Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Universitat Rostock (Germany) 2005
  • M.S., Chinese Academy of Sciences (China) 2002
• 

  Previous Appointments & Affiliations

  • Associate Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 2017 - 2020
  • Assistant Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 2009 - 2017
• Research
• 

  Selected Grants

  • Hypoperfusion, Hemodynamic Control Domains and Neurovascular Dysregulation in AD brain pathology awarded by National Institutes of Health 2023 - 2027
  • The Unfolded Protein Response and Neuroprotection in Stroke awarded by National Institutes of Health 2016 - 2026
  • Integrated Training in Anesthesiology Research awarded by National Institutes of Health 1996 - 2026
  • Duke Testing Site for Stroke Preclinical Assessment Network awarded by National Institutes of Health 2023 - 2025
  • Immunosuppression after cardiac arrest and resuscitation awarded by National Institutes of Health 2022 - 2025
  • Targeted neuromodulation to enhance recovery of the aged brain after ischemic stroke awarded by National Institutes of Health 2022 - 2024
  • High-resolution High-speed Photoacoustic and Ultrasound Imaging of Small Vessels Functions in Ischemic Stroke awarded by National Institutes of Health 2019 - 2024
  • Vagal control of tissue SUMOylation as a novel anti-inflammatory target in IBD awarded by National Institutes of Health 2022 - 2024
  • Head-mounted Photoacoustic Imaging of Deep-brain Neural Activities in Freely Behaving Animals awarded by National Institutes of Health 2020 - 2024
  • Mast cell activation as a determinant of neurologic injury after cardiac arrest awarded by National Institutes of Health 2020 - 2023
  • Cognitive Effects of Body Temperature During Hypothermic Circulatory Arrest awarded by National Institutes of Health 2016 - 2023
  • Enhanced neutrophil SUMOylation as a key to anti-inflammatory effects of hypothermia awarded by  American Heart Association 2019 - 2021
  • Effect of Aging on Brain Ischemia/Stroke Outcome; Pathways, Mechanisms, and Rescue awarded by National Institutes of Health 2016 - 2020
  • Role of SUMO Conjugation in Ischemia: Significance, Mechanisms and Pathways awarded by National Institutes of Health 2012 - 2017
  • Restoration of Endoplasmic Reticulum Function in Experimental Stroke awarded by National Institutes of Health 2012 - 2015
  • SUMO Conjugation and Deep Hypothermia-Induced Organ Protection awarded by National Institutes of Health 2010 - 2014
  • Shutdown of Translation and Ischemia/Stroke-Induced Cell Death awarded by National Institutes of Health 2008 - 2010
  • Conditional Gene Silencing in Ischemia/Stroke Research awarded by National Institutes of Health 2008 - 2010
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Sheng, Huaxin, Lihong Dang, Xuan Li, Zhong Yang, and Wei Yang. “A Modified Transcranial Middle Cerebral Artery Occlusion Model to Study Stroke Outcomes in Aged Mice.” J Vis Exp, no. 195 (May 5, 2023). https://doi.org/10.3791/65345.
       Full Text  Link to Item
    • Li, Ran, Weina Duan, Dong Zhang, Ulrike Hoffmann, Junjie Yao, Wei Yang, and Huaxin Sheng. “Mouse Cardiac Arrest Model for Brain Imaging and Brain Physiology Monitoring During Ischemia and Resuscitation.” J Vis Exp, no. 194 (April 14, 2023). https://doi.org/10.3791/65340.
       Full Text  Link to Item
    • Wang, Zhuoran, Qiang Li, Brad J. Kolls, Brian Mace, Shu Yu, Xuan Li, Wei Liu, et al. “Sustained overexpression of spliced X-box-binding protein-1 in neurons leads to spontaneous seizures and sudden death in mice.” Commun Biol 6, no. 1 (March 9, 2023): 252. https://doi.org/10.1038/s42003-023-04594-8.
       Full Text  Link to Item
    • Menozzi, Luca, Ángela Del Águila, Tri Vu, Chenshuo Ma, Wei Yang, and Junjie Yao. “Three-dimensional non-invasive brain imaging of ischemic stroke by integrated photoacoustic, ultrasound and angiographic tomography (PAUSAT).” Photoacoustics 29 (February 2023): 100444. https://doi.org/10.1016/j.pacs.2022.100444.
