulation of furosemide administered subcutaneously (SC) for treatment of acute decompensated heart failure (HF). BACKGROUND: Congestion requiring intravenous (IV) ... Full text Link to item Cite

Social Support Moderates the Relationship Between Perceived Stress and Quality of Life in Patients With a Left Ventricular Assist Device.

Journal Article J Cardiovasc Nurs · 2018 BACKGROUND: Living with a left ventricular assist device has significant psychosocial sequelae that affect health-related quality of life (HRQOL). OBJECTIVE: The purpose of this study was to (1) describe psychosocial indicators of stress including perceive ... Full text Link to item Cite

Physiological and Psychological Stress in Patients Living With a Left Ventricular Assist Device.

Journal Article ASAIO J · 2018 Patients with a left ventricular assist device (LVAD) commonly experience psychological distress post-implantation, but physiological stress and differences by implant strategy remain unstudied. This study describes indicators of physiological (salivary co ... Full text Link to item Cite

Exercise, fitness, and cancer outcomes

Chapter · January 1, 2018 This chapter focuses on physical activity and exercise among cancer patients. Physical inactivity and poor fitness level are known to have multiple deleterious effects in healthy individuals, and there are data for similar effects among cancer patients. Th ... Full text Cite

Effect of Age and Renal Function on Survival After Left Ventricular Assist Device Implantation.

Journal Article Am J Cardiol · December 15, 2017 Left ventricular assist devices (LVAD) are increasingly used, especially as destination therapy in in older patients. The aim of this study was to evaluate the effect of age on renal function and mortality in the first year after implantation. A retrospect ... Full text Link to item Cite

Usefulness of Coronary Artery Calcium to Predict Heart Failure With Preserved Ejection Fraction in Men Versus Women (from the Multi-Ethnic Study of Atherosclerosis).

Journal Article Am J Cardiol · November 15, 2017 We studied the association of coronary artery calcium (CAC) and risk of heart failure with preserved ejection fraction (HFpEF) among men and women in a multiethnic cohort. Coronary artery disease is a risk factor for development of HFpEF and assessment of ... Full text Link to item Cite

Long-term follow-up of continuous flow left ventricular assist devices: complications and predisposing risk factors.

Journal Article Int J Artif Organs · October 27, 2017 PURPOSE: To assess LVAD complications and their overall effect on mortality and determine factors associated with development of early and long-term complications. METHODS: A retrospective cohort study of patients who underwent continuous flow LVAD placeme ... Full text Link to item Cite

Cardiovascular adverse events in the drug-development program of bupropion for smoking cessation: A systematic retrospective adjudication effort.

Journal Article Clin Cardiol · October 2017 BACKGROUND: In 2011, the US Food and Drug Administration requested that GlaxoSmithKline perform retrospective adjudication of cardiovascular (CV) events reported in the bupropion drug-development trials for smoking cessation. HYPOTHESIS: Retrospective adju ... Full text Link to item Cite

Usefulness of Pulse Amplitude Changes During the Valsalva Maneuver Measured Using Finger Photoplethysmography to Identify Elevated Pulmonary Capillary Wedge Pressure in Patients With Heart Failure.

Journal Article Am J Cardiol · September 15, 2017 The pulse amplitude ratio, the ratio of pulse pressure at the end of a Valsalva maneuver to before the onset of Valsalva, correlates with filling pressure. This study aimed to noninvasively estimate cardiac filling pressure in patients with heart failure. ... Full text Link to item Cite

Heart Failure Is Common and Under-Recognized in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia.

Journal Article Circ Heart Fail · September 2017 BACKGROUND: Heart failure (HF) prevalence in arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) varies depending on study cohort and is not well characterized. This study sought to determine prevalence and predictors of HF in ARVC/D. METHOD ... Full text Link to item Cite

Right-Sided Cardiac Dysfunction in Heart Failure With Preserved Ejection Fraction and Worsening Renal Function.

Journal Article Am J Cardiol · July 15, 2017 In urban populations, worsening renal function (WRF) is well established in patients hospitalized with acute decompensated heart failure with preserved ejection fraction (HFpEF). However, the mechanisms for development of WRF in the setting of acute HF in ... Full text Link to item Cite

Fatigability, Exercise Intolerance, and Abnormal Skeletal Muscle Energetics in Heart Failure.

Journal Article Circ Heart Fail · July 2017 BACKGROUND: Among central and peripheral factors contributing to exercise intolerance (EI) in heart failure (HF), the extent to which skeletal muscle (SM) energy metabolic abnormalities occur and contribute to EI and increased fatigability in HF patients w ... Full text Link to item Cite

Decision-Making of Patients With Implantable Cardioverter-Defibrillators at End of Life: Family Members' Experiences.

Journal Article Am J Hosp Palliat Care · July 2017 INTRODUCTION: Many patients with advanced heart failure (HF) experience the life-extending benefits of implantable cardioverter-defibrillators (ICD), but at the end stage of HF, patients may experience shocks with increasing frequency and change the plan f ... Full text Link to item Cite

Genetic testing improves identification of transthyretin amyloid (ATTR) subtype in cardiac amyloidosis.

Journal Article Amyloid · June 2017 Amyloidosis is a group of conditions characterized by the accumulation of amyloid deposits in various tissues. Among these disorders, ATTR amyloidosis occurs either with or without a TTR pathogenic variant. Treatment for amyloidosis depends on the subtype, ... Full text Link to item Cite

Survival After Orthotopic Heart Transplantation in Patients Undergoing Bridge to Transplantation With the HeartWare HVAD Versus the Heartmate II.

Journal Article Ann Thorac Surg · May 2017 BACKGROUND: Our objective was to determine whether the choice of a HeartWare HVAD as opposed to a Heartmate II left ventricular assist device (HMII LVAD), impacts survival after heart transplantation after controlling for patient, donor, and center charact ... Full text Link to item Cite

Angiotensin II antagonism is associated with reduced risk for gastrointestinal bleeding caused by arteriovenous malformations in patients with left ventricular assist devices.

Journal Article J Heart Lung Transplant · April 2017 BACKGROUND: Angiogenesis is implicated in formation of gastrointestinal arteriovenous malformations (AVMs). Angiotensin II signaling is involved in angiogenesis through the vascular endothelial growth factor (VEGF) and angiopoietin-2 pathways. We hypothesi ... Full text Link to item Cite

Baseline Characteristics Predict the Presence of Amyloid on Endomyocardial Biopsy.

Journal Article J Card Fail · April 2017 BACKGROUND: Recent studies have suggested a high prevalence of cardiac amyloidosis (CAm) in heart failure (HF) patients. CAm might be underdiagnosed owing to low clinical suspicion. METHODS AND RESULTS: We performed retrospective analysis of 259 patients w ... Full text Link to item Cite

Patients Commonly Believe Their Heart Failure Hospitalizations Are Preventable and Identify Worsening Heart Failure, Nonadherence, and a Knowledge Gap as Reasons for Admission.

Journal Article J Card Fail · March 2017 BACKGROUND: There are few data describing patient-identified precipitants of heart failure (HF) hospitalization. We hypothesized a patient's perception of reason for or preventability of an admission may be related to 30-day readmission rates. METHODS AND ... Full text Link to item Cite

Evaluation of Structural Progression in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy.

Journal Article JAMA Cardiol · March 1, 2017 IMPORTANCE: Considerable research has described the arrhythmic course of arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C). However, objective data characterizing structural progression, such as ventricular enlargement and cardiac dysfunct ... Full text Link to item Cite

The Effects of Immunosuppressive and Cytotoxic Drugs on the Heart

Chapter · February 22, 2017 Antiinflammatory therapy is the principal therapy for most rheumatic diseases with the primary therapeutic goal being to reduce the destructive effects of the inflammatory process without causing systemic side effects due to overimmunosuppression. The hear ... Full text Cite

Pump speed modulations and sub-maximal exercise tolerance in left ventricular assist device recipients: A double-blind, randomized trial.

Journal Article J Heart Lung Transplant · January 2017 BACKGROUND: The effect of pump speed increase on sub-maximal exercise tolerance, corresponding to activities of daily living (ADLs), is unknown. The aim of this study was to determine the effects of increasing pump speed during exercise at a sub-maximal le ... Full text Link to item Cite

Inpatient Unit Heart Failure Discharge Volume Predicts All-cause 30-Day Hospital Readmission.

Journal Article J Cardiovasc Nurs · 2017 BACKGROUND: All-cause 30-day hospital readmission is a heart failure (HF) quality of care metric. Readmission costs the healthcare system $30.7 million annually. Specific structure, process, or patient factors that predispose patients to readmission are un ... Full text Link to item Cite

Macrophages and cardiac fibroblasts are the main producers of eotaxins and regulate eosinophil trafficking to the heart.

Journal Article Eur J Immunol · December 2016 Cardiac manifestations are a major cause of morbidity and mortality in patients with eosinophil-associated diseases. Eosinophils are thought to play a pathogenic role in myocarditis. We investigated the pathways that recruit eosinophils to the heart using ... Full text Link to item Cite

Cardiac Index Declines During Long-Term Left Ventricular Device Support.

