Emily R. Derbyshire
Assistant Professor of Chemistry
The Derbyshire Lab uses both chemical tools and biological methods to uncover novel aspects of malaria parasite biology with the ultimate aim of identifying druggable targets. Projects range from developing assays for phenotypic and target-based screens to exploring biological pathways and identifying small molecules with potential therapeutic value. Their interdisciplinary collaborative program integrates chemical biology, molecular biology and biochemistry to globally interrogate parasite biology.
Current Appointments & Affiliations
- Assistant Professor of Chemistry, Chemistry, Trinity College of Arts & Sciences 2014
- Assistant Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2014
Contact Information
- 3218 French Science Center, Durham, NC 27708
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emily.derbyshire@duke.edu
(919) 660-1511
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Derbyshire Research Group
- Background
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Education, Training, & Certifications
- NIH Postdoctoral Fellow, Biological Chemistry & Molecular Pharmacology, Harvard Medical School 2009 - 2014
- Ph.D., University of California at Berkeley 2008
- B.S., Trinity College 2002
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Duke Appointment History
- Scholar in Residence in the Department of Chemistry, Chemistry, Trinity College of Arts & Sciences 2013 - 2014
- Recognition
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In the News
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MAY 22, 2018 -
OCT 5, 2017 -
JAN 11, 2017 -
OCT 2, 2014 -
AUG 25, 2014
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- Publications & Artistic Works
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Selected Publications
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Academic Articles
- Raphemot, R, Eubanks, AL, Toro-Moreno, M, Geiger, RA, Hughes, PF, Lu, K-Y, Haystead, TAJ, and Derbyshire, ER. "Plasmodium PK9 Inhibitors Promote Growth of Liver-Stage Parasites." Cell Chemical Biology 26, no. 3 (March 2019): 411-419.e7. Full Text
- Eubanks, AL, Perkins, MM, Sylvester, K, Ganley, JG, Posfai, D, Sanschargrin, PC, Hong, J, Sliz, P, and Derbyshire, ER. "In silico Screening and Evaluation of Plasmodium falciparum Protein Kinase 5 (PK5) Inhibitors." Chemmedchem (October 16, 2018). Full Text
- Ganley, JG, Carr, G, Ioerger, TR, Sacchettini, JC, Clardy, J, and Derbyshire, ER. "Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes." Chembiochem : a European Journal of Chemical Biology 19, no. 15 (August 2018): 1590-1594. Full Text
- Posfai, D, Sylvester, K, Reddy, A, Ganley, JG, Wirth, J, Cullen, QE, Dave, T, Kato, N, Dave, SS, and Derbyshire, ER. "Plasmodium parasite exploits host aquaporin-3 during liver stage malaria infection." Plos Pathogens 14, no. 5 (May 18, 2018): e1007057-null. Full Text Open Access Copy
- Posfai, D, Sylvester, K, Reddy, A, Ganley, JG, Wirth, J, Cullen, QE, Dave, T, Kato, N, Dave, SS, and Derbyshire, ER. "Plasmodium parasite exploits host aquaporin-3 during liver stage malaria infection." Plos Pathogens 14, no. 5 (May 1, 2018). (Academic Article) Full Text Link to Item
- Posfai, D, Eubanks, AL, Keim, AI, Lu, K-Y, Wang, GZ, Hughes, PF, Kato, N, Haystead, TA, and Derbyshire, ER. "Identification of Hsp90 Inhibitors with Anti-Plasmodium Activity." Antimicrobial Agents and Chemotherapy 62, no. 4 (April 2018). Full Text
- Ganley, JG, Toro-Moreno, M, and Derbyshire, ER. "Exploring the Untapped Biosynthetic Potential of Apicomplexan Parasites." Biochemistry 57, no. 4 (January 2018): 365-375. (Review) Full Text
- Totzke, J, Gurbani, D, Raphemot, R, Hughes, PF, Bodoor, K, Carlson, DA, Loiselle, DR, Bera, AK, Eibschutz, LS, Perkins, MM, Eubanks, AL, Campbell, PL, Fox, DA, Westover, KD, Haystead, TAJ, and Derbyshire, ER. "Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease." Cell chemical biology 24, no. 8 (August 2017): 1029-1039.e7. Full Text
