Susan Kay Murphy | Scholars@Duke

Susan Kay Murphy
Associate Professor in Obstetrics and Gynecology

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

Current Research Interests

ovarian cancer epigenetics
therapeutic prevention of ovarian cancer recurrence
development of epigenetic screening tools
developmental origins of health and disease (DOHaD)
preconceptional environmental impact on the epigenome
intergenerational and transgenerational epigenetic effects
in vitro models of cellular differentiation

Current Appointments & Affiliations

Associate Professor in Obstetrics and Gynecology, Obstetrics and Gynecology, Reproductive Sciences, Obstetrics and Gynecology 2014
Chief, Division of Reproductive Sciences in the Department of Obstetrics and Gynecology, Obstetrics and Gynecology, Reproductive Sciences, Obstetrics and Gynecology 2017
Associate Professor in Pathology, Pathology, Clinical Science Departments 2012
Associate Professor in the Division of Environmental Science and Policy, Environmental Sciences and Policy, Nicholas School of the Environment 2017
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1998

Contact Information

119 B Wing LSRC, 308 Research Drive, Durham, NC 27708
Box 91012, Durham, NC 27708-1012
susan.murphy@duke.edu (919) 681-3423
CIPHERS Project
Murphy lab web site
NICHES Children's Environmental Health Center

Background
Education, Training, & Certifications
- Ph.D., Wake Forest University 1998
- B.A., University of North Carolina at Charlotte 1992
Duke Appointment History
- Associate Professor in Obstetrics and Gynecology, Obstetrics and Gynecology, Gynecologic Oncology, Obstetrics and Gynecology 2012 - 2014
- Assistant Professor in Obstetrics and Gynecology, Obstetrics and Gynecology, Gynecologic Oncology, Obstetrics and Gynecology 2008 - 2012
- Assistant Professor in Pathology, Pathology, Clinical Science Departments 2008 - 2012
- Assistant Professor in Obstetrics and Gynecology, Obstetrics and Gynecology, Gynecologic Oncology, Obstetrics and Gynecology 2006 - 2007
- Assistant Research Professor in Obstetrics and Gynecology, Obstetrics and Gynecology, Gynecologic Oncology, Obstetrics and Gynecology 2003 - 2006
Leadership & Clinical Positions at Duke
- 2017 Division Chief, Reproductive Sciences, Department of Obstetrics and Gynecology
  2016 Program Director, CIPHERS study of the impact of cannabis on the sperm epigenome
  2014-2015 Director, Duke Epigenetics and Epigenomics Program
  2013 Program Director, NICHES Children's Environmental Health and Disease Prevention Research Center
  2012-2014 Co-Director, Duke Epigenetics and Epigenomics Program
  2011- Founder and Executive Committee Member, Duke Epigenetic and Epigenomics Program
  2003 Director, Epigenetics Research Laboratory
  2002-2003 Founder and Director, Mentorship Program, Duke University Postdoctoral Association
  2001-2003 Advocacy Chair, Duke University Postdoctoral Association
Recognition
In the News
- AUG 27, 2019 Duke Health News
  
  Gene Linked to Autism Undergoes Changes in Men’s Sperm After Pot Use
- DEC 6, 2013
  
  New Children's Center Studies Association Between ADHD and Secondhand Smoke
- SEP 23, 2013 NPR
  
