Exploring the Untapped Biosynthetic Potential of Apicomplexan Parasites.

Published

Journal Article (Review)

Apicomplexan parasites encompass a diverse group of eukaryotic intracellular pathogens that infect various animal hosts to cause disease. Intriguingly, apicomplexans possess a unique organelle of algal origin, the apicoplast, which phylogenetically links these parasites to dinoflagellates and photosynthetic, coral-associated organisms. While production of secondary metabolites in closely related organisms has been thoroughly examined, it remains widely unexplored in apicomplexans. In this Perspective, we discuss previous work toward understanding secondary metabolite building block biosynthesis in apicomplexans and highlight the unexplored enzymology and biosynthetic potential of these parasites in the context of evolution.

Full Text

Duke Authors

Cited Authors

  • Ganley, JG; Toro-Moreno, M; Derbyshire, ER

Published Date

  • January 2018

Published In

Volume / Issue

  • 57 / 4

Start / End Page

  • 365 - 375

PubMed ID

  • 28976181

Pubmed Central ID

  • 28976181

Electronic International Standard Serial Number (EISSN)

  • 1520-4995

International Standard Serial Number (ISSN)

  • 0006-2960

Digital Object Identifier (DOI)

  • 10.1021/acs.biochem.7b00877

Language

  • eng