Journal Article Artif Organs · December 2016 To investigate longitudinal trends in valvular and ventricular function with long-term left ventricular assist device (LVAD) therapy, we analyzed hemodynamic and echocardiographic data of patients with at least 2 years of continuous LVAD support. All 130 p ... Full text Link to item Cite

The predictors of post-transplant coronary events among liver transplant recipients.

Journal Article Hepatol Int · November 2016 BACKGROUND/PURPOSE: Cardiac morbidities can occur during the peri- and post-liver transplant (LT) period, affecting the long-term survival. The purpose of this study was to identify the potential factors that predict a coronary event post-transplantation. ... Full text Link to item Cite

The ABCs of managing systolic heart failure: Past, present, and future.

Journal Article Cleve Clin J Med · October 2016 Heart failure management is complex and constantly evolving. The American College of Cardiology and the American Heart Association (ACC/AHA) last issued evidence-based guidelines in 2013, and since then, new drugs and devices have been developed. This revi ... Full text Link to item Cite

Outcomes and predictors of recovery in acute-onset cardiomyopathy: A single-center experience of patients undergoing endomyocardial biopsy for new heart failure.

Journal Article Am Heart J · September 2016 BACKGROUND: About one-third of patients with unexplained acute-onset heart failure (HF) recover left ventricular (LV) function; however, characterization of these patients in the setting of contemporary HF therapies is limited. We aim to describe baseline ... Full text Link to item Cite

Cardiac Allograft Vasculopathy: What We Know in 2016

Journal Article Current Transplantation Reports · September 1, 2016 Cardiac allograft vasculopathy (CAV) is an immune and nonimmune-mediated process in which heart transplantation patients develop neointimal proliferative hyperplasia of the coronary arteries, typically starting distally and resulting in diffuse luminal nar ... Full text Cite

Outcomes in Patients Bridged With Univentricular and Biventricular Devices in the Modern Era of Heart Transplantation.

Journal Article Ann Thorac Surg · July 2016 BACKGROUND: Biventricular support before orthotopic heart transplantation (OHT) has been shown to adversely affect short- and long-term outcomes, but the comparative effect of support type is largely unknown. This study determined the comparative effect of ... Full text Link to item Cite

Effects of the Novel Long-Acting GLP-1 Agonist, Albiglutide, on Cardiac Function, Cardiac Metabolism, and Exercise Capacity in Patients With Chronic Heart Failure and Reduced Ejection Fraction.

Journal Article JACC Heart Fail · July 2016 OBJECTIVES: This study sought to determine if glucagon-like peptide (GLP)-1 ameliorates myocardial metabolic abnormalities in chronic heart failure. BACKGROUND: Albiglutide (GSK716155) is a GLP-1 agonist indicated for type 2 diabetes. METHODS: We performed ... Full text Link to item Cite

Right ventricular afterload sensitivity dramatically increases after left ventricular assist device implantation: A multi-center hemodynamic analysis.

Journal Article J Heart Lung Transplant · July 2016 BACKGROUND: Right ventricular (RV) failure is a source of morbidity and mortality after left ventricular assist device (LVAD) implantation. In this study we sought to define hemodynamic changes in afterload and RV adaptation to afterload both early after i ... Full text Link to item Cite

Transcriptomic Analysis Identifies the Effect of Beta-Blocking Agents on a Molecular Pathway of Contraction in the Heart and Predicts Response to Therapy

Journal Article JACC: Basic to Translational Science · April 1, 2016 Over the last decades, beta-blockers have been a key component of heart failure therapy. However, currently there is no method to identify patients who will benefit from beta-blocking therapy versus those who will be unresponsive or worsen. Furthermore, th ... Full text Cite

Portopulmonary Hypertension and Liver Transplant: Recent Review of the Literature.

Journal Article Exp Clin Transplant · April 2016 Portopulmonary hypertension is one of the main pulmonary conditions affecting patients with liver disease and/or portal hypertension. Other conditions include hepatopulmonary syndrome and hepatic hydrothorax. Portopulmonary hypertension is caused by pulmon ... Link to item Cite

Variables Measured During Cardiopulmonary Exercise Testing as Predictors of Mortality in Chronic Systolic Heart Failure.

Journal Article J Am Coll Cardiol · February 23, 2016 BACKGROUND: Data from a cardiopulmonary exercise (CPX) test are used to determine prognosis in patients with chronic heart failure (HF). However, few published studies have simultaneously compared the relative prognostic strength of multiple CPX variables. ... Full text Link to item Cite

Pregnancy course and outcomes in women with arrhythmogenic right ventricular cardiomyopathy.

Journal Article Heart · February 15, 2016 OBJECTIVES: To characterise pregnancy course and outcomes in women with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C). METHODS: From a combined Johns Hopkins/Dutch ARVD/C registry, we identified 26 women affected with ARVD/C (by 2010 T ... Full text Link to item Cite

Associations of Preimplant Red Blood Cell Distribution Width with Clinical Outcomes Among Individuals with Left Ventricular Assist Devices.

Journal Article ASAIO J · 2016 Left ventricular assist devices (LVADs) are increasingly used for end-stage heart failure. However, post-LVAD complications are potentially devastating and remain unpredictable. The red blood cell distribution width (RDW) is a predictor of adverse events i ... Full text Link to item Cite

Ramp Study Hemodynamics, Functional Capacity, and Outcome in Heart Failure Patients with Continuous-Flow Left Ventricular Assist Devices.

Journal Article ASAIO J · 2016 Ramp studies-measuring changes in cardiac parameters as a function of serial pump speed changes (revolutions per minute [rpm])-are increasingly used to evaluate function and malfunction of continuous-flow left ventricular assist devices (CF-LVADs). We hypo ... Full text Link to item Cite

Outcomes and worsening renal function in patients hospitalized with heart failure with preserved ejection fraction.

Journal Article Am J Cardiol · November 15, 2015 Heart failure with preserved ejection fraction (HFpEF) has been described as a disease of elderly subjects with female predominance and hypertension. Our clinical experience suggests patients with HFpEF from an urban population are far more heterogenous, w ... Full text Link to item Cite

MELD-XI Score Predicts Early Mortality in Patients After Heart Transplantation.

Journal Article Ann Thorac Surg · November 2015 BACKGROUND: The aim of this study was to determine the utility of the Model for End-Stage Liver Disease Excluding INR (MELD-XI) in predicting early outcomes (30 days and 1 year) and late outcomes (5 years) in patients after orthotopic heart transplantation ... Full text Link to item Cite

The influence of institutional volume on the incidence of complications and their effect on mortality after heart transplantation.

Conference J Heart Lung Transplant · November 2015 BACKGROUND: The aim of this study was to determine whether institutional volume influenced the effect of postoperative complications on short-term and long-term survival after orthotopic heart transplantation (OHT). METHODS: The United Network for Organ Sh ... Full text Link to item Cite

Mechanistic Insights into Sympathetic Neuronal Regeneration: Multitracer Molecular Imaging of Catecholamine Handling After Cardiac Transplantation.

Journal Article Circ Cardiovasc Imaging · August 2015 BACKGROUND: Post-transplant reinnervation is a unique model to study sympathetic neuronal regeneration in vivo. The differential role of subcellular mechanisms of catecholamine handling in nerve terminals has not been investigated. METHODS AND RESULTS: Thr ... Full text Link to item Cite

Incidence and early outcomes associated with pre-transplant antivimentin antibodies in the cardiac transplantation population.

Journal Article Clin Transplant · August 2015 BACKGROUND: In cardiac transplant recipients, the development of antibodies to the endothelial intermediate filament protein vimentin (antivimentin antibodies, AVA) has been associated with rejection and poor outcomes. However, the incidence of these antib ... Full text Link to item Cite

Clinical Presentation, Long-Term Follow-Up, and Outcomes of 1001 Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Patients and Family Members.

Journal Article Circ Cardiovasc Genet · June 2015 BACKGROUND: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is a progressive cardiomyopathy. We aimed to define long-term outcome in a transatlantic cohort of 1001 individuals. METHODS AND RESULTS: Clinical and genetic characteristics an ... Full text Link to item Cite

Exercise heart rates in patients with hypertrophic cardiomyopathy.

Journal Article Am J Cardiol · April 15, 2015 The exercise heart rate (HR) profile and its relation to cardiac function and arrhythmias were investigated in patients with hypertrophic cardiomyopathy (HC). Chronotropic response (CR) and heart rate recovery (HRR) were computed during and after treadmill ... Full text Link to item Cite

Impact of genotype on clinical course in arrhythmogenic right ventricular dysplasia/cardiomyopathy-associated mutation carriers.

Journal Article Eur Heart J · April 7, 2015 AIMS: We sought to determine the influence of genotype on clinical course and arrhythmic outcome among arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C)-associated mutation carriers. METHODS AND RESULTS: Pathogenic mutations in desmosomal ... Full text Link to item Cite

Role of coronary artery calcium score in identifying occult coronary artery disease in patients evaluated for deceased-donor liver transplant - a preliminary report.

Journal Article Exp Clin Transplant · April 2015 Coronary artery disease may affect cirrhotic patients regardless of age and etiology of the underlying liver disease. Early identification of coronary artery disease is important to be able to achieve the best posttransplant outcomes and survival. The coro ... Link to item Cite

The diastolic pulmonary gradient does not predict survival in patients with pulmonary hypertension due to left heart disease.

