Templated mineralization of synthetic hydrogels for bone-like composite materials: role of matrix hydrophobicity.


Journal Article

Bone-mimetic mineral-polymer composite materials have several applications ranging from artificial bone grafts to scaffolds for bone tissue engineering; templated mineralization is an effective approach to fabricate such composites. In this study, we synthesized bone-like composites using synthetic hydrogels having pendant side chains terminating with carboxyl groups as a template for mineralization. The role of matrix hydrophobicity on mineralization was examined using poly(ethylene glycol) hydrogels modified with varying lengths of anionic pendant side chains (CH(2) horizontal lineCHCONH(CH(2))(n)COOH, where n = 1, 3, 5, and 7). The ability of these hydrogels to undergo templated mineralization was found to be strongly dependent upon the length of the pendant side chain as is evident from the extent of calcification and morphology of the minerals. Moreover, mineralized phases formed on the hydrogels were confirmed to resemble apatite-like structures. In addition to demonstrating the importance of material hydrophobicity as a design parameter for the development of bone-like synthetic materials, our study also provides a potential explanation for the in vitro differences between the apatite-nucleating capacity of aspartate-rich osteopontin and glutamate-rich bone sialoprotein.

Full Text

Duke Authors

Cited Authors

  • Phadke, A; Zhang, C; Hwang, Y; Vecchio, K; Varghese, S

Published Date

  • August 9, 2010

Published In

Volume / Issue

  • 11 / 8

Start / End Page

  • 2060 - 2068

PubMed ID

  • 20690714

Pubmed Central ID

  • 20690714

Electronic International Standard Serial Number (EISSN)

  • 1526-4602

Digital Object Identifier (DOI)

  • 10.1021/bm100425p


  • eng

Conference Location

  • United States