  How a pregnant woman's choices could shape a child's health
Awards & Honors
Expertise
Subject Headings
Global Scholarship
- Research
- Teaching
  - Utah (State or Province)
Research
Selected Grants
- Population Health Research Support IDIQ Base awarded by National Institutes of Health 2018 - 2025
- Duke University Program in Environmental Health awarded by National Institutes of Health 2013 - 2024
- Duke KURe Program awarded by National Institutes of Health 2013 - 2023
- Duke KURe Program awarded by National Institutes of Health 2013 - 2023
- Follow-up and Maintenance of the Newborn Epigenetics STudy (NEST) Cohort awarded by North Carolina State University 2018 - 2023
- Does exposure to mitochondrial toxicants during germ cell development result in lifelong alterations in mitochondrial function mediated by epigenetic changes? awarded by National Institutes of Health 2017 - 2022
- Does exposure to mitochondrial toxicants during germ cell development result in lifelong alterations in mitochondrial function mediated by epigenetic changes? awarded by National Institutes of Health 2017 - 2022
- Building Interdisciplinary Research Careers in Women's Health awarded by National Institutes of Health 2002 - 2022
- Building Interdisciplinary Research Careers in Women's Health awarded by National Institutes of Health 2002 - 2022
- Potential pathophysiologic mechanisms linking air pollution exposure in pregnant women to reduced birth weight awarded by University of Rochester 2017 - 2022
- Potential pathophysiologic mechanisms linking air pollution exposure in pregnant women to reduced birth weight awarded by University of Rochester 2017 - 2022
- Translational Research in Surgical Oncology awarded by National Institutes of Health 2002 - 2021
- Translational Research in Surgical Oncology awarded by National Institutes of Health 2002 - 2021
- Duke University Medical Center (DUMC) Pelvic Floor Disorders Network (PFDN) Clinical Site awarded by National Institutes of Health 2007 - 2021
- Population Health Research Support - Study of Pregnancy and Neonatal Health (SPAN) Task A awarded by National Institutes of Health 2019 - 2021
- Children Exposure to SVOC Mixtures Indoors and Associations with Obesity awarded by National Institutes of Health 2017 - 2020
- Paternal Transgenerational Epigenetic Legacy from Use of Cannabis awarded by John Templeton Foundation 2017 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
- Epigenomics in insulin resistance associated overactive bladder awarded by National Institutes of Health 2017 - 2020
- Clarifying the role of tobacco retail outlets on maternal smoking during pregnancy and child secondhand smoke exposure awarded by Virginia Commonwealth University 2019 - 2020
- Genetic and Epigenetic Markers of Progressive Nonalcoholic Fatty Liver Disease awarded by American Association for the Study of Liver Diseases 2018 - 2019
- Validation and interrogation of differentially expressed and alternatively spliced genes in African American prostate ca awarded by Department of Defense 2014 - 2019
- Epigenetics and the Development of Nonalcoholic Fatty Liver Disease awarded by American College of Gastroenterology 2015 - 2019
- Duke University Program in Environmental Health awarded by National Institute of Environmental Health Sciences 2013 - 2019
- Social adversities, epigenetics, and the obesity epidemic awarded by North Carolina State University 2017 - 2019
- Neurodevelopment and Improving Children's Health Following EtS Exposure (NICHES) awarded by National Institutes of Health 2013 - 2019
- Neurodevelopment and Improving Children's Health following EtS exposure (NICHES) awarded by Environmental Protection Agency 2013 - 2019
- Triggering human anti-tumor stringent response to target recurrent ovarian cancer awarded by Department of Defense 2017 - 2019
- Immune regulated amino acid pathways in Alzheimer's Disease awarded by National Institutes of Health 2016 - 2018
- Pilot Project: Effects of Cannabis on the Epigenome of Humans and Rats awarded by John Templeton Foundation 2016 - 2017
- Joint Environmental, Genetic and Epigenetic Regulation of Tyrosine Receptor Kinases and Childhood Respiratory Disease awarded by University of Southern California 2013 - 2017
- Functional Genomic Screens of Tumor Recurrence in Ovarian Cancer awarded by Department of Defense 2014 - 2017
- Cancer Biology Training Grant awarded by National Cancer Institute 1993 - 2016
- Obesity and deregulation of imprinted genes in early life awarded by National Institutes of Health 2010 - 2015
- Epigenetic influence on early childhood self-regulation capacities and obesity awarded by National Institutes of Health 2011 - 2014
- Ovarian Cancer Initiating Cells: Metabolic Characterization awarded by National Institutes of Health 2012 - 2014
- Gene Regulation in Recurrent Ovarian Cancers 2011 - 2014
- Disparities in cervical cancer precursors and deregulation of imprinted genes awarded by National Institutes of Health 2010 - 2014
- Nutrition, Deregulation of Imprinted Genes awarded by National Institutes of Health 2009 - 2014
- Characterizing Alcohol's Effects on Repair of Liver Injury awarded by National Institutes of Health 2009 - 2012
- Identification and Characterization of Epigenetically Labile Genes awarded by National Institutes of Health 2006 - 2010
- In-utero Exposure and Infant Loss of IGF2 Imprinting awarded by National Institutes of Health 2006 - 2008
- Imprinted PEG3 Domain at 19q13.4 and carcinogenesis awarded by National Institutes of Health 2001 - 2003
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Xue H, Maguire RL, Liu J, Kollins SH, Murphy SK, Hoyo C, et al. Snacking frequency and dietary intake in toddlers and preschool children.. Appetite. 2019 Nov 1;142.
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  - Schrott R, Acharya K, Itchon-Ramos N, Hawkey AB, Pippen E, Mitchell JT, et al. Cannabis use is associated with potentially heritable widespread changes in autism candidate gene DLGAP2 DNA methylation in sperm.. Epigenetics. 2019 Aug 26;1–13.
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  - Hansen LJ, Sun R, Yang R, Singh SX, Chen LH, Pirozzi CJ, et al. MTAP Loss Promotes Stemness in Glioblastoma and Confers Unique Susceptibility to Purine Starvation.. Cancer Res. 2019 Jul 1;79(13):3383–94.
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  - Hawkey AB, White H, Pippen E, Greengrove E, Rezvani AH, Murphy SK, et al. Paternal nicotine exposure in rats produces long-lasting neurobehavioral effects in the offspring.. Neurotoxicol Teratol. 2019 Jul;74.
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  - Levin ED, Hawkey AB, Hall BJ, Cauley M, Slade S, Yazdani E, et al. Paternal THC exposure in rats causes long-lasting neurobehavioral effects in the offspring.. Neurotoxicol Teratol. 2019 Jul;74.
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  - Meekins AR, Murphy SK, Grenier C, Huang Z, Bradley MS, Amundsen CL, et al. Role of β-3 adrenergic receptor polymorphism in overactive bladder.. Neurourol Urodyn. 2019 Jun;38(5):1261–5.
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  - Reese SE, Xu C-J, den Dekker HT, Lee MK, Sikdar S, Ruiz-Arenas C, et al. Epigenome-wide meta-analysis of DNA methylation and childhood asthma.. J Allergy Clin Immunol. 2019 Jun;143(6):2062–74.
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  - Chawla D, Fuemmeler B, Benjamin-Neelon SE, Hoyo C, Murphy S, Daniels JL. Early prenatal vitamin D concentrations and social-emotional development in infants.. J Matern Fetal Neonatal Med. 2019 May;32(9):1441–8.
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  - Küpers LK, Monnereau C, Sharp GC, Yousefi P, Salas LA, Ghantous A, et al. Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight.. Nat Commun. 2019 Apr 23;10(1).
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  - Martin CL, Jima D, Sharp GC, McCullough LE, Park SS, Gowdy KM, et al. Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood: an epigenome-wide association study.. Epigenetics. 2019 Apr;14(4):325–40.
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  - Tagliafierro L, Ilich E, Moncalvo M, Gu J, Sriskanda A, Grenier C, et al. Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models.. J Vis Exp. 2019 Mar 29;(145).
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  - Fuemmeler BF, Zucker N, Sheng Y, Sanchez CE, Maguire R, Murphy SK, et al. Pre-Pregnancy Weight and Symptoms of Attention Deficit Hyperactivity Disorder and Executive Functioning Behaviors in Preschool Children.. Int J Environ Res Public Health. 2019 Feb 25;16(4).
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  - Do EK, Zucker NL, Huang ZY, Schechter JC, Kollins SH, Maguire RL, et al. Associations between imprinted gene differentially methylated regions, appetitive traits and body mass index in children.. Pediatr Obes. 2019 Feb;14(2).
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  - Sorrow P, Maguire R, Murphy SK, Belcher SM, Hoyo C. Elevated metabolites of acetaminophen in cord blood of children with obesity.. Pediatr Obes. 2019 Jan;14(1).
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  - Schechter J, Do EK, Zhang JJ, Hoyo C, Murphy SK, Kollins SH, et al. Effect of Prenatal Smoke Exposure on Birth Weight: The Moderating Role of Maternal Depressive Symptoms.. Nicotine Tob Res. 2018 Dec 24;
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  - Kantor B, Tagliafierro L, Gu J, Zamora ME, Ilich E, Grenier C, et al. Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD.. Mol Ther. 2018 Nov 7;26(11):2638–49.
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  - Gomih A, Smith JS, North KE, Hudgens MG, Brewster WR, Huang Z, et al. DNA methylation of imprinted gene control regions in the regression of low-grade cervical lesions.. Int J Cancer. 2018 Aug 1;143(3):552–60.
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  - Gao L, Liu X, Millstein J, Siegmund KD, Dubeau L, Maguire RL, et al. Self-reported prenatal tobacco smoke exposure, AXL gene-body methylation, and childhood asthma phenotypes.. Clin Epigenetics. 2018 Jul 20;10(1).
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  - Green AJ, Hoyo C, Mattingly CJ, Luo Y, Tzeng J-Y, Murphy SK, et al. Cadmium exposure increases the risk of juvenile obesity: a human and zebrafish comparative study.. Int J Obes (Lond). 2018 Jul;42(7):1285–95.
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  - Dozmorov MG, Bilbo SD, Kollins SH, Zucker N, Do EK, Schechter JC, et al. Associations between maternal cytokine levels during gestation and measures of child cognitive abilities and executive functioning.. Brain Behav Immun. 2018 May;70:390–7.
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  - Benjamin Neelon SE, White AJ, Vidal AC, Schildkraut JM, Murtha AP, Murphy SK, et al. Maternal vitamin D, DNA methylation at imprint regulatory regions and offspring weight at birth, 1 year and 3 years.. Int J Obes (Lond). 2018 Apr;42(4):587–93.
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  - Bradley MS, Burke EE, Grenier C, Amundsen CL, Murphy SK, Siddiqui NY. A genome-scale DNA methylation study in women with interstitial cystitis/bladder pain syndrome.. Neurourol Urodyn. 2018 Apr;37(4):1485–93.
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  - Schrott R, Murphy SK. Folic acid throughout pregnancy: too much?. Am J Clin Nutr. 2018 Apr 1;107(4):497–8.
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  - Felix JF, Joubert BR, Baccarelli AA, Sharp GC, Almqvist C, Annesi-Maesano I, et al. Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium.. Int J Epidemiol. 2018 Feb 1;47(1):22-23u.
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  - Schechter JC, Fuemmeler BF, Hoyo C, Murphy SK, Zhang JJ, Kollins SH. Impact of Smoking Ban on Passive Smoke Exposure in Pregnant Non-Smokers in the Southeastern United States.. Int J Environ Res Public Health. 2018 Jan 6;15(1).
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  - Gonzalez-Nahm S, Mendez MA, Benjamin-Neelon SE, Murphy SK, Hogan VK, Rowley DL, et al. DNA methylation of imprinted genes at birth is associated with child weight status at birth, 1 year, and 3 years.. Clin Epigenetics. 2018;10.
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  - House JS, Mendez M, Maguire RL, Gonzalez-Nahm S, Huang Z, Daniels J, et al. Periconceptional Maternal Mediterranean Diet Is Associated With Favorable Offspring Behaviors and Altered CpG Methylation of Imprinted Genes.. Frontiers in Cell and Developmental Biology. 2018 Jan;6.
