Shyni Varghese
Professor of Orthopaedic Surgery
Shyni Varghese has a triple appointment in the Duke departments of Biomedical Engineering, Mechanical Engineering and Materials Science, and Orthopaedic Surgery. She is the first MEDx Investigator.
A leader in the field of biomaterials and stem cells, Varghese will develop her research at Duke in three major areas:
- Musculoskeletal tissue repair
- Disease biophysics, and
- Organ-on-a-chip technology
A new initiative of the Pratt School of Engineering and Duke School of Medicine, Duke MEDx seeks to enhance and form new collaborations between doctors and engineers.
Current Research Interests
Current Appointments & Affiliations
- Professor of Orthopaedic Surgery, Orthopaedic Surgery, Clinical Science Departments 2017
- Professor in the Department of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2017
- Professor in the Department of Mechanical Engineering and Materials Science, Pratt School of Engineering, Duke University 2017
- Affiliate of the Duke Regeneration Center, Regeneration Next Initiative, Basic Science Departments 2021
Contact Information
- Background
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Education, Training, & Certifications
- Ph.D., National Chemical Laboratory (India) 2002
- Recognition
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In the News
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NOV 24, 2021 Duke Science & Technology -
MAR 25, 2021 Pratt School of Engineering -
JAN 9, 2020 -
DEC 13, 2019 Pratt School of Engineering -
NOV 1, 2019 Pratt School of Engineering -
AUG 22, 2019 Pratt School of Engineering -
NOV 18, 2016 Pratt School of Engineering
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- Research
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Selected Grants
- Microglia-Amyloid interactions in delirium superimposed on dementia awarded by National Institutes of Health 2017 - 2027
- Targeting the HIF-2 Signaling Pathway as a Radioprotective Strategy for Bone awarded by National Institutes of Health 2022 - 2027
- University Training Program in Biomolecular and Tissue Engineering awarded by National Institutes of Health 1994 - 2027
- Localization of adenosine to promote fracture healing awarded by National Institutes of Health 2022 - 2027
- Supramolecular biomaterials for tuning the inflammatory properties of the complement system awarded by National Institutes of Health 2022 - 2027
- Modulation of local adenosine signaling to attenuate fracture pain awarded by National Institutes of Health 2021 - 2026
- Targeting the metastasis initiating cell in undifferentiated pleomorphic sarcoma awarded by National Institutes of Health 2021 - 2026
- Duke Center for Advancement of Child Health (CAtCH). awarded by National Institutes of Health 2021 - 2026
- Understanding the role of senescence on post-operative neuroinflammation awarded by National Institutes of Health 2022 - 2025
- Acquisition of a VRS1250 Video-Rate Imaging Module for a Shared-Use Asylum-Cypher Atomic Force Microscope (AFM) awarded by North Carolina Biotechnology Center 2023 - 2024
- Nicotine Pouches: Chemical Composition, Toxicity and Behavioral Effects of a New Tobacco Product Category awarded by National Institutes of Health 2022 - 2023
- Duke KURe Program awarded by National Institutes of Health 2013 - 2023
- Acquisition of a Biacore T200 Surface Plasmon Resonance Instrument for Shared Use awarded by North Carolina Biotechnology Center 2022 - 2023
- Adenosine A2B Receptor in Bone Health and Osteoporosis awarded by National Institutes of Health 2017 - 2023
- Bioinspired Synthetic Grafts for Bone Regeneration awarded by National Institutes of Health 2017 - 2019
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External Relationships
- Burroughs Wellcome Foundation
- Mehta Family Center for Engineering in medicine (MFCEM) at IIT Kanpur, India
- Mehta Family Foundation
- ONCO DiSCOVER
- Osteocure Cure Therapeutics
- Royal Society of Chemistry
- Publications & Artistic Works
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Selected Publications
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Books
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Varghese, S., and J. H. Elisseeff. Hydrogels for musculoskeletal tissue engineering. Vol. 203, 2006. https://doi.org/10.1007/12_072.Full Text
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Academic Articles
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Rana, Isha, Sunny Kataria, Tuan Lin Tan, Edries Yousaf Hajam, Deepak Kumar Kashyap, Dyuti Saha, Johan Ajnabi, et al. “Mindin (SPON2) Is Essential for Cutaneous Fibrogenesis in a Mouse Model of Systemic Sclerosis.” J Invest Dermatol 143, no. 5 (May 2023): 699-710.e10. https://doi.org/10.1016/j.jid.2022.10.011.Full Text Link to Item
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Kumar, Vardhman, David Kingsley, Sajeeshkumar Madhurakkat Perikamana, Pankaj Mogha, C Rory Goodwin, and Shyni Varghese. “Self-assembled innervated vasculature-on-a-chip to study nociception.” Biofabrication 15, no. 3 (April 13, 2023). https://doi.org/10.1088/1758-5090/acc904.Full Text Link to Item
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Newman, Hunter, and Shyni Varghese. “Extracellular adenosine signaling in bone health and disease.” Curr Opin Pharmacol 70 (April 10, 2023): 102378. https://doi.org/10.1016/j.coph.2023.102378.Full Text Link to Item
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Yang, Ting, Ravikanth Velagapudi, Cuicui Kong, Unghyeon Ko, Vardhman Kumar, Paris Brown, Nathan O. Franklin, et al. “Protective effects of omega-3 fatty acids in a blood-brain barrier-on-chip model and on postoperative delirium-like behaviour in mice.” Br J Anaesth 130, no. 2 (February 2023): e370–80. https://doi.org/10.1016/j.bja.2022.05.025.Full Text Link to Item
