Emily R. Derbyshire | Scholars@Duke

Emily R. Derbyshire
Assistant Professor of Chemistry

The Derbyshire Lab uses both chemical tools and biological methods to uncover novel aspects of malaria parasite biology with the ultimate aim of identifying druggable targets. Projects range from developing assays for phenotypic and target-based screens to exploring biological pathways and identifying small molecules with potential therapeutic value. Their interdisciplinary collaborative program integrates chemical biology, molecular biology and biochemistry to globally interrogate parasite biology.

Current Appointments & Affiliations

Assistant Professor of Chemistry, Chemistry, Trinity College of Arts & Sciences 2014
Assistant Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2014

Contact Information

3218 French Science Center, Durham, NC 27708
emily.derbyshire@duke.edu (919) 660-1511
Derbyshire Research Group

Background
Education, Training, & Certifications
- NIH Postdoctoral Fellow, Biological Chemistry & Molecular Pharmacology, Harvard Medical School 2009 - 2014
- Ph.D., University of California at Berkeley 2008
- B.S., Trinity College 2002
Duke Appointment History
- Scholar in Residence in the Department of Chemistry, Chemistry, Trinity College of Arts & Sciences 2013 - 2014
Recognition
In the News
- JUN 27, 2019
  
  Malaria Parasites Hijack Your Genes to Set up Camp Inside Your Liver
- MAY 22, 2018
  