       Full Text  Link to Item
    • Li, Xuan, and Wei Yang. “Targeting O-GlcNAcylation in ischemic stroke.” Neural Regen Res 17, no. 11 (November 2022): 2427–28. https://doi.org/10.4103/1673-5374.335806.
       Full Text  Link to Item
    • Hochrainer, Karin, and Wei Yang. “Stroke Proteomics: From Discovery to Diagnostic and Therapeutic Applications.” Circ Res 130, no. 8 (April 15, 2022): 1145–66. https://doi.org/10.1161/CIRCRESAHA.122.320110.
       Full Text  Link to Item
    • Li, Xuan, Jingjun Lyu, Ran Li, Vaibhav Jain, Yuntian Shen, Ángela Del Águila, Ulrike Hoffmann, Huaxin Sheng, and Wei Yang. “Single-cell transcriptomic analysis of the immune cell landscape in the aged mouse brain after ischemic stroke.” J Neuroinflammation 19, no. 1 (April 7, 2022): 83. https://doi.org/10.1186/s12974-022-02447-5.
       Full Text  Open Access Copy  Link to Item
    • Duan, Weina, Qian Sun, Xiaojing Wu, Zhongyuan Xia, David S. Warner, Luis Ulloa, Wei Yang, and Huaxin Sheng. “Cervical Vagus Nerve Stimulation Improves Neurologic Outcome After Cardiac Arrest in Mice by Attenuating Oxidative Stress and Excessive Autophagy.” Neuromodulation 25, no. 3 (April 2022): 414–23. https://doi.org/10.1016/j.neurom.2021.12.014.
       Full Text  Open Access Copy  Link to Item
    • Li, Xuan, Ran Li, Liping Lu, Ashis Dhar, Huaxin Sheng, and Wei Yang. “Beneficial effects of neuronal ATF6 activation in permanent ischemic stroke.” Front Cell Neurosci 16 (2022): 1016391. https://doi.org/10.3389/fncel.2022.1016391.
       Full Text  Link to Item
    • Menozzi, Luca, Wei Yang, Wuwei Feng, and Junjie Yao. “Sound out the impaired perfusion: Photoacoustic imaging in preclinical ischemic stroke.” Front Neurosci 16 (2022): 1055552. https://doi.org/10.3389/fnins.2022.1055552.
       Full Text  Link to Item
    • Li, Xuan, and Wei Yang. “An update on the unfolded protein response in brain ischemia: Experimental evidence and therapeutic opportunities.” Neurochem Int 151 (December 2021): 105218. https://doi.org/10.1016/j.neuint.2021.105218.
       Full Text  Link to Item
    • Li, Ran, Yuntian Shen, Xuan Li, Liping Lu, Zhuoran Wang, Huaxin Sheng, Ulrike Hoffmann, and Wei Yang. “Activation of the XBP1s/O-GlcNAcylation Pathway Improves Functional Outcome After Cardiac Arrest and Resuscitation in Young and Aged Mice.” Shock 56, no. 5 (November 1, 2021): 755–61. https://doi.org/10.1097/SHK.0000000000001732.
       Full Text  Open Access Copy  Link to Item
    • Li, Wei, Michael Chopp, Alex Zacharek, Wei Yang, Zhili Chen, Julie Landschoot-Ward, Poornima Venkat, and Jieli Chen. “SUMO1 Deficiency Exacerbates Neurological and Cardiac Dysfunction after Intracerebral Hemorrhage in Aged Mice.” Transl Stroke Res 12, no. 4 (August 2021): 631–42. https://doi.org/10.1007/s12975-020-00837-6.
       Full Text  Link to Item
    • Turner, Dennis A., and Wei Yang. “Phase-specific manipulation of neuronal activity: a promising stroke therapy approach.” Neural Regen Res 16, no. 7 (July 2021): 1425–26. https://doi.org/10.4103/1673-5374.301005.
       Full Text  Link to Item
    • Zhang, Dong, Ran Li, Maomao Chen, Tri Vu, Huaxin Sheng, Wei Yang, Ulrike Hoffmann, Jianwen Luo, and Junjie Yao. “Photoacoustic imaging of in vivo hemodynamic responses to sodium nitroprusside.” J Biophotonics 14, no. 7 (July 2021): e202000478. https://doi.org/10.1002/jbio.202000478.
