Susan Kay Murphy | Scholars@Duke

Susan Kay Murphy
Associate Professor in Obstetrics and Gynecology

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Current Research Interests

ovarian cancer epigenetics
therapeutic prevention of ovarian cancer recurrence
development of epigenetic screening tools
developmental origins of health and disease (DOHaD)
preconceptional environmental impact on the epigenome
intergenerational and transgenerational epigenetic effects
in vitro models of cellular differentiation

Current Appointments & Affiliations

Associate Professor in Obstetrics and Gynecology, Obstetrics and Gynecology, Gynecologic Oncology, Obstetrics and Gynecology 2014
Associate Professor in Pathology, Pathology, Clinical Science Departments 2012
Associate Professor in the Division of Environmental Science and Policy, Environmental Sciences and Policy, Nicholas School of the Environment 2017
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1998

Contact Information

226 B Wing LSRC, 450 Research Drive, Durham, NC 27708
Box 91012, Durham, NC 27708-1012
susan.murphy@duke.edu (919) 681-3423
CIPHERS Project
Murphy lab web site
NICHES Children's Environmental Health Center

Background
Education, Training, & Certifications
- Ph.D., Wake Forest University 1998
- B.A., University of North Carolina at Charlotte 1992
Duke Appointment History
- Associate Professor in Obstetrics and Gynecology, Obstetrics and Gynecology, Gynecologic Oncology, Obstetrics and Gynecology 2012 - 2014
- Assistant Professor in Obstetrics and Gynecology, Obstetrics and Gynecology, Gynecologic Oncology, Obstetrics and Gynecology 2008 - 2012
- Assistant Professor in Pathology, Pathology, Clinical Science Departments 2008 - 2012
- Assistant Professor in Obstetrics and Gynecology, Obstetrics and Gynecology, Gynecologic Oncology, Obstetrics and Gynecology 2006 - 2007
- Assistant Research Professor in Obstetrics and Gynecology, Obstetrics and Gynecology, Gynecologic Oncology, Obstetrics and Gynecology 2003 - 2006
Leadership & Clinical Positions at Duke
- 2017 Division Chief, Reproductive Sciences, Department of Obstetrics and Gynecology
  2016 Program Director, CIPHERS study of the impact of cannabis on the sperm epigenome
  2014-2015 Director, Duke Epigenetics and Epigenomics Program
  2013 Program Director, NICHES Children's Environmental Health and Disease Prevention Research Center
  2012-2014 Co-Director, Duke Epigenetics and Epigenomics Program
  2011- Founder and Executive Committee Member, Duke Epigenetic and Epigenomics Program
  2003 Director, Epigenetics Research Laboratory
  2002-2003 Founder and Director, Mentorship Program, Duke University Postdoctoral Association
  2001-2003 Advocacy Chair, Duke University Postdoctoral Association
Recognition
In the News
- DEC 6, 2013
  
  New Children's Center Studies Association Between ADHD and Secondhand Smoke
- SEP 23, 2013 NPR
  