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Aung, Aereas, Shruti K. Davey, Jomkuan Theprungsirikul, Vardhman Kumar, and Shyni Varghese. “Deciphering the Mechanics of Cancer Spheroid Growth in 3D Environments through Microfluidics Driven Mechanical Actuation.” Adv Healthc Mater, November 14, 2022, e2201842. https://doi.org/10.1002/adhm.202201842.Full Text Link to Item
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Hoque, Jiaul, Yuze Zeng, Hunter Newman, Gavin Gonzales, Cheryl Lee, and Shyni Varghese. “Microgel-Assisted Delivery of Adenosine to Accelerate Fracture Healing.” Acs Biomater Sci Eng 8, no. 11 (November 14, 2022): 4863–72. https://doi.org/10.1021/acsbiomaterials.2c00977.Full Text Link to Item
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Chansoria, P., J. Blackwell, E. L. Etter, E. E. Bonacquisti, N. Jasiewicz, T. Neal, S. A. Kamal, et al. “Rationally Designed Anisotropic and Auxetic Hydrogel Patches for Adaptation to Dynamic Organs.” Advanced Functional Materials 32, no. 43 (October 1, 2022). https://doi.org/10.1002/adfm.202207590.Full Text
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Newman, Hunter, Jiaul Hoque, Yu-Ru V. Shih, Gabrielle Marushack, Unghyeon Ko, Gavin Gonzales, and Shyni Varghese. “pH-Sensitive nanocarrier assisted delivery of adenosine to treat osteoporotic bone loss.” Biomater Sci 10, no. 18 (September 13, 2022): 5340–55. https://doi.org/10.1039/d2bm00843b.Full Text Link to Item
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Bartholf DeWitt, Suzanne, Sarah Hoskinson Plumlee, Hailey E. Brighton, Dharshan Sivaraj, E. J. Martz, Maryam Zand, Vardhman Kumar, et al. “Loss of ATRX promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin binding.” Jci Insight 7, no. 17 (September 8, 2022). https://doi.org/10.1172/jci.insight.151583.Full Text Link to Item
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Ko, Ung Hyun, Vardhman Kumar, Benjamin Rosen, and Shyni Varghese. “Characterization of bending balloon actuators.” Front Robot Ai 9 (2022): 991748. https://doi.org/10.3389/frobt.2022.991748.Full Text Link to Item
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Kumar, Vardhman, Sajeesh Kumar Madhurakkat Perikamana, Aleksandra Tata, Jiaul Hoque, Anna Gilpin, Purushothama Rao Tata, and Shyni Varghese. “An In Vitro Microfluidic Alveolus Model to Study Lung Biomechanics.” Front Bioeng Biotechnol 10 (2022): 848699. https://doi.org/10.3389/fbioe.2022.848699.Full Text Link to Item
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Madhurakkat Perikamana, S. K., N. Seale, J. Hoque, J. H. Ryu, V. Kumar, Y. V. Shih, and S. Varghese. “Molecularly Tailored Interface for Long-Term Xenogeneic Cell Transplantation.” Advanced Functional Materials 32, no. 4 (January 1, 2022). https://doi.org/10.1002/adfm.202108221.Full Text
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Gilpin, Anna, Yuze Zeng, Jiaul Hoque, Ji Hyun Ryu, Yong Yang, Stefan Zauscher, William Eward, and Shyni Varghese. “Self-Healing of Hyaluronic Acid to Improve In Vivo Retention and Function.” Adv Healthc Mater 10, no. 23 (December 2021): e2100777. https://doi.org/10.1002/adhm.202100777.Full Text Link to Item
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Andress, Benjamin, Jason H. Kim, Hattie C. Cutcliffe, Annunziato Amendola, Adam P. Goode, Shyni Varghese, Louis E. DeFrate, and Amy L. McNulty. “Meniscus cell regional phenotypes: Dedifferentiation and reversal by biomaterial embedding.” J Orthop Res 39, no. 10 (October 2021): 2177–86. https://doi.org/10.1002/jor.24954.Full Text Link to Item
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Newman, Hunter, Yuru Vernon Shih, and Shyni Varghese. “Resolution of inflammation in bone regeneration: From understandings to therapeutic applications.” Biomaterials 277 (October 2021): 121114. https://doi.org/10.1016/j.biomaterials.2021.121114.Full Text Link to Item
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Kumar, Vardhman, Ung Hyun Ko, Yilong Zhou, Jiaul Hoque, Gaurav Arya, and Shyni Varghese. “Microengineered Materials with Self‐Healing Features for Soft Robotics.” Advanced Intelligent Systems 3, no. 7 (July 2021): 2100005–2100005. https://doi.org/10.1002/aisy.202100005.Full Text
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Hoque, Jiaul, Yu-Ru V. Shih, Yuze Zeng, Hunter Newman, Nivedita Sangaj, Neha Arjunji, and Shyni Varghese. “Bone targeting nanocarrier-assisted delivery of adenosine to combat osteoporotic bone loss.” Biomaterials 273 (June 2021): 120819. https://doi.org/10.1016/j.biomaterials.2021.120819.Full Text Link to Item
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Nayak, P., A. Colas, M. Mercola, S. Varghese, and S. Subramaniam. “Temporal mechanisms of myogenic specification in human induced pluripotent stem cells.” Sci Adv 7, no. 12 (March 2021). https://doi.org/10.1126/sciadv.abf7412.Full Text Link to Item
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Moreno, Ana M., Xin Fu, Jie Zhu, Dhruva Katrekar, Yu-Ru V. Shih, John Marlett, Jessica Cabotaje, et al. “In Situ Gene Therapy via AAV-CRISPR-Cas9-Mediated Targeted Gene Regulation.” Mol Ther 28, no. 8 (August 5, 2020): 1931. https://doi.org/10.1016/j.ymthe.2020.06.027.Full Text Link to Item
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Zeng, Yuze, Yu-Ru V. Shih, Gurpreet S. Baht, and Shyni Varghese. “In Vivo Sequestration of Innate Small Molecules to Promote Bone Healing.” Adv Mater 32, no. 8 (February 2020): e1906022. https://doi.org/10.1002/adma.201906022.Full Text Link to Item
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Aung, Aereas, Vardhman Kumar, Jomkuan Theprungsirikul, Shruti K. Davey, and Shyni Varghese. “An Engineered Tumor-on-a-Chip Device with Breast Cancer-Immune Cell Interactions for Assessing T-cell Recruitment.” Cancer Res 80, no. 2 (January 15, 2020): 263–75. https://doi.org/10.1158/0008-5472.CAN-19-0342.Full Text Link to Item
