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Haloperidol versus ondansetron for prophylaxis of postoperative nausea and vomiting.

Publication ,  Journal Article
Rosow, CE; Haspel, KL; Smith, SE; Grecu, L; Bittner, EA
Published in: Anesth Analg
May 2008

BACKGROUND: Haloperidol is effective for postoperative nausea and vomiting prophylaxis, but there are almost no data comparing it to 5-HT(3) antagonists. METHODS: Two hundred forty-four adults were randomized to receive i.v. haloperidol 1 mg or ondansetron 4 mg, during general anesthesia. Nausea, vomiting, need for rescue, sedation, extrapyramidal effects, QTc intervals, and time to postanesthesia care unit discharge were evaluated with a third-party blind design. RESULTS: There was no intergroup difference in any measure of efficacy or toxicity. Haloperidol and ondansetron subjects (78.2% and 76.8%) had complete response. Postoperatively, prolonged QTc occurred in 28.9% and 22.1% (N.S.). CONCLUSIONS: In a mixed surgical population, the efficacy and toxicity of postoperative nausea and vomiting prophylaxis with haloperidol 1 mg was not significantly different from ondansetron 4 mg.

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Published In

Anesth Analg

DOI

EISSN

1526-7598

Publication Date

May 2008

Volume

106

Issue

5

Start / End Page

1407 / 1409

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Serotonin Antagonists
  • Serotonin 5-HT3 Receptor Antagonists
  • Receptors, Serotonin, 5-HT3
  • Postoperative Nausea and Vomiting
  • Ondansetron
  • Middle Aged
  • Male
  • Humans
  • Heart Conduction System
 

Citation

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Rosow, C. E., Haspel, K. L., Smith, S. E., Grecu, L., & Bittner, E. A. (2008). Haloperidol versus ondansetron for prophylaxis of postoperative nausea and vomiting. Anesth Analg, 106(5), 1407–1409. https://doi.org/10.1213/ane.0b013e3181609022
Rosow, Carl E., Kenneth L. Haspel, Sarah E. Smith, Loreta Grecu, and Edward A. Bittner. “Haloperidol versus ondansetron for prophylaxis of postoperative nausea and vomiting.Anesth Analg 106, no. 5 (May 2008): 1407–9. https://doi.org/10.1213/ane.0b013e3181609022.
Rosow CE, Haspel KL, Smith SE, Grecu L, Bittner EA. Haloperidol versus ondansetron for prophylaxis of postoperative nausea and vomiting. Anesth Analg. 2008 May;106(5):1407–9.
Rosow, Carl E., et al. “Haloperidol versus ondansetron for prophylaxis of postoperative nausea and vomiting.Anesth Analg, vol. 106, no. 5, May 2008, pp. 1407–09. Pubmed, doi:10.1213/ane.0b013e3181609022.
Rosow CE, Haspel KL, Smith SE, Grecu L, Bittner EA. Haloperidol versus ondansetron for prophylaxis of postoperative nausea and vomiting. Anesth Analg. 2008 May;106(5):1407–1409.

Published In

Anesth Analg

DOI

EISSN

1526-7598

Publication Date

May 2008

Volume

106

Issue

5

Start / End Page

1407 / 1409

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Serotonin Antagonists
  • Serotonin 5-HT3 Receptor Antagonists
  • Receptors, Serotonin, 5-HT3
  • Postoperative Nausea and Vomiting
  • Ondansetron
  • Middle Aged
  • Male
  • Humans
  • Heart Conduction System