  Malaria-Causing Parasite Manipulates Liver Cells to Survive
- OCT 5, 2017
  
  Two Duke Faculty Win NIH New Innovator Awards
- JAN 11, 2017
  
  Chemistry Professor Wins 2017 Marion Milligan Mason Award
- OCT 2, 2014
  
  Emily Derbyshire: Prospecting for Malaria Drugs
- AUG 25, 2014
  
  Cancer-Fighting Drugs Might Also Stop Malaria Early
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Raphemot, Rene, Maria Toro-Moreno, Kuan-Yi Lu, Dora Posfai, and Emily Rose Derbyshire. “Discovery of Druggable Host Factors Critical to Plasmodium Liver-Stage Infection..” Cell Chemical Biology, June 12, 2019. https://doi.org/10.1016/j.chembiol.2019.05.011.
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  - Szamosvári, Dávid, Kayla Sylvester, Philipp Schmid, Kuan-Yi Lu, Emily R. Derbyshire, and Thomas Böttcher. “Close the ring to break the cycle: tandem quinolone-alkyne-cyclisation gives access to tricyclic pyrrolo[1,2-a]quinolin-5-ones with potent anti-protozoal activity..” Chemical Communications (Cambridge, England) 55, no. 49 (June 2019): 7009–12. https://doi.org/10.1039/c9cc01689a.
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  - Lee, Hyunji, Kayla Sylvester, Emily R. Derbyshire, and Jiyong Hong. “Synthesis and Analysis of Natural-Product-Like Macrocycles by Tandem Oxidation/Oxa-Conjugate Addition Reactions..” Chemistry (Weinheim an Der Bergstrasse, Germany) 25, no. 26 (May 2019): 6500–6504. https://doi.org/10.1002/chem.201900620.
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  - Raphemot, Rene, Amber Leigh Eubanks, Maria Toro-Moreno, Rechel Anne Geiger, Philip Floyd Hughes, Kuan-Yi Lu, Timothy Arthur James Haystead, and Emily Rose Derbyshire. “Plasmodium PK9 Inhibitors Promote Growth of Liver-Stage Parasites..” Cell Chem Biol 26, no. 3 (March 21, 2019): 411-419.e7. https://doi.org/10.1016/j.chembiol.2018.11.003.
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  - Eubanks, Amber L., Marisha M. Perkins, Kayla Sylvester, Jack G. Ganley, Dora Posfai, Paul C. Sanschargrin, Jiyong Hong, Piotr Sliz, and Emily R. Derbyshire. “In silico Screening and Evaluation of Plasmodium falciparum Protein Kinase 5 (PK5) Inhibitors..” Chemmedchem 13, no. 23 (December 2018): 2479–83. https://doi.org/10.1002/cmdc.201800625.
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  - Ganley, Jack G., Gavin Carr, Thomas R. Ioerger, James C. Sacchettini, Jon Clardy, and Emily R. Derbyshire. “Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes..” Chembiochem : A European Journal of Chemical Biology 19, no. 15 (August 2018): 1590–94. https://doi.org/10.1002/cbic.201800124.
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  - Posfai, Dora, Kayla Sylvester, Anupama Reddy, Jack G. Ganley, Johannes Wirth, Quinlan E. Cullen, Tushar Dave, Nobutaka Kato, Sandeep S. Dave, and Emily R. Derbyshire. “Plasmodium parasite exploits host aquaporin-3 during liver stage malaria infection..” Plos Pathog 14, no. 5 (May 2018). https://doi.org/10.1371/journal.ppat.1007057.
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  - Posfai, Dora, Kayla Sylvester, Anupama Reddy, Jack G. Ganley, Johannes Wirth, Quinlan E. Cullen, Tushar Dave, Nobutaka Kato, Sandeep S. Dave, and Emily R. Derbyshire. “Plasmodium parasite exploits host aquaporin-3 during liver stage malaria infection.” Plos Pathogens 14, no. 5 (May 1, 2018). https://doi.org/10.1371/journal.ppat.100757.
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  - Posfai, Dora, Amber L. Eubanks, Allison I. Keim, Kuan-Yi Lu, Grace Z. Wang, Philip F. Hughes, Nobutaka Kato, Timothy A. Haystead, and Emily R. Derbyshire. “Identification of Hsp90 Inhibitors with Anti-Plasmodium Activity..” Antimicrob Agents Chemother 62, no. 4 (April 2018). https://doi.org/10.1128/AAC.01799-17.
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  - Ganley, Jack G., Maria Toro-Moreno, and Emily R. Derbyshire. “Exploring the Untapped Biosynthetic Potential of Apicomplexan Parasites..” Biochemistry 57, no. 4 (January 2018): 365–75. https://doi.org/10.1021/acs.biochem.7b00877.
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  - Totzke, Juliane, Deepak Gurbani, Rene Raphemot, Philip F. Hughes, Khaldon Bodoor, David A. Carlson, David R. Loiselle, et al. “Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease..” Cell Chem Biol 24, no. 8 (August 17, 2017): 1029-1039.e7. https://doi.org/10.1016/j.chembiol.2017.07.011.
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  - Kato, Nobutaka, Eamon Comer, Tomoyo Sakata-Kato, Arvind Sharma, Manmohan Sharma, Micah Maetani, Jessica Bastien, et al. “Diversity-oriented synthesis yields novel multistage antimalarial inhibitors..” Nature 538, no. 7625 (October 2016): 344–49. https://doi.org/10.1038/nature19804.
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  - Raphemot, Rene, Dora Posfai, and Emily R. Derbyshire. “Current therapies and future possibilities for drug development against liver-stage malaria..” The Journal of Clinical Investigation 126, no. 6 (June 2016): 2013–20. https://doi.org/10.1172/JCI82981.
