Multifunctional chondroitin sulphate for cartilage tissue-biomaterial integration.

Journal Article (Journal Article)

A biologically active, high-strength tissue adhesive is needed for numerous medical applications in tissue engineering and regenerative medicine. Integration of biomaterials or implants with surrounding native tissue is crucial for both immediate functionality and long-term performance of the tissue. Here, we use the biopolymer chondroitin sulphate (CS), one of the major components of cartilage extracellular matrix, to develop a novel bioadhesive that is readily applied and acts quickly. CS was chemically functionalized with methacrylate and aldehyde groups on the polysaccharide backbone to chemically bridge biomaterials and tissue proteins via a twofold covalent link. Three-dimensional hydrogels (with and without cells) bonded to articular cartilage defects. In in vitro and in vivo functional studies this approach led to mechanical stability of the hydrogel and tissue repair in cartilage defects.

Full Text

Duke Authors

Cited Authors

  • Wang, D-A; Varghese, S; Sharma, B; Strehin, I; Fermanian, S; Gorham, J; Fairbrother, DH; Cascio, B; Elisseeff, JH

Published Date

  • May 2007

Published In

Volume / Issue

  • 6 / 5

Start / End Page

  • 385 - 392

PubMed ID

  • 17435762

Pubmed Central ID

  • PMC8128046

International Standard Serial Number (ISSN)

  • 1476-1122

Digital Object Identifier (DOI)

  • 10.1038/nmat1890


  • eng

Conference Location

  • England