https://orcid.org/0000-0001-6664-8844
Overview
The Derbyshire Lab uses both chemical tools and biological methods to uncover novel aspects of malaria parasite biology with the ultimate aim of identifying druggable targets. Projects range from developing assays for phenotypic and target-based screens to exploring biological pathways and identifying small molecules with potential therapeutic value. Their interdisciplinary collaborative program integrates chemical biology, molecular biology and biochemistry to globally interrogate parasite biology.
Current Duke Appointments & Affiliations
Pelham Wilder Distinguished Professor of Chemistry
·
2026 - Present
Chemistry,
Trinity College of Arts & Sciences
Professor of Chemistry
·
2024 - Present
Chemistry,
Trinity College of Arts & Sciences
Professor of Molecular Genetics and Microbiology
·
2024 - Present
Molecular Genetics and Microbiology,
Basic Science Departments
Associate Professor of Cell Biology
·
2022 - Present
Cell Biology,
Basic Science Departments
Associate of the Duke Initiative for Science & Society
·
2021 - Present
Duke Science & Society,
University Initiatives & Academic Support Units
Bass Fellow
·
2026 - Present
Chemistry,
Trinity College of Arts & Sciences
Recent Scholarly Works
Development of domain-specific probes of Plasmodium falciparum heat shock protein 70-1.
Journal article Antimicrob Agents Chemother · August 5, 2026 In the malaria parasite Plasmodium falciparum, the essential chaperone PfHsp70-1 regulates proteostasis through protein folding, but its domain-specific functions remain poorly defined. The protein contains an N-terminal nucleotide-binding domain (NBD) and ... Full text Link to item CiteCorrection to "Hyperpolarized 15N2-Diazirine-Tagged MRI Probe for Monitoring γ-Glutamyl Transferase Activity".
Journal article ACS sensors · August 2026 Full text CiteVAMP3 vesicles support host protein recruitment and <i>Plasmodium</i> liver stage development.
Journal article mBio · August 2026 Plasmodium remodels the host liver cell as an obligatory step in malaria infection. Although several host proteins are recruited to the parasitophorous vacuole membrane (PVM) after invasion, the mechanisms underlying this acquisition remain unknown. ... Full text CiteEducation
University of California, Berkeley ·
2008
Ph.D.
Trinity College ·
2002
B.S.