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  - Murphy SK, Itchon-Ramos N, Visco Z, Huang Z, Grenier C, Schrott R, et al. Cannabinoid exposure and altered DNA methylation in rat and human sperm.. Epigenetics. 2018;13(12):1208–21.
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  - Wegermann K, Henao R, Diehl AM, Murphy SK, Abdelmalek MF, Moylan CA. Branched chain amino acid transaminase 1 (BCAT1) is overexpressed and hypomethylated in patients with non-alcoholic fatty liver disease who experience adverse clinical events: A pilot study.. Plos One. 2018 Jan;13(9).
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  - Sharp GC, Salas LA, Monnereau C, Allard C, Yousefi P, Everson TM, et al. Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium.. Human Molecular Genetics. 2017 Oct;26(20):4067–85.
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  - Cordero FJ, Huang Z, Grenier C, He X, Hu G, McLendon RE, et al. Histone H3.3K27M Represses p16 to Accelerate Gliomagenesis in a Murine Model of DIPG.. Mol Cancer Res. 2017 Sep;15(9):1243–54.
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  - Liu Y, Reynolds LM, Ding J, Hou L, Lohman K, Young T, et al. Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis.. Nat Commun. 2017 Aug 30;8(1).
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  - McCullough LE, Miller EE, Calderwood LE, Shivappa N, Steck SE, Forman MR, et al. Maternal inflammatory diet and adverse pregnancy outcomes: Circulating cytokines and genomic imprinting as potential regulators?. Epigenetics. 2017 Aug;12(8):688–97.
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  - Gonzalez-Nahm S, Mendez M, Robinson W, Murphy SK, Hoyo C, Hogan V, et al. Low maternal adherence to a Mediterranean diet is associated with increase in methylation at the MEG3-IG differentially methylated region in female infants.. Environ Epigenet. 2017 May;3(2).
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  - Luo Y, McCullough LE, Tzeng J-Y, Darrah T, Vengosh A, Maguire RL, et al. Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight.. Bmc Public Health. 2017 Apr 24;17(1).
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  - Breton CV, Marsit CJ, Faustman E, Nadeau K, Goodrich JM, Dolinoy DC, et al. Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group.. Environ Health Perspect. 2017 Apr;125(4):511–26.
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  - Hoffman K, Butt CM, Webster TF, Preston EV, Hammel SC, Makey C, et al. Temporal Trends in Exposure to Organophosphate Flame Retardants in the United States.. Environ Sci Technol Lett. 2017 Mar 14;4(3):112–8.
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  - Mwinyi J, Boström AE, Pisanu C, Murphy SK, Erhart W, Schafmayer C, et al. NAFLD is associated with methylation shifts with relevance for the expression of genes involved in lipoprotein particle composition.. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Mar;1862(3):314–23.
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  - Gao L, Millstein J, Siegmund KD, Dubeau L, Maguire R, Gilliland FD, et al. Epigenetic regulation of AXL and risk of childhood asthma symptoms.. Clin Epigenetics. 2017;9.
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  - Maguire RL, Vidal AC, Murphy SK, Hoyo C. Disparities in Cervical Cancer Incidence and Mortality: Can Epigenetics Contribute to Eliminating Disparities?. Adv Cancer Res. 2017;133:129–56.
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  - Soubry A, Hoyo C, Butt CM, Fieuws S, Price TM, Murphy SK, et al. Human exposure to flame-retardants is associated with aberrant DNA methylation at imprinted genes in sperm.. Environ Epigenet. 2017 Jan;3(1).
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  - Yamanoi K, Matsumura N, Murphy SK, Baba T, Abiko K, Hamanishi J, et al. Suppression of ABHD2, identified through a functional genomics screen, causes anoikis resistance, chemoresistance and poor prognosis in ovarian cancer.. Oncotarget. 2016 Jul 26;7(30):47620–36.
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  - Schiöth HB, Boström A, Murphy SK, Erhart W, Hampe J, Moylan C, et al. A targeted analysis reveals relevant shifts in the methylation and transcription of genes responsible for bile acid homeostasis and drug metabolism in non-alcoholic fatty liver disease.. Bmc Genomics. 2016 Jun 14;17.
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  - Fuemmeler BF, Wang L, Iversen ES, Maguire R, Murphy SK, Hoyo C. Association between Prepregnancy Body Mass Index and Gestational Weight Gain with Size, Tempo, and Velocity of Infant Growth: Analysis of the Newborn Epigenetic Study Cohort.. Child Obes. 2016 Jun;12(3):210–8.
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  - Dewi FN, Wood CE, Willson CJ, Register TC, Lees CJ, Howard TD, et al. Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques.. Cancer Prev Res (Phila). 2016 May;9(5):385–95.
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  - Li Y, Xie C, Murphy SK, Skaar D, Nye M, Vidal AC, et al. Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood.. Environ Health Perspect. 2016 May;124(5):666–73.
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  - Murakami R, Matsumura N, Mandai M, Yoshihara K, Tanabe H, Nakai H, et al. Establishment of a Novel Histopathological Classification of High-Grade Serous Ovarian Carcinoma Correlated with Prognostically Distinct Gene Expression Subtypes.. Am J Pathol. 2016 May;186(5):1103–13.
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  - Joubert BR, Felix JF, Yousefi P, Bakulski KM, Just AC, Breton C, et al. DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis.. Am J Hum Genet. 2016 Apr 7;98(4):680–96.
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  - Peng J, Yoshioka Y, Mandai M, Matsumura N, Baba T, Yamaguchi K, et al. The BMP signaling pathway leads to enhanced proliferation in serous ovarian cancer-A potential therapeutic target.. Mol Carcinog. 2016 Apr;55(4):335–45.
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  - Matsumura N, Yamanoi K, Murphy SK, Hamanishi J, Abiko K, Yamaguchi K, et al. Abstract A38: Identification through functional genomics screening of factors whose downregulation enhances the side population in ovarian cancer.. Molecular Drivers of Ovarian Cancer (Other Than P53). 2016 Jan 15;
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  - Fuemmeler BF, Lee C-T, Soubry A, Iversen ES, Huang Z, Murtha AP, et al. DNA Methylation of Regulatory Regions of Imprinted Genes at Birth and Its Relation to Infant Temperament.. Genet Epigenet. 2016;8:59–67.
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  - King KE, Kane JB, Scarbrough P, Hoyo C, Murphy SK. Neighborhood and Family Environment of Expectant Mothers May Influence Prenatal Programming of Adult Cancer Risk: Discussion and an Illustrative DNA Methylation Example.. Biodemography Soc Biol. 2016;62(1):87–104.
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  - McCullough LE, Miller EE, Mendez MA, Murtha AP, Murphy SK, Hoyo C. Maternal B vitamins: effects on offspring weight and DNA methylation at genomically imprinted domains.. Clin Epigenetics. 2016;8.
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  - Nye MD, King KE, Darrah TH, Maguire R, Jima DD, Huang Z, et al. Maternal blood lead concentrations, DNA methylation of MEG3 DMR regulating the DLK1/MEG3 imprinted domain and early growth in a multiethnic cohort.. Environ Epigenet. 2016;2(1).
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  - Soubry A, Guo L, Huang Z, Hoyo C, Romanus S, Price T, et al. Obesity-related DNA methylation at imprinted genes in human sperm: Results from the TIEGER study.. Clin Epigenetics. 2016;8.
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  - Su D, Wang X, Campbell MR, Porter DK, Pittman GS, Bennett BD, et al. Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes.. Plos One. 2016;11(12).
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  - Peng J, Hamanishi J, Matsumura N, Abiko K, Murat K, Baba T, et al. Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor-κB to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer.. Cancer Res. 2015 Dec 1;75(23):5034–45.
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  - Sachdeva M, Dodd RD, Huang Z, Grenier C, Ma Y, Lev DC, et al. Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182.. Cancer Lett. 2015 Dec 1;369(1):202–11.
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  - Hemachandra LPMP, Shin D-H, Dier U, Iuliano JN, Engelberth SA, Uusitalo LM, et al. Mitochondrial Superoxide Dismutase Has a Protumorigenic Role in Ovarian Clear Cell Carcinoma.. Cancer Res. 2015 Nov 15;75(22):4973–84.
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  - Varadaraj A, Patel P, Serrao A, Bandyopadhay T, Lee NY, Jazaeri AA, et al. Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia.. Neoplasia. 2015 Nov;17(11):826–38.
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  - King KE, Darrah TH, Money E, Meentemeyer R, Maguire RL, Nye MD, et al. Geographic clustering of elevated blood heavy metal levels in pregnant women.. Bmc Public Health. 2015 Oct 9;15.
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  - Ding J, Reynolds LM, Zeller T, Müller C, Lohman K, Nicklas BJ, et al. Alterations of a Cellular Cholesterol Metabolism Network Are a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular Disease.. Diabetes. 2015 Oct;64(10):3464–74.
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  - Keenan MM, Liu B, Tang X, Wu J, Cyr D, Stevens RD, et al. ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate.. Plos Genet. 2015 Oct;11(10).
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  - Murphy SK, Erginer E, Huang Z, Visco Z, Hoyo C. Genotype-Epigenotype Interaction at the IGF2 DMR.. Genes (Basel). 2015 Aug 28;6(3):777–89.
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  - Vidal AC, Semenova V, Darrah T, Vengosh A, Huang Z, King K, et al. Maternal cadmium, iron and zinc levels, DNA methylation and birth weight.. Bmc Pharmacol Toxicol. 2015 Jul 15;16.
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  - King K, Murphy S, Hoyo C. Epigenetic regulation of Newborns' imprinted genes related to gestational growth: patterning by parental race/ethnicity and maternal socioeconomic status.. J Epidemiol Community Health. 2015 Jul;69(7):639–47.
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  - Baba T, Kang HS, Hosoe Y, Kharma B, Abiko K, Matsumura N, et al. Menstrual cyclic change of metastin/GPR54 in endometrium.. Med Mol Morphol. 2015 Jun;48(2):76–84.
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  - Nye MD, Hoyo C, Murphy SK. In vitro lead exposure changes DNA methylation and expression of IGF2 and PEG1/MEST.. Toxicol in Vitro. 2015 Apr;29(3):544–50.
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  - Soubry A, Murphy SK, Wang F, Huang Z, Vidal AC, Fuemmeler BF, et al. Newborns of obese parents have altered DNA methylation patterns at imprinted genes.. Int J Obes (Lond). 2015 Apr;39(4):650–7.
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  - Tang X, Keenan MM, Wu J, Lin C-A, Dubois L, Thompson JW, et al. Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis.. Plos Genet. 2015 Apr;11(4).
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  - McCullough LE, Mendez MA, Miller EE, Murtha AP, Murphy SK, Hoyo C. Associations between prenatal physical activity, birth weight, and DNA methylation at genomically imprinted domains in a multiethnic newborn cohort.. Epigenetics. 2015;10(7):597–606.
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  - Mo L, Pospichalova V, Huang Z, Murphy SK, Payne S, Wang F, et al. Ascites Increases Expression/Function of Multidrug Resistance Proteins in Ovarian Cancer Cells.. Plos One. 2015;10(7).
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  - Nagura M, Matsumura N, Baba T, Murakami R, Kharma B, Hamanishi J, et al. Invasion of uterine cervical squamous cell carcinoma cells is facilitated by locoregional interaction with cancer-associated fibroblasts via activating transforming growth factor-beta.. Gynecol Oncol. 2015 Jan;136(1):104–11.
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  - Okamoto T, Mandai M, Matsumura N, Yamaguchi K, Kondoh H, Amano Y, et al. Hepatocyte nuclear factor-1β (HNF-1β) promotes glucose uptake and glycolytic activity in ovarian clear cell carcinoma.. Mol Carcinog. 2015 Jan;54(1):35–49.