       Full Text  Open Access Copy  Link to Item
    • Shen, Yuntian, Ran Li, Shu Yu, Qiang Zhao, Zhuoran Wang, Huaxin Sheng, and Wei Yang. “Activation of the ATF6 (Activating Transcription Factor 6) Signaling Pathway in Neurons Improves Outcome After Cardiac Arrest in Mice.” J Am Heart Assoc 10, no. 12 (June 15, 2021): e020216. https://doi.org/10.1161/JAHA.120.020216.
       Full Text  Open Access Copy  Link to Item
    • Wang, Wei, Ran Li, Wanying Miao, Cody Evans, Liping Lu, Jingjun Lyu, Xuan Li, et al. “Development and Evaluation of a Novel Mouse Model of Asphyxial Cardiac Arrest Revealed Severely Impaired Lymphopoiesis After Resuscitation.” J Am Heart Assoc 10, no. 11 (June 2021): e019142. https://doi.org/10.1161/JAHA.120.019142.
       Full Text  Open Access Copy  Link to Item
    • Wang, Zhuoran, Xuan Li, Ivan Spasojevic, Liping Lu, Yuntian Shen, Xingguang Qu, Ulrike Hoffmann, et al. “Increasing O-GlcNAcylation is neuroprotective in young and aged brains after ischemic stroke.” Exp Neurol 339 (May 2021): 113646. https://doi.org/10.1016/j.expneurol.2021.113646.
       Full Text  Open Access Copy  Link to Item
    • Zhao, Qiang, Yuntian Shen, Ran Li, Jiangbo Wu, Jingjun Lyu, Maorong Jiang, Liping Lu, et al. “Cardiac arrest and resuscitation activates the hypothalamic-pituitary-adrenal axis and results in severe immunosuppression.” J Cereb Blood Flow Metab 41, no. 5 (May 2021): 1091–1102. https://doi.org/10.1177/0271678X20948612.
       Full Text  Open Access Copy  Link to Item
    • Shemetov, Anton A., Mikhail V. Monakhov, Qinrong Zhang, Jose Ernesto Canton-Josh, Manish Kumar, Maomao Chen, Mikhail E. Matlashov, et al. “A near-infrared genetically encoded calcium indicator for in vivo imaging.” Nat Biotechnol 39, no. 3 (March 2021): 368–77. https://doi.org/10.1038/s41587-020-0710-1.
       Full Text  Link to Item
    • Karhausen, Jörn, Luis Ulloa, and Wei Yang. “SUMOylation Connects Cell Stress Responses and Inflammatory Control: Lessons From the Gut as a Model Organ.” Front Immunol 12 (2021): 646633. https://doi.org/10.3389/fimmu.2021.646633.
       Full Text  Link to Item
    • Yu, Shu, Francesca Galeffi, Ramona M. Rodriguiz, Zhuoran Wang, Yuntian Shen, Jingjun Lyu, Ran Li, et al. “Small ubiquitin-like modifier 2 (SUMO2) is critical for memory processes in mice.” Faseb J 34, no. 11 (November 2020): 14750–67. https://doi.org/10.1096/fj.202000850RR.
       Full Text  Open Access Copy  Link to Item
    • Jiang, Maorong, Ran Li, Jingjun Lyu, Xuan Li, Wei Wang, Zhuoran Wang, Huaxin Sheng, Weiguo Zhang, Jörn Karhausen, and Wei Yang. “MCC950, a selective NLPR3 inflammasome inhibitor, improves neurologic function and survival after cardiac arrest and resuscitation.” J Neuroinflammation 17, no. 1 (August 31, 2020): 256. https://doi.org/10.1186/s12974-020-01933-y.
       Full Text  Open Access Copy  Link to Item
    • Wang, Ya-Chao, Xuan Li, Yuntian Shen, Jingjun Lyu, Huaxin Sheng, Wulf Paschen, and Wei Yang. “PERK (Protein Kinase RNA-Like ER Kinase) Branch of the Unfolded Protein Response Confers Neuroprotection in Ischemic Stroke by Suppressing Protein Synthesis.” Stroke 51, no. 5 (May 2020): 1570–77. https://doi.org/10.1161/STROKEAHA.120.029071.