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Shih, Yu-Ru V., Mengqian Liu, Seong Keun Kwon, Masayuki Iida, Ya Gong, Nivedita Sangaj, and Shyni Varghese. “Dysregulation of ectonucleotidase-mediated extracellular adenosine during postmenopausal bone loss.” Sci Adv 5, no. 8 (August 2019): eaax1387. https://doi.org/10.1126/sciadv.aax1387.Full Text Link to Item
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Zeng, Yuze, Jiaul Hoque, and Shyni Varghese. “Biomaterial-assisted local and systemic delivery of bioactive agents for bone repair.” Acta Biomater 93 (July 15, 2019): 152–68. https://doi.org/10.1016/j.actbio.2019.01.060.Full Text Link to Item
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Serrano, Ricardo, Aereas Aung, Yi-Ting Yeh, Shyni Varghese, Juan C. Lasheras, and Juan C. Del Álamo. “Three-Dimensional Monolayer Stress Microscopy.” Biophys J 117, no. 1 (July 9, 2019): 111–28. https://doi.org/10.1016/j.bpj.2019.03.041.Full Text Link to Item
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Shih, Yuru Vernon, and Shyni Varghese. “Tissue engineered bone mimetics to study bone disorders ex vivo: Role of bioinspired materials.” Biomaterials 198 (April 2019): 107–21. https://doi.org/10.1016/j.biomaterials.2018.06.005.Full Text Link to Item
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Katrekar, Dhruva, Genghao Chen, Dario Meluzzi, Ashwin Ganesh, Atharv Worlikar, Yu-Ru Shih, Shyni Varghese, and Prashant Mali. “In vivo RNA editing of point mutations via RNA-guided adenosine deaminases.” Nat Methods 16, no. 3 (March 2019): 239–42. https://doi.org/10.1038/s41592-019-0323-0.Full Text Link to Item
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Kumar, Vardhman, and Shyni Varghese. “Ex Vivo Tumor-on-a-Chip Platforms to Study Intercellular Interactions within the Tumor Microenvironment.” Adv Healthc Mater 8, no. 4 (February 2019): e1801198. https://doi.org/10.1002/adhm.201801198.Full Text Link to Item
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Hoque, Jiaul, Nivedita Sangaj, and Shyni Varghese. “Stimuli-Responsive Supramolecular Hydrogels and Their Applications in Regenerative Medicine.” Macromol Biosci 19, no. 1 (January 2019): e1800259. https://doi.org/10.1002/mabi.201800259.Full Text Link to Item
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Ryu, Ji Hyun, Gyeong Jin Lee, Yu-Ru V. Shih, Tae-Il Kim, and Shyni Varghese. “Phenylboronic Acid-polymers for Biomedical Applications.” Curr Med Chem 26, no. 37 (2019): 6797–6816. https://doi.org/10.2174/0929867325666181008144436.Full Text Link to Item
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Kang, Heemin, Yuze Zeng, and Shyni Varghese. “Functionally graded multilayer scaffolds for in vivo osteochondral tissue engineering.” Acta Biomater 78 (September 15, 2018): 365–77. https://doi.org/10.1016/j.actbio.2018.07.039.Full Text Link to Item
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Liu, Mengqian, Manando Nakasaki, Yu-Ru Vernon Shih, and Shyni Varghese. “Effect of age on biomaterial-mediated in situ bone tissue regeneration.” Acta Biomater 78 (September 15, 2018): 329–40. https://doi.org/10.1016/j.actbio.2018.06.035.Full Text Link to Item
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Seale, Nailah, Suvasini Ramaswamy, Yu-Ru Shih, Inder Verma, and Shyni Varghese. “Macroporous Dual-compartment Hydrogels for Minimally Invasive Transplantation of Primary Human Hepatocytes.” Transplantation 102, no. 9 (September 2018): e373–81. https://doi.org/10.1097/TP.0000000000002330.Full Text Link to Item
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Moreno, Ana M., Xin Fu, Jie Zhu, Dhruva Katrekar, Yu-Ru V. Shih, John Marlett, Jessica Cabotaje, et al. “In Situ Gene Therapy via AAV-CRISPR-Cas9-Mediated Targeted Gene Regulation.” Mol Ther 26, no. 7 (July 5, 2018): 1818–27. https://doi.org/10.1016/j.ymthe.2018.04.017.Full Text Link to Item
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González Díaz, Eva C., Yu-Ru V. Shih, Manando Nakasaki, Mengqian Liu, and Shyni Varghese. “Mineralized Biomaterials Mediated Repair of Bone Defects Through Endogenous Cells.” Tissue Eng Part A 24, no. 13–14 (July 2018): 1148–56. https://doi.org/10.1089/ten.TEA.2017.0297.Full Text Link to Item
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Kang, Heemin, Yu-Ru V. Shih, and Shyni Varghese. “Direct Conversion of Human Pluripotent Stem Cells to Osteoblasts With a Small Molecule.” Curr Protoc Stem Cell Biol 44 (February 28, 2018): 1F.21.1-1F.21.6. https://doi.org/10.1002/cpsc.44.Full Text Link to Item
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Hwang, Yongsung, Timothy Seo, Sara Hariri, Chulmin Choi, and Shyni Varghese. “Matrix Topographical Cue-Mediated Myogenic Differentiation of Human Embryonic Stem Cell Derivatives.” Polymers (Basel) 9, no. 11 (November 5, 2017). https://doi.org/10.3390/polym9110580.Full Text Link to Item
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Agrawal, Gaurav, Aereas Aung, and Shyni Varghese. “Skeletal muscle-on-a-chip: an in vitro model to evaluate tissue formation and injury.” Lab Chip 17, no. 20 (October 11, 2017): 3447–61. https://doi.org/10.1039/c7lc00512a.Full Text Link to Item
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Shih, Yu-Ru, Heemin Kang, Vikram Rao, Yu-Jui Chiu, Seong Keun Kwon, and Shyni Varghese. “In vivo engineering of bone tissues with hematopoietic functions and mixed chimerism.” Proc Natl Acad Sci U S A 114, no. 21 (May 23, 2017): 5419–24. https://doi.org/10.1073/pnas.1702576114.Full Text Link to Item
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González-Díaz, E. C., and S. Varghese. “Hydrogels as extracellular matrix analogs.” Gels 2, no. 3 (September 1, 2016). https://doi.org/10.3390/gels2030020.Full Text
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Kang, Heemin, Yu-Ru V. Shih, Manando Nakasaki, Harsha Kabra, and Shyni Varghese. “Small molecule-driven direct conversion of human pluripotent stem cells into functional osteoblasts.” Sci Adv 2, no. 8 (August 2016): e1600691. https://doi.org/10.1126/sciadv.1600691.Full Text Link to Item