Journal Article JACC Heart Fail · January 2015 OBJECTIVES: This study sought to evaluate if diastolic pulmonary gradient (DPG) can predict survival in patients with pulmonary hypertension due to left heart disease (PH-LHD). BACKGROUND: Patients with combined post- and pre-capillary PH-LHD have worse pr ... Full text Link to item Cite

Exercise in heart failure: Effectiveness versus safety

Chapter · January 1, 2015 Exercise training in patients with heart failure has been shown to improve exercise tolerance and quality of life and reduce symptoms of heart failure. Recently, the first large-scale trial evaluating the effects of exercise training in heart failure, the ... Full text Cite

Stage A Heart Failure Is Not Adequately Recognized in US Adults: Analysis of the National Health and Nutrition Examination Surveys, 2007-2010.

Journal Article PLoS One · 2015 BACKGROUND: Stage A heart failure (HF) is defined as people without HF symptoms or structural heart disease, but with predisposing conditions for HF. This classification is used to identify high risk patients to prevent progression to symptomatic HF. While ... Full text Link to item Cite

Relation between pressure and volume unloading during ramp testing in patients supported with a continuous-flow left ventricular assist device.

Journal Article ASAIO J · 2015 Pulmonary capillary wedge pressure (PCWP) is the key to describing left ventricular (LV) unloading; however, the relation between pressure and the echocardiography-derived surrogate of LV volume (LV end-diastolic diameter [LVEDD]) as a function of pump spe ... Full text Link to item Cite

Exercise has a disproportionate role in the pathogenesis of arrhythmogenic right ventricular dysplasia/cardiomyopathy in patients without desmosomal mutations.

Journal Article J Am Heart Assoc · December 2014 BACKGROUND: Exercise is associated with age‐related penetrance and arrhythmic risk in carriers of arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C)‐associated desmosomal mutations; however, its role in patients without desmosomal mutations ... Full text Link to item Cite

Functional status in left ventricular assist device-supported patients: a literature review.

Journal Article J Card Fail · December 2014 The prevalence of advanced heart failure (HF) is increasing because of the aging population and improvements in HF management strategies. Left ventricular assist device (LVAD) technology and management continue to advance rapidly, and it is anticipated tha ... Full text Link to item Cite

Can we now find the needle in the haystack?

Journal Article JACC Heart Fail · October 2014 Full text Link to item Cite

Sildenafil does not improve cardiomyopathy in Duchenne/Becker muscular dystrophy.

Journal Article Ann Neurol · October 2014 OBJECTIVE: Duchenne and Becker muscular dystrophies (DBMD) are allelic disorders caused by mutations in dystrophin. Adults with DBMD develop life-threatening cardiomyopathy. Inhibition of phosphodiesterase 5 (PDE5) improves cardiac function in mouse models ... Full text Link to item Cite

Outpatient management of heart failure in the United States, 2006-2008.

Journal Article Tex Heart Inst J · June 2014 Better outpatient management of heart failure might improve outcomes and reduce the number of rehospitalizations. This study describes recent outpatient heart-failure management in the United States. We analyzed data from the National Ambulatory Medical Ca ... Full text Link to item Cite

Does recipient age impact functional outcomes of orthotopic heart transplantation?

Journal Article Ann Thorac Surg · May 2014 BACKGROUND: This study evaluated changes in physical functional performance after orthotopic heart transplantation (OHT) with particular attention to the impact of recipient age on functional outcomes. METHODS: Retrospective review of all first-time, singl ... Full text Link to item Cite

Effect of increasing pump speed during exercise on peak oxygen uptake in heart failure patients supported with a continuous-flow left ventricular assist device. A double-blind randomized study.

Journal Article Eur J Heart Fail · April 2014 AIMS: Continuous-flow left ventricular assist device (CF-LVAD) implantation is associated with improved quality of life, but the effect on exercise capacity is less well documented. It is uncertain whether a fixed CF-LVAD pump speed, which allows for suffi ... Full text Link to item Cite

Report from a consensus conference on primary graft dysfunction after cardiac transplantation.

Journal Article J Heart Lung Transplant · April 2014 Although primary graft dysfunction (PGD) is fairly common early after cardiac transplant, standardized schemes for diagnosis and treatment remain contentious. Most major cardiac transplant centers use different definitions and parameters of cardiac functio ... Full text Link to item Cite

Pre-operative risk factors of bleeding and stroke during left ventricular assist device support: an analysis of more than 900 HeartMate II outpatients.

Journal Article J Am Coll Cardiol · March 11, 2014 OBJECTIVES: This study sought to determine the pre-operative risk factors related to late bleeding, stroke, and pump thrombosis in patients with HeartMate II (HMII) left ventricular assist devices (LVADs) (Thoratec Corporation, Pleasanton, California) that ... Full text Link to item Cite

Incidence and survival of hospitalized acute decompensated heart failure in four US communities (from the Atherosclerosis Risk in Communities Study).

Journal Article Am J Cardiol · February 1, 2014 Most population-based estimates of incident hospitalized heart failure (HF) have not differentiated acute decompensated heart failure (ADHF) from chronic stable HF nor included racially diverse populations. The Atherosclerosis Risk in Communities Study con ... Full text Link to item Cite

Pharmacist-managed international normalized ratio patient self-testing is associated with increased time in therapeutic range in patients with left ventricular assist devices at an academic medical center.

Journal Article ASAIO J · 2014 Patients with left ventricular assist devices (LVADs) are at increased risk of bleeding and thrombotic complications making warfarin therapy particularly challenging. Patient self-testing (PST) using point-of-care international normalized ratio (INR) devic ... Full text Link to item Cite

Arginine vasopressin as a target in the treatment of acute heart failure

Journal Article World Journal of Cardiology · January 1, 2014 � 2014 Baishideng Publishing Group Inc. Congestive heart failure (CHF) is one of the most common reasons for hospitalization in the United States. Despite multiple different beneficial medications for the treatment of chronic CHF, there are no therapies ... Full text Cite

Exercise increases age-related penetrance and arrhythmic risk in arrhythmogenic right ventricular dysplasia/cardiomyopathy-associated desmosomal mutation carriers.

Journal Article J Am Coll Cardiol · October 1, 2013 OBJECTIVES: This study sought to determine how exercise influences penetrance of arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) among patients with desmosomal mutations. BACKGROUND: Although animal models and anecdotal evidence suggest ... Full text Link to item Cite

Right ventricular dysfunction in systemic sclerosis-associated pulmonary arterial hypertension.

Journal Article Circ Heart Fail · September 1, 2013 BACKGROUND: Systemic sclerosis–associated pulmonary artery hypertension (SScPAH) has a worse prognosis compared with idiopathic pulmonary arterial hypertension (IPAH), with a median survival of 3 years after diagnosis often caused by right ventricular (RV) ... Full text Link to item Cite

Outcomes of cholecystectomy in US heart transplant recipients.

Journal Article Ann Surg · August 2013 OBJECTIVE: The aim of this study was to evaluate outcomes and predictors of in-hospital mortality after cholecystectomy in heart transplant (HTx) recipients. BACKGROUND: There is a paucity of data on outcomes after cholecystectomy in HTx recipients. METHOD ... Full text Link to item Cite

Evaluation of the role of endomyocardial biopsy in 851 patients with unexplained heart failure from 2000-2009.

Journal Article Circ Heart Fail · July 2013 BACKGROUND: Endomyocardial biopsy (EMB) is often considered when the pathogenesis of heart failure cannot be determined by noninvasive testing. Uncertainty remains about the diagnostic and clinical use of EMB in various clinical scenarios. METHODS AND RESU ... Full text Link to item Cite

Algorithm for the diagnosis and management of suspected pump thrombus.

Journal Article J Heart Lung Transplant · July 2013 Pump thrombosis is a dreaded complication of long-term implantable ventricular assist devices. No guidance exists regarding the diagnosis and management of this entity despite its significant morbidity. After considerable thought and deliberation, a group ... Full text Link to item Cite

Risk stratification in arrhythmogenic right ventricular dysplasia/cardiomyopathy-associated desmosomal mutation carriers.

Journal Article Circ Arrhythm Electrophysiol · June 2013 BACKGROUND: We investigated the role of phenotypic characteristics in stratifying the risk of sustained ventricular arrhythmias in patients harboring arrhythmogenic right ventricular dysplasia/cardiomyopathy-associated mutations. METHODS AND RESULTS: Clini ... Full text Link to item Cite

Patient selection for mechanical circulatory support.

Journal Article Heart Fail Rev · January 2013 Heart failure continues to be associated with high morbidity and mortality. Over the past decade, left ventricular assist devices have been shown to improve the survival and quality of life. However, it is quite clear that very sick patients do not do as w ... Full text Link to item Cite

Reoperative sternotomy is associated with increased mortality after heart transplantation.

Journal Article Ann Thorac Surg · December 2012 BACKGROUND: Although several studies have examined factors affecting survival after orthotopic heart transplantation (OHT), few have evaluated the impact of reoperative sternotomy. We undertook this study to examine the incidence and impact of repeat stern ... Full text Link to item Cite

Cerebral blood flow autoregulation is preserved after continuous-flow left ventricular assist device implantation.