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  - Raphemot, Rene, Maria J. Lafuente-Monasterio, Francisco Javier Gamo-Benito, Jon Clardy, and Emily R. Derbyshire. “Discovery of Dual-Stage Malaria Inhibitors with New Targets..” Antimicrobial Agents and Chemotherapy 60, no. 3 (December 14, 2015): 1430–37. https://doi.org/10.1128/AAC.02110-15.
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  - Herman, Jonathan D., Lauren R. Pepper, Joseph F. Cortese, Guillermina Estiu, Kevin Galinsky, Vanessa Zuzarte-Luis, Emily R. Derbyshire, et al. “The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs..” Science Translational Medicine 7, no. 288 (May 2015). https://doi.org/10.1126/scitranslmed.aaa3575.
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  - Derbyshire, Emily R., Vanessa Zuzarte-Luís, Andreia D. Magalhães, Nobutaka Kato, Paul C. Sanschagrin, Jinhua Wang, Wenjun Zhou, et al. “Chemical interrogation of the malaria kinome..” Chembiochem : A European Journal of Chemical Biology 15, no. 13 (September 2014): 1920–30. https://doi.org/10.1002/cbic.201400025.
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  - Derbyshire, E. R., J. Min, W. A. Guiguemde, J. A. Clark, M. C. Connelly, A. D. Magalhães, R. K. Guy, and J. Clardya. “Dihydroquinazolinone inhibitors of proliferation of blood and liver stage malaria parasites.” Antimicrobial Agents and Chemotherapy 58, no. 3 (March 1, 2014): 1516–22. https://doi.org/10.1128/AAC.02148-13.
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  - Derbyshire, Emily R., Jaeki Min, W Armand Guiguemde, Julie A. Clark, Michele C. Connelly, Andreia D. Magalhães, R Kiplin Guy, and Jon Clardy. “Dihydroquinazolinone inhibitors of proliferation of blood and liver stage malaria parasites..” Antimicrobial Agents and Chemotherapy 58, no. 3 (January 2014): 1516–22. https://doi.org/10.1128/AAC.02148-13.
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  - Derbyshire, Emily R., and Jon Clardy. “Closing in on a new treatment for sleeping sickness..” Elife 2 (January 2013). https://doi.org/10.7554/eLife.01042.
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  - Fernhoff, Nathaniel B., Emily R. Derbyshire, Eric S. Underbakke, and Michael A. Marletta. “Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide..” The Journal of Biological Chemistry 287, no. 51 (December 2012): 43053–62. https://doi.org/10.1074/jbc.M112.393892.
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  - Gunn, Alexander, Emily R. Derbyshire, Michael A. Marletta, and R David Britt. “Conformationally distinct five-coordinate heme-NO complexes of soluble guanylate cyclase elucidated by multifrequency electron paramagnetic resonance (EPR)..” Biochemistry 51, no. 42 (October 9, 2012): 8384–90. https://doi.org/10.1021/bi300831m.
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  - Carr, Gavin, Emily R. Derbyshire, Eric Caldera, Cameron R. Currie, and Jon Clardy. “Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp..” Journal of Natural Products 75, no. 10 (October 2012): 1806–9. https://doi.org/10.1021/np300380t.
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  - Derbyshire, Emily R., Miguel Prudêncio, Maria M. Mota, and Jon Clardy. “Liver-stage malaria parasites vulnerable to diverse chemical scaffolds..” Proceedings of the National Academy of Sciences of the United States of America 109, no. 22 (May 14, 2012): 8511–16. https://doi.org/10.1073/pnas.1118370109.
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  - Derbyshire, Emily R., Ralph Mazitschek, and Jon Clardy. “Characterization of Plasmodium liver stage inhibition by halofuginone..” Chemmedchem 7, no. 5 (May 2012): 844–49. https://doi.org/10.1002/cmdc.201200045.
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  - Derbyshire, Emily R., and Michael A. Marletta. “Structure and regulation of soluble guanylate cyclase..” Annual Review of Biochemistry 81 (January 2012): 533–59. https://doi.org/10.1146/annurev-biochem-050410-100030.
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  - Dong, Carolyn K., Sameer Urgaonkar, Joseph F. Cortese, Francisco-Javier Gamo, Jose F. Garcia-Bustos, Maria J. Lafuente, Vishal Patel, et al. “Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors..” Chemistry & Biology 18, no. 12 (December 2011): 1602–10. https://doi.org/10.1016/j.chembiol.2011.09.016.
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  - Derbyshire, Emily R., Maria M. Mota, and Jon Clardy. “The next opportunity in anti-malaria drug discovery: the liver stage..” Plos Pathogens 7, no. 9 (September 22, 2011). https://doi.org/10.1371/journal.ppat.1002178.
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  - Derbyshire, Emily R., Michael B. Winter, Mohammed Ibrahim, Sarah Deng, Thomas G. Spiro, and Michael A. Marletta. “Probing domain interactions in soluble guanylate cyclase..” Biochemistry 50, no. 20 (May 3, 2011): 4281–90. https://doi.org/10.1021/bi200341b.