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  - Soubry A, Murphy SK, Wang F, Huang Z, Vidal AC, Fuemmeler BF, et al. Newborns of obese parents have altered DNA methylation patterns at imprinted genes. International Journal of Obesity. 2015 Jan 1;39(4):650–7.
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  - Vidal AC, Skaar D, Maguire R, Dodor S, Musselwhite LW, Bartlett JA, et al. IL-10, IL-15, IL-17, and GMCSF levels in cervical cancer tissue of Tanzanian women infected with HPV16/18 vs. non-HPV16/18 genotypes.. Infect Agent Cancer. 2015;10.
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  - Kharma B, Baba T, Matsumura N, Kang HS, Hamanishi J, Murakami R, et al. STAT1 drives tumor progression in serous papillary endometrial cancer.. Cancer Res. 2014 Nov 15;74(22):6519–30.
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  - Nye MD, Hoyo C, Wang F, Murtha AP, Schildkraut JM, Kurtzberg J, et al. Abstract B22: Altered methylation profiles of imprinted genes in response to prenatal exposure to cigarette smoke in the Newborn Epigenetic STudy (NEST) cohort. Epidemiology, Lifestyle, and Genetics. 2014 Nov;
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  - Hoyo C, Daltveit AK, Iversen E, Benjamin-Neelon SE, Fuemmeler B, Schildkraut J, et al. Erythrocyte folate concentrations, CpG methylation at genomically imprinted domains, and birth weight in a multiethnic newborn cohort.. Epigenetics. 2014 Aug;9(8):1120–30.
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  - Vidal AC, Smith JS, Valea F, Bentley R, Gradison M, Yarnall KSH, et al. HPV genotypes and cervical intraepithelial neoplasia in a multiethnic cohort in the southeastern USA.. Cancer Causes Control. 2014 Aug;25(8):1055–62.
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  - Yamaguchi K, Huang Z, Matsumura N, Mandai M, Okamoto T, Baba T, et al. Epigenetic determinants of ovarian clear cell carcinoma biology.. Int J Cancer. 2014 Aug 1;135(3):585–97.
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  - Murphy SK. Obesity: Paternal obesity--a risk factor for autism?. Nat Rev Endocrinol. 2014 Jul;10(7):389–90.
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  - Smeester L, Yosim AE, Nye MD, Hoyo C, Murphy SK, Fry RC. Imprinted genes and the environment: links to the toxic metals arsenic, cadmium, lead and mercury.. Genes (Basel). 2014 Jun 11;5(2):477–96.
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  - Soubry A, Hoyo C, Jirtle RL, Murphy SK. A paternal environmental legacy: evidence for epigenetic inheritance through the male germ line.. Bioessays. 2014 Apr;36(4):359–71.
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  - Soubry A, Hoyo C, Jirtle RL, Murphy SK. A paternal environmental legacy: Evidence for epigenetic inheritance through the male germ line. Bioessays. 2014 Apr 1;36(4):359–71.
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  - Vidal AC, Henry NM, Murphy SK, Oneko O, Nye M, Bartlett JA, et al. PEG1/MEST and IGF2 DNA methylation in CIN and in cervical cancer. Clinical and Translational Oncology. 2014 Mar 1;16(3):266–72.
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  - Vidal AC, Henry NM, Murphy SK, Oneko O, Nye M, Bartlett JA, et al. PEG1/MEST and IGF2 DNA methylation in CIN and in cervical cancer.. Clin Transl Oncol. 2014 Mar;16(3):266–72.
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  - Moylan CA, Pang H, Dellinger A, Suzuki A, Garrett ME, Guy CD, et al. Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease.. Hepatology. 2014 Feb;59(2):471–82.
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  - Secord AA, Teoh D, Jia J, Nixon AB, Grace L, Adams DJ, et al. Dasatinib (BMS-35482) interacts synergistically with docetaxel, gemcitabine, topotecan, and doxorubicin in ovarian cancer cells with high SRC pathway activation and protein expression.. Int J Gynecol Cancer. 2014 Feb;24(2):218–25.
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  - Davidson BA, Rubatt JM, Corcoran DL, Teoh DK, Bernardini MQ, Grace LA, et al. Differential Angiogenic Gene Expression in TP53 Wild-Type and Mutant Ovarian Cancer Cell Lines.. Front Oncol. 2014;4.
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  - Nye MD, Fry RC, Hoyo C, Murphy SK. Investigating Epigenetic Effects of Prenatal Exposure to Toxic Metals in Newborns: Challenges and Benefits.. Med Epigenet. 2014;2(1):53–9.
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  - Vidal AC, Benjamin Neelon SE, Liu Y, Tuli AM, Fuemmeler BF, Hoyo C, et al. Maternal stress, preterm birth, and DNA methylation at imprint regulatory sequences in humans.. Genet Epigenet. 2014;6:37–44.
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  - Vidal AC, Henry NM, Murphy SK, Oneko O, Nye M, Bartlett JA, et al. PEG1/MEST and IGF2 DNA methylation in CIN and in cervical cancer. Clinical and Translational Oncology. 2014;16(3):266–72.
  - Vidal AC, Murphy SK, Hoyo C. What are the implications of distinct HPV genotypes in women of different ethnic/racial ancestry?. Journal of Vaccines and Vaccination. 2014 Jan 1;5(3).
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  - Vidal AC, Smith JS, Valea F, Bentley R, Gradison M, Yarnall KSH, et al. HPV genotypes and cervical intraepithelial Neoplasiain a multiethnic cohort in the southeastern United States. Journal of Vaccines and Vaccination. 2014 Jan 1;5(3).
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  - Vidal AC, Smith JS, Valea F, Bentley R, Gradison M, Yarnall KSH, et al. HPV genotypes and cervical intraepithelial neoplasia in a multiethnic cohort in the southeastern USA. Cancer Causes and Control. 2014 Jan 1;25(8):1055–62.
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  - Yamaguchi K, Matsumura N, Mandai M, Baba T, Konishi I, Murphy SK. Epigenetic and genetic dispositions of ovarian carcinomas.. Oncoscience. 2014;1(9):574–9.
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  - Kharma B, Baba T, Mandai M, Matsumura N, Murphy SK, Kang HS, et al. Utilization of genomic signatures to identify high-efficacy candidate drugs for chemorefractory endometrial cancers.. Int J Cancer. 2013 Nov;133(9):2234–44.
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  - Murphy SK, Yang H, Moylan CA, Pang H, Dellinger A, Abdelmalek MF, et al. Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease.. Gastroenterology. 2013 Nov;145(5):1076–87.
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  - Amano Y, Yamaguchi K, Mandai M, Matsumura N, Hamanishi J, Baba T, et al. Abstract PR08: HNF1β confers resistance to oxidative stress of ovarian clear cell carcinoma. Targeting Drug Resistance. 2013 Oct 1;
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  - Hamanishi J, Matsumura N, Jin P, Abiko K, Horikawa N, Yamaguchi K, et al. Abstract A83: Induction of PD-L1 expression by cytotoxic agents through activation of NF-kB signal. Immunotherapy on the Horizon. 2013 Oct 1;
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  - Matsumura N, Yamanoi K, Amano Y, Hamanishi J, Baba T, Murphy SK, et al. Abstract B19: Functional genomics approach links anchorage-independence with tumor dormancy in ovarian cancer. High Throughput Analysis in Ovarian Cancer. 2013 Oct 1;
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  - Murphy SK. Prenatal sensitization of a postnatal trigger for metabolic disease.. J Clin Invest. 2013 Jul;123(7):2786–8.
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  - Vidal AC, Murphy SK, Murtha AP, Schildkraut JM, Soubry A, Huang Z, et al. Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring.. Int J Obes (Lond). 2013 Jul;37(7):907–13.
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  - Liu Y, Hoyo C, Murphy S, Huang Z, Overcash F, Thompson J, et al. DNA methylation at imprint regulatory regions in preterm birth and infection.. Am J Obstet Gynecol. 2013 May;208(5):395.e1-395.e7.
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  - Sfakianos GP, Iversen ES, Whitaker R, Akushevich L, Schildkraut JM, Murphy SK, et al. Validation of ovarian cancer gene expression signatures for survival and subtype in formalin fixed paraffin embedded tissues.. Gynecol Oncol. 2013 Apr;129(1):159–64.
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  - Murphy SK, Hollingsworth JW. Stress: a possible link between genetics, epigenetics, and childhood asthma.. Am J Respir Crit Care Med. 2013 Mar 15;187(6):563–4.
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  - Soubry A, Schildkraut JM, Murtha A, Wang F, Huang Z, Bernal A, et al. Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort.. Bmc Med. 2013 Feb 6;11.
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  - Alvarez Secord A, Bernardini MQ, Broadwater G, Grace LA, Huang Z, Baba T, et al. TP53 Status is Associated with Thrombospondin1 Expression In vitro.. Front Oncol. 2013;3.
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  - Bassil CF, Huang Z, Murphy SK. Bisulfite pyrosequencing.. Methods Mol Biol. 2013;1049:95–107.
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  - Huang Z, Bassil CF, Murphy SK. Bisulfite sequencing of cloned alleles.. Methods Mol Biol. 2013;1049:83–94.
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  - Huang Z, Bassil CF, Murphy SK. Methylation-specific PCR.. Methods Mol Biol. 2013;1049:75–82.
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  - Huang Z, Murphy SK. Increased Intragenic IGF2 Methylation is Associated with Repression of Insulator Activity and Elevated Expression in Serous Ovarian Carcinoma.. Front Oncol. 2013;3.
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  - Murphy SK, Bassil CF, Huang Z. Main principles and outcomes of DNA methylation analysis.. Methods Mol Biol. 2013;1049:67–74.
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  - Nye MD, Hoyo C, Huang Z, Vidal AC, Wang F, Overcash F, et al. Associations between methylation of paternally expressed gene 3 (PEG3), cervical intraepithelial neoplasia and invasive cervical cancer.. Plos One. 2013;8(2).
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  - Vidal AC, Murphy SK, Murtha AP, Schildkraut JM, Soubry A, Huang Z, et al. Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring. International Journal of Obesity. 2013;37(7):907–13.
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  - Vidal AC, Murtha AP, Murphy SK, Fortner K, Overcash F, Henry N, et al. Maternal BMI, IGF-I Levels, and Birth Weight in African American and White Infants.. Int J Pediatr. 2013;2013.
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  - Vidal AC, Overcash F, Murphy SK, Murtha AP, Schildkraut JM, Forman MR, et al. Associations between birth and one year anthropometric measurements and IGF2 and IGF2R genetic variants in African American and Caucasian American infants.. J Pediatr Genet. 2013;2(3).
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  - Joubert BR, Håberg SE, Nilsen RM, Wang X, Vollset SE, Murphy SK, et al. 450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy.. Environ Health Perspect. 2012 Oct;120(10):1425–31.
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  - Korch C, Spillman MA, Jackson TA, Jacobsen BM, Murphy SK, Lessey BA, et al. DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.. Gynecol Oncol. 2012 Oct;127(1):241–8.
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  - Das R, Anderson N, Koran MI, Weidman JR, Mikkelsen TS, Kamal M, et al. Convergent and divergent evolution of genomic imprinting in the marsupial Monodelphis domestica.. Bmc Genomics. 2012 Aug 16;13.
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  - Liu Y, Murphy SK, Murtha AP, Fuemmeler BF, Schildkraut J, Huang Z, et al. Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements.. Epigenetics. 2012 Jul;7(7):735–46.
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  - Perkins E, Murphy SK, Murtha AP, Schildkraut J, Jirtle RL, Demark-Wahnefried W, et al. Insulin-like growth factor 2/H19 methylation at birth and risk of overweight and obesity in children.. J Pediatr. 2012 Jul;161(1):31–9.
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  - Huang Z, Lowery WJ, Berchuck A, Murphy SK. Abstract 5363: Aggregation rather than monoclonal expansion explains ovarian cancer spheroid formation. Tumor Biology. 2012 Apr 15;
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  - Okamoto T, Yamaguchi K, Huang Z, Whitaker R, Konishi I, Berchuck A, et al. Abstract LB-87: Methylated-mediated repression ofZNF154in ovarian cancer is associated with poor overall survival. Molecular and Cellular Biology. 2012 Apr 15;