Journal Article J Cardiothorac Vasc Anesth · December 2012 OBJECTIVE: To compare cerebral blood flow (CBF) autoregulation in patients undergoing continuous-flow left ventricular assist device (LVAD) implantation with that in patients undergoing coronary artery bypass grafting (CABG). DESIGN: Prospective, observati ... Full text Link to item Cite

The variable natural history of idiopathic dilated cardiomyopathy.

Journal Article Isr Med Assoc J · November 2012 BACKGROUND: Determining the prognosis of patients with heart failure is essential for patient management and clinical trial conduct. The relative value of traditional prognostic criteria remains unclear and the assessment of long-term prognosis for individ ... Link to item Cite

Update on device technologies for monitoring heart failure

Journal Article Current Treatment Options in Cardiovascular Medicine · October 1, 2012 Congestive heart failure (CHF) affects more than 5 million people in the United States and is one of the most common reasons for recurrent hospitalizations. Since the majority of admissions related to CHF are secondary to progressively worsening congestion ... Full text Cite

The spectrum of complications following left ventricular assist device placement.

Journal Article J Card Surg · September 2012 INTRODUCTION: Left ventricular assist device (LVAD) support is associated with many complications, but relatively few studies have examined the full spectrum of complications beyond infectious and bleeding events. METHODS: We conducted a retrospective revi ... Full text Link to item Cite

Prediction of incident heart failure in general practice: the Atherosclerosis Risk in Communities (ARIC) Study.

Journal Article Circ Heart Fail · July 1, 2012 BACKGROUND: A simple and effective heart failure (HF) risk score would facilitate the primary prevention and early diagnosis of HF in general practice. We examined the external validity of existing HF risk scores, optimized a 10-year HF risk function, and ... Full text Link to item Cite

Outcomes of catheter ablation of ventricular tachycardia in arrhythmogenic right ventricular dysplasia/cardiomyopathy.

Journal Article Circ Arrhythm Electrophysiol · June 1, 2012 BACKGROUND: Prior studies evaluating the efficacy of catheter ablation of ventricular tachycardia (VT) among patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) have reported varied outcomes. More recently, studies have suggest ... Full text Link to item Cite

BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes.

Journal Article Heart Rhythm · May 2012 BACKGROUND: Heart failure is a growing epidemic, and a typical aspect of heart failure pathophysiology is altered calcium transients. Normal cardiac calcium transients are initiated by Cav1.2 channels at cardiac T tubules. Bridging integrator 1 (BIN1) is a ... Full text Link to item Cite

Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial.

Journal Article Lancet · March 10, 2012 BACKGROUND: Cardiosphere-derived cells (CDCs) reduce scarring after myocardial infarction, increase viable myocardium, and boost cardiac function in preclinical models. We aimed to assess safety of such an approach in patients with left ventricular dysfunc ... Full text Link to item Cite

Development of a quantitative donor risk index to predict short-term mortality in orthotopic heart transplantation.

Journal Article J Heart Lung Transplant · March 2012 BACKGROUND: No standard index based on donor factors exists for predicting mortality after orthotopic heart transplantation (OHT). We utilized United Network for Organ Sharing (UNOS) data to develop a quantitative donor risk score for OHT. METHODS: We exam ... Full text Link to item Cite

Pulmonary capillary wedge pressure augments right ventricular pulsatile loading.

Journal Article Circulation · January 17, 2012 BACKGROUND: Right ventricular failure from increased pulmonary vascular loading is a major cause of morbidity and mortality, yet its modulation by disease remains poorly understood. We tested the hypotheses that, unlike the systemic circulation, pulmonary ... Full text Link to item Cite

Increased lipofuscin on endomyocardial biopsy predicts greater cardiac improvement in adolescents and young adults.

Journal Article Cardiovasc Pathol · 2012 BACKGROUND: The presence of interstitial fibrosis and lipofuscin in endomyocardial biopsies may indicate the chronicity of heart failure. Fibrosis is known to increase in the failing heart. Lipofuscin increases with age, but its relationship to heart funct ... Full text Link to item Cite

Insurance and education predict long-term survival after orthotopic heart transplantation in the United States.

Journal Article J Heart Lung Transplant · January 2012 BACKGROUND: Insurance status and education are known to affect health outcomes. However, their importance in orthotopic heart transplantation (OHT) is unknown. The United Network for Organ Sharing (UNOS) database provides a large cohort of OHT recipients i ... Full text Link to item Cite

Institutional volume and the effect of recipient risk on short-term mortality after orthotopic heart transplant.

Journal Article J Thorac Cardiovasc Surg · January 2012 OBJECTIVE: We developed a validated 50-point recipient risk index predicting short-term mortality after orthotopic heart transplant (OHT). This study examined the relationship between institutional volume and recipient risk on post-OHT mortality. METHODS: ... Full text Link to item Cite

Neurocognitive function in destination therapy patients receiving continuous-flow vs pulsatile-flow left ventricular assist device support.

Journal Article J Heart Lung Transplant · January 2012 BACKGROUND: The HeartMate II (Thoratec Corp, Pleasanton, CA) continuous-flow left ventricular assist device (LVAD) improved survival in destination therapy (DT) patients during a randomized trial compared with pulsatile-flow LVADs. This study documented ch ... Full text Link to item Cite

Marital status improves survival after orthotopic heart transplantation.

Journal Article J Heart Lung Transplant · December 2011 BACKGROUND: Large national registries lack information on social support, which is increasingly recognized as an important factor associated with improved outcomes after solid-organ transplantation. We examined our institutional database to identify social ... Full text Link to item Cite

Effect of sensitization in US heart transplant recipients bridged with a ventricular assist device: update in a modern cohort.

Journal Article J Thorac Cardiovasc Surg · November 2011 OBJECTIVE: Preformed anti-human leukocyte antigen antibodies have been associated with prolonged wait times and increased mortality in orthotopic heart transplantation. We used United Network for Organ Sharing data to examine panel reactive antibody titers ... Full text Link to item Cite

Incidence and predictors of implantable cardioverter-defibrillator therapy in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy undergoing implantable cardioverter-defibrillator implantation for primary prevention.

Journal Article J Am Coll Cardiol · September 27, 2011 OBJECTIVES: The purpose of this study was to define the incidence and predictors of implantable cardioverter-defibrillator (ICD) therapy in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) after placement of an ICD for prima ... Full text Link to item Cite

Creation of a quantitative recipient risk index for mortality prediction after cardiac transplantation (IMPACT).

Journal Article Ann Thorac Surg · September 2011 BACKGROUND: No recipient risk index exists predicting short-term mortality after orthotopic heart transplantation (OHT). We utilized United Network for Organ Sharing (UNOS) data to develop a novel quantitative recipient risk score for use in OHT. METHODS: ... Full text Link to item Cite

Effects of BG9928, an adenosine A₁ receptor antagonist, in patients with congestive heart failure.

Journal Article J Clin Pharmacol · June 2011 Previous studies suggest that adenosine A₁ receptor antagonists may promote natriuresis without deleterious effects on renal function. This study evaluated renal and hemodynamic effects as well as safety, pharmacokinetics, and tolerability of BG9928, a sel ... Full text Link to item Cite

Capnocytophagia canimorsus sepsis in an asplenic heart transplant candidate with a left ventricular assist system.

Journal Article Prog Transplant · June 2011 Fulminant septic shock associated with Capnocytophagia canimorsus bacteremia developed in a 54-year-old asplenic man, a heart transplantation candidate who was supported with a HeartMate II left ventricular assist system, after he experienced a dog bite. H ... Full text Link to item Cite

Results of the post-U.S. Food and Drug Administration-approval study with a continuous flow left ventricular assist device as a bridge to heart transplantation: a prospective study using the INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support).

Journal Article J Am Coll Cardiol · May 10, 2011 OBJECTIVES: The aim of this study was to determine whether results with the HeartMate (HM) II left ventricular assist device (LVAD) (Thoratec Corporation, Pleasanton, California) in a commercial setting are comparable to other available devices for the sam ... Full text Link to item Cite

178 Risk of Bleeding and Stroke in 700 HeartMate II LVAD Outpatients

Conference The Journal of Heart and Lung Transplantation · April 2011 Full text Cite

Transcriptomic biomarkers for the accurate diagnosis of myocarditis.

Journal Article Circulation · March 22, 2011 BACKGROUND: Lymphocytic myocarditis is a clinically important condition that is difficult to diagnose and distinguish. We hypothesized that the transcriptome obtained from an endomyocardial biopsy would yield clinically relevant and accurate molecular sign ... Full text Link to item Cite

Bleeding complications and blood product utilization with left ventricular assist device implantation.

Journal Article Ann Thorac Surg · March 2011 BACKGROUND: Bleeding complications are a major source of morbidity and reoperation after left ventricular assist device (LVAD) implantation, yet remain poorly characterized in patients receiving LVADs. We assessed bleeding complications in an institutional ... Full text Link to item Cite

Report from a consensus conference on antibody-mediated rejection in heart transplantation.

Journal Article J Heart Lung Transplant · March 2011 BACKGROUND: The problem of AMR remains unsolved because standardized schemes for diagnosis and treatment remains contentious. Therefore, a consensus conference was organized to discuss the current status of antibody-mediated rejection (AMR) in heart transp ... Full text Link to item Cite

Infectious complications after pulsatile-flow and continuous-flow left ventricular assist device implantation.

