Transcriptomic Analysis Identifies the Effect of Beta-Blocking Agents on a Molecular Pathway of Contraction in the Heart and Predicts Response to Therapy
Publication
, Journal Article
Heidecker, B; Kittleson, MM; Kasper, EK; Wittstein, IS; Champion, HC; Russell, SD; Baughman, KL; Hare, JM
Published in: JACC: Basic to Translational Science
April 1, 2016
Over the last decades, beta-blockers have been a key component of heart failure therapy. However, currently there is no method to identify patients who will benefit from beta-blocking therapy versus those who will be unresponsive or worsen. Furthermore, there is an unmet need to better understand molecular mechanisms through which heart failure therapies, such as beta-blockers, improve cardiac function, in order to design novel targeted therapies. Solving these issues is an important step towards personalized medicine. Here, we present a comprehensive transcriptomic analysis of molecular pathways that are affected by beta-blocking agents and a transcriptomic biomarker to predict therapy response.
Duke Scholars
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Published In
JACC: Basic to Translational Science
DOI
ISSN
2452-302X
Publication Date
April 1, 2016
Volume
1
Issue
3
Start / End Page
107 / 121
Related Subject Headings
- 3201 Cardiovascular medicine and haematology
- 1103 Clinical Sciences
- 1102 Cardiorespiratory Medicine and Haematology
Citation
APA
Chicago
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Heidecker, B., Kittleson, M. M., Kasper, E. K., Wittstein, I. S., Champion, H. C., Russell, S. D., … Hare, J. M. (2016). Transcriptomic Analysis Identifies the Effect of Beta-Blocking Agents on a Molecular Pathway of Contraction in the Heart and Predicts Response to Therapy. JACC: Basic to Translational Science, 1(3), 107–121. https://doi.org/10.1016/j.jacbts.2016.02.001
Heidecker, B., M. M. Kittleson, E. K. Kasper, I. S. Wittstein, H. C. Champion, S. D. Russell, K. L. Baughman, and J. M. Hare. “Transcriptomic Analysis Identifies the Effect of Beta-Blocking Agents on a Molecular Pathway of Contraction in the Heart and Predicts Response to Therapy.” JACC: Basic to Translational Science 1, no. 3 (April 1, 2016): 107–21. https://doi.org/10.1016/j.jacbts.2016.02.001.
Heidecker B, Kittleson MM, Kasper EK, Wittstein IS, Champion HC, Russell SD, et al. Transcriptomic Analysis Identifies the Effect of Beta-Blocking Agents on a Molecular Pathway of Contraction in the Heart and Predicts Response to Therapy. JACC: Basic to Translational Science. 2016 Apr 1;1(3):107–21.
Heidecker, B., et al. “Transcriptomic Analysis Identifies the Effect of Beta-Blocking Agents on a Molecular Pathway of Contraction in the Heart and Predicts Response to Therapy.” JACC: Basic to Translational Science, vol. 1, no. 3, Apr. 2016, pp. 107–21. Scopus, doi:10.1016/j.jacbts.2016.02.001.
Heidecker B, Kittleson MM, Kasper EK, Wittstein IS, Champion HC, Russell SD, Baughman KL, Hare JM. Transcriptomic Analysis Identifies the Effect of Beta-Blocking Agents on a Molecular Pathway of Contraction in the Heart and Predicts Response to Therapy. JACC: Basic to Translational Science. 2016 Apr 1;1(3):107–121.
Published In
JACC: Basic to Translational Science
DOI
ISSN
2452-302X
Publication Date
April 1, 2016
Volume
1
Issue
3
Start / End Page
107 / 121
Related Subject Headings
- 3201 Cardiovascular medicine and haematology
- 1103 Clinical Sciences
- 1102 Cardiorespiratory Medicine and Haematology