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Mo, Alexander H., Preston B. Landon, Karla Santacruz Gomez, Heemin Kang, Joon Lee, Chen Zhang, Woraphong Janetanakit, et al. “Magnetically-responsive silica-gold nanobowls for targeted delivery and SERS-based sensing.” Nanoscale 8, no. 23 (June 9, 2016): 11840–50. https://doi.org/10.1039/c6nr02445a.Full Text Link to Item
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Aung, Aereas, Jomkuan Theprungsirikul, Han Liang Lim, and Shyni Varghese. “Chemotaxis-driven assembly of endothelial barrier in a tumor-on-a-chip platform.” Lab Chip 16, no. 10 (May 21, 2016): 1886–98. https://doi.org/10.1039/c6lc00184j.Full Text Link to Item
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Sharma, Blanka, and Shyni Varghese. “Progress in orthopedic biomaterials and drug delivery.” Drug Deliv Transl Res 6, no. 2 (April 2016): 75–76. https://doi.org/10.1007/s13346-016-0288-9.Full Text Link to Item
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Wen, Cai, Heemin Kang, Yu-Ru V. Shih, YongSung Hwang, and Shyni Varghese. “In vivo comparison of biomineralized scaffold-directed osteogenic differentiation of human embryonic and mesenchymal stem cells.” Drug Deliv Transl Res 6, no. 2 (April 2016): 121–31. https://doi.org/10.1007/s13346-015-0242-2.Full Text Link to Item
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Aung, Aereas, Ivneet Singh Bhullar, Jomkuan Theprungsirikul, Shruti Krishna Davey, Han Liang Lim, Yu-Jui Chiu, Xuanyi Ma, et al. “3D cardiac μtissues within a microfluidic device with real-time contractile stress readout.” Lab Chip 16, no. 1 (January 7, 2016): 153–62. https://doi.org/10.1039/c5lc00820d.Full Text Link to Item
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Kar, Mrityunjoy, Yu-Ru Vernon Shih, Daniel Ortiz Velez, Pedro Cabrales, and Shyni Varghese. “Poly(ethylene glycol) hydrogels with cell cleavable groups for autonomous cell delivery.” Biomaterials 77 (January 2016): 186–97. https://doi.org/10.1016/j.biomaterials.2015.11.018.Full Text Link to Item
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Seale, N. M., and S. Varghese. “Biomaterials for pluripotent stem cell engineering: From fate determination to vascularization.” Journal of Materials Chemistry B 4, no. 20 (January 1, 2016): 3454–63. https://doi.org/10.1039/c5tb02658j.Full Text
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Davey, Shruti Krishna, Aereas Aung, Gaurav Agrawal, Han Liang Lim, Mrityunjoy Kar, and Shyni Varghese. “Embedded 3D Photopatterning of Hydrogels with Diverse and Complex Architectures for Tissue Engineering and Disease Models.” Tissue Eng Part C Methods 21, no. 11 (November 2015): 1188–96. https://doi.org/10.1089/ten.TEC.2015.0179.Full Text Link to Item
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Nakasaki, Manando, Yongsung Hwang, Yun Xie, Sunny Kataria, Rupali Gund, Edries Y. Hajam, Rekha Samuel, et al. “The matrix protein Fibulin-5 is at the interface of tissue stiffness and inflammation in fibrosis.” Nat Commun 6 (October 15, 2015): 8574. https://doi.org/10.1038/ncomms9574.Full Text Link to Item
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Shih, Yu-Ru, Ameya Phadke, Tomonori Yamaguchi, Heemin Kang, Nozomu Inoue, Koichi Masuda, and Shyni Varghese. “Synthetic bone mimetic matrix-mediated in situ bone tissue formation through host cell recruitment.” Acta Biomater 19 (June 2015): 1–9. https://doi.org/10.1016/j.actbio.2015.03.017.Full Text Link to Item
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Kang, Heemin, Yu-Ru V. Shih, and Shyni Varghese. “Biomineralized matrices dominate soluble cues to direct osteogenic differentiation of human mesenchymal stem cells through adenosine signaling.” Biomacromolecules 16, no. 3 (March 9, 2015): 1050–61. https://doi.org/10.1021/acs.biomac.5b00099.Full Text Link to Item
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Kim, Hwan D., Jiseung Heo, Yongsung Hwang, Seon-Yeong Kwak, Ok Kyu Park, Hyunbum Kim, Shyni Varghese, and Nathaniel S. Hwang. “Extracellular-matrix-based and Arg-Gly-Asp-modified photopolymerizing hydrogels for cartilage tissue engineering.” Tissue Eng Part A 21, no. 3–4 (February 2015): 757–66. https://doi.org/10.1089/ten.TEA.2014.0233.Full Text Link to Item
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Kabra, Harsha, Yongsung Hwang, Han Liang Lim, Mrityunjoy Kar, Gaurav Arya, and Shyni Varghese. “Biomimetic Material-Assisted Delivery of Human Embryonic Stem Cell Derivatives for Enhanced In Vivo Survival and Engraftment.” Acs Biomater Sci Eng 1, no. 1 (January 12, 2015): 7–12. https://doi.org/10.1021/ab500021a.Full Text Link to Item
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Rao, V., Y. R. V. Shih, H. Kang, H. Kabra, and S. Varghese. “Adenosine signaling mediates osteogenic differentiation of human embryonic stem cells on mineralized matrices.” Frontiers in Bioengineering and Biotechnology 3, no. NOV (January 1, 2015). https://doi.org/10.3389/fbioe.2015.00185.Full Text
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Aung, Aereas, Young N. Seo, Shaoying Lu, Yingxiao Wang, Colin Jamora, Juan C. del Álamo, and Shyni Varghese. “3D traction stresses activate protease-dependent invasion of cancer cells.” Biophys J 107, no. 11 (December 2, 2014): 2528–37. https://doi.org/10.1016/j.bpj.2014.07.078.Full Text Link to Item
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Kang, Heemin, Yu-Ru V. Shih, Yongsung Hwang, Cai Wen, Vikram Rao, Timothy Seo, and Shyni Varghese. “Mineralized gelatin methacrylate-based matrices induce osteogenic differentiation of human induced pluripotent stem cells.” Acta Biomater 10, no. 12 (December 2014): 4961–70. https://doi.org/10.1016/j.actbio.2014.08.010.Full Text Link to Item
