Joint model for a diagnostic test without a gold standard in the presence of a dependent terminal event.


Journal Article

Breast cancer patients after breast conservation therapy often develop ipsilateral breast tumor relapse (IBTR), whose classification (true local recurrence versus new ipsilateral primary tumor) is subject to error, and there is no available gold standard. Some patients may die because of breast cancer before IBTR develops. Because this terminal event may be related to the individual patient's unobserved disease status and time to IBTR, the terminal mechanism is non-ignorable. This article presents a joint analysis framework to model the binomial regression with misclassified binary outcome and the correlated time to IBTR, subject to a dependent terminal event and in the absence of a gold standard. Shared random effects are used to link together two survival times. The proposed approach is evaluated by a simulation study and is applied to a breast cancer data set consisting of 4477 breast cancer patients. The proposed joint model can be conveniently fit using adaptive Gaussian quadrature tools implemented in SAS 9.3 (SAS Institute Inc., Cary, NC, USA) procedure NLMIXED.

Full Text

Duke Authors

Cited Authors

  • Luo, S; Su, X; DeSantis, SM; Huang, X; Yi, M; Hunt, KK

Published Date

  • July 10, 2014

Published In

Volume / Issue

  • 33 / 15

Start / End Page

  • 2554 - 2566

PubMed ID

  • 24473943

Pubmed Central ID

  • 24473943

Electronic International Standard Serial Number (EISSN)

  • 1097-0258

Digital Object Identifier (DOI)

  • 10.1002/sim.6101


  • eng

Conference Location

  • England