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Portopulmonary Hypertension and Liver Transplant: Recent Review of the Literature.

Publication ,  Journal Article
Cosarderelioglu, C; Cosar, AM; Gurakar, M; Pustavoitau, A; Russell, SD; Dagher, NN; Gurakar, A
Published in: Exp Clin Transplant
April 2016

Portopulmonary hypertension is one of the main pulmonary conditions affecting patients with liver disease and/or portal hypertension. Other conditions include hepatopulmonary syndrome and hepatic hydrothorax. Portopulmonary hypertension is caused by pulmonary vasoconstriction and increased pulmonary vascular resistance. It develops as a result of portal hypertension with or without liver disease and is associated with a higher morbidity and mortality. However, portopulmonary hypertension is usually asymptomatic; the most common symptoms are dyspnea, fatigue, and peripheral edema. All liver transplant candidates should be screened for potential portopulmonary hypertension because its coexistence can affect survival rates after transplant. All patients with cirrhosis who present with dyspnea should also be screened. Transthoracic echocardiography is a noninvasive, useful method for screening, but right heart-sided catheterization remains the criterion standard for diagnosis. Portopulmonary hypertension carries a poor prognosis without liver transplant, and its severe form is considered to be a contraindication for liver transplant. Treating patients with pulmonary arterial hypertension-specific therapies before liver transplant for moderate and severe portopulmonary hypertension appears to be beneficial.

Duke Scholars

Published In

Exp Clin Transplant

EISSN

2146-8427

Publication Date

April 2016

Volume

14

Issue

2

Start / End Page

113 / 120

Location

Turkey

Related Subject Headings

  • Vasoconstriction
  • Vascular Resistance
  • Treatment Outcome
  • Surgery
  • Risk Factors
  • Risk Assessment
  • Pulmonary Circulation
  • Pulmonary Artery
  • Portal Pressure
  • Patient Selection
 

Citation

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Cosarderelioglu, C., Cosar, A. M., Gurakar, M., Pustavoitau, A., Russell, S. D., Dagher, N. N., & Gurakar, A. (2016). Portopulmonary Hypertension and Liver Transplant: Recent Review of the Literature. Exp Clin Transplant, 14(2), 113–120.
Cosarderelioglu, Caglar, Arif M. Cosar, Merve Gurakar, Aliaksei Pustavoitau, Stuart D. Russell, Nabil N. Dagher, and Ahmet Gurakar. “Portopulmonary Hypertension and Liver Transplant: Recent Review of the Literature.Exp Clin Transplant 14, no. 2 (April 2016): 113–20.
Cosarderelioglu C, Cosar AM, Gurakar M, Pustavoitau A, Russell SD, Dagher NN, et al. Portopulmonary Hypertension and Liver Transplant: Recent Review of the Literature. Exp Clin Transplant. 2016 Apr;14(2):113–20.
Cosarderelioglu, Caglar, et al. “Portopulmonary Hypertension and Liver Transplant: Recent Review of the Literature.Exp Clin Transplant, vol. 14, no. 2, Apr. 2016, pp. 113–20.
Cosarderelioglu C, Cosar AM, Gurakar M, Pustavoitau A, Russell SD, Dagher NN, Gurakar A. Portopulmonary Hypertension and Liver Transplant: Recent Review of the Literature. Exp Clin Transplant. 2016 Apr;14(2):113–120.

Published In

Exp Clin Transplant

EISSN

2146-8427

Publication Date

April 2016

Volume

14

Issue

2

Start / End Page

113 / 120

Location

Turkey

Related Subject Headings

  • Vasoconstriction
  • Vascular Resistance
  • Treatment Outcome
  • Surgery
  • Risk Factors
  • Risk Assessment
  • Pulmonary Circulation
  • Pulmonary Artery
  • Portal Pressure
  • Patient Selection