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Kang, J., H. M. Park, Y. W. Kim, Y. H. Kim, S. Varghese, H. K. Seok, Y. G. Kim, and S. H. Kim. “Control of mesenchymal stem cell phenotype and differentiation depending on cell adhesion mechanism.” Eur Cell Mater 28 (November 25, 2014): 387–403. https://doi.org/10.22203/ecm.v028a27.Full Text Link to Item
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Kang, H., C. Wen, Y. Hwang, Y. R. V. Shih, M. Kar, S. W. Seo, and S. Varghese. “Biomineralized matrix-assisted osteogenic differentiation of human embryonic stem cells.” Journal of Materials Chemistry B 2, no. 34 (September 14, 2014): 5676–88. https://doi.org/10.1039/c4tb00714j.Full Text
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Hwang, Yongsung, Samuel Suk, Yu-Ru Vernon Shih, Timothy Seo, Bin Du, Yun Xie, Ziyang Li, and Shyni Varghese. “WNT3A promotes myogenesis of human embryonic stem cells and enhances in vivo engraftment.” Sci Rep 4 (August 1, 2014): 5916. https://doi.org/10.1038/srep05916.Full Text Link to Item
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Caro-Diaz, E. J. E., A. Aung, J. Xu, S. Varghese, and E. A. Theodorakis. “Fusarisetins: structure-function studies on a novel class of cell migration inhibitors.” Organic Chemistry Frontiers 1, no. 2 (April 1, 2014): 135–39. https://doi.org/10.1039/c3qo00067b.Full Text
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Shih, Yu-Ru V., YongSung Hwang, Ameya Phadke, Heemin Kang, Nathaniel S. Hwang, Eduardo J. Caro, Steven Nguyen, et al. “Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling.” Proc Natl Acad Sci U S A 111, no. 3 (January 21, 2014): 990–95. https://doi.org/10.1073/pnas.1321717111.Full Text Link to Item
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Lim, H. L., Y. Hwang, M. Kar, and S. Varghese. “Smart hydrogels as functional biomimetic systems.” Biomaterials Science 2, no. 5 (January 1, 2014): 603–18. https://doi.org/10.1039/c3bm60288e.Full Text
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Hwang, Nathaniel S., Shyni Varghese, H Janice Lee, Zijun Zhang, and Jennifer Elisseeff. “Biomaterials directed in vivo osteogenic differentiation of mesenchymal cells derived from human embryonic stem cells.” Tissue Eng Part A 19, no. 15–16 (August 2013): 1723–32. https://doi.org/10.1089/ten.TEA.2013.0064.Full Text Link to Item
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Phadke, Ameya, YongSung Hwang, Su Hee Kim, Soo Hyun Kim, Tomonori Yamaguchi, Koichi Masuda, and Shyni Varghese. “Effect of scaffold microarchitecture on osteogenic differentiation of human mesenchymal stem cells.” Eur Cell Mater 25 (January 18, 2013): 114–29. https://doi.org/10.22203/ecm.v025a08.Full Text Link to Item
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Chang, Chien-Wen, Yongsung Hwang, Dave Brafman, Thomas Hagan, Catherine Phung, and Shyni Varghese. “Engineering cell-material interfaces for long-term expansion of human pluripotent stem cells.” Biomaterials 34, no. 4 (January 2013): 912–21. https://doi.org/10.1016/j.biomaterials.2012.10.020.Full Text Link to Item
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Hwang, Yongsung, Samuel Suk, Susan Lin, Matthew Tierney, Bin Du, Timothy Seo, Aaron Mitchell, Alessandra Sacco, and Shyni Varghese. “Directed in vitro myogenesis of human embryonic stem cells and their in vivo engraftment.” Plos One 8, no. 8 (2013): e72023. https://doi.org/10.1371/journal.pone.0072023.Full Text Link to Item
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Nguyen, Quynhhoa T., Yongsung Hwang, Albert C. Chen, Shyni Varghese, and Robert L. Sah. “Cartilage-like mechanical properties of poly (ethylene glycol)-diacrylate hydrogels.” Biomaterials 33, no. 28 (October 2012): 6682–90. https://doi.org/10.1016/j.biomaterials.2012.06.005.Full Text Link to Item
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Varghese, S., and C. Jamora. “Hydrogels: A versatile tool with a myriad of biomedical and research applications for the skin.” Expert Review of Dermatology 7, no. 4 (August 1, 2012): 315–17. https://doi.org/10.1586/edm.12.28.Full Text
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Phadke, Ameya, Yu-Ru V. Shih, and Shyni Varghese. “Mineralized synthetic matrices as an instructive microenvironment for osteogenic differentiation of human mesenchymal stem cells.” Macromol Biosci 12, no. 8 (August 2012): 1022–32. https://doi.org/10.1002/mabi.201100289.Full Text Link to Item
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Soman, Pranav, Jin Woo Lee, Ameya Phadke, Shyni Varghese, and Shaochen Chen. “Spatial tuning of negative and positive Poisson's ratio in a multi-layer scaffold.” Acta Biomater 8, no. 7 (July 2012): 2587–94. https://doi.org/10.1016/j.actbio.2012.03.035.Full Text Link to Item
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Soman, P., D. Y. Fozdar, J. W. Lee, A. Phadke, S. Varghese, and S. Chen. “A three-dimensional polymer scaffolding material exhibiting a zero Poisson's ratio.” Soft Matter 8, no. 18 (May 14, 2012): 4946–51. https://doi.org/10.1039/c2sm07354d.Full Text
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Phadke, Ameya, Chao Zhang, Bedri Arman, Cheng-Chih Hsu, Raghunath A. Mashelkar, Ashish K. Lele, Michael J. Tauber, Gaurav Arya, and Shyni Varghese. “Rapid self-healing hydrogels.” Proc Natl Acad Sci U S A 109, no. 12 (March 20, 2012): 4383–88. https://doi.org/10.1073/pnas.1201122109.Full Text Link to Item
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Zhang, Chao, Nivedita Sangaj, Yongsung Hwang, Ameya Phadke, Chien-Wen Chang, and Shyni Varghese. “Oligo(trimethylene carbonate)-poly(ethylene glycol)-oligo(trimethylene carbonate) triblock-based hydrogels for cartilage tissue engineering.” Acta Biomater 7, no. 9 (September 2011): 3362–69. https://doi.org/10.1016/j.actbio.2011.05.024.Full Text Link to Item
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Hwang, Yongsung, Ameya Phadke, and Shyni Varghese. “Engineered microenvironments for self-renewal and musculoskeletal differentiation of stem cells.” Regen Med 6, no. 4 (July 2011): 505–24. https://doi.org/10.2217/rme.11.38.Full Text Link to Item