       Full Text  Open Access Copy  Link to Item
    • Wang, Ya-Chao, Francesca Galeffi, Wei Wang, Xuan Li, Liping Lu, Huaxin Sheng, Ulrike Hoffmann, Dennis A. Turner, and Wei Yang. “Chemogenetics-mediated acute inhibition of excitatory neuronal activity improves stroke outcome.” Exp Neurol 326 (April 2020): 113206. https://doi.org/10.1016/j.expneurol.2020.113206.
       Full Text  Open Access Copy  Link to Item
    • Yu, H-M Ivy, Trunee Hsu, Eri O. Maruyama, Wulf Paschen, Wei Yang, and Wei Hsu. “The requirement of SUMO2/3 for SENP2 mediated extraembryonic and embryonic development.” Dev Dyn 249, no. 2 (February 2020): 237–44. https://doi.org/10.1002/dvdy.125.
       Full Text  Link to Item
    • Bernstock, Joshua D., Daniel G. Ye, Dagoberto Estevez, Gustavo Chagoya, Ya-Chao Wang, Florian Gessler, John M. Hallenbeck, and Wei Yang. “The Role of SUMOylation and Ubiquitination in Brain Ischaemia: Critical Concepts and Clinical Implications.” Curr Issues Mol Biol 35 (2020): 127–44. https://doi.org/10.21775/cimb.035.127.
       Full Text  Link to Item
    • Ma, Shuang, Dongmei Chu, Litao Li, Jennifer A. Creed, Yu-Mi Ryang, Huaxin Sheng, Wei Yang, David S. Warner, Dennis A. Turner, and Ulrike Hoffmann. “Argon Inhalation for 24 Hours After Onset of Permanent Focal Cerebral Ischemia in Rats Provides Neuroprotection and Improves Neurologic Outcome.” Crit Care Med 47, no. 8 (August 2019): e693–99. https://doi.org/10.1097/CCM.0000000000003809.
       Full Text  Open Access Copy  Link to Item
    • Wang, Zhuoran, and Wei Yang. “Impaired capacity to restore proteostasis in the aged brain after ischemia: Implications for translational brain ischemia research.” Neurochem Int 127 (July 2019): 87–93. https://doi.org/10.1016/j.neuint.2018.12.018.
       Full Text  Link to Item
    • Lan, Bangxin, Wei Liu, Ya-Chao Wang, Junhui Shi, Yang Li, Song Xu, Huaxin Sheng, et al. “High-speed widefield photoacoustic microscopy of small-animal hemodynamics.” Biomed Opt Express 9, no. 10 (October 1, 2018): 4689–4701. https://doi.org/10.1364/BOE.9.004689.
       Full Text  Open Access Copy  Link to Item
    • Shen, Yuntian, Baihui Yan, Qiang Zhao, Zhuoran Wang, Jiangbo Wu, Jiafa Ren, Wei Wang, et al. “Aging Is Associated With Impaired Activation of Protein Homeostasis-Related Pathways After Cardiac Arrest in Mice.” J Am Heart Assoc 7, no. 17 (September 4, 2018): e009634. https://doi.org/10.1161/JAHA.118.009634.
       Full Text  Open Access Copy  Link to Item
    • Karhausen, Jörn, Joshua D. Bernstock, Kory R. Johnson, Huaxin Sheng, Qing Ma, Yuntian Shen, Wei Yang, John M. Hallenbeck, and Wulf Paschen. “Ubc9 overexpression and SUMO1 deficiency blunt inflammation after intestinal ischemia/reperfusion.” Lab Invest 98, no. 6 (June 2018): 799–813. https://doi.org/10.1038/s41374-018-0035-6.
       Full Text  Open Access Copy  Link to Item
    • Bernstock, Joshua D., Daniel Ye, Jayden A. Smith, Yang-Ja Lee, Florian A. Gessler, Adam Yasgar, Jennifer Kouznetsova, et al. “Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2.” Faseb J 32, no. 3 (March 2018): 1677–91. https://doi.org/10.1096/fj.201700711R.
       Full Text  Link to Item
    • Liu, Huaqin, Zhui Yu, Ying Li, Bin Xu, Baihui Yan, Wulf Paschen, David S. Warner, Wei Yang, and Huaxin Sheng. “Novel Modification of Potassium Chloride Induced Cardiac Arrest Model for Aged Mice.” Aging Dis 9, no. 1 (February 2018): 31–39. https://doi.org/10.14336/AD.2017.0221.
