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Controlled differentiation of stem cells.

Publication ,  Journal Article
Hwang, NS; Varghese, S; Elisseeff, J
Published in: Adv Drug Deliv Rev
January 14, 2008

The extracellular microenvironment plays a significant role in controlling cellular behavior. Identification of appropriate biomaterials that support cellular attachment, proliferation and, most importantly in the case of human embryonic stem cells, lineage-specific differentiation is critical for tissue engineering and cellular therapy. In addition to growth factors and morphogenetic factors known to induce lineage commitment of stem cells, a number of scaffolding materials, including synthetic and naturally-derived biomaterials, have been utilized in tissue engineering approaches to direct differentiation. This review focuses on recent emerging findings and well-characterized differentiation models of human embryonic stem cells. Additionally, we also discuss about various strategies that have been used in stem cell expansion.

Duke Scholars

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Published In

Adv Drug Deliv Rev

DOI

ISSN

0169-409X

Publication Date

January 14, 2008

Volume

60

Issue

2

Start / End Page

199 / 214

Location

Netherlands

Related Subject Headings

  • Tissue Scaffolds
  • Tissue Engineering
  • Pharmacology & Pharmacy
  • Intercellular Signaling Peptides and Proteins
  • Humans
  • Embryonic Stem Cells
  • Cell Differentiation
  • Cell Culture Techniques
  • Biocompatible Materials
  • 3214 Pharmacology and pharmaceutical sciences
 

Citation

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Hwang, N. S., Varghese, S., & Elisseeff, J. (2008). Controlled differentiation of stem cells. Adv Drug Deliv Rev, 60(2), 199–214. https://doi.org/10.1016/j.addr.2007.08.036
Hwang, Nathaniel S., Shyni Varghese, and Jennifer Elisseeff. “Controlled differentiation of stem cells.Adv Drug Deliv Rev 60, no. 2 (January 14, 2008): 199–214. https://doi.org/10.1016/j.addr.2007.08.036.
Hwang NS, Varghese S, Elisseeff J. Controlled differentiation of stem cells. Adv Drug Deliv Rev. 2008 Jan 14;60(2):199–214.
Hwang, Nathaniel S., et al. “Controlled differentiation of stem cells.Adv Drug Deliv Rev, vol. 60, no. 2, Jan. 2008, pp. 199–214. Pubmed, doi:10.1016/j.addr.2007.08.036.
Hwang NS, Varghese S, Elisseeff J. Controlled differentiation of stem cells. Adv Drug Deliv Rev. 2008 Jan 14;60(2):199–214.
Journal cover image

Published In

Adv Drug Deliv Rev

DOI

ISSN

0169-409X

Publication Date

January 14, 2008

Volume

60

Issue

2

Start / End Page

199 / 214

Location

Netherlands

Related Subject Headings

  • Tissue Scaffolds
  • Tissue Engineering
  • Pharmacology & Pharmacy
  • Intercellular Signaling Peptides and Proteins
  • Humans
  • Embryonic Stem Cells
  • Cell Differentiation
  • Cell Culture Techniques
  • Biocompatible Materials
  • 3214 Pharmacology and pharmaceutical sciences