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  - Hoyo C, Fortner K, Murtha AP, Schildkraut JM, Soubry A, Demark-Wahnefried W, et al. Association of cord blood methylation fractions at imprinted insulin-like growth factor 2 (IGF2), plasma IGF2, and birth weight.. Cancer Causes Control. 2012 Apr;23(4):635–45.
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  - Berchuck A, Sfakianos G, Whitaker R, Levine D, Murphy S, Marks J, et al. Frequency of the cancer genome atlas expression subtypes differs between early and advanced stage high grade serous ovarian cancers. Gynecologic Oncology. 2012 Mar;125:S133–S133.
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  - Murphy S, Yang H, Yamaguchi K, Huang Z, Konishi I, Berchuck A. DNA Methylation Profiles Distinguish Serous, Mucinous and Clear Cell but not Endometrioid Epithelial Ovarian Cancers. Gynecologic Oncology. 2012 Mar;125:S99–S99.
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  - Murphy SK, Adigun A, Huang Z, Overcash F, Wang F, Jirtle RL, et al. Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke.. Gene. 2012 Feb 15;494(1):36–43.
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  - Murphy SK. Targeting the epigenome in ovarian cancer.. Future Oncol. 2012 Feb;8(2):151–64.
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  - Hoyo C, Murphy SK, Schildkraut JM, Vidal AC, Skaar D, Millikan RC, et al. IGF2R genetic variants, circulating IGF2 concentrations and colon cancer risk in African Americans and Whites.. Dis Markers. 2012;32(2):133–41.
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  - Murphy SK, Huang Z, Hoyo C. Differentially methylated regions of imprinted genes in prenatal, perinatal and postnatal human tissues.. Plos One. 2012;7(7).
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  - Skaar DA, Li Y, Bernal AJ, Hoyo C, Murphy SK, Jirtle RL. The human imprintome: regulatory mechanisms, methods of ascertainment, and roles in disease susceptibility.. Ilar J. 2012;53(3–4):341–58.
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  - Yamamura S, Matsumura N, Mandai M, Huang Z, Oura T, Baba T, et al. The activated transforming growth factor-beta signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer.. Int J Cancer. 2012 Jan 1;130(1):20–8.
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  - Bernal AJ, Murphy SK, Jirtle RL. Mouse models of epigenetic inheritance. 2011 Dec 1;233–49.
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  - Bondurant AE, Huang Z, Whitaker RS, Simel LR, Berchuck A, Murphy SK. Quantitative detection of RASSF1A DNA promoter methylation in tumors and serum of patients with serous epithelial ovarian cancer.. Gynecol Oncol. 2011 Dec;123(3):581–7.
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  - Murphy SK, Berchuck A. Ovarian cancer progenitor/stem cells: Therapeutic potential. 2011 Dec 1;223–44.
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  - Vidal AC, Murphy SK, Hernandez BY, Vasquez B, Bartlett JA, Oneko O, et al. Distribution of HPV genotypes in cervical intraepithelial lesions and cervical cancer in Tanzanian women.. Infect Agent Cancer. 2011 Nov 14;6(1).
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  - Alvarez Secord A, Darcy KM, Hutson A, Huang Z, Lee PS, Jewell EL, et al. The regulation of MASPIN expression in epithelial ovarian cancer: association with p53 status, and MASPIN promoter methylation: a gynecologic oncology group study.. Gynecol Oncol. 2011 Nov;123(2):314–9.
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  - Soubry A, Murphy S, Huang Z, Murtha A, Schildkraut J, Jirtle R, et al. The effects of depression and use of antidepressive medicines during pregnancy on the methylation status of the IGF2 imprinted control regions in the offspring.. Clin Epigenetics. 2011 Oct 26;3.
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  - Hoyo C, Murtha AP, Schildkraut JM, Jirtle RL, Demark-Wahnefried W, Forman MR, et al. Methylation variation at IGF2 differentially methylated regions and maternal folic acid use before and during pregnancy.. Epigenetics. 2011 Jul;6(7):928–36.
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  - Zhang A, Skaar DA, Li Y, Huang D, Price TM, Murphy SK, et al. Novel retrotransposed imprinted locus identified at human 6p25.. Nucleic Acids Res. 2011 Jul;39(13):5388–400.
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  - Huang Z, Yamaguchi K, Berchuck A, Murphy SK. Abstract 3014: Quantitative accuracy of Illumina HumanMethylation27 Infinium BeadChip data assessed by pyrosequencing. Cellular and Molecular Biology. 2011 Apr 15;
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  - Soubry A, Murphy SK, Huang Z, Murtha A, Schildkraut JM, Jirtle RL, et al. Abstract 2754: Maternal use of antidepressants in pregnancy is associated with hypermethylation at theIGF2imprinted control regions in the offspring in a race-dependent fashion. Epidemiology. 2011 Apr 15;
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  - Kang HS, Baba T, Mandai M, Matsumura N, Hamanishi J, Kharma B, et al. GPR54 is a target for suppression of metastasis in endometrial cancer.. Mol Cancer Ther. 2011 Apr;10(4):580–90.
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  - Teoh D, Ayeni TA, Rubatt JM, Adams DJ, Grace L, Starr MD, et al. Dasatinib (BMS-35482) has synergistic activity with paclitaxel and carboplatin in ovarian cancer cells.. Gynecol Oncol. 2011 Apr;121(1):187–92.
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  - Sfakianos G, Yan J, Whitaker R, Murphy S, Berchuck A. Concordant gene expression profiles in matched primary and recurrent serous ovarian cancers predict platinum response. Gynecologic Oncology. 2011 Mar;120:S46–S46.
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  - Yamaguchi K, Baba T, Konishi I, Matsumura N, Murphy S, Huang Z, et al. Genes functionally regulated by methylation in ovarian cancer are involved in cell proliferation, development and morphogenesis. Gynecologic Oncology. 2011 Mar;120:S69–S69.
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  - Yamaguchi K, Baba T, Matsumura N, Mandai M, Konishi I, Berchuck A, et al. Genomewide methylation analyses reveal a prominent role of HINF1 network genes, via hypomethylation, in ovarian clear cell carcinoma. Gynecologic Oncology. 2011 Mar;120:S8–S8.
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  - Hoyo C, Murtha AP, Schildkraut JM, Forman MR, Calingaert B, Demark-Wahnefried W, et al. Folic acid supplementation before and during pregnancy in the Newborn Epigenetics STudy (NEST).. Bmc Public Health. 2011 Jan 21;11(1).
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  - Matsumura N, Huang Z, Mori S, Baba T, Fujii S, Konishi I, et al. Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer.. Genome Res. 2011 Jan;21(1):74–82.
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  - Matsumura N, Mandai M, Okamoto T, Yamaguchi K, Yamamura S, Oura T, et al. Sorafenib efficacy in ovarian clear cell carcinoma revealed by transcriptome profiling.. Cancer Sci. 2010 Dec;101(12):2658–63.
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  - Bernardini MQ, Baba T, Lee PS, Barnett JC, Sfakianos GP, Secord AA, et al. Expression signatures of TP53 mutations in serous ovarian cancers.. Bmc Cancer. 2010 May 26;10.
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  - Kondoh E, Mori S, Yamaguchi K, Baba T, Matsumura N, Cory Barnett J, et al. Targeting slow-proliferating ovarian cancer cells.. Int J Cancer. 2010 May 15;126(10):2448–56.
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  - Yamaguchi K, Mandai M, Oura T, Matsumura N, Hamanishi J, Baba T, et al. Identification of an ovarian clear cell carcinoma gene signature that reflects inherent disease biology and the carcinogenic processes.. Oncogene. 2010 Mar 25;29(12):1741–52.
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  - Lee PS, Teaberry VS, Bland AE, Huang Z, Whitaker RS, Baba T, et al. Elevated MAL expression is accompanied by promoter hypomethylation and platinum resistance in epithelial ovarian cancer.. Int J Cancer. 2010 Mar 15;126(6):1378–89.
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  - Barnett JC, Bean SM, Whitaker RS, Kondoh E, Baba T, Fujii S, et al. Ovarian cancer tumor infiltrating T-regulatory (T(reg)) cells are associated with a metastatic phenotype.. Gynecol Oncol. 2010 Mar;116(3):556–62.
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  - Sfakianos G, Yamaguchi K, Murphy S, Berchuck A. Gene expression profiling of invasive serous ovarian cancers from formalin-fixed, paraffin-embedded tissues using DASL. Gynecologic Oncology. 2010 Mar 1;116(3):S136–7.
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  - Murphy SK. Targeting ovarian cancer-initiating cells.. Anticancer Agents Med Chem. 2010 Feb;10(2):157–63.
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  - Barnett JC, Bean SM, Nakayama JM, Kondoh E, Murphy SK, Berchuck A. High poly(adenosine diphosphate-ribose) polymerase expression and poor survival in advanced-stage serous ovarian cancer.. Obstet Gynecol. 2010 Jan;115(1):49–54.
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  - Hoyo C, Schildkraut JM, Murphy SK, Chow W-H, Vaughan TL, Risch H, et al. IGF2R polymorphisms and risk of esophageal and gastric adenocarcinomas.. Int J Cancer. 2009 Dec 1;125(11):2673–8.
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  - Gregory SG, Connelly JJ, Towers AJ, Johnson J, Biscocho D, Markunas CA, et al. Genomic and epigenetic evidence for oxytocin receptor deficiency in autism.. Bmc Med. 2009 Oct 22;7.
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  - Hoyo C, Murphy SK, Jirtle RL. Imprint regulatory elements as epigenetic biosensors of exposure in epidemiological studies.. J Epidemiol Community Health. 2009 Sep;63(9):683–4.
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  - Mori S, Chang JT, Andrechek ER, Matsumura N, Baba T, Yao G, et al. Anchorage-independent cell growth signature identifies tumors with metastatic potential.. Oncogene. 2009 Aug 6;28(31):2796–805.
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  - Ding X, Mohd AB, Huang Z, Baba T, Bernardini MQ, Lyerly HK, et al. MLH1 expression sensitises ovarian cancer cells to cell death mediated by XIAP inhibition.. Br J Cancer. 2009 Jul 21;101(2):269–77.
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  - Huang Z, Wen Y, Simel L, Price T, Berchuck A, Murphy SK. CTCF binding at a novel intragenic binding site is associated with elevated IGF2 expression in serous epithelial ovarian cancer. Cancer Research. 2009 May 1;69.
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  - Kondoh E, Baba T, Matsumura N, Konishi I, Fujii S, Berchuck A, et al. UCN-01 is effective in targeting ovarian cancer spheroids. Cancer Research. 2009 May 1;69.
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  - Berchuck A, Iversen ES, Luo J, Clarke JP, Horne H, Levine DA, et al. Microarray analysis of early stage serous ovarian cancers shows profiles predictive of favorable outcome.. Clin Cancer Res. 2009 Apr 1;15(7):2448–55.
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  - Kondoh E, Okamoto T, Higuchi T, Tatsumi K, Baba T, Murphy SK, et al. Stress affects uterine receptivity through an ovarian-independent pathway.. Hum Reprod. 2009 Apr;24(4):945–53.
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  - Baba T, Kang HS, Matsumura N, Hamanishi J, Mandai M, Berchuck A, et al. Loss of GPR54 correlates with stem cell activity in high-grade endometrial cancer. Gynecologic Oncology. 2009 Feb 1;112(2):S78–S78.
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  - Barnett JC, Iverson E, Dressman H, Whitaker R, Murphy SK, Lancaster J, et al. Validation of the MAL gene as a predictor of survival in advanced-stage high-grade serous ovarian cancer. Gynecologic Oncology. 2009 Feb 1;112(2):S123–4.
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  - Barnett JC, Kondoh E, Whitaker R, Murphy SK, Berchuck A. High poly (ADP-ribose) polymerase (PARP) expression is associated with poor survival in advanced-stage serous ovarian cancer. Gynecologic Oncology. 2009 Feb 1;112(2):S107–S107.
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  - Barnett JC, Whitaker R, Kondoh E, Baba T, Murphy SK, Berchuck A. Ovarian cancer tumor-infiltrating regulatory T cells are associated with a metastatic phenotype. Gynecologic Oncology. 2009 Feb 1;112(2):S11–S11.
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  - Horne HN, Lee PS, Murphy SK, Alonso MA, Olson JA, Marks JR. Inactivation of the MAL gene in breast cancer is a common event that predicts benefit from adjuvant chemotherapy.. Mol Cancer Res. 2009 Feb;7(2):199–209.