  How a pregnant woman's choices could shape a child's health
Awards & Honors
Expertise
Subject Headings
Global Scholarship
- Research
Research
Selected Grants
- Does exposure to mitochondrial toxicants during germ cell development result in lifelong alterations in mitochondrial function mediated by epigenetic changes? awarded by National Institutes of Health 2017 - 2022
- Building Interdisciplinary Research Careers in Women's Health awarded by National Institutes of Health 2002 - 2022
- Potential pathophysiologic mechanisms linking air pollution exposure in pregnant women to reduced birth weight awarded by University of Rochester 2017 - 2022
- Translational Research in Surgical Oncology awarded by National Institutes of Health 2002 - 2021
- Duke University Medical Center (DUMC) Pelvic Floor Disorders Network (PFDN) Clinical Site awarded by National Institutes of Health 2007 - 2021
- Paternal Transgenerational Epigenetic Legacy from Use of Cannabis awarded by John Templeton Foundation 2017 - 2020
- Epigenomics in insulin resistance associated overactive bladder awarded by National Institutes of Health 2017 - 2020
- Epigenetics and the Development of Nonalcoholic Fatty Liver Disease awarded by American College of Gastroenterology 2015 - 2019
- Children Exposure to SVOC Mixtures Indoors and Associations with Obesity awarded by National Institutes of Health 2007 - 2019
- Triggering human anti-tumor stringent response to target recurrent ovarian cancer awarded by Department of Defense 2017 - 2019
- Validation and interrogation of differentially expressed and alternatively spliced genes in African American prostate ca awarded by Department of Defense 2014 - 2018
- Immune regulated amino acid pathways in Alzheimer's Disease awarded by National Institutes of Health 2016 - 2018
- Duke KURe Program awarded by National Institutes of Health 2013 - 2018
- Duke University Program in Environmental Health awarded by National Institute of Environmental Health Sciences 2013 - 2018
- Neurodevelopment and Improving Children's Health Following EtS Exposure (NICHES) awarded by National Institutes of Health 2013 - 2018
- Neurodevelopment and Improving Children's Health following EtS exposure (NICHES) awarded by Environmental Protection Agency 2013 - 2018
- Social adversities, epigenetics, and the obesity epidemic awarded by North Carolina State University 2017 - 2018
- Pilot Project: Effects of Cannabis on the Epigenome of Humans and Rats awarded by John Templeton Foundation 2016 - 2017
- Joint Environmental, Genetic and Epigenetic Regulation of Tyrosine Receptor Kinases and Childhood Respiratory Disease awarded by University of Southern California 2013 - 2017
- Functional Genomic Screens of Tumor Recurrence in Ovarian Cancer awarded by Department of Defense 2014 - 2017
- Obesity and deregulation of imprinted genes in early life awarded by National Institutes of Health 2010 - 2015
- Epigenetic influence on early childhood self-regulation capacities and obesity awarded by National Institutes of Health 2011 - 2014
- Ovarian Cancer Initiating Cells: Metabolic Characterization awarded by National Institutes of Health 2012 - 2014
- Gene Regulation in Recurrent Ovarian Cancers awarded by Gynecologic Cancer Foundation 2011 - 2014
- Disparities in cervical cancer precursors and deregulation of imprinted genes awarded by National Institutes of Health 2010 - 2014
- Nutrition, Deregulation of Imprinted Genes awarded by National Institutes of Health 2009 - 2014
- Characterizing Alcohol's Effects on Repair of Liver Injury awarded by National Institutes of Health 2009 - 2012
- Identification and Characterization of Epigenetically Labile Genes awarded by National Institutes of Health 2006 - 2010
- In-utero Exposure and Infant Loss of IGF2 Imprinting awarded by National Institutes of Health 2006 - 2008
- Imprinted PEG3 Domain at 19q13.4 and carcinogenesis awarded by National Institutes of Health 2001 - 2003
Publications & Artistic Works
Selected Publications
- Book Sections
  - Moylan CA, Murphy SK. DNA Methylation: Basic Principles. In: Medical Epigenetics. 2016 Jul 1. p. 11-31. Full Text
  - Taylor MM, Murphy SK. Systems Biology and the Epigenome. In: Systems Biology in Toxicology and Environmental Health. 2015 Jul 7. p. 43-56. Full Text
- Conference Papers
  - Li X, Moylan CA, Baker SS, Liu W, Baker RD, Murphy SK, Abdelmalek MF, Zhu R, Diehl AM, Zhu L. Altered liver methylome and transcriptome provide evidence for epigenetic contribution to NAFLD pathogenesis. 2017 Oct:1071A-1072A. Link to Item
  - Moylan CA, Mavis AM, Bashir MR, Malik D, Bozdogan E, Buie S, Hoyo C, Diehl AM, Murphy SK, Abdelmalek MF. Visceral and subcutaneous adipose tissue measurements associate with increased metabolic risk for NAFLD in pre-pubertal obese children. 2017 Oct:665A-665A. Link to Item
  - Murphy SK, Schrott R, Visco Z, Huang Z, Grenier C, Mitchell J, Schechter J, Lucas J, Levin ED, Price T, Kollins SH. Environment and Gametic Epigenetic Reprogramming. 2017 Sep:S28-S28. Link to Item
  - Moylan CA, Giraldo RH, Murphy SK, Diehl AM, Abdelmalek MF. Differential DNA Methylation in Whole Blood Reflects that in Liver and Distinguishes Patients with Advanced NAFLD Fibrosis from Those with Normal Histology: A Potential Non-Invasive Tool. 2017 Apr:S1069-S1070. Full Text
  - Moylan CA, Wegermann KJ, Henao RG, Murphy SK, Diehl AM, Abdelmalek MF. BCAT1 Is Associated with Clinical Decompensation in Nonalcoholic Fatty Liver Disease: a Pilot Study. 2016 Oct:S381-S381. Link to Item
  - Murphy SK, Keyhan S, Guo L, Tomins K, Taylor M, Joglekar R, Huang Z, Grenier C, Liao Y, Massarsky A, Soubry A, Lea A, Burke EE, Cauley M, Hall BJ, Lucas JE, Hoyo C, Di Giulio RT, Levin ED, Price TM. Environmental Influence on Preconceptional and Gestational DNA Methylation Profiles. 2016 Sep:S39-S39. Link to Item
  - Moylan CA, Murphy SK, Grenier C, Abdelmalek MF, Diehl AM. DNA Methylation Profiles of Fibrosis-Associated Gene in Blood Reflects Liver Fibrosis Severity in Human Nonalcoholic Fatty Liver Disease. 2015 Oct:648A-649A. Link to Item
  - Huang Z, Visco Z, Sfakianos G, Whitaker R, Berchuck A, Murphy SK. Abstract 2236: Emergence of epigenetic regulation of tight junction genes in recurrent serous epithelial ovarian cancer. 2015 Aug 1:2236-2236. Full Text
  - Cobb L, Whitaker R, Hall A, Broadwater G, Murphy S, Berchuck A, Gaillard S. Evaluation of ERRα expression and association with survival in advanced ovarian cancer. 2015 Apr:204-204. Full Text
  - Kharma B, Baba T, Matsumura N, Kang HS, Murakami R, Yamaguchi K, Hamanishi J, Mandai M, Murphy SK, Konishi I. Abstract LB-123: Novel function of STAT1 pathway as a modulator of tumor progression in serous papillary endometrial cancer. 2014 Oct 1:LB-123-LB-123. Full Text
  - Stevens EV, Whitaker R, Guinet A, Chang C-Y, Grenier C, Marks J, McDonnell DP, Murphy SK, Berchuck A, Gaillard S. Abstract 4570: Role of ERRalpha in ovarian cancer. 2014 Oct 1:4570-4570. Full Text
  - Wang X, Pittman GS, Su D, Adamski KN, Campbell MR, Joubert BR, Huang ZY, Hoyo C, Murphy SK, London SA, Bell DA. Abstract 3647: Dose-dependent alteration of CpG methylation in AHRR and GFI1 in mononuclear cell DNA of smokers. 2013 Apr 15:3647-3647. Full Text
  - Murphy SK, Nye MD, Hoyo C. Methylation at Imprinted Insulin-Like Growth Factor-2 (IGF2) Is Vulnerable to Lead Exposure in Human Embryonic Kidney Cells. 2013 Mar:203A-204A. Link to Item
  - Garrett ME, Moylan CA, Gibson J, Yang H, Pang H, Dellinger A, Suzuki A, Tillmann HL, Guy CD, Abdelmalek MF, Murphy SK, Diehl AM, Hauser M, Ashley-Koch AE. Expression QTL analysis of a gene expression signature which predicts advanced non-alcoholic fatty liver disease. 2012 Oct:267A-268A. Link to Item
  - Moylan CA, Yang H, Pang H, Dellinger A, Suzuki A, Tillmann HL, Guy CD, Ashley-Koch AE, Garrett ME, Abdelmalek MF, Hauser MA, Murphy SK, Diehl AM. Epigenetic Regulation of Gene Expression in NAFLD. 2012 May:S929-S929. Link to Item
  - Murphy SK, Jayes FL, Feng L, Huang Z, Leppert PC. Methylation of THBS1, the Gene Encoding Thrombospondin-1 in Uterine Fibroids and Myometrium. 2009 Mar:214A-214A. Link to Item
  - Murphy SK, Jayes FL, Feng L, Huang Z, Leppert PC. Altered IGF2/H19 Imprint Center Methylation in Uterine Fibroids but Not in Adjacent Myometrium. 2009 Mar:216A-216A. Link to Item
  - Baba T, Convery PA, Matsumura N, Whitaker RS, Perry T, Huang Z, Mori S, Kondoh E, Bentley RC, Fujii S, Marks JR, Berchuck A, Murphy SK. Stem cell marker CD133 (PROMININ-1) is epigenetically regulated in ovarian cancer. 2008 Mar:S104-S104. Link to Item
  - Lee PS, Teaberry V, Bland AE, Huang Z, Secord AA, Berchuck A, Murphy SK. MAL, a gene associated with survival in epithelial ovarian cancer, is epigenetically regulated. 2008 Mar:S125-S125. Link to Item
  - Baba T, Convey P, Matsumura N, Whitaker RS, Perry T, Huang Z, Mori S, Kondoh E, Bentley RC, Fujii S, Berchuck A, Murphy SK, Marks JR. Stem cell marker CD133 (PROMININ-1) is epigenetically regulated in ovarian cancer. 2008:175-176. Link to Item
  - Dietz L, Wylie AA, Rauen KA, Murphy SK, Jirtle RL, Cotter PD. Exclusion of maternal uniparental disomy of chromosome 14 in Prader-Willi syndrome referrals using a rapid methylation PCR assay. 2002 Oct:553-553. Link to Item
- Journal Articles
  - Bradley MS, Burke EE, Grenier C, Amundsen CL, Murphy SK, Siddiqui NY. A genome-scale DNA methylation study in women with interstitial cystitis/bladder pain syndrome. Neurourology and urodynamics. 2018 Apr;37(4):1485-1493. PubMed PMID: 29363787. Full Text
  - Schrott R, Murphy SK. Folic acid throughout pregnancy: too much?. The American journal of clinical nutrition. 2018 Apr;107(4):497-498. PubMed PMID: 29635510. Full Text
  - Dozmorov MG, Bilbo SD, Kollins SH, Zucker N, Do EK, Schechter JC, Zhang JJ, Murphy SK, Hoyo C, Fuemmeler BF. Associations between maternal cytokine levels during gestation and measures of child cognitive abilities and executive functioning. Brain, behavior, and immunity. 2018 Mar 24. PubMed PMID: 29588230. Full Text
  - Gomih A, Smith JS, North KE, Hudgens MG, Brewster WR, Huang Z, Skaar D, Valea F, Bentley RC, Vidal AC, Maguire RL, Jirtle RL, Murphy SK, Hoyo C. DNA methylation of imprinted gene control regions in the regression of low-grade cervical lesions. International journal of cancer. 2018 Feb 28. PubMed PMID: 29490428. Full Text
  - Green AJ, Hoyo C, Mattingly CJ, Luo Y, Tzeng J-Y, Murphy SK, Buchwalter DB, Planchart A. Cadmium exposure increases the risk of juvenile obesity: a human and zebrafish comparative study. International journal of obesity (2005). 2018 Feb 20. PubMed PMID: 29511319. Full Text