- Kato, N, Comer, E, Sakata-Kato, T, Sharma, A, Sharma, M, Maetani, M, Bastien, J, Brancucci, NM, Bittker, JA, Corey, V, Clarke, D, Derbyshire, ER, Dornan, GL, Duffy, S, Eckley, S, Itoe, MA, Koolen, KMJ, Lewis, TA, Lui, PS, Lukens, AK, Lund, E, March, S, Meibalan, E, Meier, BC, McPhail, JA, Mitasev, B, Moss, EL, Sayes, M, Van Gessel, Y, Wawer, MJ, Yoshinaga, T, Zeeman, A-M, Avery, VM, Bhatia, SN, Burke, JE, Catteruccia, F, Clardy, JC, Clemons, PA, Dechering, KJ, Duvall, JR, Foley, MA, Gusovsky, F, Kocken, CHM, Marti, M, Morningstar, ML, Munoz, B, Neafsey, DE, Sharma, A, Winzeler, EA, Wirth, DF, Scherer, CA, and Schreiber, SL. "Diversity-oriented synthesis yields novel multistage antimalarial inhibitors." Nature 538, no. 7625 (October 2016): 344-349. Full Text
- Raphemot, R, Posfai, D, and Derbyshire, ER. "Current therapies and future possibilities for drug development against liver-stage malaria." The Journal of Clinical Investigation 126, no. 6 (June 2016): 2013-2020. (Review) Full Text
- Raphemot, R, Lafuente-Monasterio, MJ, Gamo-Benito, FJ, Clardy, J, and Derbyshire, ER. "Discovery of Dual-Stage Malaria Inhibitors with New Targets." Antimicrobial agents and chemotherapy 60, no. 3 (December 14, 2015): 1430-1437. Full Text
- Herman, JD, Pepper, LR, Cortese, JF, Estiu, G, Galinsky, K, Zuzarte-Luis, V, Derbyshire, ER, Ribacke, U, Lukens, AK, Santos, SA, Patel, V, Clish, CB, Sullivan, WJ, Zhou, H, Bopp, SE, Schimmel, P, Lindquist, S, Clardy, J, Mota, MM, Keller, TL, Whitman, M, Wiest, O, Wirth, DF, and Mazitschek, R. "The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs." Science Translational Medicine 7, no. 288 (May 2015): 288ra77-null. Full Text
- Derbyshire, ER, Zuzarte-Luís, V, Magalhães, AD, Kato, N, Sanschagrin, PC, Wang, J, Zhou, W, Miduturu, CV, Mazitschek, R, Sliz, P, Mota, MM, Gray, NS, and Clardy, J. "Chemical interrogation of the malaria kinome." Chembiochem : a European journal of chemical biology 15, no. 13 (September 2014): 1920-1930. Full Text
- Derbyshire, ER, Min, J, Guiguemde, WA, Clark, JA, Connelly, MC, Magalhães, AD, Guy, RK, and Clardya, J. "Dihydroquinazolinone inhibitors of proliferation of blood and liver stage malaria parasites." Antimicrobial Agents and Chemotherapy 58, no. 3 (March 1, 2014): 1516-1522. Full Text
- Derbyshire, ER, Min, J, Guiguemde, WA, Clark, JA, Connelly, MC, Magalhães, AD, Guy, RK, and Clardy, J. "Dihydroquinazolinone inhibitors of proliferation of blood and liver stage malaria parasites." Antimicrobial Agents and Chemotherapy 58, no. 3 (January 2014): 1516-1522. Full Text
- Derbyshire, ER, and Clardy, J. "Closing in on a new treatment for sleeping sickness." Elife 2 (January 2013): e01042-null. Full Text
- Fernhoff, NB, Derbyshire, ER, Underbakke, ES, and Marletta, MA. "Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide." The Journal of Biological Chemistry 287, no. 51 (December 2012): 43053-43062. Full Text
- Gunn, A, Derbyshire, ER, Marletta, MA, and Britt, RD. "Conformationally distinct five-coordinate heme-NO complexes of soluble guanylate cyclase elucidated by multifrequency electron paramagnetic resonance (EPR)." Biochemistry 51, no. 42 (October 9, 2012): 8384-8390. Full Text
- Carr, G, Derbyshire, ER, Caldera, E, Currie, CR, and Clardy, J. "Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp." Journal of Natural Products 75, no. 10 (October 2012): 1806-1809. Full Text
- Derbyshire, ER, Prudêncio, M, Mota, MM, and Clardy, J. "Liver-stage malaria parasites vulnerable to diverse chemical scaffolds." Proc Natl Acad Sci U S A 109, no. 22 (May 29, 2012): 8511-8516. Full Text Link to Item
- Derbyshire, ER, Mazitschek, R, and Clardy, J. "Characterization of Plasmodium liver stage inhibition by halofuginone." ChemMedChem 7, no. 5 (May 2012): 844-849. Full Text Link to Item
- Derbyshire, ER, and Marletta, MA. "Structure and regulation of soluble guanylate cyclase." Annual Review of Biochemistry 81 (January 2012): 533-559. (Review) Full Text
- Dong, CK, Urgaonkar, S, Cortese, JF, Gamo, F-J, Garcia-Bustos, JF, Lafuente, MJ, Patel, V, Ross, L, Coleman, BI, Derbyshire, ER, Clish, CB, Serrano, AE, Cromwell, M, Barker, RH, Dvorin, JD, Duraisingh, MT, Wirth, DF, Clardy, J, and Mazitschek, R. "Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors." Chem Biol 18, no. 12 (December 23, 2011): 1602-1610. Full Text Link to Item