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  - Kondoh E, Baba T, Malsumura N, Konishi I, Fujii S, Berchuck A, et al. 7-hydroxystaurosporine (UCN-01) is effective in targeting ovarian cancer spheroids. Gynecologic Oncology. 2009 Feb 1;112(2):S161–2.
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  - Matsumura N, Huang Z, Baba T, Lee PS, Barnett JC, Mori S, et al. Yin yang 1 modulates taxane response in epithelial ovarian cancer.. Mol Cancer Res. 2009 Feb;7(2):210–20.
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  - Murphy SK, Chen L. Imprinted Neuronatin: A potential epigenetie biomarker of ovarian cancer. Gynecologic Oncology. 2009 Feb 1;112(2):S135–S135.
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  - Murphy SK, Huang Z, Wen Y, Simel LR, Price TM, Berchuck A. Intragenic methylation at a novel CTCF binding site is associated with elevated IGF2 expression in serous epithelial ovarian cancer. Gynecologic Oncology. 2009 Feb 1;112(2):S138–S138.
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  - Resnick KE, Alder H, Secord AA, Whitaker R, Richardson DL, Heaphy C, et al. MiRNA patterns in ovarian cancer cell lines: Correlation with serum studies. Gynecologic Oncology. 2009 Feb 1;112(2):S115–6.
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  - Yamaguchi K, Mandai M, Matsumura N, Baba T, Oura T, Matsui S, et al. Gene signature specific for ovarian clear cell carcinoma is induced by the contents of endometriotic cysts. Gynecologic Oncology. 2009 Feb 1;112(2):S132–S132.
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  - Baba T, Convery PA, Matsumura N, Whitaker RS, Kondoh E, Perry T, et al. Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells.. Oncogene. 2009 Jan 15;28(2):209–18.
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  - Baba T, Mori S, Matsumura N, Bernardini M, Fujii S, Berchuck A, et al. Microarray analysis identifies NSC668814 as a potentially active chemotherapeutic agent for platinum-resistant ovarian cancers with TP53 mutations. Gynecologic Oncology. 2008 Mar 1;108(3):S72–S72.
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  - Bernardini MQ, Lee P, Baba T, Whitaker RS, Murphy SK, Berchuck A. Microarray analysis defines patterns of gene expression associated with mutation of TP53 in ovarian cancer. Gynecologic Oncology. 2008 Mar 1;108(3):S84–S84.
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  - Kondoh E, Baba T, Matsurnura N, Fujii S, Berchuck A, Murphy SK. Targeting dormant ovarian cancer cells. Gynecologic Oncology. 2008 Mar 1;108(3):S13–4.
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  - Matsumura N, Huang Z, Perry T, Kroyer D, Baba T, Mori S, et al. Methylation in ovarian cancer is related to poor prognosis and suppression of the transforming growth factor signaling pathway. Gynecologic Oncology. 2008 Mar 1;108(3):S104–S104.
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  - O’Sullivan FM, Murphy SK, Simel LR, McCann A, Callanan JJ, Nolan CM. Imprinted expression of the canine IGF2R, in the absence of an anti-sense transcript or promoter methylation.. Evol Dev. 2007 Nov;9(6):579–89.
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  - Baba T, Mori S, Matsumura N, Kariya M, Murphy SK, Kondoh E, et al. Trophinin is a potent prognostic marker of ovarian cancer involved in platinum sensitivity.. Biochem Biophys Res Commun. 2007 Aug 24;360(2):363–9.
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  - Hempel N, How T, Dong M, Murphy SK, Fields TA, Blobe GC. Loss of betaglycan expression in ovarian cancer: role in motility and invasion.. Cancer Res. 2007 Jun 1;67(11):5231–8.
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  - Spillman MA, Lacy J, Murphy SK, Whitaker RS, Grace L, Teaberry V, et al. Regulation of the metastasis suppressor gene MKK4 in ovarian cancer.. Gynecol Oncol. 2007 May;105(2):312–20.
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  - Price TM, Murphy SK, Younglai EV. Perspectives: the possible influence of assisted reproductive technologies on transgenerational reproductive effects of environmental endocrine disruptors.. Toxicol Sci. 2007 Apr;96(2):218–26.
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  - Risinger JI, Chandramouli GVR, Maxwell GL, Custer M, Pack S, Loukinov D, et al. Global expression analysis of cancer/testis genes in uterine cancers reveals a high incidence of BORIS expression.. Clin Cancer Res. 2007 Mar 15;13(6):1713–9.
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  - Schildkraut JM, Murphy SK, Palmieri RT, Iversen E, Moorman PG, Huang Z, et al. Trinucleotide repeat polymorphisms in the androgen receptor gene and risk of ovarian cancer.. Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):473–80.
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  - Goh L, Murphy SK, Muhkerjee S, Furey TS. Genomic sweeping for hypermethylated genes.. Bioinformatics. 2007 Feb 1;23(3):281–8.
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  - Weidman JR, Dolinoy DC, Murphy SK, Jirtle RL. Cancer susceptibility: epigenetic manifestation of environmental exposures.. Cancer J. 2007 Jan;13(1):9–16.
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  - Murphy SK, Huang Z, Wen Y, Spillman MA, Whitaker RS, Simel LR, et al. Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer.. Mol Cancer Res. 2006 Apr;4(4):283–92.
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  - Murphy SK, Nolan CM, Huang Z, Kucera KS, Freking BA, Smith TPL, et al. Callipyge mutation affects gene expression in cis: a potential role for chromatin structure.. Genome Research. 2006 Mar;16(3):340–6.
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  - Huang Z, Wen Y, Shandilya R, Marks JR, Berchuck A, Murphy SK. High throughput detection of M6P/IGF2R intronic hypermethylation and LOH in ovarian cancer.. Nucleic Acids Res. 2006;34(2):555–63.
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  - Berchuck A, Iversen ES, Lancaster JM, Pittman J, Luo J, Lee P, et al. Patterns of gene expression that characterize long-term survival in advanced stage serous ovarian cancers.. Clin Cancer Res. 2005 May 15;11(10):3686–96.
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  - Spillman MA, Schildkraut JM, Halabi S, Moorman P, Calingaert B, Bentley RC, et al. Transforming growth factor beta receptor I polyalanine repeat polymorphism does not increase ovarian cancer risk.. Gynecol Oncol. 2005 May;97(2):543–9.
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  - Wang W, Huper G, Guo Y, Murphy SK, Olson JA, Marks JR. Analysis of methylation-sensitive transcriptome identifies GADD45a as a frequently methylated gene in breast cancer.. Oncogene. 2005 Apr;24(16):2705–14.
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  - Murphy SK, Freking BA, Smith TPL, Leymaster K, Nolan CM, Wylie AA, et al. Abnormal postnatal maintenance of elevated DLK1 transcript levels in callipyge sheep.. Mamm Genome. 2005 Mar;16(3):171–83.
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  - Weidman JR, Murphy SK, Nolan CM, Dietrich FS, Jirtle RL. Phylogenetic footprint analysis of IGF2 in extant mammals.. Genome Res. 2004 Sep;14(9):1726–32.
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  - Murphy SK, Wylie AA, Coveler KJ, Cotter PD, Papenhausen PR, Sutton VR, et al. Epigenetic detection of human chromosome 14 uniparental disomy.. Hum Mutat. 2003 Jul;22(1):92–7.
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  - Murphy SK, Jirtle RL. Imprinting evolution and the price of silence.. Bioessays. 2003 Jun;25(6):577–88.
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  - Dietz LG, Wylie AA, Rauen KA, Murphy SK, Jirtle RL, Cotter PD. Exclusion of maternal uniparental disomy of chromosome 14 in patients referred for Prader-Willi syndrome using a multiplex methylation polymerase chain reaction assay.. J Med Genet. 2003 Apr;40(4).
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  - Freking BA, Murphy SK, Wylie AA, Rhodes SJ, Keele JW, Leymaster KA, et al. Identification of the single base change causing the callipyge muscle hypertrophy phenotype, the only known example of polar overdominance in mammals.. Genome Res. 2002 Oct;12(10):1496–506.
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  - Li T, Vu TH, Lee K-O, Yang Y, Nguyen CV, Bui HQ, et al. An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa.. J Biol Chem. 2002 Apr 19;277(16):13518–27.
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  - Evans HK, Wylie AA, Murphy SK, Jirtle RL. NNATresides in a micro-imprinted domain on human chromosome 20q11.2.. American Journal of Human Genetics. 2001 Oct 1;69(4):346–346.
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  - Murphy SK, Wylie AA, McVie-Wylie AJ, Pulford D, Nolan CM, Orton TC, et al. Development and characterization of a conditional M6p/Igf2r knockout mouse.. American Journal of Human Genetics. 2001 Oct 1;69(4):363–363.
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  - Evans HK, Wylie AA, Murphy SK, Jirtle RL. The neuronatin gene resides in a "micro-imprinted" domain on human chromosome 20q11.2.. Genomics. 2001 Sep;77(1–2):99–104.
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  - Keller MA, Murphy SK, Parks GD. RNA replication from the simian virus 5 antigenomic promoter requires three sequence-dependent elements separated by sequence-independent spacer regions.. J Virol. 2001 Apr;75(8):3993–8.
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  - Murphy SK, Wylie AA, Jirtle RL. Imprinting of PEG3, the human homologue of a mouse gene involved in nurturing behavior.. Genomics. 2001 Jan;71(1):110–7.
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  - Wylie AA, Murphy SK, Orton TC, Jirtle RL. Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation.. Genome Res. 2000 Nov;10(11):1711–8.
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  - Murphy SK, Wylie AA, Jirtle RL. Imprinting of PEG3, the human homolog of a gene involved in nurturing behaviour.. American Journal of Human Genetics. 2000 Oct 1;67(4):189–189.
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  - Wylie AA, Murphy SK, Orton TC, Jirtle RL. Identification of a novel imprinted domain at human chromosome 14q32.. American Journal of Human Genetics. 2000 Oct 1;67(4):190–190.
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  - Murphy SK, Jirtle RL. Imprinted genes as potential genetic and epigenetic toxicologic targets.. Environ Health Perspect. 2000 Mar;108 Suppl 1:5–11.
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  - Murphy SK, Parks GD. RNA replication for the paramyxovirus simian virus 5 requires an internal repeated (CGNNNN) sequence motif.. J Virol. 1999 Jan;73(1):805–9.
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  - Murphy SK, Ito Y, Parks GD. A functional antigenomic promoter for the paramyxovirus simian virus 5 requires proper spacing between an essential internal segment and the 3' terminus.. J Virol. 1998 Jan;72(1):10–9.
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  - Murphy SK, Parks GD. Genome nucleotide lengths that are divisible by six are not essential but enhance replication of defective interfering RNAs of the paramyxovirus simian virus 5.. Virology. 1997 May 26;232(1):145–57.
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  - Murphy SK, Oliver JD. Effects of temperature abuse on survival of Vibrio vulnificus in oysters.. Appl Environ Microbiol. 1992 Sep;58(9):2771–5.
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  - Bradley MS, Boudreau M-H, Grenier C, Huang Z, Murphy SK, Siddiqui NY. Urine RNA Processing in a Clinical Setting: Comparison of 3 Protocols.. Female Pelvic Med Reconstr Surg. 25(3):247–51.
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- Book Sections
  - Moylan CA, Murphy SK. DNA Methylation: Basic Principles. In: Medical Epigenetics. 2016. p. 11–31.
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  - Taylor MM, Murphy SK. Systems Biology and the Epigenome. In: Systems Biology in Toxicology and Environmental Health. 2015. p. 43–56.
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- Conference Papers
  - Moylan CA, Grenier C, Hyun J, Du K, Henao R, Abdelmalek MF, et al. DYSREGULATED DNA METHYLATION OF FGFR2, CASP1, AND BCAT1 ASSOCIATES WITH NONALCOHOLIC FATTY LIVER DISEASE SEVERITY AND CAN BE IDENTIFIED IN PERIPHERAL BLOOD. In: Gastroenterology. W B SAUNDERS CO-ELSEVIER INC; 2019. p. S1360–1.