Journal Article J Heart Lung Transplant · February 2011 BACKGROUND: Infection is a significant source of morbidity and mortality after left ventricular assist device (LVAD) implantation. Newer generation continuous-flow (CF) LVADs are smaller, requiring smaller pump pockets and drive-line exit sites as compared ... Full text Link to item Cite

Adequate health literacy is associated with higher heart failure knowledge and self-care confidence in hospitalized patients.

Journal Article J Cardiovasc Nurs · 2011 Heart failure (HF) patients with inadequate health literacy are at increased risk for poor self-care and negative health outcomes such as hospital readmission. The purpose of the present study was to examine the prevalence of inadequate health literacy, th ... Full text Link to item Cite

HeartMate® II continuous-flow left ventricular assist system.

Journal Article Expert Rev Med Devices · January 2011 Left ventricular assist devices (LVADs) have emerged as a beneficial therapeutic strategy proven to improve the morbidity and mortality of patients with advanced heart failure. Continuous-flow rotary LVADs have been developed in the hopes of delivering cir ... Full text Link to item Cite

Tonapofylline: a selective adenosine-1 receptor antagonist for the treatment of heart failure.

Journal Article Expert Opin Pharmacother · October 2010 IMPORTANCE OF THE FIELD: The heart failure and cardiorenal syndromes are major public health hazards, affecting one in five persons during their lifetime. Alternatives to traditional loop-diuretics, including vasopressin and adenosine A(1) receptor antagon ... Full text Link to item Cite

Left ventricular dysfunction as a risk factor for cardiovascular and noncardiovascular hospitalizations in African Americans.

Journal Article Am Heart J · September 2010 BACKGROUND: A substantial portion of the public health burden of heart failure is due to hospitalizations, many of which are for causes other than cardiovascular disease. We assessed whether left ventricular (LV) systolic dysfunction was associated with in ... Full text Link to item Cite

Independent adjudication of symptomatic heart failure with the use of doxorubicin and cyclophosphamide followed by trastuzumab adjuvant therapy: a combined review of cardiac data from the National Surgical Adjuvant breast and Bowel Project B-31 and the North Central Cancer Treatment Group N9831 clinical trials.

Journal Article J Clin Oncol · July 20, 2010 PURPOSE: An independent Adjuvant Cardiac Review and Evaluation Committee (ACREC) systematically reviewed cases of symptomatic heart failure events to uniformly define the cardiac event rate across two large trials (National Surgical Adjuvant Breast and Bow ... Full text Link to item Cite

Post-cardiac transplant survival after support with a continuous-flow left ventricular assist device: impact of duration of left ventricular assist device support and other variables.

Journal Article J Thorac Cardiovasc Surg · July 2010 OBJECTIVE: Although left ventricular assist devices (LVADs) are associated with excellent outcomes in patients with end-stage heart failure, there are conflicting reports on posttransplant survival in these patients. Furthermore, prior studies with pulsati ... Full text Link to item Cite

Post-operative heparin may not be required for transitioning patients with a HeartMate II left ventricular assist system to long-term warfarin therapy.

Journal Article J Heart Lung Transplant · June 2010 BACKGROUND: Anti-coagulation with heparin is often used after left ventricular assist device implantation as a transition to long-term warfarin therapy. We retrospectively evaluated the effects of heparin use on thromboembolic and bleeding complications af ... Full text Link to item Cite

The impact of race on survival after heart transplantation: an analysis of more than 20,000 patients.

Journal Article Ann Thorac Surg · June 2010 BACKGROUND: Evidence exists for race-linked discrepancies in survival after orthotopic heart transplantation (OHT). The United Network for Organ Sharing database provides an opportunity to examine the effect of race on outcomes in a large cohort of adult O ... Full text Link to item Cite

The gene expression profile of patients with new-onset heart failure reveals important gender-specific differences.

Journal Article Eur Heart J · May 2010 AIMS: We sought to test the hypothesis that inherent biological factors contribute to gender differences in disease pathophysiology of new-onset heart failure (HF), which can be detected from the transcriptome of a single endomyocardial biopsy (EMB). METHO ... Full text Link to item Cite

New diagnostic devices in heart failure.

Journal Article Curr Opin Cardiol · May 2010 PURPOSE OF REVIEW: Heart failure is among the leading causes of morbidity and mortality in the United States. In recent years, implantable devices have been developed that aim to predict impending heart failure events in time to prevent clinical decompensa ... Full text Link to item Cite

Right ventricular failure in patients with the HeartMate II continuous-flow left ventricular assist device: incidence, risk factors, and effect on outcomes.

Journal Article J Thorac Cardiovasc Surg · May 2010 OBJECTIVE: The aim of this study was to evaluate the incidence, risk factors, and effect on outcomes of right ventricular failure in a large population of patients implanted with continuous-flow left ventricular assist devices. METHODS: Patients (n = 484) ... Full text Link to item Cite

Continuous flow left ventricular assist device improves functional capacity and quality of life of advanced heart failure patients.

Journal Article J Am Coll Cardiol · April 27, 2010 OBJECTIVES: This study sought to assess the impact of continuous flow left ventricular assist devices (LVADs) on functional capacity and heart failure-related quality of life. BACKGROUND: Newer continuous-flow LVAD are smaller and quieter than pulsatile-fl ... Full text Link to item Cite

Clinical management of continuous-flow left ventricular assist devices in advanced heart failure.

Journal Article J Heart Lung Transplant · April 2010 Continuous-flow left ventricular assist devices (LVAD) have emerged as the standard of care for advanced heart failure patients requiring long-term mechanical circulatory support. Evidence-based clinical management of LVAD-supported patients is becoming in ... Full text Link to item Cite

Quality of life and functional status in patients surviving 12 months after left ventricular assist device implantation.

Journal Article J Heart Lung Transplant · March 2010 BACKGROUND: As left ventricular assist device (LVAD) support duration increases, quality of life (QoL) becomes a concern. We reviewed the QoL in patients on LVAD support for >or=1 year. METHODS: We retrospectively reviewed our prospective database for pati ... Full text Link to item Cite

Renal and hepatic function improve in advanced heart failure patients during continuous-flow support with the HeartMate II left ventricular assist device.

Journal Article Circulation · December 8, 2009 BACKGROUND: The effects of continuous blood flow and reduced pulsatility on major organ function have not been studied in detail. METHODS AND RESULTS: We evaluated renal (creatinine and blood urea nitrogen) and hepatic (aspartate transaminase, alanine tran ... Full text Link to item Cite

Advanced heart failure treated with continuous-flow left ventricular assist device.

Journal Article N Engl J Med · December 3, 2009 BACKGROUND: Patients with advanced heart failure have improved survival rates and quality of life when treated with implanted pulsatile-flow left ventricular assist devices as compared with medical therapy. New continuous-flow devices are smaller and may b ... Full text Link to item Cite

Evaluation of risk indices in continuous-flow left ventricular assist device patients.

Journal Article Ann Thorac Surg · December 2009 BACKGROUND: The Leitz-Miller (LM), Columbia (COL), Acute Physiology and Chronic Health Evaluation II (APACHE II), Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS), and Seattle Heart Failure Model (SHFM) risk scores have been u ... Full text Link to item Cite

Impact of recipient body mass index on organ allocation and mortality in orthotopic heart transplantation.

Journal Article J Heart Lung Transplant · November 2009 BACKGROUND: It is unknown whether obesity affects organ allocation in orthotopic heart transplantation (OHT). The United Network for Organ Sharing (UNOS) database provides an opportunity to examine this issue. METHODS: We reviewed UNOS data to identify 27, ... Full text Link to item Cite

Comprehensive desmosome mutation analysis in north americans with arrhythmogenic right ventricular dysplasia/cardiomyopathy.

Journal Article Circ Cardiovasc Genet · October 2009 BACKGROUND: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is an inherited disorder typically caused by mutations in components of the cardiac desmosome. The prevalence and significance of desmosome mutations among patients with ARVD/C ... Full text Link to item Cite

Outcomes, health policy, and managed care: relationships between patient-reported outcome measures and clinical measures in outpatients with heart failure.

Journal Article Am Heart J · October 2009 BACKGROUND: Patient-reported outcomes are increasingly used to assess the efficacy of new treatments. Understanding relationships between these and clinical measures can facilitate their interpretation. We examined associations between patient-reported mea ... Full text Link to item Cite

Safety of symptom-limited cardiopulmonary exercise testing in patients with chronic heart failure due to severe left ventricular systolic dysfunction.

Journal Article Am Heart J · October 2009 BACKGROUND: To assess the safety of symptom-limited exercise testing in patients with New York Heart Association class II-IV heart failure symptoms due to left ventricular systolic dysfunction, we investigated the frequency of all-cause fatal and nonfatal ... Full text Link to item Cite

New York Heart Association functional class predicts exercise parameters in the current era.

Journal Article Am Heart J · October 2009 BACKGROUND: The New York Heart Association (NYHA) functional class is a subjective estimate of a patient's functional ability based on symptoms that do not always correlate with the objective estimate of functional capacity, peak oxygen consumption (peak V ... Full text Link to item Cite

Heart transplantation for adults with congenital heart disease: analysis of the United network for organ sharing database.

