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Lack of effect of increased inspired oxygen concentrations on maximal exercise capacity or ventilation in stable heart failure.

Publication ,  Journal Article
Russell, SD; Koshkarian, GM; Medinger, AE; Carson, PE; Higginbotham, MB
Published in: Am J Cardiol
December 15, 1999

Recent uncontrolled studies have suggested improved maximal exercise capacity and decreased exercise ventilation in heart failure after administration of increased inspired oxygen concentrations. To study the responses further, 16 patients performed staged, symptom-limited cycle ergometry with humidified 21% and 60% inspired oxygen concentrations using a randomized, double-blind, crossover study design. Serial measurements of minute ventilation, heart rate, blood pressure, leg blood flow, and arterial and venous lactate and oxygen content were obtained. Exercise time did not change between the 2 tests (595 +/- 179 seconds and 602 +/- 181 seconds for 21% and 60% oxygen concentrations, respectively). Similarly, measurements of the ventilatory response to exercise and of leg blood flow were not different between the 2 oxygen concentrations. Although hemoglobin oxygen saturation increased from 96.7 +/- 2.1% to 97.9 +/- 1.5% at rest, at both rest and maximal exercise there was no statistically significant difference in arterial or venous oxygen content. This study failed to demonstrate any physiologic or functional benefit from the administration of increased oxygen concentrations to patients with stable heart failure.

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Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

December 15, 1999

Volume

84

Issue

12

Start / End Page

1412 / 1416

Location

United States

Related Subject Headings

  • Pulmonary Gas Exchange
  • Oxygen Inhalation Therapy
  • Middle Aged
  • Male
  • Lactic Acid
  • Humans
  • Hemodynamics
  • Heart Failure
  • Female
  • Exercise Test
 

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Russell, S. D., Koshkarian, G. M., Medinger, A. E., Carson, P. E., & Higginbotham, M. B. (1999). Lack of effect of increased inspired oxygen concentrations on maximal exercise capacity or ventilation in stable heart failure. Am J Cardiol, 84(12), 1412–1416. https://doi.org/10.1016/s0002-9149(99)00587-1
Russell, S. D., G. M. Koshkarian, A. E. Medinger, P. E. Carson, and M. B. Higginbotham. “Lack of effect of increased inspired oxygen concentrations on maximal exercise capacity or ventilation in stable heart failure.Am J Cardiol 84, no. 12 (December 15, 1999): 1412–16. https://doi.org/10.1016/s0002-9149(99)00587-1.
Russell SD, Koshkarian GM, Medinger AE, Carson PE, Higginbotham MB. Lack of effect of increased inspired oxygen concentrations on maximal exercise capacity or ventilation in stable heart failure. Am J Cardiol. 1999 Dec 15;84(12):1412–6.
Russell, S. D., et al. “Lack of effect of increased inspired oxygen concentrations on maximal exercise capacity or ventilation in stable heart failure.Am J Cardiol, vol. 84, no. 12, Dec. 1999, pp. 1412–16. Pubmed, doi:10.1016/s0002-9149(99)00587-1.
Russell SD, Koshkarian GM, Medinger AE, Carson PE, Higginbotham MB. Lack of effect of increased inspired oxygen concentrations on maximal exercise capacity or ventilation in stable heart failure. Am J Cardiol. 1999 Dec 15;84(12):1412–1416.
Journal cover image

Published In

Am J Cardiol

DOI

ISSN

0002-9149

Publication Date

December 15, 1999

Volume

84

Issue

12

Start / End Page

1412 / 1416

Location

United States

Related Subject Headings

  • Pulmonary Gas Exchange
  • Oxygen Inhalation Therapy
  • Middle Aged
  • Male
  • Lactic Acid
  • Humans
  • Hemodynamics
  • Heart Failure
  • Female
  • Exercise Test