Emily R. Derbyshire | Scholars@Duke

Emily R. Derbyshire
Assistant Professor of Chemistry

The Derbyshire Lab uses both chemical tools and biological methods to uncover novel aspects of malaria parasite biology with the ultimate aim of identifying druggable targets. Projects range from developing assays for phenotypic and target-based screens to exploring biological pathways and identifying small molecules with potential therapeutic value. Their interdisciplinary collaborative program integrates chemical biology, molecular biology and biochemistry to globally interrogate parasite biology.

Current Appointments & Affiliations

Assistant Professor of Chemistry, Chemistry, Trinity College of Arts & Sciences 2014
Assistant Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2014

Contact Information

3218 French Science Center, Durham, NC 27708
emily.derbyshire@duke.edu (919) 660-1511
Derbyshire Research Group

Background
Education, Training, & Certifications
- NIH Postdoctoral Fellow, Biological Chemistry & Molecular Pharmacology, Harvard Medical School 2009 - 2014
- Ph.D., University of California at Berkeley 2008
- B.S., Trinity College 2002
Duke Appointment History
- Scholar in Residence in the Department of Chemistry, Chemistry, Trinity College of Arts & Sciences 2013 - 2014
Recognition
In the News
- OCT 5, 2017
  
  Two Duke Faculty Win NIH New Innovator Awards
- JAN 11, 2017
  
  Chemistry Professor Wins 2017 Marion Milligan Mason Award
- OCT 2, 2014
  
  Emily Derbyshire: Prospecting for Malaria Drugs
- AUG 25, 2014
  
  Cancer-Fighting Drugs Might Also Stop Malaria Early
Publications & Artistic Works
Selected Publications
- Journal Articles
  - Posfai, D, Eubanks, AL, Keim, AI, Lu, K-Y, Wang, GZ, Hughes, PF, Kato, N, Haystead, TA, and Derbyshire, ER. "Identification of Hsp90 inhibitors with anti-Plasmodium activity." Antimicrobial agents and chemotherapy (January 16, 2018). Full Text
  - Totzke, J, Gurbani, D, Raphemot, R, Hughes, PF, Bodoor, K, Carlson, DA, Loiselle, DR, Bera, AK, Eibschutz, LS, Perkins, MM, Eubanks, AL, Campbell, PL, Fox, DA, Westover, KD, Haystead, TAJ, and Derbyshire, ER. "Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease." Cell chemical biology 24, no. 8 (August 2017): 1029-1039.e7. Full Text
  - Kato, N, Comer, E, Sakata-Kato, T, Sharma, A, Sharma, M, Maetani, M, Bastien, J, Brancucci, NM, Bittker, JA, Corey, V, Clarke, D, Derbyshire, ER, Dornan, GL, Duffy, S, Eckley, S, Itoe, MA, Koolen, KMJ, Lewis, TA, Lui, PS, Lukens, AK, Lund, E, March, S, Meibalan, E, Meier, BC, McPhail, JA, Mitasev, B, Moss, EL, Sayes, M, Van Gessel, Y, Wawer, MJ, Yoshinaga, T, Zeeman, A-M, Avery, VM, Bhatia, SN, Burke, JE, Catteruccia, F, Clardy, JC, Clemons, PA, Dechering, KJ, Duvall, JR, Foley, MA, and Gusovsky, F et al. "Diversity-oriented synthesis yields novel multistage antimalarial inhibitors." Nature 538, no. 7625 (October 2016): 344-349. Full Text
  - Raphemot, R, Posfai, D, and Derbyshire, ER. "Current therapies and future possibilities for drug development against liver-stage malaria." The Journal of clinical investigation 126, no. 6 (June 2016): 2013-2020. (Review) Full Text
  - Raphemot, R, Lafuente-Monasterio, MJ, Gamo-Benito, FJ, Clardy, J, and Derbyshire, ER. "Discovery of Dual-Stage Malaria Inhibitors with New Targets." Antimicrobial agents and chemotherapy 60, no. 3 (December 14, 2015): 1430-1437. Full Text