Journal Article Ann Thorac Surg · September 2009 BACKGROUND: Congenital heart disease (CHD) in the adult is an uncommon indication for heart transplantation but has been increasing. We assessed survival and predictors of death after heart transplantation for adults with CHD. METHODS: Adult primary heart ... Full text Link to item Cite

Low thromboembolism and pump thrombosis with the HeartMate II left ventricular assist device: analysis of outpatient anti-coagulation.

Journal Article J Heart Lung Transplant · September 2009 BACKGROUND: The HeartMate II (Thoratec, Pleasanton, CA) is an effective bridge to transplantation (BTT) but requires anti-coagulation with warfarin and aspirin. We evaluated the risk of thromboembolism and hemorrhage related to the degree of anti-coagulati ... Full text Link to item Cite

Glenn shunt facilitated weaning of right ventricular mechanical support.

Journal Article Ann Thorac Surg · September 2009 Management of biventricular mechanical circulatory support patients can be complex and can require different systems for support of the right and left ventricles. We describe the use of a Glenn shunt to facilitate weaning from a right ventricular assist de ... Full text Link to item Cite

The impact of donor-recipient sex matching on survival after orthotopic heart transplantation: analysis of 18 000 transplants in the modern era.

Journal Article Circ Heart Fail · September 2009 INTRODUCTION: Single-institution series have suggested that men receiving orthotopic heart transplantation from female donors have decreased survival. No multi-institutional series has comprehensively addressed the issue of donor and recipient sex matching ... Full text Link to item Cite

Heart failure disease management program experience in 4,545 heart failure admissions to a community hospital.

Journal Article Am Heart J · September 2009 BACKGROUND: Disease management programs (DMPs) are developed to address the high morbi-mortality and costs of congestive heart failure (CHF). Most studies have focused on intensive programs in academic centers. Washington County Hospital (WCH) in Hagerstow ... Full text Link to item Cite

Electrocardiographic features of arrhythmogenic right ventricular dysplasia.

Journal Article Circulation · August 11, 2009 BACKGROUND: The purpose of this study was to reevaluate the ECG features of arrhythmogenic right ventricular dysplasia (ARVD). The second objective was to evaluate the sensitivity and specificity of the standard and newly proposed diagnostic ECG markers in ... Full text Link to item Cite

Extended mechanical circulatory support with a continuous-flow rotary left ventricular assist device.

Journal Article J Am Coll Cardiol · July 21, 2009 OBJECTIVES: This study sought to evaluate the use of a continuous-flow rotary left ventricular assist device (LVAD) as a bridge to heart transplantation. BACKGROUND: LVAD therapy is an established treatment modality for patients with advanced heart failure ... Full text Link to item Cite

The change in B-type natriuretic peptide levels over time predicts significant rejection in cardiac transplant recipients.

Journal Article J Heart Lung Transplant · July 2009 BACKGROUND: B-type natriuretic peptide (BNP) correlates with cardiac filling pressures and outcomes in patients with heart failure. In heart transplant recipients, we hypothesize that a within-individual change in BNP over time would be more helpful than a ... Full text Link to item Cite

Neurocognitive assessments in advanced heart failure patients receiving continuous-flow left ventricular assist devices.

Journal Article J Heart Lung Transplant · June 2009 BACKGROUND: Neurocognitive (NC) changes in heart failure patients receiving left ventricular assist devices (LVADs) are not well understood. The purpose of this study was to document changes in the cognitive performance of patients with the continuous-flow ... Full text Link to item Cite

Prolonged RV endocardial activation duration: a novel marker of arrhythmogenic right ventricular dysplasia/cardiomyopathy.

Journal Article Heart Rhythm · June 2009 BACKGROUND: Parietal block, defined as intra right ventricular (RV) conduction slowing, is a major diagnostic criterion for arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C). OBJECTIVE: We evaluated the utility of total RV endocardial acti ... Full text Link to item Cite

Aortic valve replacement in a diseased bicuspid valve eleven years after transplantation.

Journal Article Interact Cardiovasc Thorac Surg · May 2009 Cardiac allotransplantation is subject to a number of chronic complications that may limit graft survival. These include allograft coronary artery disease, renal dysfunction, hypertension, and malignancy, which are largely due to the immuno-modulatory and ... Full text Link to item Cite

Morphologic variants of familial arrhythmogenic right ventricular dysplasia/cardiomyopathy a genetics-magnetic resonance imaging correlation study.

Journal Article J Am Coll Cardiol · April 14, 2009 OBJECTIVES: The purpose of this study was to determine the extent of left ventricular (LV) involvement in individuals predisposed to developing arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C), and to investigate novel morphologic variant ... Full text Link to item Cite

Disparities in access to left ventricular assist device therapy.

Journal Article J Surg Res · March 2009 BACKGROUND: Implantation of a left ventricular assist device (LVAD) has been shown to improve survival and quality of life among selected patients with end-stage heart failure. We hypothesized that utilization of this complex and expensive treatment modali ... Full text Link to item Cite

283: Post Transplant Survival Following Support with a Continuous Flow Left Ventricular Assist Device

Conference The Journal of Heart and Lung Transplantation · February 2009 Full text Cite

Prognostic value of left ventricular apical tissue removed for HeartMate II left ventricular assist device placement.

Journal Article Cardiovasc Pathol · 2009 BACKGROUND: With the increasing use of left ventricular assist devices, the left ventricular apical core has become a more frequently encountered surgical pathology tissue. We investigated the prognostic value of this cardiac tissue in short-term patient m ... Full text Link to item Cite

Trends from 1987 to 2004 in sudden death due to coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study.

Journal Article Am Heart J · January 2009 BACKGROUND: Few data are available on the secular changes in sudden coronary heart disease (CHD) death in US communities. METHODS: We examined trends in sudden CHD death from 1987 to 2004, using data from the Atherosclerosis Risk in Communities (ARIC) stud ... Full text Link to item Cite

Fusion of aortic valve commissures in patients supported by a continuous axial flow left ventricular assist device.

Journal Article J Heart Lung Transplant · December 2008 BACKGROUND: Left ventricular assist devices (LVADs) are an important therapy for selected individuals with advanced heart failure unable to wait for a suitable donor for transplantation. Pulsatile LVADs are associated with commissural fusion of the aortic ... Full text Link to item Cite

HbA 1c as a risk factor for heart failure in persons with diabetes: the Atherosclerosis Risk in Communities (ARIC) study.

Journal Article Diabetologia · December 2008 AIMS/HYPOTHESIS: Heart failure (HF) incidence in diabetes in both the presence and absence of CHD is rising. Prospective population-based studies can help describe the relationship between HbA(1c), a measure of glycaemia control, and HF risk. METHODS: We s ... Full text Link to item Cite

PDE5A inhibitor treatment of persistent pulmonary hypertension after mechanical circulatory support.

Journal Article Circ Heart Fail · November 2008 BACKGROUND: Pulmonary hypertension (PH) secondary to left heart failure portends a poor prognosis and is a relative contraindication to heart transplantation at many centers. We tested the hypothesis that when PH persists after adequate left ventricle unlo ... Full text Link to item Cite

Increased mortality at low-volume orthotopic heart transplantation centers: should current standards change?

Journal Article Ann Thorac Surg · October 2008 BACKGROUND: The Centers for Medicare and Medicaid Services (CMS) mandate that orthotopic heart transplantation (OHT) centers perform 10 transplants per year to qualify for funding. We sought to determine whether this cutoff is meaningful and establish reco ... Full text Link to item Cite

Impact of donor-to-recipient weight ratio on survival after heart transplantation: analysis of the United Network for Organ Sharing Database.

Journal Article Circulation · September 30, 2008 BACKGROUND: Generally accepted donor criteria for heart transplantation limit allografts from donors within approximately 20% to 30% of the recipient's weight. We analyzed the impact of donor-to-recipient weight ratio on survival after heart transplantatio ... Full text Link to item Cite

Reproducibility of peak oxygen uptake and other cardiopulmonary exercise testing parameters in patients with heart failure (from the Heart Failure and A Controlled Trial Investigating Outcomes of exercise traiNing).

Journal Article Am J Cardiol · September 15, 2008 Peak oxygen uptake (pVo2) is an important parameter in assessing the functional capacity and prognosis of patients with heart failure. In heart failure trials, change in pVo2 was often used to assess the effectiveness of an intervention. However, the withi ... Full text Link to item Cite

Right heart dysfunction after left ventricular assist device implantation: a comparison of the pulsatile HeartMate I and axial-flow HeartMate II devices.

Journal Article Ann Thorac Surg · September 2008 BACKGROUND: Right heart dysfunction confers significant morbidity and mortality after left ventricular assist device implantation and historically occurs in as many as a third of patients. It is unknown whether newer axial flow pumps have a different impac ... Full text Link to item Cite

Value of clinician assessment of hemodynamics in advanced heart failure: the ESCAPE trial.

Journal Article Circ Heart Fail · September 2008 BACKGROUND: We determined whether estimated hemodynamics from history and physical examination (H&P) reflect invasive measurements and predict outcomes in advanced heart failure (HF). The role of the H&P in medical decision making has declined in favor of ... Full text Link to item Cite

Transcriptomic biomarkers for individual risk assessment in new-onset heart failure.

