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Shyni Varghese

Laszlo Ormandy Distinguished Professor of Orthopaedic Surgery
Orthopaedic Surgery

Overview


Shyni Varghese has a triple appointment in the Duke departments of Biomedical Engineering, Mechanical Engineering and Materials Science, and Orthopaedic Surgery. She is the first MEDx Investigator.

A leader in the field of biomaterials and stem cells, Varghese will develop her research at Duke in three major areas:

  • Musculoskeletal tissue repair
  • Disease biophysics, and
  • Organ-on-a-chip technology

A new initiative of the Pratt School of Engineering and Duke School of Medicine, Duke MEDx seeks to enhance and form new collaborations between doctors and engineers.

Current Appointments & Affiliations


Laszlo Ormandy Distinguished Professor of Orthopaedic Surgery · 2023 - Present Orthopaedic Surgery, Clinical Science Departments
Professor of Orthopaedic Surgery · 2017 - Present Orthopaedic Surgery, Clinical Science Departments
Professor in the Department of Mechanical Engineering and Materials Science · 2017 - Present Pratt School of Engineering
Professor in the Department of Biomedical Engineering · 2017 - Present Biomedical Engineering, Pratt School of Engineering
Affiliate of the Duke Regeneration Center · 2021 - Present Duke Regeneration Center, Basic Science Departments

In the News


Published February 25, 2025
Three Engineering Projects to Build Greener Materials
Published November 12, 2024
Injecting Hope
Published December 5, 2023
Protecting Bones from Cancer Treatment

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Recent Publications


Enabling adenosine signaling to promote aged fracture healing.

Journal Article NPJ Regenerative medicine · April 2025 Bone fractures and related complications are a significant concern for older adults, particularly with the growing aging population. Therapeutic interventions that promote bone tissue regeneration are attractive for geriatric fracture repair. Extracellular ... Full text Cite

Depletion of senescent cells improves surgery-induced neuroinflammation in aged mice

Journal Article PNAS Nexus · March 27, 2025 AbstractAging has been identified as a leading risk factor for many diseases, including neurodegenerative disorders. While cellular senescence has been linked to age-related neurodegenerative conditions, its ... Full text Cite

Extensive Periosteal Injury During Fracture Induces Long-Term Pain in Mice.

Journal Article J Orthop Res · March 10, 2025 Bone fractures pose a significant public health challenge, often necessitating surgical interventions to facilitate bone healing and functional recovery. Sensory nerve fibers innervate various compartments of the bone tissue, with the periosteum exhibiting ... Full text Link to item Cite
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Recent Grants


Boston Children's/UCLA/Duke Next Generation Regeneration for Osteoarthritis (BUD NextGenRegen for OA)

ResearchSite Leader · Awarded by Advanced Research Projects Agency for Health · 2024 - 2029

Duke KURe Program

Inst. Training Prgm or CMEMentor · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2013 - 2028

Molecular engineering of HA-based lubricants for articular cartilage

ResearchPrincipal Investigator · Awarded by National Institute of Arthritis and Musculoskeletal and Skin Diseases · 2023 - 2028

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Education, Training & Certifications


National Chemical Laboratory (India) · 2002 Ph.D.

External Links


Varghese Lab