DNA methylation of imprinted genes in Mexican-American newborn children with prenatal phthalate exposure.

Journal Article (Journal Article)

AIM: Imprinted genes exhibit expression in a parent-of-origin-dependent manner and are critical for child development. Recent limited evidence suggests that prenatal exposure to phthalates, ubiquitous endocrine disruptors, can affect their epigenetic dysregulation. MATERIALS & METHODS: We quantified DNA methylation of nine imprinted gene differentially methylated regions by pyrosequencing in 296 cord blood DNA samples in a Mexican-American cohort. Fetal exposure was estimated by phthalate metabolite concentrations in maternal urine samples during pregnancy. RESULTS: Several differentially methylated regions of imprinted genes were associated with high molecular weight phthalates. The most consistent, positive, and false discovery rate significant associations were observed for MEG3. CONCLUSION: Phthalate exposure in utero may affect methylation status of imprinted genes in newborn children.

Full Text

Duke Authors

Cited Authors

  • Tindula, G; Murphy, SK; Grenier, C; Huang, Z; Huen, K; Escudero-Fung, M; Bradman, A; Eskenazi, B; Hoyo, C; Holland, N

Published Date

  • July 2018

Published In

Volume / Issue

  • 10 / 7

Start / End Page

  • 1011 - 1026

PubMed ID

  • 29957030

Pubmed Central ID

  • PMC6088267

Electronic International Standard Serial Number (EISSN)

  • 1750-192X

Digital Object Identifier (DOI)

  • 10.2217/epi-2017-0178


  • eng

Conference Location

  • England