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Pyridoxine-dependent seizures and cognition in adulthood.

Publication ,  Journal Article
Baynes, K; Farias, ST; Gospe, SM
Published in: Dev Med Child Neurol
November 2003

A case report of neonatal onset pyridoxine-dependent seizures in a male patient with early diagnosis and treatment is presented. The patient's epilepsy was recognized and treated with pyridoxine (vitamin B6) within 8 hours of birth. Treatment has been nearly continuous since that time. This paper reports the results of a full neuropsychological evaluation at age 37 years and MRI completed at age 31 years. Consistent with other case reports in the literature, there was a significant Performance IQ (PIQ) advantage with decreased Verbal IQ (VIQ) and expressive language skills (Full-Scale IQ 71, VIQ 64, PIQ 85). MRI demonstrated characteristic thinning of the posterior corpus callosum. This report provides an example of early treatment that nonetheless results in a mild mental retardation. The similarity of the structural changes on MRI and the cognitive profile of this patient to those of others reported in the literature suggest that the underlying mechanism for both may be the same.

Duke Scholars

Published In

Dev Med Child Neurol

DOI

ISSN

0012-1622

Publication Date

November 2003

Volume

45

Issue

11

Start / End Page

782 / 785

Location

England

Related Subject Headings

  • Severity of Illness Index
  • Pyridoxine
  • Pediatrics
  • Neuropsychological Tests
  • Male
  • Magnetic Resonance Imaging
  • Intellectual Disability
  • Humans
  • Epilepsy
  • Electroencephalography
 

Citation

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Baynes, K., Farias, S. T., & Gospe, S. M. (2003). Pyridoxine-dependent seizures and cognition in adulthood. Dev Med Child Neurol, 45(11), 782–785. https://doi.org/10.1017/s0012162203001440
Baynes, Kathleen, Sarah Tomaszewski Farias, and Sidney M. Gospe. “Pyridoxine-dependent seizures and cognition in adulthood.Dev Med Child Neurol 45, no. 11 (November 2003): 782–85. https://doi.org/10.1017/s0012162203001440.
Baynes K, Farias ST, Gospe SM. Pyridoxine-dependent seizures and cognition in adulthood. Dev Med Child Neurol. 2003 Nov;45(11):782–5.
Baynes, Kathleen, et al. “Pyridoxine-dependent seizures and cognition in adulthood.Dev Med Child Neurol, vol. 45, no. 11, Nov. 2003, pp. 782–85. Pubmed, doi:10.1017/s0012162203001440.
Baynes K, Farias ST, Gospe SM. Pyridoxine-dependent seizures and cognition in adulthood. Dev Med Child Neurol. 2003 Nov;45(11):782–785.
Journal cover image

Published In

Dev Med Child Neurol

DOI

ISSN

0012-1622

Publication Date

November 2003

Volume

45

Issue

11

Start / End Page

782 / 785

Location

England

Related Subject Headings

  • Severity of Illness Index
  • Pyridoxine
  • Pediatrics
  • Neuropsychological Tests
  • Male
  • Magnetic Resonance Imaging
  • Intellectual Disability
  • Humans
  • Epilepsy
  • Electroencephalography