  - Felix JF, Joubert BR, Baccarelli AA, Sharp GC, Almqvist C, Annesi-Maesano I, Arshad H, Baïz N, Bakermans-Kranenburg MJ, Bakulski KM, Binder EB, Bouchard L, Breton CV, Brunekreef B, Brunst KJ, Burchard EG, Bustamante M, Chatzi L, Cheng Munthe-Kaas M, Corpeleijn E, Czamara D, Dabelea D, Davey Smith G, De Boever P, Duijts L, Dwyer T, Eng C, Eskenazi B, Everson TM, Falahi F, Fallin MD, Farchi S, Fernandez MF, Gao L, Gaunt TR, Ghantous A, Gillman MW, Gonseth S et al. Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium. International journal of epidemiology. 2018 Feb;47(1):22-23u. PubMed PMID: 29025028. Full Text
  - Schechter JC, Fuemmeler BF, Hoyo C, Murphy SK, Zhang JJ, Kollins SH. Impact of Smoking Ban on Passive Smoke Exposure in Pregnant Non-Smokers in the Southeastern United States. International journal of environmental research and public health. 2018 Jan 6;15(1). PubMed PMID: 29316617. Full Text
  - Chawla D, Fuemmeler B, Benjamin-Neelon SE, Hoyo C, Murphy S, Daniels JL. Early prenatal vitamin D concentrations and social-emotional development in infants. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2017 Dec 4:1-8. PubMed PMID: 29157031. Full Text
  - Sharp GC, Salas LA, Monnereau C, Allard C, Yousefi P, Everson TM, Bohlin J, Xu Z, Huang R-C, Reese SE, Xu C-J, Baïz N, Hoyo C, Agha G, Roy R, Holloway JW, Ghantous A, Merid SK, Bakulski KM, Küpers LK, Zhang H, Richmond RC, Page CM, Duijts L, Lie RT, Melton PE, Vonk JM, Nohr EA, Williams-DeVane C, Huen K, Rifas-Shiman SL, Ruiz-Arenas C, Gonseth S, Rezwan FI, Herceg Z, Ekström S, Croen L, Falahi F, Perron P, Karagas MR, Quraishi BM, Suderman M, Magnus MC et al. Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium. Human molecular genetics. 2017 Oct;26(20):4067-4085. PubMed PMID: 29016858. Full Text Open Access Copy
  - Cordero FJ, Huang Z, Grenier C, He X, Hu G, McLendon RE, Murphy SK, Hashizume R, Becher OJ. Histone H3.3K27M Represses p16 to Accelerate Gliomagenesis in a Murine Model of DIPG. Molecular cancer research : MCR. 2017 Sep;15(9):1243-1254. PubMed PMID: 28522693. Full Text
  - Liu Y, Reynolds LM, Ding J, Hou L, Lohman K, Young T, Cui W, Huang Z, Grenier C, Wan M, Stunnenberg HG, Siscovick D, Hou L, Psaty BM, Rich SS, Rotter JI, Kaufman JD, Burke GL, Murphy S, Jacobs DR, Post W, Hoeschele I, Bell DA, Herrington D, Parks JS, Tracy RP, McCall CE, Stein JH. Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis. Nature communications. 2017 Aug 30;8(1):393-. PubMed PMID: 28855511. Full Text
  - McCullough LE, Miller EE, Calderwood LE, Shivappa N, Steck SE, Forman MR, A Mendez M, Maguire R, Fuemmeler BF, Kollins SH, D Bilbo S, Huang Z, Murtha AP, Murphy SK, Hébert JR, Hoyo C. Maternal inflammatory diet and adverse pregnancy outcomes: Circulating cytokines and genomic imprinting as potential regulators?. Epigenetics. 2017 Aug;12(8):688-697. PubMed PMID: 28678596. Full Text
  - Benjamin Neelon SE, White AJ, Vidal AC, Schildkraut JM, Murtha AP, Murphy SK, Kullman SW, Hoyo C. Maternal vitamin D, DNA methylation at imprint regulatory regions and offspring weight at birth, 1 year and 3 years. International journal of obesity (2005). 2017 Jul 5. PubMed PMID: 28676681. Full Text
  - Gonzalez-Nahm S, Mendez M, Robinson W, Murphy SK, Hoyo C, Hogan V, Rowley D. Low maternal adherence to a Mediterranean diet is associated with increase in methylation at the MEG3-IG differentially methylated region in female infants. Environmental epigenetics. 2017 May 6;3(2):dvx007-. PubMed PMID: 29492309. Full Text
  - Luo Y, McCullough LE, Tzeng J-Y, Darrah T, Vengosh A, Maguire RL, Maity A, Samuel-Hodge C, Murphy SK, Mendez MA, Hoyo C. Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight. BMC public health. 2017 Apr 24;17(1):354-. PubMed PMID: 28438148. Full Text Open Access Copy
  - Breton CV, Marsit CJ, Faustman E, Nadeau K, Goodrich JM, Dolinoy DC, Herbstman J, Holland N, LaSalle JM, Schmidt R, Yousefi P, Perera F, Joubert BR, Wiemels J, Taylor M, Yang IV, Chen R, Hew KM, Freeland DMH, Miller R, Murphy SK. Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group. Environmental health perspectives. 2017 Apr;125(4):511-526. PubMed PMID: 28362264. Full Text
  - Hoffman K, Butt CM, Webster TF, Preston EV, Hammel SC, Makey C, Lorenzo AM, Cooper EM, Carignan C, Meeker JD, Hauser R, Soubry A, Murphy SK, Price TM, Hoyo C, Mendelsohn E, Congleton J, Daniels JL, Stapleton HM. Temporal Trends in Exposure to Organophosphate Flame Retardants in the United States. Environmental science & technology letters. 2017 Mar;4(3):112-118. PubMed PMID: 28317001. Full Text
  - Mwinyi J, Boström AE, Pisanu C, Murphy SK, Erhart W, Schafmayer C, Hampe J, Moylan C, Schiöth HB. NAFLD is associated with methylation shifts with relevance for the expression of genes involved in lipoprotein particle composition. Biochimica et biophysica acta. 2017 Mar;1862(3):314-323. PubMed PMID: 27993651. Full Text
  - Gao L, Millstein J, Siegmund KD, Dubeau L, Maguire R, Gilliland FD, Murphy SK, Hoyo C, Breton CV. Epigenetic regulation of AXL and risk of childhood asthma symptoms. Clinical epigenetics. 2017 Jan;9:121-. PubMed PMID: 29177020. Full Text
  - Maguire RL, Vidal AC, Murphy SK, Hoyo C. Disparities in Cervical Cancer Incidence and Mortality: Can Epigenetics Contribute to Eliminating Disparities?. Advances in cancer research. 2017 Jan;133:129-156. PubMed PMID: 28052819. (Review) Full Text
  - Soubry A, Hoyo C, Butt CM, Fieuws S, Price TM, Murphy SK, Stapleton HM. Human exposure to flame-retardants is associated with aberrant DNA methylation at imprinted genes in sperm. Environmental epigenetics. 2017 Jan;3(1):dvx003-. PubMed PMID: 29492305. Full Text
  - Yamanoi K, Matsumura N, Murphy SK, Baba T, Abiko K, Hamanishi J, Yamaguchi K, Koshiyama M, Konishi I, Mandai M. Suppression of ABHD2, identified through a functional genomics screen, causes anoikis resistance, chemoresistance and poor prognosis in ovarian cancer. Oncotarget. 2016 Jul;7(30):47620-47636. PubMed PMID: 27323405. Full Text
  - Schiöth HB, Boström A, Murphy SK, Erhart W, Hampe J, Moylan C, Mwinyi J. A targeted analysis reveals relevant shifts in the methylation and transcription of genes responsible for bile acid homeostasis and drug metabolism in non-alcoholic fatty liver disease. BMC genomics. 2016 Jun 14;17:462-. PubMed PMID: 27301979. Full Text
  - Fuemmeler BF, Wang L, Iversen ES, Maguire R, Murphy SK, Hoyo C. Association between Prepregnancy Body Mass Index and Gestational Weight Gain with Size, Tempo, and Velocity of Infant Growth: Analysis of the Newborn Epigenetic Study Cohort. Childhood obesity (Print). 2016 Jun;12(3):210-218. PubMed PMID: 27135650. Full Text
  - Dewi FN, Wood CE, Willson CJ, Register TC, Lees CJ, Howard TD, Huang Z, Murphy SK, Tooze JA, Chou JW, Miller LD, Cline JM. Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques. Cancer prevention research (Philadelphia, Pa.). 2016 May;9(5):385-395. PubMed PMID: 27006379. Full Text
  - Li Y, Xie C, Murphy SK, Skaar D, Nye M, Vidal AC, Cecil KM, Dietrich KN, Puga A, Jirtle RL, Hoyo C. Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood. Environmental health perspectives. 2016 May;124(5):666-673. PubMed PMID: 26115033. Full Text
  - Murakami R, Matsumura N, Mandai M, Yoshihara K, Tanabe H, Nakai H, Yamanoi K, Abiko K, Yoshioka Y, Hamanishi J, Yamaguchi K, Baba T, Koshiyama M, Enomoto T, Okamoto A, Murphy SK, Mori S, Mikami Y, Minamiguchi S, Konishi I. Establishment of a Novel Histopathological Classification of High-Grade Serous Ovarian Carcinoma Correlated with Prognostically Distinct Gene Expression Subtypes. The American journal of pathology. 2016 May;186(5):1103-1113. PubMed PMID: 26993207. Full Text
  - Joubert BR, Felix JF, Yousefi P, Bakulski KM, Just AC, Breton C, Reese SE, Markunas CA, Richmond RC, Xu C-J, Küpers LK, Oh SS, Hoyo C, Gruzieva O, Söderhäll C, Salas LA, Baïz N, Zhang H, Lepeule J, Ruiz C, Ligthart S, Wang T, Taylor JA, Duijts L, Sharp GC, Jankipersadsing SA, Nilsen RM, Vaez A, Fallin MD, Hu D, Litonjua AA, Fuemmeler BF, Huen K, Kere J, Kull I, Munthe-Kaas MC, Gehring U, Bustamante M, Saurel-Coubizolles MJ, Quraishi BM, Ren J, Tost J et al. DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. American journal of human genetics. 2016 Apr;98(4):680-696. PubMed PMID: 27040690. Full Text
  - Peng J, Yoshioka Y, Mandai M, Matsumura N, Baba T, Yamaguchi K, Hamanishi J, Kharma B, Murakami R, Abiko K, Murphy SK, Konishi I. The BMP signaling pathway leads to enhanced proliferation in serous ovarian cancer-A potential therapeutic target. Molecular carcinogenesis. 2016 Apr;55(4):335-345. PubMed PMID: 25663289. Full Text
  - McCullough LE, Miller EE, Mendez MA, Murtha AP, Murphy SK, Hoyo C. Maternal B vitamins: effects on offspring weight and DNA methylation at genomically imprinted domains. Clinical epigenetics. 2016 Jan 22;8:8-. PubMed PMID: 26807160. Full Text
  - Matsumura N, Yamanoi K, Murphy SK, Hamanishi J, Abiko K, Yamaguchi K, Baba T, Koshiyama M, Konishi I. Abstract A38: Identification through functional genomics screening of factors whose downregulation enhances the side population in ovarian cancer. Clinical Cancer Research. 2016 Jan 15;22(2 Supplement):A38-A38. Full Text
  - Fuemmeler BF, Lee C-T, Soubry A, Iversen ES, Huang Z, Murtha AP, Schildkraut JM, Jirtle RL, Murphy SK, Hoyo C. DNA Methylation of Regulatory Regions of Imprinted Genes at Birth and Its Relation to Infant Temperament. Genetics & epigenetics. 2016 Jan;8:59-67. PubMed PMID: 27920589. Full Text
  - King KE, Kane JB, Scarbrough P, Hoyo C, Murphy SK. Neighborhood and Family Environment of Expectant Mothers May Influence Prenatal Programming of Adult Cancer Risk: Discussion and an Illustrative DNA Methylation Example. Biodemography and social biology. 2016 Jan;62(1):87-104. PubMed PMID: 27050035. Full Text
  - Nye MD, King KE, Darrah TH, Maguire R, Jima DD, Huang Z, Mendez MA, Fry RC, Jirtle RL, Murphy SK, Hoyo C. Maternal blood lead concentrations, DNA methylation of MEG3 DMR regulating the DLK1/MEG3 imprinted domain and early growth in a multiethnic cohort. Environmental Epigenetics. 2016 Jan;2(1). PubMed PMID: 28123784. Full Text
  - Soubry A, Guo L, Huang Z, Hoyo C, Romanus S, Price T, Murphy SK. Obesity-related DNA methylation at imprinted genes in human sperm: Results from the TIEGER study. Clinical epigenetics. 2016 Jan;8:51-. PubMed PMID: 27158277. Full Text
  - Su D, Wang X, Campbell MR, Porter DK, Pittman GS, Bennett BD, Wan M, Englert NA, Crowl CL, Gimple RN, Adamski KN, Huang Z, Murphy SK, Bell DA. Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes. PloS one. 2016 Jan;11(12):e0166486-. PubMed PMID: 27935972. Full Text
  - Peng J, Hamanishi J, Matsumura N, Abiko K, Murat K, Baba T, Yamaguchi K, Horikawa N, Hosoe Y, Murphy SK, Konishi I, Mandai M. Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor-κB to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer. Cancer research. 2015 Dec;75(23):5034-5045. PubMed PMID: 26573793. Full Text
  - Sachdeva M, Dodd RD, Huang Z, Grenier C, Ma Y, Lev DC, Cardona DM, Murphy SK, Kirsch DG. Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182. Cancer letters. 2015 Dec;369(1):202-211. PubMed PMID: 26314219. Full Text