  - Herman, JD, Pepper, LR, Cortese, JF, Estiu, G, Galinsky, K, Zuzarte-Luis, V, Derbyshire, ER, Ribacke, U, Lukens, AK, Santos, SA, Patel, V, Clish, CB, Sullivan, WJ, Zhou, H, Bopp, SE, Schimmel, P, Lindquist, S, Clardy, J, Mota, MM, Keller, TL, Whitman, M, Wiest, O, Wirth, DF, and Mazitschek, R. "The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs." Science translational medicine 7, no. 288 (May 2015): 288ra77-. Full Text
  - Derbyshire, ER, Zuzarte-Luís, V, Magalhães, AD, Kato, N, Sanschagrin, PC, Wang, J, Zhou, W, Miduturu, CV, Mazitschek, R, Sliz, P, Mota, MM, Gray, NS, and Clardy, J. "Chemical interrogation of the malaria kinome." Chembiochem : a European journal of chemical biology 15, no. 13 (September 2014): 1920-1930. Full Text
  - Derbyshire, ER, Min, J, Guiguemde, WA, Clark, JA, Connelly, MC, Magalhães, AD, Guy, RK, and Clardya, J. "Dihydroquinazolinone inhibitors of proliferation of blood and liver stage malaria parasites." Antimicrobial Agents and Chemotherapy 58, no. 3 (March 1, 2014): 1516-1522. Full Text
  - Derbyshire, ER, Min, J, Guiguemde, WA, Clark, JA, Connelly, MC, Magalhães, AD, Guy, RK, and Clardy, J. "Dihydroquinazolinone inhibitors of proliferation of blood and liver stage malaria parasites." Antimicrob Agents Chemother 58, no. 3 (2014): 1516-1522. Full Text Link to Item
  - Derbyshire, ER, and Clardy, J. "Closing in on a new treatment for sleeping sickness. (Published online)" Elife 2 (July 9, 2013): e01042-. Full Text Link to Item
  - Fernhoff, NB, Derbyshire, ER, Underbakke, ES, and Marletta, MA. "Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide." J Biol Chem 287, no. 51 (December 14, 2012): 43053-43062. Full Text Link to Item
  - Carr, G, Derbyshire, ER, Caldera, E, Currie, CR, and Clardy, J. "Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp." J Nat Prod 75, no. 10 (October 26, 2012): 1806-1809. Full Text Link to Item
  - Gunn, A, Derbyshire, ER, Marletta, MA, and Britt, RD. "Conformationally distinct five-coordinate heme-NO complexes of soluble guanylate cyclase elucidated by multifrequency electron paramagnetic resonance (EPR)." Biochemistry 51, no. 42 (October 23, 2012): 8384-8390. Full Text Link to Item
  - Derbyshire, ER, Prudêncio, M, Mota, MM, and Clardy, J. "Liver-stage malaria parasites vulnerable to diverse chemical scaffolds." Proc Natl Acad Sci U S A 109, no. 22 (May 29, 2012): 8511-8516. Full Text Link to Item
  - Derbyshire, ER, Mazitschek, R, and Clardy, J. "Characterization of Plasmodium liver stage inhibition by halofuginone." ChemMedChem 7, no. 5 (May 2012): 844-849. Full Text Link to Item
  - Derbyshire, ER, and Marletta, MA. "Structure and regulation of soluble guanylate cyclase." Annu Rev Biochem 81 (2012): 533-559. (Review) Full Text Link to Item
  - Dong, CK, Urgaonkar, S, Cortese, JF, Gamo, F-J, Garcia-Bustos, JF, Lafuente, MJ, Patel, V, Ross, L, Coleman, BI, Derbyshire, ER, Clish, CB, Serrano, AE, Cromwell, M, Barker, RH, Dvorin, JD, Duraisingh, MT, Wirth, DF, Clardy, J, and Mazitschek, R. "Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors." Chem Biol 18, no. 12 (December 23, 2011): 1602-1610. Full Text Link to Item
  - Derbyshire, ER, Mota, MM, and Clardy, J. "The next opportunity in anti-malaria drug discovery: the liver stage." PLoS Pathog 7, no. 9 (September 2011): e1002178-. Full Text Link to Item
  - Derbyshire, ER, Winter, MB, Ibrahim, M, Deng, S, Spiro, TG, and Marletta, MA. "Probing domain interactions in soluble guanylate cyclase." Biochemistry 50, no. 20 (May 24, 2011): 4281-4290. Full Text Link to Item
