Magnetically-responsive silica-gold nanobowls for targeted delivery and SERS-based sensing.

Journal Article (Journal Article)

Composite colloidal structures with multi-functional properties have wide applications in targeted delivery of therapeutics and imaging contrast molecules and high-throughput molecular bio-sensing. We have constructed a multifunctional composite magnetic nanobowl using the bottom-up approach on an asymmetric silica/polystyrene Janus template consisting of a silica shell around a partially exposed polystyrene core. The nanobowl consists of a silica bowl and a gold exterior shell with iron oxide magnetic nanoparticles sandwiched between the silica and gold shells. The nanobowls were characterized by electron microscopy, atomic force microscopy, magnetometry, vis-NIR and FTIR spectroscopy. Magnetically vectored transport of these nanobowls was ascertained by time-lapsed imaging of their flow in fluid through a porous hydrogel under a defined magnetic field. These magnetically-responsive nanobowls show distinct surface enhanced Raman spectroscopy (SERS) imaging capability. The PEGylated magnetically-responsive nanobowls show size-dependent cellular uptake in vitro.

Full Text

Duke Authors

Cited Authors

  • Mo, AH; Landon, PB; Gomez, KS; Kang, H; Lee, J; Zhang, C; Janetanakit, W; Sant, V; Lu, T; Colburn, DA; Akkiraju, S; Dossou, S; Cao, Y; Lee, K-F; Varghese, S; Glinsky, G; Lal, R

Published Date

  • June 9, 2016

Published In

Volume / Issue

  • 8 / 23

Start / End Page

  • 11840 - 11850

PubMed ID

  • 27228391

Pubmed Central ID

  • PMC6295298

Electronic International Standard Serial Number (EISSN)

  • 2040-3372

Digital Object Identifier (DOI)

  • 10.1039/c6nr02445a


  • eng

Conference Location

  • England