- Derbyshire, ER, Mota, MM, and Clardy, J. "The next opportunity in anti-malaria drug discovery: the liver stage." PLoS Pathog 7, no. 9 (September 2011): e1002178-. Full Text Link to Item
- Derbyshire, ER, Winter, MB, Ibrahim, M, Deng, S, Spiro, TG, and Marletta, MA. "Probing domain interactions in soluble guanylate cyclase." Biochemistry 50, no. 20 (May 24, 2011): 4281-4290. Full Text Link to Item
- Ibrahim, M, Derbyshire, ER, Soldatova, AV, Marletta, MA, and Spiro, TG. "Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidence." Biochemistry 49, no. 23 (June 15, 2010): 4864-4871. Full Text Link to Item
- Derbyshire, ER, Deng, S, and Marletta, MA. "Incorporation of tyrosine and glutamine residues into the soluble guanylate cyclase heme distal pocket alters NO and O2 binding." The Journal of Biological Chemistry 285, no. 23 (June 2010): 17471-17478. Full Text
- Ibrahim, M, Derbyshire, ER, Marletta, MA, and Spiro, TG. "Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy." Biochemistry 49, no. 18 (May 2010): 3815-3823. Full Text
- Fernhoff, NB, Derbyshire, ER, and Marletta, MA. "A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase." Proc Natl Acad Sci U S A 106, no. 51 (December 22, 2009): 21602-21607. Full Text Link to Item
- Derbyshire, ER, Fernhoff, NB, Deng, S, and Marletta, MA. "Nucleotide regulation of soluble guanylate cyclase substrate specificity." Biochemistry 48, no. 31 (August 2009): 7519-7524. Full Text
- Ibrahim, M, Derbyshire, ER, Marletta, MA, and Spiro, TG. "Interaction of allosteric effectors with soluble guanylate cyclase heme domains: Role of heme distortion and propionate hydrogen bonding on synergistic activation." ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 237 (March 22, 2009). Link to Item
- Derbyshire, ER, and Marletta, MA. "Biochemistry of soluble guanylate cyclase." Handb Exp Pharmacol , no. 191 (2009): 17-31. (Review) Full Text Link to Item
- Winger, JA, Derbyshire, ER, Lamers, MH, Marletta, MA, and Kuriyan, J. "The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase." Bmc Structural Biology 8 (October 7, 2008): 42-null. Full Text
- Derbyshire, ER, Gunn, A, Ibrahim, M, Spiro, TG, Britt, RD, and Marletta, MA. "Characterization of two different five-coordinate soluble guanylate cyclase ferrous-nitrosyl complexes." Biochemistry 47, no. 12 (March 2008): 3892-3899. Full Text
- Derbyshire, ER, and Marletta, MA. "Butyl isocyanide as a probe of the activation mechanism of soluble guanylate cyclase. Investigating the role of non-heme nitric oxide." The Journal of Biological Chemistry 282, no. 49 (December 2007): 35741-35748. Full Text
- Martin, NI, Derbyshire, ER, and Marletta, MA. "Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1." Bioorg Med Chem Lett 17, no. 17 (September 1, 2007): 4938-4941. Full Text Link to Item
- Winger, JA, Derbyshire, ER, and Marletta, MA. "Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs." J Biol Chem 282, no. 2 (January 12, 2007): 897-907. Full Text Link to Item
- Cary, SPL, Winger, JA, Derbyshire, ER, and Marletta, MA. "Nitric oxide signaling: no longer simply on or off." Trends Biochem Sci 31, no. 4 (April 2006): 231-239. (Review) Full Text Link to Item
- Derbyshire, ER, Tran, R, Mathies, RA, and Marletta, MA. "Characterization of nitrosoalkane binding and activation of soluble guanylate cyclase." Biochemistry 44, no. 49 (December 13, 2005): 16257-16265. Full Text Link to Item
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- Teaching & Mentoring
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Recent Courses
- CHEM 89S: First-Year Seminar 2019
- CHEM 393: Research Independent Study 2019
- CHEM 394: Research Independent Study 2019
- CHEM 493: Research Independent Study 2019
- CHEM 494: Research Independent Study 2019
- CHEM 517: Molecules in Life and Disease 2019
- MGM 293: Research Independent Study I 2019
- MGM 593: Research Independent Study 2019
- PHARM 693: Research Independent Study in Science Education 2018
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