Journal Article Circulation · July 15, 2008 BACKGROUND: Prediction of prognosis remains a major unmet need in new-onset heart failure (HF). Although several clinical tests are in use, none accurately distinguish between patients with poor versus excellent survival. We hypothesized that a transcripto ... Full text Link to item Cite

Outcomes in bicaval versus biatrial techniques in heart transplantation: an analysis of the UNOS database.

Journal Article J Heart Lung Transplant · February 2008 BACKGROUND: Despite 40 years of heart transplantation, the optimal atrial anastomotic technique remains unclear. The United Network for Organ Sharing (UNOS) database provides a unique and novel opportunity to address this question by examining survival in ... Full text Link to item Cite

Advanced heart failure: a call to action.

Journal Article Congest Heart Fail · 2008 Despite improvements in medical therapy for heart failure, more than 250,000 people die in the United States as a result of heart failure each year. There are multiple risk factors and models that have been created to identify these people, yet there has n ... Full text Link to item Cite

Influence of pretransplant panel-reactive antibody on outcomes in 8,160 heart transplant recipients in recent era.

Journal Article Ann Thorac Surg · November 2007 BACKGROUND: Panel-reactive antibody (PRA) screening to detect HLA antibodies is an important part of evaluation for potential heart transplant recipients. We sought to determine how different levels of PRA affect outcomes in heart transplantation. METHODS: ... Full text Link to item Cite

Use of a continuous-flow device in patients awaiting heart transplantation.

Journal Article N Engl J Med · August 30, 2007 BACKGROUND: The use of left ventricular assist devices is an accepted therapy for patients with refractory heart failure, but current pulsatile volume-displacement devices have limitations (including large pump size and limited long-term mechanical durabil ... Full text Link to item Cite

Utility of tissue Doppler and strain echocardiography in arrhythmogenic right ventricular dysplasia/cardiomyopathy.

Journal Article Am J Cardiol · August 1, 2007 Arrhythmogenic right ventricular dysplasia (ARVD) is a heritable cardiomyopathy characterized by the fibrofatty replacement of right ventricular (RV) myocardium leading to RV failure and arrhythmias. This study evaluated the potential utility of tissue Dop ... Full text Link to item Cite

Long-term efficacy of catheter ablation of ventricular tachycardia in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy.

Journal Article J Am Coll Cardiol · July 31, 2007 OBJECTIVES: This study sought to evaluate the outcomes of radiofrequency catheter ablation (RFA) of ventricular tachycardia (VT) in arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) patients. Particular focus was placed on defining the sin ... Full text Link to item Cite

Elevated uric acid levels predict allograft vasculopathy in cardiac transplant recipients.

Journal Article J Heart Lung Transplant · May 2007 BACKGROUND: Cardiac allograft vasculopathy (CAV) poses the greatest threat to the long-term survival of cardiac transplant recipients, and these individuals often exhibit elevated levels of uric acid (UA), a stimulator of T cells. We hypothesized that hype ... Full text Link to item Cite

Reduced kidney function as a risk factor for incident heart failure: the atherosclerosis risk in communities (ARIC) study.

Journal Article J Am Soc Nephrol · April 2007 Reduced kidney function is a risk factor for cardiovascular morbidity and mortality, and both heart failure (HF) and kidney failure incidences are increasing. This study therefore sought to determine the effect of decreased kidney function on HF incidence ... Full text Link to item Cite

Nonischemic cardiomyopathy associated with autoimmune polyglandular syndrome type II.

Journal Article Endocr Pract · 2007 OBJECTIVE: To report a case of nonischemic cardiomyopathy associated with autoimmune polyglandular syndrome type II (APS-II). METHODS: We describe our patient's clinical features, evaluation, and outcome. In addition, a literature review of cardiomyopathy ... Full text Link to item Cite

Initial United States experience with the Paracor HeartNet myocardial constraint device for heart failure.

Journal Article J Thorac Cardiovasc Surg · January 2007 OBJECTIVE: This study was undertaken to review the initial results and surgical safety data for the US Food and Drug Administration safety and feasibility trial of the Paracor HeartNet (Paracor Medical, Inc, Sunnyvale, Calif.) myocardial constraint device. ... Full text Link to item Cite

Impaired chronotropic and vasodilator reserves limit exercise capacity in patients with heart failure and a preserved ejection fraction.

Journal Article Circulation · November 14, 2006 BACKGROUND: Nearly half of patients with heart failure have a preserved ejection fraction (HFpEF). Symptoms of exercise intolerance and dyspnea are most often attributed to diastolic dysfunction; however, impaired systolic and/or arterial vasodilator reser ... Full text Link to item Cite

Penetrance of mutations in plakophilin-2 among families with arrhythmogenic right ventricular dysplasia/cardiomyopathy.

Journal Article J Am Coll Cardiol · October 3, 2006 OBJECTIVES: The purpose of our study was to characterize the penetrance of PKP2 mutations among family members of people with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) and to examine clinical features and predictors of disease amon ... Full text Link to item Cite

Improved outcomes in peripartum cardiomyopathy with contemporary.

Journal Article Am Heart J · September 2006 BACKGROUND: Prior studies have shown both high morbidity and mortality for patients with peripartum cardiomyopathy (PPCM). These studies were small and predated current advances in heart failure treatment. We sought to determine the outcomes of women with ... Full text Link to item Cite

Topical anesthesia with EMLA reduces pain during endomyocardial biopsy: a randomized trial.

Journal Article J Heart Lung Transplant · September 2006 Cardiac transplant recipients often anticipate and suffer varying degrees of discomfort during surveillance endomyocardial biopsy (EMBx). We performed a randomized, blinded, placebo-controlled trial to determine whether topical anesthetic was associated wi ... Full text Link to item Cite

The ESCAPE Discharge Risk Score: Don't Go Home without It

Conference Journal of Cardiac Failure · August 2006 Full text Cite

DSG2 mutations contribute to arrhythmogenic right ventricular dysplasia/cardiomyopathy.

Journal Article Am J Hum Genet · July 2006 Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is a disorder characterized by fibrofatty replacement of cardiac myocytes that typically manifests in the right ventricle. It is inherited as an autosomal dominant disease with reduced pene ... Full text Link to item Cite

Tacrolimus with mycophenolate mofetil (MMF) or sirolimus vs. cyclosporine with MMF in cardiac transplant patients: 1-year report.

Journal Article Am J Transplant · June 2006 The most advantageous combination of immunosuppressive agents for cardiac transplant recipients has not yet been established. Between November 2001 and June 2003, 343 de novo cardiac transplant recipients were randomized to receive steroids and either tacr ... Full text Link to item Cite

Histologic and electron microscopy findings in myocardium of treated Fabry disease.

Journal Article Hum Pathol · June 2006 The well-described histologic and electron microscopic findings in Fabry disease cardiomyopathy are hypertrophic vacuolated cells with electron dense concentric lamellar bodies. We present altered findings in an endomyocardial biopsy from a patient with tr ... Full text Link to item Cite

Clinical features of arrhythmogenic right ventricular dysplasia/cardiomyopathy associated with mutations in plakophilin-2.

Journal Article Circulation · April 4, 2006 BACKGROUND: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is an inherited cardiomyopathy characterized by right ventricular dysfunction and ventricular arrhythmias. A recent study reported mutations in PKP2, encoding the desmosomal pro ... Full text Link to item Cite

Right ventricle-dominant cardiac sarcoidosis with sparing of the left ventricle.

Journal Article J Heart Lung Transplant · April 2006 Cardiac sarcoidosis is a common and often fatal complication of systemic sarcoidosis. When present, cardiac sarcoid is generally a diffuse and patchy process involving predominantly the left ventricle. We report the case of a patient with known cardiac sar ... Full text Link to item Cite

Acute heart failure

Chapter · March 2, 2006 Cite

Feasibility and variability of three dimensional echocardiography in arrhythmogenic right ventricular dysplasia/cardiomyopathy.

Journal Article Am J Cardiol · March 1, 2006 Arrhythmogenic right ventricular dysplasia (ARVD/C) is a genetic cardiomyopathy characterized by fibrous fatty replacement of the right ventricular (RV) myocardium, leading to progressive RV failure and ventricular arrhythmias in young athletes. This study ... Full text Link to item Cite

305

Conference The Journal of Heart and Lung Transplantation · February 2006 Full text Cite

Beyond angiotensin-converting enzyme inhibitors and β-blockers: Nonpharmacologic therapy for chronic heart failure

Journal Article Advanced Studies in Medicine · January 1, 2006 PURPOSE: This article reviews nonpharmacologic treatment options for patients with chronic heart failure (HF). EPIDEMIOLOGY: HF is the fastest growing cardiovascular problem in the United States, driven both by the demographics of aging and the partial sho ... Cite

Arrhythmogenic right ventricular dysplasia: a United States experience.

Journal Article Circulation · December 20, 2005 BACKGROUND: Arrhythmogenic right ventricular dysplasia (ARVD) is an inherited cardiomyopathy characterized by right ventricular dysfunction and ventricular arrhythmias. The purpose of our study was to describe the presentation, clinical features, survival, ... Full text Link to item Cite

Recurrence of cardiac sarcoidosis in a heart transplant recipient.