       Full Text  Open Access Copy  Link to Item
    • Bernstock, Joshua D., Wei Yang, Daniel G. Ye, Yuntian Shen, Stefano Pluchino, Yang-Ja Lee, John M. Hallenbeck, and Wulf Paschen. “SUMOylation in brain ischemia: Patterns, targets, and translational implications.” J Cereb Blood Flow Metab 38, no. 1 (January 2018): 5–16. https://doi.org/10.1177/0271678X17742260.
       Full Text  Link to Item
    • Yang, Wei, and Wulf Paschen. “Is age a key factor contributing to the disparity between success of neuroprotective strategies in young animals and limited success in elderly stroke patients? Focus on protein homeostasis.” J Cereb Blood Flow Metab 37, no. 10 (October 2017): 3318–24. https://doi.org/10.1177/0271678X17723783.
       Full Text  Link to Item
    • Bernstock, Joshua D., Daniel Ye, Florian A. Gessler, Yang-Ja Lee, Luca Peruzzotti-Jametti, Peter Baumgarten, Kory R. Johnson, et al. “Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming.” Sci Rep 7, no. 1 (August 7, 2017): 7425. https://doi.org/10.1038/s41598-017-07631-9.
       Full Text  Link to Item
    • Jiang, Meng, Shu Yu, Zhui Yu, Huaxin Sheng, Ying Li, Shuai Liu, David S. Warner, Wulf Paschen, and Wei Yang. “XBP1 (X-Box-Binding Protein-1)-Dependent O-GlcNAcylation Is Neuroprotective in Ischemic Stroke in Young Mice and Its Impairment in Aged Mice Is Rescued by Thiamet-G.” Stroke 48, no. 6 (June 2017): 1646–54. https://doi.org/10.1161/STROKEAHA.117.016579.
       Full Text  Open Access Copy  Link to Item
    • Yu, Zhui, Huaxin Sheng, Shuai Liu, Shengli Zhao, Christopher C. Glembotski, David S. Warner, Wulf Paschen, and Wei Yang. “Activation of the ATF6 branch of the unfolded protein response in neurons improves stroke outcome.” J Cereb Blood Flow Metab 37, no. 3 (March 2017): 1069–79. https://doi.org/10.1177/0271678X16650218.
       Full Text  Open Access Copy  Link to Item
    • Zhang, Lin, Xiaozhi Liu, Huaxin Sheng, Shuai Liu, Ying Li, Julia Q. Zhao, David S. Warner, Wulf Paschen, and Wei Yang. “Neuron-specific SUMO knockdown suppresses global gene expression response and worsens functional outcome after transient forebrain ischemia in mice.” Neuroscience 343 (February 20, 2017): 190–212. https://doi.org/10.1016/j.neuroscience.2016.11.036.
       Full Text  Open Access Copy  Link to Item
    • Yang, Wei, and Wulf Paschen. “Unfolded protein response in brain ischemia: A timely update.” J Cereb Blood Flow Metab 36, no. 12 (December 2016): 2044–50. https://doi.org/10.1177/0271678X16674488.
       Full Text  Link to Item
    • Yang, Wei, Huaxin Sheng, and Haichen Wang. “Targeting the SUMO pathway for neuroprotection in brain ischaemia.” Stroke Vasc Neurol 1, no. 3 (September 2016): 101–7. https://doi.org/10.1136/svn-2016-000031.
       Full Text  Open Access Copy  Link to Item
    • Liu, Shuai, Huaxin Sheng, Zhui Yu, Wulf Paschen, and Wei Yang. “O-linked β-N-acetylglucosamine modification of proteins is activated in post-ischemic brains of young but not aged mice: Implications for impaired functional recovery from ischemic stress.” J Cereb Blood Flow Metab 36, no. 2 (February 2016): 393–98. https://doi.org/10.1177/0271678X15608393.
       Full Text  Open Access Copy  Link to Item
    • Yang, Wei, and Wulf Paschen. “SUMO proteomics to decipher the SUMO-modified proteome regulated by various diseases.” Proteomics 15, no. 5–6 (March 2015): 1181–91. https://doi.org/10.1002/pmic.201400298.
