A Bayesian approach to joint analysis of multivariate longitudinal data and parametric accelerated failure time.

Journal Article (Journal Article)

Impairment caused by Parkinson's disease (PD) is multidimensional (e.g., sensoria, functions, and cognition) and progressive. Its multidimensional nature precludes a single outcome to measure disease progression. Clinical trials of PD use multiple categorical and continuous longitudinal outcomes to assess the treatment effects on overall improvement. A terminal event such as death or dropout can stop the follow-up process. Moreover, the time to the terminal event may be dependent on the multivariate longitudinal measurements. In this article, we consider a joint random-effects model for the correlated outcomes. A multilevel item response theory model is used for the multivariate longitudinal outcomes and a parametric accelerated failure time model is used for the failure time because of the violation of proportional hazard assumption. These two models are linked via random effects. The Bayesian inference via MCMC is implemented in 'BUGS' language. Our proposed method is evaluated by a simulation study and is applied to DATATOP study, a motivating clinical trial to determine if deprenyl slows the progression of PD.

Full Text

Duke Authors

Cited Authors

  • Luo, S

Published Date

  • February 20, 2014

Published In

Volume / Issue

  • 33 / 4

Start / End Page

  • 580 - 594

PubMed ID

  • 24009073

Pubmed Central ID

  • PMC3947121

Electronic International Standard Serial Number (EISSN)

  • 1097-0258

Digital Object Identifier (DOI)

  • 10.1002/sim.5956


  • eng

Conference Location

  • England