  - Hemachandra LPMP, Shin D-H, Dier U, Iuliano JN, Engelberth SA, Uusitalo LM, Murphy SK, Hempel N. Mitochondrial Superoxide Dismutase Has a Protumorigenic Role in Ovarian Clear Cell Carcinoma. Cancer research. 2015 Nov;75(22):4973-4984. PubMed PMID: 26359457. Full Text
  - Varadaraj A, Patel P, Serrao A, Bandyopadhay T, Lee NY, Jazaeri AA, Huang Z, Murphy SK, Mythreye K. Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia. Neoplasia (New York, N.Y.). 2015 Nov;17(11):826-838. PubMed PMID: 26678910. Full Text
  - Keenan MM, Liu B, Tang X, Wu J, Cyr D, Stevens RD, Ilkayeva O, Huang Z, Tollini LA, Murphy SK, Lucas J, Muoio DM, Kim SY, Chi J-T. ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate. PLoS genetics. 2015 Oct 9;11(10):e1005599-. PubMed PMID: 26452058. Full Text Open Access Copy
  - King KE, Darrah TH, Money E, Meentemeyer R, Maguire RL, Nye MD, Michener L, Murtha AP, Jirtle R, Murphy SK, Mendez MA, Robarge W, Vengosh A, Hoyo C. Geographic clustering of elevated blood heavy metal levels in pregnant women. BMC public health. 2015 Oct 9;15:1035-. PubMed PMID: 26449855. Full Text
  - Ding J, Reynolds LM, Zeller T, Müller C, Lohman K, Nicklas BJ, Kritchevsky SB, Huang Z, de la Fuente A, Soranzo N, Soranzo N, Settlage RE, Chuang C-C, Howard T, Xu N, Goodarzi MO, Chen Y-DI, Rotter JI, Siscovick DS, Parks JS, Murphy S, Jacobs DR, Post W, Tracy RP, Wild PS, Blankenberg S, Hoeschele I, Herrington D, McCall CE, Liu Y. Alterations of a Cellular Cholesterol Metabolism Network Are a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular Disease. Diabetes. 2015 Oct;64(10):3464-3474. PubMed PMID: 26153245. Full Text
  - Murphy SK, Erginer E, Huang Z, Visco Z, Hoyo C. Genotype-Epigenotype Interaction at the IGF2 DMR. Genes. 2015 Aug 28;6(3):777-789. PubMed PMID: 26343731. Full Text
  - Vidal AC, Semenova V, Darrah T, Vengosh A, Huang Z, King K, Nye MD, Fry R, Skaar D, Maguire R, Murtha A, Schildkraut J, Murphy S, Hoyo C. Maternal cadmium, iron and zinc levels, DNA methylation and birth weight. BMC pharmacology & toxicology. 2015 Jul 15;16:20-. PubMed PMID: 26173596. Full Text
  - King K, Murphy S, Hoyo C. Epigenetic regulation of Newborns' imprinted genes related to gestational growth: patterning by parental race/ethnicity and maternal socioeconomic status. Journal of epidemiology and community health. 2015 Jul;69(7):639-647. PubMed PMID: 25678712. Full Text
  - Baba T, Kang HS, Hosoe Y, Kharma B, Abiko K, Matsumura N, Hamanishi J, Yamaguchi K, Yoshioka Y, Koshiyama M, Mandai M, Murphy SK, Konishi I. Menstrual cyclic change of metastin/GPR54 in endometrium. Medical molecular morphology. 2015 Jun;48(2):76-84. PubMed PMID: 24908069. Full Text
  - Baba T, Kang HS, Hosoe Y, Kharma B, Abiko K, Matsumura N, Hamanishi J, Yamaguchi K, Yoshioka Y, Koshiyama M, Mandai M, Murphy SK, Konishi I. Menstrual cyclic change of metastin/GPR54 in endometrium. Medical Molecular Morphology. 2015 Jun 1;48(2):76-84. Full Text
  - Tang X, Keenan MM, Wu J, Lin C-A, Dubois L, Thompson JW, Freedland SJ, Murphy SK, Chi J-T. Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis. PLoS genetics. 2015 Apr 7;11(4):e1005158-. PubMed PMID: 25849282. Full Text
  - Nye MD, Hoyo C, Murphy SK. In vitro lead exposure changes DNA methylation and expression of IGF2 and PEG1/MEST. Toxicology in vitro : an international journal published in association with BIBRA. 2015 Apr;29(3):544-550. PubMed PMID: 25596546. Full Text
  - Soubry A, Murphy SK, Wang F, Huang Z, Vidal AC, Fuemmeler BF, Kurtzberg J, Murtha A, Jirtle RL, Schildkraut JM, Hoyo C. Newborns of obese parents have altered DNA methylation patterns at imprinted genes. Int J Obes (Lond). 2015 Apr;39(4):650-657. PubMed PMID: 24158121. Full Text Link to Item
  - McCullough LE, Mendez MA, Miller EE, Murtha AP, Murphy SK, Hoyo C. Associations between prenatal physical activity, birth weight, and DNA methylation at genomically imprinted domains in a multiethnic newborn cohort. Epigenetics. 2015 Jan;10(7):597-606. PubMed PMID: 25928716. Full Text
  - Mo L, Pospichalova V, Huang Z, Murphy SK, Payne S, Wang F, Kennedy M, Cianciolo GJ, Bryja V, Pizzo SV, Bachelder RE. Ascites Increases Expression/Function of Multidrug Resistance Proteins in Ovarian Cancer Cells. PloS one. 2015 Jan;10(7):e0131579-. PubMed PMID: 26148191. Full Text
  - Nagura M, Matsumura N, Baba T, Murakami R, Kharma B, Hamanishi J, Yamaguchi K, Abiko K, Koshiyama M, Mandai M, Murata T, Murphy SK, Konishi I. Invasion of uterine cervical squamous cell carcinoma cells is facilitated by locoregional interaction with cancer-associated fibroblasts via activating transforming growth factor-beta. Gynecologic oncology. 2015 Jan;136(1):104-111. PubMed PMID: 25434636. Full Text
  - Okamoto T, Mandai M, Matsumura N, Yamaguchi K, Kondoh H, Amano Y, Baba T, Hamanishi J, Abiko K, Kosaka K, Murphy SK, Mori S, Konishi I. Hepatocyte nuclear factor-1β (HNF-1β) promotes glucose uptake and glycolytic activity in ovarian clear cell carcinoma. Molecular Carcinogenesis. 2015;54(1):35-49. Full Text
  - Okamoto T, Mandai M, Matsumura N, Yamaguchi K, Kondoh H, Amano Y, Baba T, Hamanishi J, Abiko K, Kosaka K, Murphy SK, Mori S, Konishi I. Hepatocyte nuclear factor-1β (HNF-1β) promotes glucose uptake and glycolytic activity in ovarian clear cell carcinoma. Mol Carcinog. 2015 Jan;54(1):35-49. PubMed PMID: 24105991. Full Text Link to Item
  - Soubry A, Murphy SK, Wang F, Huang Z, Vidal AC, Fuemmeler BF, Kurtzberg J, Murtha A, Jirtle RL, Schildkraut JM, Hoyo C. Newborns of obese parents have altered DNA methylation patterns at imprinted genes. International Journal of Obesity. 2015 Jan 1;39(4):650-657. Full Text
  - Vidal AC, Skaar D, Maguire R, Dodor S, Musselwhite LW, Bartlett JA, Oneko O, Obure J, Mlay P, Murphy SK, Hoyo C. IL-10, IL-15, IL-17, and GMCSF levels in cervical cancer tissue of Tanzanian women infected with HPV16/18 vs. non-HPV16/18 genotypes. Infectious agents and cancer. 2015 Jan;10:10-. PubMed PMID: 25810759. Full Text Open Access Copy
  - Kharma B, Baba T, Matsumura N, Kang HS, Hamanishi J, Murakami R, McConechy MM, Leung S, Yamaguchi K, Hosoe Y, Yoshioka Y, Murphy SK, Mandai M, Hunstman DG, Konishi I. STAT1 drives tumor progression in serous papillary endometrial cancer. Cancer research. 2014 Nov;74(22):6519-6530. PubMed PMID: 25267067. Full Text
  - Nye MD, Hoyo C, Wang F, Murtha AP, Schildkraut JM, Kurtzberg J, Jirtle RL, Huang Z, Murphy SK. Abstract B22: Altered methylation profiles of imprinted genes in response to prenatal exposure to cigarette smoke in the Newborn Epigenetic STudy (NEST) cohort. Cancer Epidemiology Biomarkers & Prevention. 2014 Nov;23(11 Supplement):B22-B22. Full Text
  - Hoyo C, Daltveit AK, Iversen E, Benjamin-Neelon SE, Fuemmeler B, Schildkraut J, Murtha AP, Overcash F, Vidal AC, Wang F, Huang Z, Kurtzberg J, Seewaldt V, Forman M, Jirtle RL, Murphy SK. Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort. Epigenetics. 2014 Aug;9(8):1120-1130. PubMed PMID: 24874916. Full Text
  - Vidal AC, Smith JS, Valea F, Bentley R, Gradison M, Yarnall KSH, Ford A, Overcash F, Grant K, Murphy SK, Hoyo C. HPV genotypes and cervical intraepithelial neoplasia in a multiethnic cohort in the southeastern USA. Cancer causes & control : CCC. 2014 Aug;25(8):1055-1062. PubMed PMID: 24928693. Full Text
  - Yamaguchi K, Huang Z, Matsumura N, Mandai M, Okamoto T, Baba T, Konishi I, Berchuck A, Murphy SK. Epigenetic determinants of ovarian clear cell carcinoma biology. Int J Cancer. 2014 Aug 1;135(3):585-597. PubMed PMID: 24382740. Full Text Link to Item
  - Yamaguchi K, Huang Z, Matsumura N, Mandai M, Okamoto T, Baba T, Konishi I, Berchuck A, Murphy SK. Epigenetic determinants of ovarian clear cell carcinoma biology. International Journal of Cancer. 2014 Aug 1;135(3):585-597. Full Text
  - Murphy SK. Obesity: Paternal obesity--a risk factor for autism?. Nature reviews. Endocrinology. 2014 Jul;10(7):389-390. PubMed PMID: 24889901. Full Text
  - Smeester L, Yosim AE, Nye MD, Hoyo C, Murphy SK, Fry RC. Imprinted genes and the environment: links to the toxic metals arsenic, cadmium, lead and mercury. Genes. 2014 Jun 11;5(2):477-496. PubMed PMID: 24921406. Full Text
  - Soubry A, Hoyo C, Jirtle RL, Murphy SK. A paternal environmental legacy: evidence for epigenetic inheritance through the male germ line. BioEssays : news and reviews in molecular, cellular and developmental biology. 2014 Apr;36(4):359-371. PubMed PMID: 24431278. Full Text
  - Soubry A, Hoyo C, Jirtle RL, Murphy SK. A paternal environmental legacy: Evidence for epigenetic inheritance through the male germ line. BioEssays. 2014 Apr 1;36(4):359-371. Full Text
  - Vidal AC, Henry NM, Murphy SK, Oneko O, Nye M, Bartlett JA, Overcash F, Huang Z, Wang F, Mlay P, Obure J, Smith J, Vasquez B, Swai B, Hernandez B, Hoyo C. PEG1/MEST and IGF2 DNA methylation in CIN and in cervical cancer. Clinical and Translational Oncology. 2014 Mar 1;16(3):266-272. Full Text
  - Vidal AC, Henry NM, Murphy SK, Oneko O, Nye M, Bartlett JA, Overcash F, Huang Z, Wang F, Mlay P, Obure J, Smith J, Vasquez B, Swai B, Hernandez B, Hoyo C. PEG1/MEST and IGF2 DNA methylation in CIN and in cervical cancer. Clin Transl Oncol. 2014 Mar;16(3):266-272. PubMed PMID: 23775149. Full Text Link to Item
  - Moylan CA, Pang H, Dellinger A, Suzuki A, Garrett ME, Guy CD, Murphy SK, Ashley-Koch AE, Choi SS, Michelotti GA, Hampton DD, Chen Y, Tillmann HL, Hauser MA, Abdelmalek MF, Diehl AM. Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease. Hepatology. 2014 Feb;59(2):471-482. PubMed PMID: 23913408. Full Text Link to Item
  - Secord AA, Teoh D, Jia J, Nixon AB, Grace L, Adams DJ, Murphy SK. Dasatinib (BMS-35482) interacts synergistically with docetaxel, gemcitabine, topotecan, and doxorubicin in ovarian cancer cells with high SRC pathway activation and protein expression. Int J Gynecol Cancer. 2014 Feb;24(2):218-225. PubMed PMID: 24407585. Full Text Link to Item
  - Cathrine Hoyo SKM. HPV Genotypes and Cervical Intraepithelial Neoplasiain a Multiethnic Cohort in the Southeastern United States. Journal of Vaccines & Vaccination. 2014;05(03). Full Text
  - Davidson BA, Rubatt JM, Corcoran DL, Teoh DK, Bernardini MQ, Grace LA, Soper WJ, Berchuck A, Siamakpour-Reihani S, Chen W, Owzar K, Murphy SK, Secord AA. Differential Angiogenic Gene Expression in TP53 Wild-Type and Mutant Ovarian Cancer Cell Lines. Frontiers in Oncology. 2014 Jan;4:163-. PubMed PMID: 24999452. Full Text
  - Murphy SK. Obesity: Paternal obesity - A risk factor for autism?. Nature Reviews Endocrinology. 2014 Jan 1;10(7):389-390. Full Text
  - Nye MD, Fry RC, Hoyo C, Murphy SK. Investigating Epigenetic Effects of Prenatal Exposure to Toxic Metals in Newborns: Challenges and Benefits. Medical epigenetics. 2014 Jan;2(1):53-59. PubMed PMID: 24955086. Full Text