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  - Acharya KS, Schrott R, Levin E, Murphy SK. Epigenetic Alterations in Cytochrome P450 Oxidoreductase (Por) in Sperm Exposed to Tetrahydrocannabinol (THC).. In: Reproductive Sciences. SAGE PUBLICATIONS INC; 2019. p. 92A-92A.
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  - Moylan CA, Sorrow PA, Mavis A, Bashir M, Jima D, Maguire R, et al. Obesity and Nonalcoholic Fatty Liver Disease in Childhood Associate with Altered DNA Methylation in Early Life. In: Hepatology. WILEY; 2018. p. 949A-950A.
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  - Tindula G, Murphy SK, Grenier C, Huang Z, Huen K, Escudero-Fung M, et al. DNA methylation of imprinted genes in Mexican-American newborn children with prenatal phthalate exposure.. In: Epigenomics. 2018. p. 1011–26.
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  - Kollins S, Levin E, Price T, Murphy S. Delta-9-Tetrahydrocannabinol Exposure Alters Sperm Methylation Profiles: Concurrent Results From Humans and Rats. In: Neuropsychopharmacology. NATURE PUBLISHING GROUP; 2017. p. S642–3.
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  - Li X, Moylan CA, Baker SS, Liu W, Baker RD, Murphy SK, et al. Altered liver methylome and transcriptome provide evidence for epigenetic contribution to NAFLD pathogenesis. In: Hepatology. WILEY; 2017. p. 1071A-1072A.
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  - Moylan CA, Mavis AM, Bashir MR, Malik D, Bozdogan E, Buie S, et al. Visceral and subcutaneous adipose tissue measurements associate with increased metabolic risk for NAFLD in pre-pubertal obese children. In: Hepatology. WILEY; 2017. p. 665A-665A.
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  - Murphy SK, Schrott R, Visco Z, Huang Z, Grenier C, Mitchell J, et al. Environment and Gametic Epigenetic Reprogramming.. In: Environmental and Molecular Mutagenesis. WILEY; 2017. p. S28–S28.
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  - Huang Z, Foster B, Grenier C, Sfakianos G, Whitaker R, Berchuck A, et al. Abstract 1991: Enhanced role of the extracellular matrix in ovarian cancer recurrence. In: Tumor Biology. American Association for Cancer Research; 2017.
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  - Moylan CA, Giraldo RH, Murphy SK, Diehl AM, Abdelmalek MF. Differential DNA Methylation in Whole Blood Reflects that in Liver and Distinguishes Patients with Advanced NAFLD Fibrosis from Those with Normal Histology: A Potential Non-Invasive Tool. In: Gastroenterology. Elsevier BV; 2017. p. S1069–70.
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  - Bradley MS, Boudreau M-H, Grenier C, Huang Z, Murphy S, Siddiqui NY. STANDARDIZATION OF RNA PROCESSING FROM URINE SEDIMENT IN A CLINICAL SETTING. In: Neurourology and Urodynamics. WILEY-BLACKWELL; 2017. p. S18–S18.
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  - Bradley MS, Burke E, Grenier C, Amundsen CL, Murphy S, Siddiqui NY. URINARY METHYLATION PATTERNS IN WOMEN WITH INTERSTITIAL CYSTITIS/BLADDER PAIN SYNDROME. In: Neurourology and Urodynamics. WILEY-BLACKWELL; 2017. p. S17–8.
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  - Moylan CA, Wegermann KJ, Henao RG, Murphy SK, Diehl AM, Abdelmalek MF. BCAT1 Is Associated with Clinical Decompensation in Nonalcoholic Fatty Liver Disease: a Pilot Study. In: American Journal of Gastroenterology. NATURE PUBLISHING GROUP; 2016. p. S381–S381.
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  - Murphy SK, Keyhan S, Guo L, Tomins K, Taylor M, Joglekar R, et al. Environmental Influence on Preconceptional and Gestational DNA Methylation Profiles.. In: Environmental and Molecular Mutagenesis. WILEY-BLACKWELL; 2016. p. S39–S39.
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  - Horikawa N, Abiko K, Matsumura N, Hamanishi J, Murphy S, Baba T, et al. Abstract B63: Expression of VEGF in ovarian cancer suppresses tumor immunity through recruitment of myeloid derived suppressor cells.. In: Ovarian Cancer Tumor Microenvironment. American Association for Cancer Research; 2016.
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  - Moylan CA, Murphy SK, Grenier C, Abdelmalek MF, Diehl AM. DNA Methylation Profiles of Fibrosis-Associated Gene in Blood Reflects Liver Fibrosis Severity in Human Nonalcoholic Fatty Liver Disease. In: Hepatology. WILEY-BLACKWELL; 2015. p. 648A-649A.
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  - Huang Z, Visco Z, Sfakianos G, Whitaker R, Berchuck A, Murphy S. Abstract POSTER-BIOL-1319: Temporal shifts in the epigenetic regulation of tight junctions from primary to recurrent ovarian cancer. In: Biology of Ovarian Cancer. American Association for Cancer Research; 2015.
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  - Huang Z, Visco Z, Sfakianos G, Whitaker R, Berchuck A, Murphy SK. Abstract 2236: Emergence of epigenetic regulation of tight junction genes in recurrent serous epithelial ovarian cancer. In: Tumor Biology. American Association for Cancer Research; 2015.
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  - Varadaraj A, Patel P, Serrao A, Bandyopadhyay T, Lee NY, Jazaeri A, et al. Abstract 3912: GDF2 promotes anoikis susceptibility in ovarian and breast epithelia. In: Molecular and Cellular Biology. American Association for Cancer Research; 2015.
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  - Cobb LP, Whitaker R, Hall A, Broadwater G, Murphy SK, Berchuck A, et al. Evaluation of ERRα expression and association with survival in advanced ovarian cancer. In: Gynecologic Oncology. Elsevier BV; 2015. p. 204–204.
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  - Mendez M, Grabich S, Nahm S, Murphy S, Hoyo C. Diet during pregnancy and disparities in fetal growth: the NEST cohort. In: Faseb Journal. FEDERATION AMER SOC EXP BIOL; 2015.
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  - Ding J, Reynolds LM, Zeller T, Muller C, Lohman K, Huang Z, et al. Alterations of a Cellular Cholesterol Metabolism Network is a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular Disease. In: Circulation. LIPPINCOTT WILLIAMS & WILKINS; 2014.
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  - Kharma B, Baba T, Matsumura N, Kang HS, Murakami R, Yamaguchi K, et al. Abstract LB-123: Novel function of STAT1 pathway as a modulator of tumor progression in serous papillary endometrial cancer. In: Molecular and Cellular Biology. American Association for Cancer Research; 2014.
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  - Stevens EV, Whitaker R, Guinet A, Chang C-Y, Grenier C, Marks J, et al. Abstract 4570: Role of ERRalpha in ovarian cancer. In: Experimental and Molecular Therapeutics. American Association for Cancer Research; 2014.
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  - Park J, Huang Z, Berchuck A, Murphy S. Abstract 4767: Preclinical mouse model of recurrent epithelial ovarian cancer.. In: Endocrinology. American Association for Cancer Research; 2013.
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  - Wang X, Pittman GS, Su D, Adamski KN, Campbell MR, Joubert BR, et al. Abstract 3647: Dose-dependent alteration of CpG methylation inAHRRandGFI1in mononuclear cell DNA of smokers.. In: Epidemiology. American Association for Cancer Research; 2013.
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  - Murphy SK, Nye MD, Hoyo C. Methylation at Imprinted Insulin-Like Growth Factor-2 (IGF2) Is Vulnerable to Lead Exposure in Human Embryonic Kidney Cells. In: Reproductive Sciences. SAGE PUBLICATIONS INC; 2013. p. 203A-204A.
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  - Garrett ME, Moylan CA, Gibson J, Yang H, Pang H, Dellinger A, et al. Expression QTL analysis of a gene expression signature which predicts advanced non-alcoholic fatty liver disease. In: Hepatology. WILEY-BLACKWELL; 2012. p. 267A-268A.
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  - Moylan CA, Yang H, Pang H, Dellinger A, Suzuki A, Tillmann HL, et al. Epigenetic Regulation of Gene Expression in NAFLD. In: Gastroenterology. W B SAUNDERS CO-ELSEVIER INC; 2012. p. S929–S929.
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  - Baba T, Kharma B, Mandai M, Yoshioka Y, Hamanishi J, Matsumura N, et al. Utilization of genomic signatures to identify Fludarabine and Temsirolimus as candidate drugs with high efficacy to chemo-refractory endometrial cancers. In: Gynecologic Oncology. Elsevier BV; 2012. p. S138–S138.
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  - Baba T, Kang H, Mandai M, Hamanishi J, Kharma B, Matsumura N, et al. Metastin-10 suppresses invasion of endometrial cancer cells. In: Gynecologic Oncology. ACADEMIC PRESS INC ELSEVIER SCIENCE; 2010. p. S76–S76.
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  - Matsumura N, Mandai M, Okamoto T, Yamaguchi K, Oura T, Baba T, et al. Sorafenib efficacy in ovarian clear cell carcinoma revealed by transcriptome profiling. In: Gynecologic Oncology. ACADEMIC PRESS INC ELSEVIER SCIENCE; 2010. p. S155–S155.
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  - Murphy S, Overcash F, Huang Z, Vasquez B, Hernandez B, Obure J, et al. Progressive epigenetic deregulation of insulin-like growth factor 2 in cervical cancer precursors in HIV plus and HIV- patients. In: Gynecologic Oncology. ACADEMIC PRESS INC ELSEVIER SCIENCE; 2010. p. S38–S38.
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  - Fortner K, Murtha A, Hoyo C, Overcash F, Huang Z, Schildkraut J, et al. 70: Epigenetic orchestration of circulating insulin-like growth factor-2 levels in cord blood. In: American Journal of Obstetrics and Gynecology. Elsevier BV; 2009. p. S39–S39.
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  - Murphy SK, Jayes FL, Feng L, Huang Z, Leppert PC. Methylation of THBS1, the Gene Encoding Thrombospondin-1 in Uterine Fibroids and Myometrium. In: Reproductive Sciences. SAGE PUBLICATIONS INC; 2009. p. 214A-214A.
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  - Murphy SK, Jayes FL, Feng L, Huang Z, Leppert PC. Altered IGF2/H19 Imprint Center Methylation in Uterine Fibroids but Not in Adjacent Myometrium. In: Reproductive Sciences. SAGE PUBLICATIONS INC; 2009. p. 216A-216A.
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  - Baba T, Convery PA, Matsumura N, Whitaker RS, Perry T, Huang Z, et al. Stem cell marker CD133 (PROMININ-1) is epigenetically regulated in ovarian cancer. In: Gynecologic Oncology. 2008. p. S104–S104.
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  - Lee PS, Teaberry V, Bland AE, Huang Z, Secord AA, Berchuck A, et al. MAL, a gene associated with survival in epithelial ovarian cancer, is epigenetically regulated. In: Gynecologic Oncology. ACADEMIC PRESS INC ELSEVIER SCIENCE; 2008. p. S125–S125.
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  - Baba T, Convey P, Matsumura N, Whitaker RS, Perry T, Huang Z, et al. Stem cell marker CD133 (PROMININ-1) is epigenetically regulated in ovarian cancer. In: Cancer Biomarkers. 2008. p. 175–6.
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  - Huang Z, Gusberg AH, Whitaker RS, Berchuck A, Murphy SK. YY1 imprint status and role in ovarian carcinogenesis. In: Cancer Research. AMER ASSOC CANCER RESEARCH; 2006.
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  - Murphy SK, Gusberg AH, Huang Z, Simel LR, Whitaker RS, Berchuck A. Overexpression of imprinted DLK1 in epithelial ovarian cancer. In: Cancer Research. AMER ASSOC CANCER RESEARCH; 2006.
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  - Schildkraut JM, French A, Calingaert B, Bentley RC, Murphy S, Marks JR, et al. Molecular epidemiology of cyclin E overexpression in epithelial ovarian cancer. In: Cancer Research. AMER ASSOC CANCER RESEARCH; 2006.
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  - Schildkraut JM, Berchuck A, Murphy S, Marks J, Moorman P, Calingaert B, et al. Trinucleotide repeat polymorphisms in the androgen receptor gene and risk of ovarian cancer.. In: Cancer Epidemiology Biomarkers & Prevention. AMER ASSOC CANCER RESEARCH; 2004. p. 1897S-1897S.
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  - Dietz L, Wylie AA, Rauen KA, Murphy SK, Jirtle RL, Cotter PD. Exclusion of maternal uniparental disomy of chromosome 14 in Prader-Willi syndrome referrals using a rapid methylation PCR assay.. In: American Journal of Human Genetics. UNIV CHICAGO PRESS; 2002. p. 553–553.
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Artistic Works & Non-Print Media
- Digital Media
  - How Epigenetics Influences the Risk of Disease. Writer. 2014
Teaching & Mentoring
Recent Courses
- PATHOL 293: Research Independent Study 2019
Advising & Mentoring
- Junior Faculty
  