  - Ibrahim, M, Derbyshire, ER, Soldatova, AV, Marletta, MA, and Spiro, TG. "Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidence." Biochemistry 49, no. 23 (June 15, 2010): 4864-4871. Full Text Link to Item
  - Derbyshire, ER, Deng, S, and Marletta, MA. "Incorporation of tyrosine and glutamine residues into the soluble guanylate cyclase heme distal pocket alters NO and O2 binding." J Biol Chem 285, no. 23 (June 4, 2010): 17471-17478. Full Text Link to Item
  - Ibrahim, M, Derbyshire, ER, Marletta, MA, and Spiro, TG. "Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy." Biochemistry 49, no. 18 (May 11, 2010): 3815-3823. Full Text Link to Item
  - Fernhoff, NB, Derbyshire, ER, and Marletta, MA. "A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase." Proc Natl Acad Sci U S A 106, no. 51 (December 22, 2009): 21602-21607. Full Text Link to Item
  - Derbyshire, ER, Fernhoff, NB, Deng, S, and Marletta, MA. "Nucleotide regulation of soluble guanylate cyclase substrate specificity." Biochemistry 48, no. 31 (August 11, 2009): 7519-7524. Full Text Link to Item
  - Ibrahim, M, Derbyshire, ER, Marletta, MA, and Spiro, TG. "Interaction of allosteric effectors with soluble guanylate cyclase heme domains: Role of heme distortion and propionate hydrogen bonding on synergistic activation." ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 237 (March 22, 2009). Link to Item
  - Derbyshire, ER, and Marletta, MA. "Biochemistry of soluble guanylate cyclase." Handb Exp Pharmacol , no. 191 (2009): 17-31. (Review) Full Text Link to Item
  - Winger, JA, Derbyshire, ER, Lamers, MH, Marletta, MA, and Kuriyan, J. "The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase. (Published online)" BMC Struct Biol 8 (October 7, 2008): 42-. Full Text Link to Item
  - Derbyshire, ER, Gunn, A, Ibrahim, M, Spiro, TG, Britt, RD, and Marletta, MA. "Characterization of two different five-coordinate soluble guanylate cyclase ferrous-nitrosyl complexes." Biochemistry 47, no. 12 (March 25, 2008): 3892-3899. Full Text Link to Item
  - Derbyshire, ER, and Marletta, MA. "Butyl isocyanide as a probe of the activation mechanism of soluble guanylate cyclase. Investigating the role of non-heme nitric oxide." J Biol Chem 282, no. 49 (December 7, 2007): 35741-35748. Full Text Link to Item
  - Martin, NI, Derbyshire, ER, and Marletta, MA. "Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1." Bioorg Med Chem Lett 17, no. 17 (September 1, 2007): 4938-4941. Full Text Link to Item
  - Winger, JA, Derbyshire, ER, and Marletta, MA. "Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs." J Biol Chem 282, no. 2 (January 12, 2007): 897-907. Full Text Link to Item
  - Cary, SPL, Winger, JA, Derbyshire, ER, and Marletta, MA. "Nitric oxide signaling: no longer simply on or off." Trends Biochem Sci 31, no. 4 (April 2006): 231-239. (Review) Full Text Link to Item
  - Derbyshire, ER, Tran, R, Mathies, RA, and Marletta, MA. "Characterization of nitrosoalkane binding and activation of soluble guanylate cyclase." Biochemistry 44, no. 49 (December 13, 2005): 16257-16265. Full Text Link to Item
Teaching & Mentoring
Recent Courses
- CHEM 393: Research Independent Study 2018
- CHEM 394: Research Independent Study 2018
- CHEM 493: Research Independent Study 2018
- CHEM 494: Research Independent Study 2018
- CHEM 517: Molecules in Life and Disease 2018
- MGM 293: Research Independent Study I 2018
- MGM 593: Research Independent Study 2018

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Education, Training, & Certifications

Duke Appointment History

In the News

Selected Publications

Journal Articles

Recent Courses