  - Susan K. Murphy CH. What are the Implications of Distinct HPV Genotypes in Women of Different Ethnic/Racial Ancestry?. Journal of Vaccines & Vaccination. 2014;05(03). Full Text
  - Vidal AC, Benjamin Neelon SE, Liu Y, Tuli AM, Fuemmeler BF, Hoyo C, Murtha AP, Huang Z, Schildkraut J, Overcash F, Kurtzberg J, Jirtle RL, Iversen ES, Murphy SK. Maternal stress, preterm birth, and DNA methylation at imprint regulatory sequences in humans. Genetics & epigenetics. 2014 Jan;6:37-44. PubMed PMID: 25512713. Full Text
  - Vidal AC, Henry NM, Murphy SK, Oneko O, Nye M, Bartlett JA, Overcash F, Huang Z, Wang F, Mlay P, Obure J, Smith J, Vasquez B, Swai B, Hernandez B, Hoyo C. PEG1/MEST and IGF2 DNA methylation in CIN and in cervical cancer. Clinical and Translational Oncology. 2014;16(3):266-272.
  - Vidal AC, Smith JS, Valea F, Bentley R, Gradison M, Yarnall KSH, Ford A, Overcash F, Grant K, Murphy SK, Hoyo C. HPV genotypes and cervical intraepithelial neoplasia in a multiethnic cohort in the southeastern USA. Cancer Causes and Control. 2014 Jan 1;25(8):1055-1062. Full Text
  - Yamaguchi K, Matsumura N, Mandai M, Baba T, Konishi I, Murphy SK. Epigenetic and genetic dispositions of ovarian carcinomas. Oncoscience. 2014 Jan;1(9):574-579. PubMed PMID: 25594067. Full Text
  - Murphy SK, Yang H, Moylan CA, Pang H, Dellinger A, Abdelmalek MF, Garrett ME, Ashley-Koch A, Suzuki A, Tillmann HL, Hauser MA, Diehl AM. Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease. Gastroenterology. 2013 Nov;145(5):1076-1087. PubMed PMID: 23916847. Full Text Link to Item
  - Amano Y, Yamaguchi K, Mandai M, Matsumura N, Hamanishi J, Baba T, Yamanoi K, Murphy SK, Konishi I. Abstract PR08: HNF1β confers resistance to oxidative stress of ovarian clear cell carcinoma. Clinical Cancer Research. 2013 Oct 1;19(19 Supplement):PR08-PR08. Full Text
  - Hamanishi J, Matsumura N, Jin P, Abiko K, Horikawa N, Yamaguchi K, Baba T, Murphy SK, Konishi I, Mandai M. Abstract A83: Induction of PD-L1 expression by cytotoxic agents through activation of NF-kB signal. Clinical Cancer Research. 2013 Oct 1;19(19 Supplement):A83-A83. Full Text
  - Matsumura N, Yamanoi K, Amano Y, Hamanishi J, Baba T, Murphy SK, Konishi I. Abstract B19: Functional genomics approach links anchorage-independence with tumor dormancy in ovarian cancer. Clinical Cancer Research. 2013 Oct 1;19(19 Supplement):B19-B19. Full Text
  - Vidal AC, Murphy SK, Murtha AP, Schildkraut JM, Soubry A, Huang Z, Neelon SEB, Fuemmeler B, Iversen E, Wang F, Kurtzberg J, Jirtle RL, Hoyo C. Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring. Int J Obes (Lond). 2013 Jul;37(7):907-913. PubMed PMID: 23609933. Full Text Link to Item
  - Liu Y, Hoyo C, Murphy S, Huang Z, Overcash F, Thompson J, Brown H, Murtha AP. DNA methylation at imprint regulatory regions in preterm birth and infection. Am J Obstet Gynecol. 2013 May;208(5):395.e1-395.e7. PubMed PMID: 23477525. Full Text Link to Item
  - Sfakianos GP, Iversen ES, Whitaker R, Akushevich L, Schildkraut JM, Murphy SK, Marks JR, Berchuck A. Validation of ovarian cancer gene expression signatures for survival and subtype in formalin fixed paraffin embedded tissues. Gynecol Oncol. 2013 Apr;129(1):159-164. PubMed PMID: 23274563. Full Text Link to Item
  - Murphy SK, Hollingsworth JW. Stress: A Possible Link between Genetics, Epigenetics, and Childhood Asthma. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2013 Mar 15;187(6):563-564. PubMed PMID: 23504358. Full Text Link to Item
  - Soubry A, Schildkraut JM, Murtha A, Wang F, Huang Z, Bernal A, Kurtzberg J, Jirtle RL, Murphy SK, Hoyo C. Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort. (Published online) BMC Med. 2013 Feb 6;11:29-. PubMed PMID: 23388414. Full Text Link to Item
  - Alvarez Secord A, Bernardini MQ, Broadwater G, Grace LA, Huang Z, Baba T, Kondoh E, Sfakianos G, Havrilesky LJ, Murphy SK. TP53 Status is Associated with Thrombospondin1 Expression In vitro. (Published online) Front Oncol. 2013;3:269-. PubMed PMID: 24195060. Full Text Link to Item
  - Bassil CF, Huang Z, Murphy SK. Bisulfite pyrosequencing. Methods Mol Biol. 2013;1049:95-107. PubMed PMID: 23913212. Full Text Link to Item
  - Huang Z, Bassil CF, Murphy SK. Bisulfite sequencing of cloned alleles. Methods Mol Biol. 2013;1049:83-94. PubMed PMID: 23913211. Full Text Link to Item
  - Huang Z, Bassil CF, Murphy SK. Methylation-specific PCR. Methods Mol Biol. 2013;1049:75-82. PubMed PMID: 23913210. Full Text Link to Item
  - Huang Z, Murphy SK. Increased Intragenic IGF2 Methylation is Associated with Repression of Insulator Activity and Elevated Expression in Serous Ovarian Carcinoma. (Published online) Front Oncol. 2013;3:131-. PubMed PMID: 23745176. Full Text Link to Item
  - Kharma B, Baba T, Mandai M, Matsumura N, Murphy SK, Kang HS, Yamanoi K, Hamanishi J, Yamaguchi K, Yoshioka Y, Konishi I. Utilization of genomic signatures to identify high-efficacy candidate drugs for chemorefractory endometrial cancers. International Journal of Cancer. 2013;133(9):2234-2244. Full Text
  - Kharma B, Baba T, Mandai M, Matsumura N, Murphy SK, Kang HS, Yamanoi K, Hamanishi J, Yamaguchi K, Yoshioka Y, al E. Utilization of genomic signatures to identify high-efficacy candidate drugs for chemorefractory endometrial cancers. International Journal of Cancer. 2013. PubMed PMID: 23595697. Full Text
  - Liu Y, Hoyo C, Murphy S, Huang Z, Overcash F, Thompson J, Brown H, Murtha AP. DNA methylation at imprint regulatory regions in preterm birth and infection. American Journal of Obstetrics and Gynecology. 2013;208(5):395.e1-395.e7. Full Text
  - Murphy SK, Bassil CF, Huang Z. Main principles and outcomes of DNA methylation analysis. Methods Mol Biol. 2013;1049:67-74. PubMed PMID: 23913209. Full Text Link to Item
  - Murphy SK. Prenatal sensitization of a postnatal trigger for metabolic disease. Journal of Clinical Investigation. 2013;123(7):2786-2788. PubMed PMID: 23926602. Full Text
  - Nye MD, Hoyo C, Huang Z, Vidal AC, Wang F, Overcash F, Smith JS, Vasquez B, Hernandez B, Swai B, Oneko O, Mlay P, Obure J, Gammon MD, Bartlett JA, Murphy SK. Associations between methylation of paternally expressed gene 3 (PEG3), cervical intraepithelial neoplasia and invasive cervical cancer. PLoS One. 2013;8(2):e56325-. PubMed PMID: 23418553. Full Text Link to Item
  - Sfakianos GP, Iversen ES, Whitaker R, Akushevich L, Schildkraut JM, Murphy SK, Marks JR, Berchuck A. Validation of ovarian cancer gene expression signatures for survival and subtype in formalin fixed paraffin embedded tissues. Gynecologic Oncology. 2013;129(1):159-164. Full Text
  - Vidal AC, Murphy SK, Murtha AP, Schildkraut JM, Soubry A, Huang Z, Neelon SEB, Fuemmeler B, Iversen E, Wang F, Kurtzberg J, Jirtle RL, Hoyo C. Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring. International Journal of Obesity. 2013;37(7):907-913. Full Text
  - Vidal AC, Murtha AP, Murphy SK, Fortner K, Overcash F, Henry N, Schildkraut JM, Forman MR, Demark-Wahnefried W, Kurtzberg J, Jirtle R, Hoyo C. Maternal BMI, IGF-I Levels, and Birth Weight in African American and White Infants. Int J Pediatr. 2013;2013:191472-. PubMed PMID: 23861689. Full Text Link to Item
  - Vidal AC, Overcash F, Murphy SK, Murtha AP, Schildkraut JM, Forman MR, Demark-Wahnefried W, Kurtzberg J, Skaar D, Jirtle RL, Hoyo C. Associations between birth and one year anthropometric measurements and IGF2 and IGF2R genetic variants in African American and Caucasian American infants. Journal of pediatric genetics. 2013 Jan;2(3). PubMed PMID: 26045971. Full Text
  - Korch C, Spillman MA, Jackson TA, Jacobsen BM, Murphy SK, Lessey BA, Jordan VC, Bradford AP. DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination. Gynecol Oncol. 2012 Oct;127(1):241-248. PubMed PMID: 22710073. Full Text Link to Item
  - Das R, Anderson N, Koran MI, Weidman JR, Mikkelsen TS, Kamal M, Murphy SK, Linblad-Toh K, Greally JM, Jirtle RL. Convergent and divergent evolution of genomic imprinting in the marsupial Monodelphis domestica. (Published online) BMC Genomics. 2012 Aug 16;13:394-. PubMed PMID: 22899817. Full Text Link to Item
  - Liu Y, Murphy SK, Murtha AP, Fuemmeler BF, Schildkraut J, Huang Z, Overcash F, Kurtzberg J, Jirtle R, Iversen ES, Forman MR, Hoyo C. Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements. Epigenetics. 2012 Jul;7(7):735-746. PubMed PMID: 22677950. Full Text Link to Item
  - Perkins E, Murphy SK, Murtha AP, Schildkraut J, Jirtle RL, Demark-Wahnefried W, Forman MR, Kurtzberg J, Overcash F, Huang Z, Hoyo C. Insulin-like growth factor 2/H19 methylation at birth and risk of overweight and obesity in children. J Pediatr. 2012 Jul;161(1):31-39. PubMed PMID: 22341586. Full Text Link to Item
  - Huang Z, Lowery WJ, Berchuck A, Murphy SK. Abstract 5363: Aggregation rather than monoclonal expansion explains ovarian cancer spheroid formation. Cancer Research. 2012 Apr 15;72(8 Supplement):5363-5363. Full Text
  - Okamoto T, Yamaguchi K, Huang Z, Whitaker R, Konishi I, Berchuck A, Murphy SK. Abstract LB-87: Methylated-mediated repression of ZNF154 in ovarian cancer is associated with poor overall survival. Cancer Research. 2012 Apr 15;72(8 Supplement):LB-87-LB-87. Full Text
  - Hoyo C, Fortner K, Murtha AP, Schildkraut JM, Soubry A, Demark-Wahnefried W, Jirtle RL, Kurtzberg J, Forman MR, Overcash F, Huang Z, Murphy SK. Association of cord blood methylation fractions at imprinted insulin-like growth factor 2 (IGF2), plasma IGF2, and birth weight. Cancer Causes Control. 2012 Apr;23(4):635-645. PubMed PMID: 22392079. Full Text Link to Item
  - Murphy SK, Adigun A, Huang Z, Overcash F, Wang F, Jirtle RL, Schildkraut JM, Murtha AP, Iversen ES, Hoyo C. Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke. Gene. 2012 Feb 15;494(1):36-43. PubMed PMID: 22202639. Full Text Link to Item
  - Murphy SK. Targeting the epigenome in ovarian cancer. Future Oncol. 2012 Feb;8(2):151-164. PubMed PMID: 22335580. (Review) Full Text Link to Item
  - Hoyo C, Murphy SK, Schildkraut JM, Vidal AC, Skaar D, Millikan RC, Galanko J, Sandler RS, Jirtle R, Keku T. IGF2R genetic variants, circulating IGF2 concentrations and colon cancer risk in African Americans and Whites. Dis Markers. 2012;32(2):133-141. PubMed PMID: 22377707. Full Text Link to Item
  - Murphy SK, Huang Z, Hoyo C. Differentially methylated regions of imprinted genes in prenatal, perinatal and postnatal human tissues. PLoS One. 2012;7(7):e40924-. PubMed PMID: 22808284. Full Text Link to Item
  - Skaar DA, Li Y, Bernal AJ, Hoyo C, Murphy SK, Jirtle RL. The Human Imprintome: Regulatory Mechanisms, Methods of Ascertainment, and Roles in Disease Susceptibility. ILAR JOURNAL. 2012;53(3-4):341-358. PubMed PMID: 23744971. Full Text Link to Item
  - Yamamura S, Matsumura N, Mandai M, Huang Z, Oura T, Baba T, Hamanishi J, Yamaguchi K, Kang HS, Okamoto T, Abiko K, Mori S, Murphy SK, Konishi I. The activated transforming growth factor-beta signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer. Int J Cancer. 2012 Jan 1;130(1):20-28. PubMed PMID: 21503873. Full Text Link to Item