  Cynthia Moylan, MD, Duke University, Gastroenterology
  K Award Co-Mentor
  
  Naz Siddiqui, MD, Duke University, OB/GYN – Urogynecology
  K Award Co-Mentor, K23 recipient
  
  Megan Bradley, MD, Duke University, OB/GYN – Urogynecology
  AUGS Foundation Co-Mentor
  
  Sherika Hill, PhD, UNC-Chapel Hill / Duke University
  Fellow, Center for Developmental Science
  
  Thesis Committees
  
  Dana Dolinoy, Duke University, UPGG, 2007
  Kristin Maloney, Duke University, UPGG, 2009 (Masters)
  Radhika Das, Duke University, UPGG, 2010
  Autumn Bernal, Duke University, UPGG, 2012
  Amanda Lea, Duke University, Biology, 2017
  Kim Cocce, Duke University, Medical Scientist Training Program, 2017
  Valerie Rojas, Pharmacology Sciences Training Program, MS 2014
  Nathaniel Mabe, Pharmacology and Cancer Biology
  Rashmi Joglekar, ITEHP, Nicholas School of the Environment, Candidate
  Rose Schrott, ITEHP, Nicholas School of the Environment
  Gynecologic Oncology Fellows
  
  Monique Spillman, MD/PhD, Gyn-Onc Fellow, Duke University, 2003-2006
  Current position: Texas Oncology – Baylor, Dallas, TX
  
  Paula Lee, MD, Gyn-Onc Fellow, Duke University, 2004-2007
  Current position: Assistant Professor, Duke University
  
  Amy E. BonDurant, MD, Gyn-Onc Fellow, Duke University, 2005-2008
  Current position: Pacific Gynecology Specialists, Seattle, WA
  
  Marcus Bernardini, MD, Visiting Fellow, University of Toronto, 2006-2007
  Current position: Assistant Professor, University of Toronto
  
  Jason Cory Barnett, MD, Gyn-Onc Fellow, Duke University, 2007-2008
  Current position: Department of OB/GYN, Fort Sam Houston Texas
  
  Gregory Sfakianos, MD, Gyn-Onc Fellow, Duke University, 2009-2010
  Current position: St. Francis Gynecologic Oncology, Columbus, GA
  
  William J. Lowery, MD, Gyn-Onc Fellow, Duke University, 2010-2011
  Current position: Gynecologic Oncologist, US Army, Rockville, MD
  
  Brittany Davidson, MD, Gyn-Onc Fellow, Duke University, 2013-2014
  Current position: Assistant Professor, Duke University
  
  Reproductive Endocrinology Fellows
  
  Sanaz Keyhan, MD, Duke University, 2015-2016
  Current position: Palo Alto Medical Foundation, San Jose, California
  
  Kelly Acharya, MD, Duke University, 2017-2018
  
  Stephanie Smeltzer, MD, Duke University, 2018-2019
  
  Postdoctoral Fellows
  
  Noriomi Matsumura, MD/PhD, 2005-2007
  Current position: Professor, Obstetrics and Gynecology, Kyoto University, Kindai University
  
  Tsukasa Baba, MD/PhD, 2006-2008
  Current position: Associate Professor, Gynecologic Oncology, Kyoto University
  
  Eiji Kondoh, MD, 2007-2009
  Current position: Assistant Professor, Gynecology and Obstetrics, Kyoto University
  
  Ken Yamaguchi, MD/PhD, 2009-2011
  Current position: Chief of Obstetrics and Gynecology, Japan Baptist Hospital, Kyoto University
  
  Abayomi Adigun, PhD, 2010-2011
  Current position: Manager, Investment Staff, Duke University
  
  Lihong Zhu, MD, 2011-2012
  Current position: Assistant Professor, Peking University, Beijing
  
  Ellen Stevens, PhD, 2011- 2013
  Current position: Senior Scientist, Baebies
  
  Takako Okamato, MD, 2011-2014
  
  Monica Nye, PhD, 2011-2014
  Current position: Assistant Professor, UNC-Charlotte
  
  Michele Taylor, PhD, 2014-2016
  Current position: Toxicologist, Environmental Protection Agency
  
  Graduate Students
  
  Katrina Slemmons, Molecular Cancer Biology (rotation) 2013
  Valerie Rojas, Pharmacology Scientist Training Program (Master’s) 2013-2015
  Rashmi Joglekar, PhD Candidate, Integrated Toxicology and Environmental Health Program 2015 -
  Amelia Poplawski, Molecular Cancer Biology (rotation) 2015
  Sara Payne, Molecular Cancer Biology (rotation) 2015-2016
  Yihan Liao, Cellular and Molecular Biology (rotation) 2016
  Rose Schrott, Integrated Toxicology and Environmental Health Program 2017 -
  Emily Liang, Integrated Toxicology and Environmental Health Program (rotation) 2017
  Christine Figan, Integrated Toxicology and Environmental Health Program (rotation) 2017
  Laura Childers, Integrated Toxicology and Environmental Health Program (rotation) 2018
  Sam Hall, Integrated Toxicology and Environmental Health Program (rotation) 2018
  Emma Dolan, Pharmacology and Cancer Biology (rotation) 2018
  
  Medical Students – Third Year Research
  
  Vanessa Teaberry Schroder, 2004-2005
  Current position: Assistant Professor of Surgery, Duke University
  
  Patricia Convery, 2006-2007
  Current position: Private Practice, Morristown, New Jersey
  
  Kerone Walker, 2008-2009
  Current Position: Obstetrics and Gynecology, UCLA Medical Center
  
  Jaemin Park, (Duke-NUS), 2011-2013 (two years of research)
  Current position: Investment Professional at Partner’s Group
  
  Isabel Rodriguez, 2014-2015
  Current position: OB/GYN Resident, Duke University
  
  Barbara Blachut, (Washington University, St. Louis), summer, 2017
  
  Cassie Hobbs, 2017-2018
  
  Undergraduate Students
  
  Yaqing Wen, Duke University, 2004-2006
  Bouncer Program, Independent Study Student
  Current position: Board Certified Internist, Charlottesville, Virginia
  
  Jacob Berchuck, Duke University, 2004
  Current position: Medical Oncologist, Dana Farber Cancer Institute
  
  Lisa Chen, Duke University, 2005-2007
  Independent Study Student, Honors Thesis Student
  Current position: Clinical Instructor, Ophthalmology, Stanford University
  
  Natasha Duggan, University of California, San Francisco, 2006-2009
  Current position: Postdoctoral Trainee, University of Miami
  
  Nancy Anoruo, University of Florida, Gainesville, 2006
  Institute for Genome Sciences and Policy Summer Research Program
  Current position: Adjunct Instructor in Biology, American University
  
  Cara Davis, University of North Carolina, Asheville, 2008
  Current position: Project Specialist, INC Research, Raleigh, North Carolina
  
  Jack Fitzgibbons, Duke University, 2010
  Independent Study Student
  Current position: Director of Strategic Initiatives, SMS Assist, Chicago, Illinois
  
  Masashi Ono, University of North Carolina, Asheville, 2010
  
  Christopher Bassil, Duke University, 2011-2012
  Current position: Medical Scientist Training Program, Duke University
  
  Shamaita Majumdar, Duke University, 2011-2014
  Independent Study Student, Honors Thesis Student
  Current position: Medical Student, Washington University St. Louis, Missouri
  
  Clara Lee, Duke University, 2012-2014
  Independent Study Student, Honors Thesis Student
  Current position: Medical Student, Emory University, Atlanta, Georgia
  
  Jason Chin, Duke University, 2012-2014
  Independent Study Student
  
  Sonya Jooma, Duke University, 2013-2014
  Independent Study Student
  Current Position: Health Policy Analyst, NHGRI
  
  Lisa Guo, Duke University, 2013-2014
  Independent Study Student, Honors Thesis Student
  
  Brittany Wenger, Duke University, 2013-2014
  TIME’s Thirty Under Thirty
  
  Kelli Tomins, Duke University, 2014-2016
  Independent Study Student
  Current Position: Research Fellow, NIH
  
  Zachary Visco, Duke University, 2014-2017
  Current Position: Medical Student, State University of New York Medical School
  
  Michelle Dalson, Duke University, 2015
  
  Marie Boudreau, Appalachian State University, 2014 - 2017
  
  Sabrina Simpson, Boston University, 2015 - 2017
  
  Catherine Birtles, McGill University, 2015
  
  Ethan Whitaker, Cambell University, 2015 - 2017
  
  Melody Iro, Duke University, 2016
  
  Brad Foster, Duke University, 2016
  
  Kamyar Yazdani, Duke University Class of 2020, 2016 -
  Independent Study Student
  
  Katarina Stephan, Duke University, 2017
  
  Katherine Maitland, Duke University Class of 2021, 2017 – 2018
  Independent Study Student, Biology Honors Research, Graduation with Distinction
  
  Olivia Neely, Duke University Class of 2020, 2018 –
  Independent Study Student
  
  Jim Liu, Duke University Class of 2019
  Independent Study Student
  
  Kaycie Hutcheson, Duke University Class of 2020
  
  Michael Williams, Duke University Class of 2021, 2018 -
  
  High School Students
  
  Danielle Dejournet, North Carolina School of Science, and Math, 2013-2014
  Kennedy Bridges, North Carolina School of Science and Math, 2014-2015
  Deepika Senthil, North Carolina School of Science and Math, 2015-2016
  Esther Son, North Carolina School of Science and Math, 2017-2018
  Andy Liu, North Carolina School of Science and Math, 2018-2019
Teaching Activities
- 1994-1997, Medical Microbiology Laboratory Instructor, Wake Forest University
  
  1994-1997, Advanced Topics in Microbiology and Immunology Instructor, Wake Forest University
  
  1997, Medical Microbiology Tutor, Wake Forest University
  
  1997, Fundamentals of Virology, ad hoclecturer, Wake Forest University
  
  2000, Duke University Bioinformatics Shared Resources Seminar Series: An Introduction to Profile Hidden Markov Models
  
  2004, Duke University Bouncer Program Undergraduate Summer Research Program
  
  2006, Duke University Institute for Genome Sciences and Policy Summer Fellowship Program (National Science Foundation Research Experience for Undergraduates)
  
  2005-2007, Independent Research, Mentor (Honors Research): Imprinted NNAT: a Potential Epigenetic Biomarker of Ovarian Cancer
  
  2012-2014, Independent Research, Mentor (Honors Research): The Role of Imprinted Gene MEG3 in Epithelial Ovarian Cancer
  
  2013-2016, Independent Research, Mentor (Honors Research): Male Overweight/Obesity and Sperm Epigenome Disturbances at Differentially Methylated Regions of Imprinted Genes
  
  2017-2018, Independent Research, Mentor (Honors Research):Effects of cannabis-linked changes in DNA methylation on AHRR gene transcription
  
  Lecturer
  
  PATH 786.01 / Duke Merits: 2013, 2016
  PATH-786 / Translational Pathobiology: 2017
  ENV-537 / Environmental Health : 2015, 2016
  CBI-206 / Anesthesiology-445C (Physiology and Medicine of Extreme Environments): 2015
  ENV-290 / Special Topics in Environmental Sciences and Policy: 2016
  ENV-819 / Mechanisms in Toxicology: 2017
  HOUSECS 59.14 / House Course (Intro to Epigenetics: How Environment Shapes Our Genes): 2018
Scholarly, Clinical, & Service Activities
Presentations & Appearances
Outreach & Engaged Scholarship
Service to the Profession
Service to Duke

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