Controlled differentiation of stem cells.

Journal Article (Journal Article;Review)

The extracellular microenvironment plays a significant role in controlling cellular behavior. Identification of appropriate biomaterials that support cellular attachment, proliferation and, most importantly in the case of human embryonic stem cells, lineage-specific differentiation is critical for tissue engineering and cellular therapy. In addition to growth factors and morphogenetic factors known to induce lineage commitment of stem cells, a number of scaffolding materials, including synthetic and naturally-derived biomaterials, have been utilized in tissue engineering approaches to direct differentiation. This review focuses on recent emerging findings and well-characterized differentiation models of human embryonic stem cells. Additionally, we also discuss about various strategies that have been used in stem cell expansion.

Full Text

Duke Authors

Cited Authors

  • Hwang, NS; Varghese, S; Elisseeff, J

Published Date

  • January 14, 2008

Published In

Volume / Issue

  • 60 / 2

Start / End Page

  • 199 - 214

PubMed ID

  • 18006108

Pubmed Central ID

  • PMC2712932

International Standard Serial Number (ISSN)

  • 0169-409X

Digital Object Identifier (DOI)

  • 10.1016/j.addr.2007.08.036


  • eng

Conference Location

  • Netherlands