  - Bondurant AE, Huang Z, Whitaker RS, Simel LR, Berchuck A, Murphy SK. Quantitative detection of RASSF1A DNA promoter methylation in tumors and serum of patients with serous epithelial ovarian cancer. Gynecol Oncol. 2011 Dec;123(3):581-587. PubMed PMID: 21955482. Full Text Link to Item
  - Murphy SK, Berchuck A. Ovarian cancer progenitor/stem cells: Therapeutic potential. 2011 Dec 1:223-244. (Chapter) Full Text
  - Vidal AC, Murphy SK, Hernandez BY, Vasquez B, Bartlett JA, Oneko O, Mlay P, Obure J, Overcash F, Smith JS, van der Kolk M, Hoyo C. Distribution of HPV genotypes in cervical intraepithelial lesions and cervical cancer in Tanzanian women. (Published online) Infect Agent Cancer. 2011 Nov 14;6(1):20-. PubMed PMID: 22081870. Full Text Open Access Copy Link to Item
  - Alvarez Secord A, Darcy KM, Hutson A, Huang Z, Lee PS, Jewell EL, Havrilesky LJ, Markman M, Muggia F, Murphy SK. The regulation of MASPIN expression in epithelial ovarian cancer: association with p53 status, and MASPIN promoter methylation: a gynecologic oncology group study. Gynecol Oncol. 2011 Nov;123(2):314-319. PubMed PMID: 21903246. Full Text Link to Item
  - Soubry A, Murphy S, Huang Z, Murtha A, Schildkraut J, Jirtle R, Wang F, Kurtzberg J, Demark-Wahnefried W, Forman M, Hoyo C. The effects of depression and use of antidepressive medicines during pregnancy on the methylation status of the IGF2 imprinted control regions in the offspring. (Published online) Clin Epigenetics. 2011 Oct 26;3:2-. PubMed PMID: 22414206. Full Text Link to Item
  - Hoyo C, Murtha AP, Schildkraut JM, Jirtle RL, Demark-Wahnefried W, Forman MR, Iversen ES, Kurtzberg J, Overcash F, Huang Z, Murphy SK. Methylation variation at IGF2 differentially methylated regions and maternal folic acid use before and during pregnancy. Epigenetics. 2011 Jul;6(7):928-936. PubMed PMID: 21636975. Link to Item
  - Zhang A, Skaar DA, Li Y, Huang D, Price TM, Murphy SK, Jirtle RL. Novel retrotransposed imprinted locus identified at human 6p25. Nucleic Acids Res. 2011 Jul;39(13):5388-5400. PubMed PMID: 21421564. Full Text Link to Item
  - Huang Z, Yamaguchi K, Berchuck A, Murphy SK. Abstract 3014: Quantitative accuracy of Illumina HumanMethylation27 Infinium BeadChip data assessed by pyrosequencing. Cancer Research. 2011 Apr 15;71(8 Supplement):3014-3014. Full Text
  - Soubry A, Murphy SK, Huang Z, Murtha A, Schildkraut JM, Jirtle RL, Wang F, Kurtzberg J, Demark-Wahnefried W, Forman M, Hoyo C. Abstract 2754: Maternal use of antidepressants in pregnancy is associated with hypermethylation at the IGF2 imprinted control regions in the offspring in a race-dependent fashion. Cancer Research. 2011 Apr 15;71(8 Supplement):2754-2754. Full Text
  - Kang HS, Baba T, Mandai M, Matsumura N, Hamanishi J, Kharma B, Kondoh E, Yoshioka Y, Oishi S, Fujii N, Murphy SK, Konishi I. GPR54 is a target for suppression of metastasis in endometrial cancer. Mol Cancer Ther. 2011 Apr;10(4):580-590. PubMed PMID: 21282360. Full Text Link to Item
  - Teoh D, Ayeni TA, Rubatt JM, Adams DJ, Grace L, Starr MD, Barry WT, Berchuck A, Murphy SK, Secord AA. Dasatinib (BMS-35482) has synergistic activity with paclitaxel and carboplatin in ovarian cancer cells. Gynecol Oncol. 2011 Apr;121(1):187-192. PubMed PMID: 21208651. Full Text Link to Item
  - Hoyo C, Murtha AP, Schildkraut JM, Forman MR, Calingaert B, Demark-Wahnefried W, Kurtzberg J, Jirtle RL, Murphy SK. Folic acid supplementation before and during pregnancy in the Newborn Epigenetics STudy (NEST). (Published online) BMC Public Health. 2011 Jan 21;11(1):46-. PubMed PMID: 21255390. Full Text Link to Item
  - Bernal AJ, Murphy SK, Jirtle RL. Mouse models of epigenetic inheritance. Handbook of Epigenetics. 2011:233-249. Full Text
  - Matsumura N, Huang Z, Mori S, Baba T, Fujii S, Konishi I, Iversen ES, Berchuck A, Murphy SK. Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer. Genome Res. 2011 Jan;21(1):74-82. PubMed PMID: 21156726. Full Text Link to Item
  - Matsumura N, Mandai M, Okamoto T, Yamaguchi K, Yamamura S, Oura T, Baba T, Hamanishi J, Kang HS, Matsui S, Mori S, Murphy SK, Konishi I. Sorafenib efficacy in ovarian clear cell carcinoma revealed by transcriptome profiling. Cancer Sci. 2010 Dec;101(12):2658-2663. PubMed PMID: 21040214. Full Text Link to Item
  - Bernardini MQ, Baba T, Lee PS, Barnett JC, Sfakianos GP, Secord AA, Murphy SK, Iversen E, Marks JR, Berchuck A. Expression signatures of TP53 mutations in serous ovarian cancers. (Published online) BMC Cancer. 2010 May 26;10:237-. PubMed PMID: 20504346. Full Text Open Access Copy Link to Item
  - Kondoh E, Mori S, Yamaguchi K, Baba T, Matsumura N, Cory Barnett J, Whitaker RS, Konishi I, Fujii S, Berchuck A, Murphy SK. Targeting slow-proliferating ovarian cancer cells. Int J Cancer. 2010 May 15;126(10):2448-2456. PubMed PMID: 19795452. Full Text Link to Item
  - Yamaguchi K, Mandai M, Oura T, Matsumura N, Hamanishi J, Baba T, Matsui S, Murphy SK, Konishi I. Identification of an ovarian clear cell carcinoma gene signature that reflects inherent disease biology and the carcinogenic processes. Oncogene. 2010 Mar 25;29(12):1741-1752. PubMed PMID: 20062075. Full Text Link to Item
  - Lee PS, Teaberry VS, Bland AE, Huang Z, Whitaker RS, Baba T, Fujii S, Secord AA, Berchuck A, Murphy SK. Elevated MAL expression is accompanied by promoter hypomethylation and platinum resistance in epithelial ovarian cancer. Int J Cancer. 2010 Mar 15;126(6):1378-1389. PubMed PMID: 19642140. Full Text Link to Item
  - Barnett JC, Bean SM, Whitaker RS, Kondoh E, Baba T, Fujii S, Marks JR, Dressman HK, Murphy SK, Berchuck A. Ovarian cancer tumor infiltrating T-regulatory (T(reg)) cells are associated with a metastatic phenotype. Gynecol Oncol. 2010 Mar;116(3):556-562. PubMed PMID: 20006900. Full Text Link to Item
  - Murphy SK. Targeting ovarian cancer-initiating cells. Anticancer Agents Med Chem. 2010 Feb;10(2):157-163. PubMed PMID: 20184540. (Review) Link to Item
  - Barnett JC, Bean SM, Nakayama JM, Kondoh E, Murphy SK, Berchuck A. High poly(adenosine diphosphate-ribose) polymerase expression and poor survival in advanced-stage serous ovarian cancer. Obstet Gynecol. 2010 Jan;115(1):49-54. PubMed PMID: 20027033. Full Text Link to Item
  - Hoyo C, Schildkraut JM, Murphy SK, Chow W-H, Vaughan TL, Risch H, Marks JR, Jirtle RL, Calingaert B, Mayne S, Fraumeni J, Gammon MD. IGF2R polymorphisms and risk of esophageal and gastric adenocarcinomas. Int J Cancer. 2009 Dec 1;125(11):2673-2678. PubMed PMID: 19626700. Full Text Link to Item
  - Gregory SG, Connelly JJ, Towers AJ, Johnson J, Biscocho D, Markunas CA, Lintas C, Abramson RK, Wright HH, Ellis P, Langford CF, Worley G, Delong GR, Murphy SK, Cuccaro ML, Persico A, Pericak-Vance MA. Genomic and epigenetic evidence for oxytocin receptor deficiency in autism. (Published online) BMC Med. 2009 Oct 22;7:62-. PubMed PMID: 19845972. Full Text Link to Item
  - Hoyo C, Murphy SK, Jirtle RL. Imprint regulatory elements as epigenetic biosensors of exposure in epidemiological studies. J Epidemiol Community Health. 2009 Sep;63(9):683-684. PubMed PMID: 19679714. Full Text Link to Item
  - Mori S, Chang JT, Andrechek ER, Matsumura N, Baba T, Yao G, Kim JW, Gatza M, Murphy S, Nevins JR. Anchorage-independent cell growth signature identifies tumors with metastatic potential. Oncogene. 2009 Aug 6;28(31):2796-2805. PubMed PMID: 19483725. Full Text Link to Item
  - Ding X, Mohd AB, Huang Z, Baba T, Bernardini MQ, Lyerly HK, Berchuck A, Murphy SK, Buermeyer AB, Devi GR. MLH1 expression sensitises ovarian cancer cells to cell death mediated by XIAP inhibition. Br J Cancer. 2009 Jul 21;101(2):269-277. PubMed PMID: 19603033. Full Text Link to Item
  - Huang Z, Wen Y, Simel L, Price T, Berchuck A, Murphy SK. CTCF binding at a novel intragenic binding site is associated with elevated IGF2 expression in serous epithelial ovarian cancer. CANCER RESEARCH. 2009 May 1;69. Link to Item
  - Berchuck A, Iversen ES, Luo J, Clarke JP, Horne H, Levine DA, Boyd J, Alonso MA, Secord AA, Bernardini MQ, Barnett JC, Boren T, Murphy SK, Dressman HK, Marks JR, Lancaster JM. Microarray analysis of early stage serous ovarian cancers shows profiles predictive of favorable outcome. Clin Cancer Res. 2009 Apr 1;15(7):2448-2455. PubMed PMID: 19318476. Full Text Link to Item
  - Kondoh E, Okamoto T, Higuchi T, Tatsumi K, Baba T, Murphy SK, Takakura K, Konishi I, Fujii S. Stress affects uterine receptivity through an ovarian-independent pathway. Hum Reprod. 2009 Apr;24(4):945-953. PubMed PMID: 19098291. Full Text Link to Item
  - Baba T, Kang HS, Matsumura N, Hamanishi J, Mandai M, Berchuck A, Murphy SK, Konishi I. Loss of GPR54 correlates with stem cell activity in high-grade endometrial cancer. GYNECOLOGIC ONCOLOGY. 2009 Feb;112(2):S78-S78. Link to Item
  - Barnett JC, Iverson E, Dressman H, Whitaker R, Murphy SK, Lancaster J, Berchuck A. Validation of the MAL gene as a predictor of survival in advanced-stage high-grade serous ovarian cancer. GYNECOLOGIC ONCOLOGY. 2009 Feb;112(2):S123-S124. Link to Item
  - Barnett JC, Kondoh E, Whitaker R, Murphy SK, Berchuck A. High poly (ADP-ribose) polymerase (PARP) expression is associated with poor survival in advanced-stage serous ovarian cancer. GYNECOLOGIC ONCOLOGY. 2009 Feb;112(2):S107-S107. Link to Item
  - Barnett JC, Whitaker R, Kondoh E, Baba T, Murphy SK, Berchuck A. Ovarian cancer tumor-infiltrating regulatory T cells are associated with a metastatic phenotype. GYNECOLOGIC ONCOLOGY. 2009 Feb;112(2):S11-S11. Link to Item
  - Horne HN, Lee PS, Murphy SK, Alonso MA, Olson JA, Marks JR. Inactivation of the MAL gene in breast cancer is a common event that predicts benefit from adjuvant chemotherapy. Mol Cancer Res. 2009 Feb;7(2):199-209. PubMed PMID: 19208741. Full Text Link to Item
  - Kondoh E, Baba T, Malsumura N, Konishi I, Fujii S, Berchuck A, Murphy SK. 7-hydroxystaurosporine (UCN-01) is effective in targeting ovarian cancer spheroids. GYNECOLOGIC ONCOLOGY. 2009 Feb;112(2):S161-S162. Link to Item
  - Matsumura N, Huang Z, Baba T, Lee PS, Barnett JC, Mori S, Chang JT, Kuo W-L, Gusberg AH, Whitaker RS, Gray JW, Fujii S, Berchuck A, Murphy SK. Yin yang 1 modulates taxane response in epithelial ovarian cancer. Mol Cancer Res. 2009 Feb;7(2):210-220. PubMed PMID: 19208743. Full Text Link to Item
  - Murphy SK, Chen L. Imprinted Neuronatin: A potential epigenetie biomarker of ovarian cancer. GYNECOLOGIC ONCOLOGY. 2009 Feb;112(2):S135-S135. Link to Item
  - Murphy SK, Huang Z, Wen Y, Simel LR, Price TM, Berchuck A. Intragenic methylation at a novel CTCF binding site is associated with elevated IGF2 expression in serous epithelial ovarian cancer. GYNECOLOGIC ONCOLOGY. 2009 Feb;112(2):S138-S138. Link to Item