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Lin, Susan, Nivedita Sangaj, Tojo Razafiarison, Chao Zhang, and Shyni Varghese. “Influence of physical properties of biomaterials on cellular behavior.” Pharm Res 28, no. 6 (June 2011): 1422–30. https://doi.org/10.1007/s11095-011-0378-9.Full Text Link to Item
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Ayala, Ramses, Chao Zhang, Darren Yang, Yongsung Hwang, Aereas Aung, Sumeet S. Shroff, Fernando T. Arce, Ratnesh Lal, Gaurav Arya, and Shyni Varghese. “Engineering the cell-material interface for controlling stem cell adhesion, migration, and differentiation.” Biomaterials 32, no. 15 (May 2011): 3700–3711. https://doi.org/10.1016/j.biomaterials.2011.02.004.Full Text Link to Item
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Gillies, Allison R., Lucas R. Smith, Richard L. Lieber, and Shyni Varghese. “Method for decellularizing skeletal muscle without detergents or proteolytic enzymes.” Tissue Eng Part C Methods 17, no. 4 (April 2011): 383–89. https://doi.org/10.1089/ten.TEC.2010.0438.Full Text Link to Item
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Lim, Han L., Jessica C. Chuang, Tuan Tran, Aereas Aung, Gaurav Arya, and Shyni Varghese. “Dynamic Electromechanical Hydrogel Matrices for Stem Cell Culture.” Adv Funct Mater 21, no. 1 (January 7, 2011). https://doi.org/10.1002/adfm.201001519.Full Text Link to Item
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Aung, Aereas, Gunjan Gupta, Ghassemian Majid, and Shyni Varghese. “Osteoarthritic chondrocyte-secreted morphogens induce chondrogenic differentiation of human mesenchymal stem cells.” Arthritis Rheum 63, no. 1 (January 2011): 148–58. https://doi.org/10.1002/art.30086.Full Text Link to Item
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Hwang, N. S., S. Varghese, H. Li, and J. Elisseeff. “Regulation of osteogenic and chondrogenic differentiation of mesenchymal stem cells in PEG-ECM hydrogels.” Cell and Tissue Research 344, no. 3 (January 1, 2011): 499–509. https://doi.org/10.1007/s00441-011-1153-2.Full Text
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Neiman, V. J., and S. Varghese. “Synthetic bio-actuators and their applications in biomedicine.” Smart Structures and Systems 7, no. 3 (January 1, 2011): 185–98. https://doi.org/10.12989/sss.2011.7.3.185.Full Text
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Sangaj, Nivedita, Phillip Kyriakakis, Darren Yang, Chien-Wen Chang, Gaurav Arya, and Shyni Varghese. “Heparin mimicking polymer promotes myogenic differentiation of muscle progenitor cells.” Biomacromolecules 11, no. 12 (December 13, 2010): 3294–3300. https://doi.org/10.1021/bm101041f.Full Text Link to Item
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Brafman, David A., Chien W. Chang, Antonio Fernandez, Karl Willert, Shyni Varghese, and Shu Chien. “Long-term human pluripotent stem cell self-renewal on synthetic polymer surfaces.” Biomaterials 31, no. 34 (December 2010): 9135–44. https://doi.org/10.1016/j.biomaterials.2010.08.007.Full Text Link to Item
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Chang, C. W., A. Van Spreeuwel, C. Zhang, and S. Varghese. “PEG/clay nanocomposite hydrogel: A mechanically robust tissue engineering scaffold.” Soft Matter 6, no. 20 (October 21, 2010): 5157–64. https://doi.org/10.1039/c0sm00067a.Full Text
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Hwang, Yongsung, Nivedita Sangaj, and Shyni Varghese. “Interconnected macroporous poly(ethylene glycol) cryogels as a cell scaffold for cartilage tissue engineering.” Tissue Eng Part A 16, no. 10 (October 2010): 3033–41. https://doi.org/10.1089/ten.TEA.2010.0045.Full Text Link to Item
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Phadke, Ameya, Chao Zhang, Yongsung Hwang, Kenneth Vecchio, and Shyni Varghese. “Templated mineralization of synthetic hydrogels for bone-like composite materials: role of matrix hydrophobicity.” Biomacromolecules 11, no. 8 (August 9, 2010): 2060–68. https://doi.org/10.1021/bm100425p.Full Text Link to Item
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Brammer, K. S., S. Oh, C. J. Frandsen, S. Varghese, and S. Jin. “Nanotube surface triggers increased chondrocyte extracellular matrix production.” Materials Science and Engineering C 30, no. 4 (May 10, 2010): 518–25. https://doi.org/10.1016/j.msec.2010.01.013.Full Text
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Varghese, Shyni, Nathaniel S. Hwang, Angela Ferran, Alexander Hillel, Parnduangjai Theprungsirikul, Adam C. Canver, Zijun Zhang, John Gearhart, and Jennifer Elisseeff. “Engineering musculoskeletal tissues with human embryonic germ cell derivatives.” Stem Cells 28, no. 4 (April 2010): 765–74. https://doi.org/10.1002/stem.325.Full Text Link to Item
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Hwang, Y., C. Zhang, and S. Varghese. “Poly(ethylene glycol) cryogels as potential cell scaffolds: Effect of polymerization conditions on cryogel microstructure and properties.” Journal of Materials Chemistry 20, no. 2 (January 1, 2010): 345–51. https://doi.org/10.1039/b917142h.Full Text
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Zhang, C., A. Aung, L. Liao, and S. Varghese. “A novel single precursor-based biodegradable hydrogel with enhanced mechanical properties.” Soft Matter 5, no. 20 (October 21, 2009): 3831–34. https://doi.org/10.1039/b912102a.Full Text
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Hillel, Alexander T., Shyni Varghese, Jennifer Petsche, Michael J. Shamblott, and Jennifer H. Elisseeff. “Embryonic germ cells are capable of adipogenic differentiation in vitro and in vivo.” Tissue Eng Part A 15, no. 3 (March 2009): 479–86. https://doi.org/10.1089/ten.tea.2007.0352.Full Text Link to Item
