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Baseline Characteristics Predict the Presence of Amyloid on Endomyocardial Biopsy.

Publication ,  Journal Article
Ton, V-K; Bhonsale, A; Gilotra, NA; Halushka, MK; Steenbergen, C; Almansa, J; Brown, E; Tedford, RJ; Wittstein, I; Sharma, K; Russell, SD; Judge, DP
Published in: J Card Fail
April 2017

BACKGROUND: Recent studies have suggested a high prevalence of cardiac amyloidosis (CAm) in heart failure (HF) patients. CAm might be underdiagnosed owing to low clinical suspicion. METHODS AND RESULTS: We performed retrospective analysis of 259 patients with HF and ejection fraction (EF) ≥50% referred for endomyocardial biopsy. Seventy-three (28%) had CAm. Multivariable independent predictors of CAm were identified. Over a mean follow-up of 2.6 ± 3.3 years, CAm patients had worse survival than those without (1.5 y vs 6.3 y; log rank P < .0001). CONCLUSIONS: Clinicians should be suspicious of CAm in patients with EF 50%-75%, >50 years of age, BMI <30 kg/m2, peripheral neuropathy, Sokolow-Lyon index ≤15 mm, and septal wall thickness ≥1.4 cm.

Duke Scholars

Published In

J Card Fail

DOI

EISSN

1532-8414

Publication Date

April 2017

Volume

23

Issue

4

Start / End Page

340 / 344

Location

United States

Related Subject Headings

  • Stroke Volume
  • Statistics as Topic
  • Retrospective Studies
  • Prognosis
  • Myocardium
  • Middle Aged
  • Maryland
  • Male
  • Humans
  • Heart Failure
 

Citation

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MLA
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Ton, V.-K., Bhonsale, A., Gilotra, N. A., Halushka, M. K., Steenbergen, C., Almansa, J., … Judge, D. P. (2017). Baseline Characteristics Predict the Presence of Amyloid on Endomyocardial Biopsy. J Card Fail, 23(4), 340–344. https://doi.org/10.1016/j.cardfail.2016.12.006
Ton, Van-Khue, Aditya Bhonsale, Nisha A. Gilotra, Marc K. Halushka, Charles Steenbergen, Johana Almansa, Emily Brown, et al. “Baseline Characteristics Predict the Presence of Amyloid on Endomyocardial Biopsy.J Card Fail 23, no. 4 (April 2017): 340–44. https://doi.org/10.1016/j.cardfail.2016.12.006.
Ton V-K, Bhonsale A, Gilotra NA, Halushka MK, Steenbergen C, Almansa J, et al. Baseline Characteristics Predict the Presence of Amyloid on Endomyocardial Biopsy. J Card Fail. 2017 Apr;23(4):340–4.
Ton, Van-Khue, et al. “Baseline Characteristics Predict the Presence of Amyloid on Endomyocardial Biopsy.J Card Fail, vol. 23, no. 4, Apr. 2017, pp. 340–44. Pubmed, doi:10.1016/j.cardfail.2016.12.006.
Ton V-K, Bhonsale A, Gilotra NA, Halushka MK, Steenbergen C, Almansa J, Brown E, Tedford RJ, Wittstein I, Sharma K, Russell SD, Judge DP. Baseline Characteristics Predict the Presence of Amyloid on Endomyocardial Biopsy. J Card Fail. 2017 Apr;23(4):340–344.
Journal cover image

Published In

J Card Fail

DOI

EISSN

1532-8414

Publication Date

April 2017

Volume

23

Issue

4

Start / End Page

340 / 344

Location

United States

Related Subject Headings

  • Stroke Volume
  • Statistics as Topic
  • Retrospective Studies
  • Prognosis
  • Myocardium
  • Middle Aged
  • Maryland
  • Male
  • Humans
  • Heart Failure