Journal Article J Heart Lung Transplant · November 2005 We present the case of a young man who received a left ventricular assist device (LVAD) as a bridge to transplantation for end-stage heart failure, in whom the diagnosis of sarcoid cardiomyopathy was made at the time of LVAD implantation. He subsequently u ... Full text Link to item Cite

Outcomes with an alternate list strategy for heart transplantation.

Journal Article J Heart Lung Transplant · November 2005 BACKGROUND: Heart transplantation (HT) is an effective therapy for end-stage heart failure, but its impact is limited by the scarcity of donor organs and stringent selection criteria for both donors and recipients. The creation of an alternate list to matc ... Full text Link to item Cite

Predictors of appropriate implantable defibrillator therapies in patients with arrhythmogenic right ventricular dysplasia.

Journal Article Heart Rhythm · November 2005 BACKGROUND: Arrhythmogenic right ventricular dysplasia (ARVD) is an inherited cardiomyopathy characterized by ventricular arrhythmias and sudden cardiac death. The risk factors for sudden death and indications for implantable cardioverter-defibrillator (IC ... Full text Link to item Cite

Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness: the ESCAPE trial.

Journal Article JAMA · October 5, 2005 CONTEXT: Pulmonary artery catheters (PACs) have been used to guide therapy in multiple settings, but recent studies have raised concerns that PACs may lead to increased mortality in hospitalized patients. OBJECTIVE: To determine whether PAC use is safe and ... Full text Link to item Cite

Graft vascular disease after cardiac transplantation and its relationship to mean acute rejection score.

Journal Article Arch Pathol Lab Med · October 2005 CONTEXT: Graft vascular disease remains a significant source of morbidity and mortality in heart transplant patients. The influence of acute cellular rejection on the development of graft vascular disease is controversial. OBJECTIVE: To determine the relat ... Full text Link to item Cite

Left ventricular assist device as destination therapy in doxorubicin-induced cardiomyopathy.

Journal Article Ann Thorac Surg · August 2005 Doxorubicin-induced cardiomyopathy is not uncommon and may progress to end-stage heart failure. Treatment of this condition with heart transplantation, however, requires that the primary malignancy be deemed "cured." We present the case of a 55- year-old w ... Full text Link to item Cite

Mortality associated with use of hepatitis C positive donors in alternate list heart transplantation

Conference The Journal of Heart and Lung Transplantation · February 2005 Full text Cite

Outcomes of an alternate list strategy for heart transplantation

Conference The Journal of Heart and Lung Transplantation · February 2005 Full text Cite

A history of orthotopic heart transplantation.

Journal Article Cardiol Rev · 2005 Orthotopic human heart transplantation today is performed at more than 150 U.S. centers, and the average survival is more than 10 years. Its prevalence and success, however, belies the fact that just 40 years ago, no one had ever attempted the procedure in ... Full text Link to item Cite

Depressive symptoms in heart transplant recipients in an alternate list program

Journal Article The Journal of Heart and Lung Transplantation · 2005 Cite

An update on the efficacy of newer immunosuppressive regimens in cardiac transplantation

Journal Article Current Opinion in Organ Transplantation · December 1, 2004 The therapeutic options now available allow the clinician to tailor the therapeutic regimen for the individual patient. On the basis of the side effect profile of each medication and the individual risks faced by the patient, the clinician can now design a ... Full text Cite

Surrogate markers for late cardiac allograft survival.

Conference Am J Transplant · July 2004 While no definite well-validated surrogate marker for late cardiac allograft outcome is available, the early detection of cardiac allograft vasculopathy represents the 'key' candidate as an effective surrogate. Intravascular ultrasound detected intimal thi ... Full text Link to item Cite

Cardiac transplantation at Duke University Medical Center.

Journal Article Clin Transpl · 2004 Since beginning cardiac transplantation in 1985, Duke University Medical Center has performed 485 de novo heart transplants in adult recipients. Our program has broadened the access of patients to transplantation through the aggressive use of ventricular a ... Link to item Cite

BVS5000 support after cardiac transplantation.

Journal Article J Thorac Cardiovasc Surg · August 2003 OBJECTIVE: This study examines short-term mechanical assist device support for cardiac transplant patients and compares their outcomes with nontransplant patients requiring similar support. METHODS: Of 350 cardiac transplant patients at our institution, 7 ... Full text Link to item Cite

Mechanical ventricular support lowers pulmonary vascular resistance in a patient with congential heart disease.

Journal Article Ann Thorac Surg · March 2003 Severely elevated pulmonary vascular resistance (PVR) is a relative contraindication to orthotopic heart transplantation. A potential novel strategy to reverse elevated PVR may be implantation of a chronic left ventricular assist device with subsequent lef ... Full text Link to item Cite

Rationale for use of an exercise end point and design for the ADVANCE (A Dose evaluation of a Vasopressin ANtagonist in CHF patients undergoing Exercise) trial.

Journal Article Am Heart J · January 2003 BACKGROUND: Exercise intolerance is a primary characteristic of chronic congestive heart failure. Exercise testing is therefore widely used to evaluate the degree of functional impairment, prognosis of underlying cardiac disease, and response to treatment. ... Full text Link to item Cite

Vasopressin receptor antagonists. Therapeutic potential in the management of acute and chronic heart failure.

Journal Article Am J Cardiovasc Drugs · 2003 Despite the use of ACE inhibitors and beta-blockers, the morbidity and mortality of patients with chronic heart failure remains quite high. This has stimulated the development of new therapies, many based on the neurohormonal hypothesis. There are now mult ... Full text Link to item Cite

Maximizing use of organs recovered from the cadaver donor: Cardiac recommendations

Conference Journal of Heart and Lung Transplantation · November 1, 2002 The shortage of available donor hearts continues to limit cardiac transplantation. For this reason, strict criteria have limited the number of patients placed on the US waiting list to ≈6000 to 8000 per year. Because the number of available donor hearts ha ... Full text Cite

Consensus conference report: maximizing use of organs recovered from the cadaver donor: cardiac recommendations, March 28-29, 2001, Crystal City, Va.

Conference Circulation · August 13, 2002 The shortage of available donor hearts continues to limit cardiac transplantation. For this reason, strict criteria have limited the number of patients placed on the US waiting list to approximately 6000 to 8000 per year. Because the number of available do ... Full text Link to item Cite

The benefit of implementing a heart failure disease management program.

Journal Article Arch Intern Med · October 8, 2001 BACKGROUND: To handle the increasing complexity of congestive heart failure (CHF) care, several new models for the care of patients with CHF have been developed to replace traditional strategies. We undertook this study to evaluate the potential benefit of ... Full text Link to item Cite

Evaluation of early postoperative results after bicaval versus standard cardiac transplantation and review of the literature.

Journal Article Am Heart J · November 2000 OBJECTIVE: Previous studies have been inconsistent in defining a clinical benefit to the bicaval cardiac transplantation technique relative to the standard technique, and many major centers have not adopted this newer approach. The purpose of this study wa ... Full text Link to item Cite

Bridging patients to cardiac transplantation

Journal Article Congestive Heart Failure · January 1, 2000 Potential recipients of heart transplants have the most advanced form of congestive heart failure, in which standard therapy fails to maintain clinical stability. In the absence of guidelines derived from evidence obtained in clinical trials, caring for th ... Full text Cite

Lack of effect of increased inspired oxygen concentrations on maximal exercise capacity or ventilation in stable heart failure.

Journal Article Am J Cardiol · December 15, 1999 Recent uncontrolled studies have suggested improved maximal exercise capacity and decreased exercise ventilation in heart failure after administration of increased inspired oxygen concentrations. To study the responses further, 16 patients performed staged ... Full text Link to item Cite

Aerobic exercise training can reverse age-related peripheral circulatory changes in healthy older men.

Journal Article Circulation · September 7, 1999 BACKGROUND: The age-related decline in maximal oxygen consumption is attenuated by habitual aerobic exercise. However, the relative effects of training on central and peripheral responses to exercise in older subjects are not known. The present study asses ... Full text Link to item Cite

Exertional dyspnea in heart failure: a symptom unrelated to pulmonary function at rest or during exercise. Duke University Clinical Cardiology Studies (DUCCS) Exercise Group.

Journal Article Am Heart J · March 1998 BACKGROUND: Exertional dyspnea is a common symptom in patients with heart failure, and the mechanisms responsible for the symptom are unknown. The purpose of this study was to identify factors responsible for the symptom of exertional dyspnea in patients w ... Full text Link to item Cite

Improvement in the mechanical efficiency of walking: an explanation for the "placebo effect" seen during repeated exercise testing of patients with heart failure. Duke University Clinical Cardiology Studies (DUCCS) Exercise Group.

Journal Article Am Heart J · January 1998 To determine the mechanism responsible for the "placebo effect" seen during serial exercise testing of patients with heart failure, we examined metabolic variables for 81 patients who underwent five baseline exercise tests as part of a multicenter drug tri ... Full text Link to item Cite

Pseudo-von Willebrand disease: a mutation in the platelet glycoprotein Ib alpha gene associated with a hyperactive surface receptor.

Journal Article Blood · April 1, 1993 Pseudo (platelet-type)-von Willebrand disease is an autosomal dominant bleeding disorder caused by the hyperfunction of a receptor on the platelet surface. The abnormal receptor, glycoprotein Ib, displays increased affinity for its ligand, von Willebrand f ... Link to item Cite