SUMOylation in brain ischemia: Patterns, targets, and translational implications.

Journal Article (Journal Article;Review)

Post-translational protein modification by small ubiquitin-like modifier (SUMO) regulates a myriad of homeostatic and stress responses. The SUMOylation pathway has been extensively studied in brain ischemia. Convincing evidence is now at hand to support the notion that a major increase in levels of SUMOylated proteins is capable of inducing tolerance to ischemic stress. Therefore, the SUMOylation pathway has emerged as a promising therapeutic target for neuroprotection in the face of brain ischemia. Despite this, it is prudent to acknowledge that there are many key questions still to be addressed in brain ischemia related to SUMOylation. Accordingly, herein, we provide a critical review of literature within the field to summarize current knowledge and in so doing highlight pertinent translational implications of the SUMOylation pathway in brain ischemia.

Full Text

Duke Authors

Cited Authors

  • Bernstock, JD; Yang, W; Ye, DG; Shen, Y; Pluchino, S; Lee, Y-J; Hallenbeck, JM; Paschen, W

Published Date

  • January 2018

Published In

Volume / Issue

  • 38 / 1

Start / End Page

  • 5 - 16

PubMed ID

  • 29148315

Pubmed Central ID

  • PMC5757445

Electronic International Standard Serial Number (EISSN)

  • 1559-7016

Digital Object Identifier (DOI)

  • 10.1177/0271678X17742260


  • eng

Conference Location

  • United States