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  - Derbyshire, Emily R., Sarah Deng, and Michael A. Marletta. “Incorporation of tyrosine and glutamine residues into the soluble guanylate cyclase heme distal pocket alters NO and O2 binding..” The Journal of Biological Chemistry 285, no. 23 (June 2010): 17471–78. https://doi.org/10.1074/jbc.M109.098269.
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  - Ibrahim, Mohammed, Emily R. Derbyshire, Alexandra V. Soldatova, Michael A. Marletta, and Thomas G. Spiro. “Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidence..” Biochemistry 49, no. 23 (June 2010): 4864–71. https://doi.org/10.1021/bi100506j.
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  - Ibrahim, Mohammed, Emily R. Derbyshire, Michael A. Marletta, and Thomas G. Spiro. “Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy..” Biochemistry 49, no. 18 (May 2010): 3815–23. https://doi.org/10.1021/bi902214j.
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  - Fernhoff, Nathaniel B., Emily R. Derbyshire, and Michael A. Marletta. “A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase..” Proceedings of the National Academy of Sciences of the United States of America 106, no. 51 (December 9, 2009): 21602–7. https://doi.org/10.1073/pnas.0911083106.
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  - Derbyshire, Emily R., Nathaniel B. Fernhoff, Sarah Deng, and Michael A. Marletta. “Nucleotide regulation of soluble guanylate cyclase substrate specificity..” Biochemistry 48, no. 31 (August 2009): 7519–24. https://doi.org/10.1021/bi900696x.
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  - Ibrahim, Mohammed, Emily R. Derbyshire, Michael A. Marletta, and Thomas G. Spiro. “Interaction of allosteric effectors with soluble guanylate cyclase heme domains: Role of heme distortion and propionate hydrogen bonding on synergistic activation.” Abstracts of Papers of the American Chemical Society 237 (March 22, 2009).
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  - Derbyshire, Emily R., and Michael A. Marletta. “Biochemistry of soluble guanylate cyclase..” Handbook of Experimental Pharmacology, no. 191 (January 2009): 17–31. https://doi.org/10.1007/978-3-540-68964-5_2.
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  - Winger, Jonathan A., Emily R. Derbyshire, Meindert H. Lamers, Michael A. Marletta, and John Kuriyan. “The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase..” Bmc Structural Biology 8 (October 7, 2008). https://doi.org/10.1186/1472-6807-8-42.
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  - Derbyshire, Emily R., Alexander Gunn, Mohammed Ibrahim, Thomas G. Spiro, R David Britt, and Michael A. Marletta. “Characterization of two different five-coordinate soluble guanylate cyclase ferrous-nitrosyl complexes..” Biochemistry 47, no. 12 (March 2008): 3892–99. https://doi.org/10.1021/bi7022943.
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  - Derbyshire, Emily R., and Michael A. Marletta. “Butyl isocyanide as a probe of the activation mechanism of soluble guanylate cyclase. Investigating the role of non-heme nitric oxide..” The Journal of Biological Chemistry 282, no. 49 (December 2007): 35741–48. https://doi.org/10.1074/jbc.m705557200.
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  - Martin, Nathaniel I., Emily R. Derbyshire, and Michael A. Marletta. “Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1..” Bioorganic & Medicinal Chemistry Letters 17, no. 17 (September 2007): 4938–41. https://doi.org/10.1016/j.bmcl.2007.06.039.
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  - Winger, Jonathan A., Emily R. Derbyshire, and Michael A. Marletta. “Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs..” The Journal of Biological Chemistry 282, no. 2 (January 2007): 897–907. https://doi.org/10.1074/jbc.m606327200.
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  - Cary, Stephen P. L., Jonathan A. Winger, Emily R. Derbyshire, and Michael A. Marletta. “Nitric oxide signaling: no longer simply on or off..” Trends in Biochemical Sciences 31, no. 4 (April 2006): 231–39. https://doi.org/10.1016/j.tibs.2006.02.003.
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  - Derbyshire, Emily R., Rosalie Tran, Richard A. Mathies, and Michael A. Marletta. “Characterization of nitrosoalkane binding and activation of soluble guanylate cyclase..” Biochemistry 44, no. 49 (December 2005): 16257–65. https://doi.org/10.1021/bi0515671.
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Teaching & Mentoring
Recent Courses
- CHEM 89S: First-Year Seminar 2019
- CHEM 393: Research Independent Study 2019
- CHEM 394: Research Independent Study 2019
- CHEM 493: Research Independent Study 2019
- CHEM 494: Research Independent Study 2019
- CHEM 517: Molecules in Life and Disease 2019
- MGM 293: Research Independent Study I 2019
- MGM 593: Research Independent Study 2019
- PHARM 693: Research Independent Study in Science Education 2018

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Education, Training, & Certifications

Duke Appointment History

In the News

Selected Publications

Academic Articles

Recent Courses