Bayesian hierarchical model for multiple repeated measures and survival data: an application to Parkinson's disease.

Published

Journal Article

Multilevel item response theory models have been increasingly used to analyze the multivariate longitudinal data of mixed types (e.g., continuous and categorical) in clinical studies. To address the possible correlation between multivariate longitudinal measures and time to terminal events (e.g., death and dropout), joint models that consist of a multilevel item response theory submodel and a survival submodel have been previously developed. However, in multisite studies, multiple patients are recruited and treated by the same clinical site. There can be a significant site correlation because of common environmental and socioeconomic status, and similar quality of care within site. In this article, we develop and study several hierarchical joint models with the hazard of terminal events dependent on shared random effects from various levels. We conduct extensive simulation study to evaluate the performance of various models under different scenarios. The proposed hierarchical joint models are applied to the motivating deprenyl and tocopherol antioxidative therapy of Parkinsonism study to investigate the effect of tocopherol in slowing Parkinson's disease progression.

Full Text

Duke Authors

Cited Authors

  • Luo, S; Wang, J

Published Date

  • October 2014

Published In

Volume / Issue

  • 33 / 24

Start / End Page

  • 4279 - 4291

PubMed ID

  • 24935619

Pubmed Central ID

  • 24935619

Electronic International Standard Serial Number (EISSN)

  • 1097-0258

International Standard Serial Number (ISSN)

  • 0277-6715

Digital Object Identifier (DOI)

  • 10.1002/sim.6228

Language

  • eng