  - Resnick KE, Alder H, Secord AA, Whitaker R, Richardson DL, Heaphy C, Murphy SK, Baba T, Croce C, Colin DE. MiRNA patterns in ovarian cancer cell lines: Correlation with serum studies. GYNECOLOGIC ONCOLOGY. 2009 Feb;112(2):S115-S116. Link to Item
  - Yamaguchi K, Mandai M, Matsumura N, Baba T, Oura T, Matsui S, Murphy SK, Berchuck A, Fujii S, Konishi I. Gene signature specific for ovarian clear cell carcinoma is induced by the contents of endometriotic cysts. GYNECOLOGIC ONCOLOGY. 2009 Feb;112(2):S132-S132. Link to Item
  - Baba T, Convery PA, Matsumura N, Whitaker RS, Kondoh E, Perry T, Huang Z, Bentley RC, Mori S, Fujii S, Marks JR, Berchuck A, Murphy SK. Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells. Oncogene. 2009 Jan 15;28(2):209-218. PubMed PMID: 18836486. Full Text Link to Item
  - Baba T, Mori S, Matsumura N, Bernardini M, Fujii S, Berchuck A, Murphy SK. Microarray analysis identifies NSC668814 as a potentially active chemotherapeutic agent for platinum-resistant ovarian cancers with TP53 mutations. GYNECOLOGIC ONCOLOGY. 2008 Mar;108(3):S72-S72. Link to Item
  - Bernardini MQ, Lee P, Baba T, Whitaker RS, Murphy SK, Berchuck A. Microarray analysis defines patterns of gene expression associated with mutation of TP53 in ovarian cancer. GYNECOLOGIC ONCOLOGY. 2008 Mar;108(3):S84-S84. Link to Item
  - Kondoh E, Baba T, Matsurnura N, Fujii S, Berchuck A, Murphy SK. Targeting dormant ovarian cancer cells. GYNECOLOGIC ONCOLOGY. 2008 Mar;108(3):S13-S14. Link to Item
  - Matsumura N, Huang Z, Perry T, Kroyer D, Baba T, Mori S, Fujii S, Berchuck A, Murphy SK. Methylation in ovarian cancer is related to poor prognosis and suppression of the transforming growth factor signaling pathway. GYNECOLOGIC ONCOLOGY. 2008 Mar;108(3):S104-S104. Link to Item
  - O'Sullivan FM, Murphy SK, Simel LR, McCann A, Callanan JJ, Nolan CM. Imprinted expression of the canine IGF2R, in the absence of an anti-sense transcript or promoter methylation. Evol Dev. 2007 Nov;9(6):579-589. PubMed PMID: 17976054. Full Text Link to Item
  - Baba T, Mori S, Matsumura N, Kariya M, Murphy SK, Kondoh E, Kusakari T, Kuroda H, Mandai M, Higuchi T, Takakura K, Fukuda MN, Fujii S. Trophinin is a potent prognostic marker of ovarian cancer involved in platinum sensitivity. Biochem Biophys Res Commun. 2007 Aug 24;360(2):363-369. PubMed PMID: 17597582. Full Text Link to Item
  - Hempel N, How T, Dong M, Murphy SK, Fields TA, Blobe GC. Loss of betaglycan expression in ovarian cancer: role in motility and invasion. Cancer Res. 2007 Jun 1;67(11):5231-5238. PubMed PMID: 17522389. Full Text Link to Item
  - Spillman MA, Lacy J, Murphy SK, Whitaker RS, Grace L, Teaberry V, Marks JR, Berchuck A. Regulation of the metastasis suppressor gene MKK4 in ovarian cancer. Gynecol Oncol. 2007 May;105(2):312-320. PubMed PMID: 17276500. Full Text Link to Item
  - Price TM, Murphy SK, Younglai EV. Perspectives: the possible influence of assisted reproductive technologies on transgenerational reproductive effects of environmental endocrine disruptors. Toxicol Sci. 2007 Apr;96(2):218-226. PubMed PMID: 17190972. (Review) Full Text Link to Item
  - Risinger JI, Chandramouli GVR, Maxwell GL, Custer M, Pack S, Loukinov D, Aprelikova O, Litzi T, Schrump DS, Murphy SK, Berchuck A, Lobanenkov V, Barrett JC. Global expression analysis of cancer/testis genes in uterine cancers reveals a high incidence of BORIS expression. Clin Cancer Res. 2007 Mar 15;13(6):1713-1719. PubMed PMID: 17363524. Full Text Link to Item
  - Schildkraut JM, Murphy SK, Palmieri RT, Iversen E, Moorman PG, Huang Z, Halabi S, Calingaert B, Gusberg A, Marks JR, Berchuck A. Trinucleotide repeat polymorphisms in the androgen receptor gene and risk of ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):473-480. PubMed PMID: 17372242. Full Text Link to Item
  - Goh L, Murphy SK, Muhkerjee S, Furey TS. Genomic sweeping for hypermethylated genes. Bioinformatics. 2007 Feb 1;23(3):281-288. PubMed PMID: 17148511. Full Text Link to Item
  - Weidman JR, Dolinoy DC, Murphy SK, Jirtle RL. Cancer susceptibility: epigenetic manifestation of environmental exposures. Cancer J. 2007 Jan;13(1):9-16. PubMed PMID: 17464241. (Review) Full Text Link to Item
  - Murphy SK, Huang Z, Wen Y, Spillman MA, Whitaker RS, Simel LR, Nichols TD, Marks JR, Berchuck A. Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer. Mol Cancer Res. 2006 Apr;4(4):283-292. PubMed PMID: 16603642. Full Text Link to Item
  - Murphy SK, Nolan CM, Huang Z, Kucera KS, Freking BA, Smith TPL, Leymaster KA, Weidman JR, Jirtle RL. Callipyge mutation affects gene expression in cis: a potential role for chromatin structure. Genome Res. 2006 Mar;16(3):340-346. PubMed PMID: 16415109. Full Text Link to Item
  - Huang Z, Wen Y, Shandilya R, Marks JR, Berchuck A, Murphy SK. High throughput detection of M6P/IGF2R intronic hypermethylation and LOH in ovarian cancer. (Published online) Nucleic Acids Res. 2006;34(2):555-563. PubMed PMID: 16432260. Full Text Link to Item
  - Berchuck A, Iversen ES, Lancaster JM, Pittman J, Luo J, Lee P, Murphy S, Dressman HK, Febbo PG, West M, Nevins JR, Marks JR. Patterns of gene expression that characterize long-term survival in advanced stage serous ovarian cancers. Clin Cancer Res. 2005 May 15;11(10):3686-3696. PubMed PMID: 15897565. Full Text Link to Item
  - Spillman MA, Schildkraut JM, Halabi S, Moorman P, Calingaert B, Bentley RC, Marks JR, Murphy S, Berchuck A. Transforming growth factor beta receptor I polyalanine repeat polymorphism does not increase ovarian cancer risk. Gynecol Oncol. 2005 May;97(2):543-549. PubMed PMID: 15863158. Full Text Link to Item
  - Wang W, Huper G, Guo Y, Murphy SK, Olson JA, Marks JR. Analysis of methylation-sensitive transcriptome identifies GADD45a as a frequently methylated gene in breast cancer. Oncogene. 2005 Apr 14;24(16):2705-2714. PubMed PMID: 15735726. Full Text Link to Item
  - Murphy SK, Freking BA, Smith TPL, Leymaster K, Nolan CM, Wylie AA, Evans HK, Jirtle RL. Abnormal postnatal maintenance of elevated DLK1 transcript levels in callipyge sheep. Mamm Genome. 2005 Mar;16(3):171-183. PubMed PMID: 15834634. Full Text Link to Item
  - Weidman JR, Murphy SK, Nolan CM, Dietrich FS, Jirtle RL. Phylogenetic footprint analysis of IGF2 in extant mammals. Genome Res. 2004 Sep;14(9):1726-1732. PubMed PMID: 15342558. Full Text Link to Item
  - Murphy SK, Wylie AA, Coveler KJ, Cotter PD, Papenhausen PR, Sutton VR, Shaffer LG, Jirtle RL. Epigenetic detection of human chromosome 14 uniparental disomy. Hum Mutat. 2003 Jul;22(1):92-97. PubMed PMID: 12815599. Full Text Link to Item
  - Murphy SK, Jirtle RL. Imprinting evolution and the price of silence. Bioessays. 2003 Jun;25(6):577-588. PubMed PMID: 12766947. (Review) Full Text Link to Item
  - Dietz LG, Wylie AA, Rauen KA, Murphy SK, Jirtle RL, Cotter PD. Exclusion of maternal uniparental disomy of chromosome 14 in patients referred for Prader-Willi syndrome using a multiplex methylation polymerase chain reaction assay. J Med Genet. 2003 Apr;40(4):e46-. PubMed PMID: 12676919. (Letter) Link to Item
  - Freking BA, Murphy SK, Wylie AA, Rhodes SJ, Keele JW, Leymaster KA, Jirtle RL, Smith TPL. Identification of the single base change causing the callipyge muscle hypertrophy phenotype, the only known example of polar overdominance in mammals. Genome Res. 2002 Oct;12(10):1496-1506. PubMed PMID: 12368241. Full Text Link to Item
  - Li T, Vu TH, Lee K-O, Yang Y, Nguyen CV, Bui HQ, Zeng Z-L, Nguyen BT, Hu J-F, Murphy SK, Jirtle RL, Hoffman AR. An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa. Journal of Biological Chemistry. 2002;277(16):13518-13527. PubMed PMID: 11821432. Full Text
  - Evans HK, Wylie AA, Murphy SK, Jirtle RL. NNATresides in a micro-imprinted domain on human chromosome 20q11.2. AMERICAN JOURNAL OF HUMAN GENETICS. 2001 Oct;69(4):346-346. Link to Item
  - Murphy SK, Wylie AA, McVie-Wylie AJ, Pulford D, Nolan CM, Orton TC, Jirtle RL. Development and characterization of a conditional M6p/Igf2r knockout mouse. AMERICAN JOURNAL OF HUMAN GENETICS. 2001 Oct;69(4):363-363. Link to Item
  - Evans HK, Wylie AA, Murphy SK, Jirtle RL. The neuronatin gene resides in a "micro-imprinted" domain on human chromosome 20q11.2. Genomics. 2001 Sep;77(1-2):99-104. PubMed PMID: 11543638. Full Text Link to Item
  - Keller MA, Murphy SK, Parks GD. RNA replication from the simian virus 5 antigenomic promoter requires three sequence-dependent elements separated by sequence-independent spacer regions. J Virol. 2001 Apr;75(8):3993-3998. PubMed PMID: 11264390. Full Text Link to Item
  - Murphy SK, Wylie AA, Jirtle RL. Imprinting of PEG3, the human homologue of a mouse gene involved in nurturing behavior. Genomics. 2001 Jan 1;71(1):110-117. PubMed PMID: 11161803. Full Text Link to Item
  - Wylie AA, Murphy SK, Orton TC, Jirtle RL. Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation. Genome Res. 2000 Nov;10(11):1711-1718. PubMed PMID: 11076856. Link to Item
  - Murphy SK, Wylie AA, Jirtle RL. Imprinting of PEG3, the human homolog of a gene involved in nurturing behaviour. AMERICAN JOURNAL OF HUMAN GENETICS. 2000 Oct;67(4):189-189. Link to Item
  - Wylie AA, Murphy SK, Orton TC, Jirtle RL. Identification of a novel imprinted domain at human chromosome 14q32. AMERICAN JOURNAL OF HUMAN GENETICS. 2000 Oct;67(4):190-190. Link to Item
  - Murphy SK, Jirtle RL. Imprinted genes as potential genetic and epigenetic toxicologic targets. Environ Health Perspect. 2000 Mar;108 Suppl 1:5-11. PubMed PMID: 10698719. (Review) Link to Item
  - Murphy SK, Parks GD. RNA replication for the paramyxovirus simian virus 5 requires an internal repeated (CGNNNN) sequence motif. J Virol. 1999 Jan;73(1):805-809. PubMed PMID: 9847393. Link to Item
  - Murphy SK, Ito Y, Parks GD. A functional antigenomic promoter for the paramyxovirus simian virus 5 requires proper spacing between an essential internal segment and the 3' terminus. J Virol. 1998 Jan;72(1):10-19. PubMed PMID: 9420195. Link to Item
  - Murphy SK, Parks GD. Genome nucleotide lengths that are divisible by six are not essential but enhance replication of defective interfering RNAs of the paramyxovirus simian virus 5. Virology. 1997 May 26;232(1):145-157. PubMed PMID: 9185598. Full Text Link to Item
  - Murphy SK, Oliver JD. Effects of temperature abuse on survival of Vibrio vulnificus in oysters. Applied and Environmental Microbiology. 1992;58(9):2771-2775. PubMed PMID: 1332610.
  - Joubert BR, Håberg SE, Nilsen RM, Wang X, Vollset SE, Murphy SK, Huang Z, Hoyo C, Midttun Ø, Cupul-Uicab LA, Ueland PM, Wu MC, Nystad W, Bell DA, Peddada SD, London SJ. 450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy. Environ Health Perspect. 120(10):1425-1431. PubMed PMID: 22851337. Full Text Link to Item
Artistic Works & Non-Print Media
- Digital Media
  - How Epigenetics Influences the Risk of Disease. Writer. 2014
Teaching & Mentoring
Recent Courses
- PATHOL 293: Research Independent Study 2018
Advising & Mentoring
- Junior Faculty
  