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Hwang, Nathaniel S., Chao Zhang, Yong-Sung Hwang, and Shyni Varghese. “Mesenchymal stem cell differentiation and roles in regenerative medicine.” Wiley Interdiscip Rev Syst Biol Med 1, no. 1 (2009): 97–106. https://doi.org/10.1002/wsbm.26.Full Text Link to Item
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Hwang, Nathaniel S., Shyni Varghese, H Janice Lee, Zijun Zhang, Zhaohui Ye, Jongwoo Bae, Linzhao Cheng, and Jennifer Elisseeff. “In vivo commitment and functional tissue regeneration using human embryonic stem cell-derived mesenchymal cells.” Proc Natl Acad Sci U S A 105, no. 52 (December 30, 2008): 20641–46. https://doi.org/10.1073/pnas.0809680106.Full Text Link to Item
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Lee, H. J., C. Yu, T. Chansakul, N. S. Hwang, S. Varghese, S. M. Yu, and J. H. Elisseeff. “Enhanced chondrogenesis of mesenchymal stem cells in collagen mimetic peptide-mediated microenvironment.” Tissue Engineering Part A. 14, no. 11 (November 1, 2008): 1843–51. https://doi.org/10.1089/ten.tea.2007.0204.Full Text
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Hwang, Nathaniel S., Shyni Varghese, and Jennifer Elisseeff. “Derivation of chondrogenically-committed cells from human embryonic cells for cartilage tissue regeneration.” Plos One 3, no. 6 (June 25, 2008): e2498. https://doi.org/10.1371/journal.pone.0002498.Full Text Link to Item
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Lee, H Janice, Christopher Yu, Thanissara Chansakul, Shyni Varghese, Nathaniel S. Hwang, and Jennifer H. Elisseeff. “Enhanced chondrogenic differentiation of embryonic stem cells by coculture with hepatic cells.” Stem Cells Dev 17, no. 3 (June 2008): 555–63. https://doi.org/10.1089/scd.2007.0177.Full Text Link to Item
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Hwang, Nathaniel S., Shyni Varghese, and Jennifer Elisseeff. “Controlled differentiation of stem cells.” Adv Drug Deliv Rev 60, no. 2 (January 14, 2008): 199–214. https://doi.org/10.1016/j.addr.2007.08.036.Full Text Link to Item
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Varghese, Shyni, Nathaniel S. Hwang, Adam C. Canver, Parnduangji Theprungsirikul, Debora W. Lin, and Jennifer Elisseeff. “Chondroitin sulfate based niches for chondrogenic differentiation of mesenchymal stem cells.” Matrix Biol 27, no. 1 (January 2008): 12–21. https://doi.org/10.1016/j.matbio.2007.07.002.Full Text Link to Item
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Hwang, Nathaniel S., Shyni Varghese, H Janice Lee, Parnduangjai Theprungsirikul, Adam Canver, Blanka Sharma, and Jennifer Elisseeff. “Response of zonal chondrocytes to extracellular matrix-hydrogels.” Febs Lett 581, no. 22 (September 4, 2007): 4172–78. https://doi.org/10.1016/j.febslet.2007.07.049.Full Text Link to Item
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Hwang, Nathaniel S., Shyni Varghese, Christopher Puleo, Zijun Zhang, and Jennifer Elisseeff. “Morphogenetic signals from chondrocytes promote chondrogenic and osteogenic differentiation of mesenchymal stem cells.” J Cell Physiol 212, no. 2 (August 2007): 281–84. https://doi.org/10.1002/jcp.21052.Full Text Link to Item
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Wang, Dong-An, Shyni Varghese, Blanka Sharma, Iossif Strehin, Sara Fermanian, Justin Gorham, D Howard Fairbrother, Brett Cascio, and Jennifer H. Elisseeff. “Multifunctional chondroitin sulphate for cartilage tissue-biomaterial integration.” Nat Mater 6, no. 5 (May 2007): 385–92. https://doi.org/10.1038/nmat1890.Full Text Link to Item
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Varghese, S., P. Theprungsirikul, S. Sahani, N. Hwang, K. J. Yarema, and J. H. Elisseeff. “Glucosamine modulates chondrocyte proliferation, matrix synthesis, and gene expression.” Osteoarthritis Cartilage 15, no. 1 (January 2007): 59–68. https://doi.org/10.1016/j.joca.2006.06.008.Full Text Link to Item
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Hwang, Nathaniel S., Shyni Varghese, and Jennifer Elisseeff. “Cartilage tissue engineering: Directed differentiation of embryonic stem cells in three-dimensional hydrogel culture.” Methods Mol Biol 407 (2007): 351–73. https://doi.org/10.1007/978-1-59745-536-7_24.Full Text Link to Item
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Hwang, Nathaniel S., Shyni Varghese, Parnduangjai Theprungsirikul, Adam Canver, and Jennifer Elisseeff. “Enhanced chondrogenic differentiation of murine embryonic stem cells in hydrogels with glucosamine.” Biomaterials 27, no. 36 (December 2006): 6015–23. https://doi.org/10.1016/j.biomaterials.2006.06.033.Full Text Link to Item
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Hwang, Nathaniel S., Shyni Varghese, Zijun Zhang, and Jennifer Elisseeff. “Chondrogenic differentiation of human embryonic stem cell-derived cells in arginine-glycine-aspartate-modified hydrogels.” Tissue Eng 12, no. 9 (September 2006): 2695–2706. https://doi.org/10.1089/ten.2006.12.2695.Full Text Link to Item
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Elisseeff, J., A. Ferran, S. Hwang, S. Varghese, and Z. Zhang. “The role of biomaterials in stem cell differentiation: applications in the musculoskeletal system.” Stem Cells Dev 15, no. 3 (June 2006): 295–303. https://doi.org/10.1089/scd.2006.15.295.Full Text Link to Item
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Varghese, S., A. Lele, and R. Mashelkar. “Metal-ion-mediated healing of gels.” Journal of Polymer Science, Part A: Polymer Chemistry 44, no. 1 (January 1, 2006): 666–70. https://doi.org/10.1002/pola.21177.Full Text
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Varghese, Shyni, Paranduangji Theprungsirikul, Angela Ferran, Nathaniel Hwang, Adam Canver, and Jennifer Elisseeff. “Chondrogenic differentiation of human embryonic germ cell derived cells in hydrogels.” Conf Proc Ieee Eng Med Biol Soc 2006 (2006): 2643–46. https://doi.org/10.1109/IEMBS.2006.259710.Full Text Link to Item
