Skip to main content

Shyni Varghese

Laszlo Ormandy Distinguished Professor of Orthopaedic Surgery
Orthopaedic Surgery

Research Interests


Musculoskeletal tissue repair, disease biophysics and organ-on-a-chip technology

Selected Grants


Boston Children's/UCLA/Duke Next Generation Regeneration for Osteoarthritis (BUD NextGenRegen for OA)

ResearchSite Leader · Awarded by Advanced Research Projects Agency for Health · 2024 - 2029

Duke KURe Program

Inst. Training Prgm or CMEMentor · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2013 - 2028

Molecular engineering of HA-based lubricants for articular cartilage

ResearchPrincipal Investigator · Awarded by National Institute of Arthritis and Musculoskeletal and Skin Diseases · 2023 - 2028

Targeting the HIF-2 Signaling Pathway as a Radioprotective Strategy for Bone

ResearchCollaborator · Awarded by National Institute of Arthritis and Musculoskeletal and Skin Diseases · 2022 - 2027

University Training Program in Biomolecular and Tissue Engineering

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1994 - 2027

Localization of adenosine to promote fracture healing

ResearchPrincipal Investigator · Awarded by National Institute on Aging · 2022 - 2027

Supramolecular biomaterials for tuning the inflammatory properties of the complement system

ResearchCo Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2022 - 2027

Training Program in Developmental and Stem Cell Biology

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2001 - 2027

Modulation of local adenosine signaling to attenuate fracture pain

ResearchPrincipal Investigator · Awarded by National Institute of Arthritis and Musculoskeletal and Skin Diseases · 2021 - 2026

Targeting the metastasis initiating cell in undifferentiated pleomorphic sarcoma

ResearchCo Investigator · Awarded by National Cancer Institute · 2021 - 2026

Duke Center for Advancement of Child Health (CAtCH).

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2021 - 2026

Understanding the role of senescence on post-operative neuroinflammation

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2025

Acquisition of a Photoelectron Spectrometer (XPS) for Fundamental and Applied Biomedical Research, Education and Training

EquipmentMajor User · Awarded by North Carolina Biotechnology Center · 2024 - 2025

Acquisition of a VRS1250 Video-Rate Imaging Module for a Shared-Use Asylum-Cypher Atomic Force Microscope (AFM)

EquipmentMajor User · Awarded by North Carolina Biotechnology Center · 2023 - 2024

Nicotine Pouches: Chemical Composition, Toxicity and Behavioral Effects of a New Tobacco Product Category

ResearchCo Investigator · Awarded by National Institutes of Health · 2022 - 2024

Acquisition of a Biacore T200 Surface Plasmon Resonance Instrument for Shared Use

EquipmentMajor User · Awarded by North Carolina Biotechnology Center · 2022 - 2023

Adenosine A2B Receptor in Bone Health and Osteoporosis

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2017 - 2023

Bioinspired Synthetic Grafts for Bone Regeneration

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2017 - 2019

External Relationships


  • Burroughs Wellcome Foundation
  • Mehta Family Center for Engineering in medicine (MFCEM) at IIT Kanpur, India
  • Mehta Family Foundation
  • ONCO DiSCOVER
  • OsteoCure Therapeutics
  • Royal Society of Chemistry

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.