  Cynthia Moylan, MD, Duke University, Gastroenterology
  K Award Co-Mentor
  
  Naz Siddiqui, MD, Duke University, OB/GYN – Urogynecology
  K Award Co-Mentor, K23 recipient
  
  Megan Bradley, MD, Duke University, OB/GYN – Urogynecology
  AUGS Foundation Co-Mentor
  
  Sherika Hill, PhD, UNC-Chapel Hill / Duke University
  Fellow, Center for Developmental Science
  
  Thesis Committees
  
  Dana Dolinoy, Duke University, UPGG, 2007
  Kristin Maloney, Duke University, UPGG, 2009 (Masters)
  Radhika Das, Duke University, UPGG, 2010
  Autumn Bernal, Duke University, UPGG, 2012
  Amanda Lea, Duke University, Biology, 2017
  Kim Cocce, Duke University, Medical Scientist Training Program, 2017
  Valerie Rojas, Pharmacology Sciences Training Program, MS 2014
  Nathaniel Mabe, Pharmacology and Cancer Biology
  Rashmi Joglekar, ITEHP, Nicholas School of the Environment, Candidate
  Rose Schrott, ITEHP, Nicholas School of the Environment
  Gynecologic Oncology Fellows
  
  Monique Spillman, MD/PhD, Gyn-Onc Fellow, Duke University, 2003-2006
  Current position: Texas Oncology – Baylor, Dallas, TX
  
  Paula Lee, MD, Gyn-Onc Fellow, Duke University, 2004-2007
  Current position: Assistant Professor, Duke University
  
  Amy E. BonDurant, MD, Gyn-Onc Fellow, Duke University, 2005-2008
  Current position: Pacific Gynecology Specialists, Seattle, WA
  
  Marcus Bernardini, MD, Visiting Fellow, University of Toronto, 2006-2007
  Current position: Assistant Professor, University of Toronto
  
  Jason Cory Barnett, MD, Gyn-Onc Fellow, Duke University, 2007-2008
  Current position: Department of OB/GYN, Fort Sam Houston Texas
  
  Gregory Sfakianos, MD, Gyn-Onc Fellow, Duke University, 2009-2010
  Current position: St. Francis Gynecologic Oncology, Columbus, GA
  
  William J. Lowery, MD, Gyn-Onc Fellow, Duke University, 2010-2011
  Current position: Gynecologic Oncologist, US Army, Rockville, MD
  
  Brittany Davidson, MD, Gyn-Onc Fellow, Duke University, 2013-2014
  Current position: Assistant Professor, Duke University
  
  Reproductive Endocrinology Fellows
  
  Sanaz Keyhan, MD, Duke University, 2015-2016
  Current position: Palo Alto Medical Foundation, San Jose, California
  
  Kelly Acharya, MD, Duke University, 2017-2018
  
  Stephanie Smeltzer, MD, Duke University, 2018-2019
  
  Postdoctoral Fellows
  
  Noriomi Matsumura, MD/PhD, 2005-2007
  Current position: Professor, Obstetrics and Gynecology, Kyoto University, Kindai University
  
  Tsukasa Baba, MD/PhD, 2006-2008
  Current position: Associate Professor, Gynecologic Oncology, Kyoto University
  
  Eiji Kondoh, MD, 2007-2009
  Current position: Assistant Professor, Gynecology and Obstetrics, Kyoto University
  
  Ken Yamaguchi, MD/PhD, 2009-2011
  Current position: Chief of Obstetrics and Gynecology, Japan Baptist Hospital, Kyoto University
  
  Abayomi Adigun, PhD, 2010-2011
  Current position: Manager, Investment Staff, Duke University
  
  Lihong Zhu, MD, 2011-2012
  Current position: Assistant Professor, Peking University, Beijing
  
  Ellen Stevens, PhD, 2011- 2013
  Current position: Senior Scientist, Baebies
  
  Takako Okamato, MD, 2011-2014
  
  Monica Nye, PhD, 2011-2014
  Current position: Assistant Professor, UNC-Charlotte
  
  Michele Taylor, PhD, 2014-2016
  Current position: Toxicologist, Environmental Protection Agency
  
  Graduate Students
  
  Katrina Slemmons, Molecular Cancer Biology (rotation) 2013
  Valerie Rojas, Pharmacology Scientist Training Program (Master’s) 2013-2015
  Rashmi Joglekar, PhD Candidate, Integrated Toxicology and Environmental Health Program 2015 -
  Amelia Poplawski, Molecular Cancer Biology (rotation) 2015
  Sara Payne, Molecular Cancer Biology (rotation) 2015-2016
  Yihan Liao, Cellular and Molecular Biology (rotation) 2016
  Rose Schrott, Integrated Toxicology and Environmental Health Program 2017 -
  Emily Liang, Integrated Toxicology and Environmental Health Program (rotation) 2017
  Christine Figan, Integrated Toxicology and Environmental Health Program (rotation) 2017
  Laura Childers, Integrated Toxicology and Environmental Health Program (rotation) 2018
  Sam Hall, Integrated Toxicology and Environmental Health Program (rotation) 2018
  Emma Dolan, Pharmacology and Cancer Biology (rotation) 2018
  
  Medical Students – Third Year Research
  
  Vanessa Teaberry Schroder, 2004-2005
  Current position: Assistant Professor of Surgery, Duke University
  
  Patricia Convery, 2006-2007
  Current position: Private Practice, Morristown, New Jersey
  
  Kerone Walker, 2008-2009
  Current Position: Obstetrics and Gynecology, UCLA Medical Center
  
  Jaemin Park, (Duke-NUS), 2011-2013 (two years of research)
  Current position: Investment Professional at Partner’s Group
  
  Isabel Rodriguez, 2014-2015
  Current position: OB/GYN Resident, Duke University
  
  Barbara Blachut, (Washington University, St. Louis), summer, 2017
  
  Cassie Hobbs, 2017-2018
  
  Undergraduate Students
  
  Yaqing Wen, Duke University, 2004-2006
  Bouncer Program, Independent Study Student
  Current position: Board Certified Internist, Charlottesville, Virginia
  
  Jacob Berchuck, Duke University, 2004
  Current position: Medical Oncologist, Dana Farber Cancer Institute
  
  Lisa Chen, Duke University, 2005-2007
  Independent Study Student, Honors Thesis Student
  Current position: Clinical Instructor, Ophthalmology, Stanford University
  
  Natasha Duggan, University of California, San Francisco, 2006-2009
  Current position: Postdoctoral Trainee, University of Miami
  
  Nancy Anoruo, University of Florida, Gainesville, 2006
  Institute for Genome Sciences and Policy Summer Research Program
  Current position: Adjunct Instructor in Biology, American University
  
  Cara Davis, University of North Carolina, Asheville, 2008
  Current position: Project Specialist, INC Research, Raleigh, North Carolina
  
  Jack Fitzgibbons, Duke University, 2010
  Independent Study Student
  Current position: Director of Strategic Initiatives, SMS Assist, Chicago, Illinois
  
  Masashi Ono, University of North Carolina, Asheville, 2010
  
  Christopher Bassil, Duke University, 2011-2012
  Current position: Medical Scientist Training Program, Duke University
  
  Shamaita Majumdar, Duke University, 2011-2014
  Independent Study Student, Honors Thesis Student
  Current position: Medical Student, Washington University St. Louis, Missouri
  
  Clara Lee, Duke University, 2012-2014
  Independent Study Student, Honors Thesis Student
  Current position: Medical Student, Emory University, Atlanta, Georgia
  
  Jason Chin, Duke University, 2012-2014
  Independent Study Student
  
  Sonya Jooma, Duke University, 2013-2014
  Independent Study Student
  Current Position: Health Policy Analyst, NHGRI
  
  Lisa Guo, Duke University, 2013-2014
  Independent Study Student, Honors Thesis Student
  
  Brittany Wenger, Duke University, 2013-2014
  TIME’s Thirty Under Thirty
  
  Kelli Tomins, Duke University, 2014-2016
  Independent Study Student
  Current Position: Research Fellow, NIH
  
  Zachary Visco, Duke University, 2014-2017
  Current Position: Medical Student, State University of New York Medical School
  
  Michelle Dalson, Duke University, 2015
  
  Marie Boudreau, Appalachian State University, 2014 - 2017
  
  Sabrina Simpson, Boston University, 2015 - 2017
  
  Catherine Birtles, McGill University, 2015
  
  Ethan Whitaker, Cambell University, 2015 - 2017
  
  Melody Iro, Duke University, 2016
  
  Brad Foster, Duke University, 2016
  
  Kamyar Yazdani, Duke University Class of 2020, 2016 -
  Independent Study Student
  
  Katarina Stephan, Duke University, 2017
  
  Katherine Maitland, Duke University Class of 2021, 2017 – 2018
  Independent Study Student, Biology Honors Research, Graduation with Distinction
  
  Olivia Neely, Duke University Class of 2020, 2018 –
  Independent Study Student
  
  Jim Liu, Duke University Class of 2019
  Independent Study Student
  
  Kaycie Hutcheson, Duke University Class of 2020
  
  Michael Williams, Duke University Class of 2021, 2018 -
  
  High School Students
  
  Danielle Dejournet, North Carolina School of Science, and Math, 2013-2014
  Kennedy Bridges, North Carolina School of Science and Math, 2014-2015
  Deepika Senthil, North Carolina School of Science and Math, 2015-2016
  Esther Son, North Carolina School of Science and Math, 2017-2018
  Andy Liu, North Carolina School of Science and Math, 2018-2019
Teaching Activities
- 1994-1997, Medical Microbiology Laboratory Instructor, Wake Forest University
  
  1994-1997, Advanced Topics in Microbiology and Immunology Instructor, Wake Forest University
  
  1997, Medical Microbiology Tutor, Wake Forest University
  
  1997, Fundamentals of Virology, ad hoclecturer, Wake Forest University
  
  2000, Duke University Bioinformatics Shared Resources Seminar Series: An Introduction to Profile Hidden Markov Models
  
  2004, Duke University Bouncer Program Undergraduate Summer Research Program
  
  2006, Duke University Institute for Genome Sciences and Policy Summer Fellowship Program (National Science Foundation Research Experience for Undergraduates)
  
  2005-2007, Independent Research, Mentor (Honors Research): Imprinted NNAT: a Potential Epigenetic Biomarker of Ovarian Cancer
  
  2012-2014, Independent Research, Mentor (Honors Research): The Role of Imprinted Gene MEG3 in Epithelial Ovarian Cancer
  
  2013-2016, Independent Research, Mentor (Honors Research): Male Overweight/Obesity and Sperm Epigenome Disturbances at Differentially Methylated Regions of Imprinted Genes
  
  2017-2018, Independent Research, Mentor (Honors Research):Effects of cannabis-linked changes in DNA methylation on AHRR gene transcription
  
  Lecturer
  
  PATH 786.01 / Duke Merits: 2013, 2016
  PATH-786 / Translational Pathobiology: 2017
  ENV-537 / Environmental Health : 2015, 2016
  CBI-206 / Anesthesiology-445C (Physiology and Medicine of Extreme Environments): 2015
  ENV-290 / Special Topics in Environmental Sciences and Policy: 2016
  ENV-819 / Mechanisms in Toxicology: 2017
  HOUSECS 59.14 / House Course (Intro to Epigenetics: How Environment Shapes Our Genes): 2018
Scholarly, Clinical, & Service Activities
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