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Varghese, S., A. K. Lele, D. Srinivas, M. Sastry, and R. A. Mashelkar. “Novel macroscopic self-organization in polymer gels.” Advanced Materials 13, no. 20 (October 16, 2001): 1544–48. https://doi.org/10.1002/1521-4095(200110)13:20<1544::AID-ADMA1544>3.0.CO;2-F.Full Text
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Varghese, S., A. K. Lele, D. Srinivas, and R. A. Mashelkar. “Role of hydrophobicity on structure of polymer-metal complexes.” Journal of Physical Chemistry B 105, no. 23 (June 14, 2001): 5368–73. https://doi.org/10.1021/jp002310+.Full Text
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Varghese, S., A. K. Lele, and R. A. Mashelkar. “Designing new thermoreversible gels by molecular tailoring of hydrophilic-hydrophobic interactions.” Journal of Chemical Physics 112, no. 6 (February 8, 2000): 3063–70. https://doi.org/10.1063/1.480881.Full Text
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Varghese, S., A. K. Lele, D. Srinivas, and R. A. Mashelkar. “Effect of Polymer-Metal Complexation on the Phase Transition of Thermoreversible Copolymer Gels.” Journal of Physical Chemistry B 103, no. 44 (November 4, 1999): 9530–32. https://doi.org/10.1021/jp992510p.Full Text
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Badiger, M. V., A. K. Lele, V. S. Bhalerao, S. Varghese, and R. A. Mashelkar. “Molecular tailoring of thermoreversible copolymer gels: Some new mechanistic insights.” Journal of Chemical Physics 109, no. 3 (December 1, 1998): 1175–84. https://doi.org/10.1063/1.476663.Full Text
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Bhalerao, V. S., S. Varghese, A. K. Lele, and M. V. Badiger. “Thermoreversible hydrogel based on radiation induced copolymerisation of poly(N-isopropyl acrylamide) and poly(ethylene oxide) †.” Polymer 39, no. 11 (January 1, 1998): 2255–60. https://doi.org/10.1016/S0032-3861(97)00502-8.Full Text
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Book Sections
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Seale, Nailah, Yuze Zeng, and S. Varghese. “Biomimetic Tissue Engineering for Musculoskeletal Tissues.” edited by Martin Stoddart, April Craft, Girish Pattappa, and Oliver Gardner, 2018. https://doi.org/10.1016/B978-0-12-811467-4.00009-7.Full Text Link to Item
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Phadke, A., and S. Varghese. “Synthetic Biomaterials and Stem Cells for Connective Tissue Engineering.” In Molecular, Cellular, and Tissue Engineering, 36-1-36–18, 2018.
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Kang, H., Y. R. V. Shih, V. Rao, and S. Varghese. “Biomineralized matrices as intelligent scaffolds for bone tissue regeneration.” In Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine, 2nd Edition, 59–84, 2017. https://doi.org/10.1201/9781315364698.Full Text
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Varghese, S., and A. J. Engler. “Musculoskeletal cell mechanics.” In Orthopaedic Biomechanics, 301–23, 2012. https://doi.org/10.1201/b13733.Full Text
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Sangaj, N., and S. Varghese. “Controlling stem cells with biomaterials.” In Biomaterials for Tissue Engineering Applications: A Review of the Past and Future Trends, 511–38, 2011. https://doi.org/10.1007/978-3-7091-0385-2_18.Full Text
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Phadke, A., C. W. Chang, and S. Varghese. “Functional Biomaterials for Controlling Stem Cell Differentiation.” In Studies in Mechanobiology, Tissue Engineering and Biomaterials, 2:19–44, 2010. https://doi.org/10.1007/8415_2010_2.Full Text
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Conference Papers
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Jabba, S. V., A. N. Diaz, A. I. Caceres, H. C. Erythropel, V. Kumar, S. Varghese, J. B. Zimmerman, and S. E. Jordt. “Cellular Respiratory Toxicity of Novel Flavor-Solvent Adducts in Electronic Cigarettes.” In American Journal of Respiratory and Critical Care Medicine, Vol. 203, 2021.Link to Item
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Varghese, Shyni. “Role of Matrix Proteins in Balancing Tissue Stiffness and Inflammation in Fibrosis.” In Biophysical Journal, 114:23A-23A. CELL PRESS, 2018.Link to Item
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Aung, A., and S. Varghese. “Traction stress as a modulator for protease dependent invasion of cancer cells.” In Food, Pharmaceutical and Bioengineering Division 2013 Core Programming Area at the 2013 Aiche Annual Meeting: Global Challenges for Engineering a Sustainable Future, 847–48, 2013.
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Castro-Ceseña, A. B., E. E. Novitskaya, A. Phadke, S. Varghese, and J. McKittrick. “Isolation of collagen from cortical bovine bone for preparation of porous collagen sponges.” In Conference Proceedings of the Society for Experimental Mechanics Series, 5:73–78, 2013. https://doi.org/10.1007/978-1-4614-4427-5_11.Full Text
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- Teaching & Mentoring
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Recent Courses
- BME 493: Projects in Biomedical Engineering (GE) 2023
- BME 590: Special Topics in Biomedical Engineering 2023
- BME 791: Graduate Independent Study 2023
- EGR 393: Research Projects in Engineering 2023
- NEUROSCI 493: Research Independent Study 1 2023
- BME 394: Projects in Biomedical Engineering (GE) 2022
- BME 590: Special Topics in Biomedical Engineering 2022
- ME 592: Research Independent Study in Mechanical Engineering or Material Science 2022
- BME 394: Projects in Biomedical Engineering (GE) 2021
- BME 493: Projects in Biomedical Engineering (GE) 2021
- BME 494: Projects in Biomedical Engineering (GE) 2021
- BME 590: Special Topics in Biomedical Engineering 2021
- ME 555: Advanced Topics in Mechanical Engineering 2021
- ME 591: Research Independent Study in Mechanical Engineering or Material Science 2021
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