       Full Text  Link to Item
    • Wang, Liangli, Carolien Wansleeben, Shengli Zhao, Pei Miao, Wulf Paschen, and Wei Yang. “SUMO2 is essential while SUMO3 is dispensable for mouse embryonic development.” Embo Rep 15, no. 8 (August 2014): 878–85. https://doi.org/10.15252/embr.201438534.
       Full Text  Link to Item
    • Wang, Liangli, Ramona M. Rodriguiz, William C. Wetsel, Huaxin Sheng, Shengli Zhao, Xiaozhi Liu, Wulf Paschen, and Wei Yang. “Neuron-specific Sumo1-3 knockdown in mice impairs episodic and fear memories.” J Psychiatry Neurosci 39, no. 4 (July 2014): 259–66. https://doi.org/10.1503/jpn.130148.
       Full Text  Open Access Copy  Link to Item
    • Yang, Wei, Huaxin Sheng, J Will Thompson, Shengli Zhao, Liangli Wang, Pei Miao, Xiaozhi Liu, M Arthur Moseley, and Wulf Paschen. “Small ubiquitin-like modifier 3-modified proteome regulated by brain ischemia in novel small ubiquitin-like modifier transgenic mice: putative protective proteins/pathways.” Stroke 45, no. 4 (April 2014): 1115–22. https://doi.org/10.1161/STROKEAHA.113.004315.
       Full Text  Open Access Copy  Link to Item
    • Iwabuchi, Masahiro, Huaxin Sheng, J Will Thompson, Liangli Wang, Laura G. Dubois, David Gooden, Marthur Moseley, Wulf Paschen, and Wei Yang. “Characterization of the ubiquitin-modified proteome regulated by transient forebrain ischemia.” J Cereb Blood Flow Metab 34, no. 3 (March 2014): 425–32. https://doi.org/10.1038/jcbfm.2013.210.
       Full Text  Open Access Copy  Link to Item
    • Brietzke, Andreas, Tom Goldammer, Henrike Rebl, Tomáš Korytář, Bernd Köllner, Wei Yang, Alexander Rebl, and Hans-Martin Seyfert. “Characterization of the interleukin 1 receptor-associated kinase 4 (IRAK4)-encoding gene in salmonid fish: the functional copy is rearranged in Oncorhynchus mykiss and that factor can impair TLR signaling in mammalian cells.” Fish Shellfish Immunol 36, no. 1 (January 2014): 206–14. https://doi.org/10.1016/j.fsi.2013.11.005.
       Full Text  Link to Item
    • Yang, Wei, Liangli Wang, and Wulf Paschen. “Development of a high-throughput screening assay for inhibitors of small ubiquitin-like modifier proteases.” J Biomol Screen 18, no. 5 (June 2013): 621–28. https://doi.org/10.1177/1087057113479971.
       Full Text  Link to Item
    • Wang, Z., R. Wang, H. Sheng, S. P. Sheng, W. Paschen, and W. Yang. “Transient ischemia induces massive nuclear accumulation of SUMO2/3-conjugated proteins in spinal cord neurons.” Spinal Cord 51, no. 2 (February 2013): 139–43. https://doi.org/10.1038/sc.2012.100.
       Full Text  Open Access Copy  Link to Item
    • Yang, Wei, Liangli Wang, Gabriele Roehn, Robert D. Pearlstein, Francis Ali-Osman, Hongjie Pan, Roland Goldbrunner, Matthew Krantz, Christoph Harms, and Wulf Paschen. “Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival.” Cancer Sci 104, no. 1 (January 2013): 70–77. https://doi.org/10.1111/cas.12047.
       Full Text  Link to Item
    • Wang, Liangli, Qing Ma, Wei Yang, G Burkhard Mackensen, and Wulf Paschen. “Moderate hypothermia induces marked increase in levels and nuclear accumulation of SUMO2/3-conjugated proteins in neurons.” J Neurochem 123, no. 3 (November 2012): 349–59. https://doi.org/10.1111/j.1471-4159.2012.07916.x.
       Full Text  Link to Item
    • Yang, Wei, J Will Thompson, Zhengfeng Wang, Liangli Wang, Huaxin Sheng, Matthew W. Foster, M Arthur Moseley, and Wulf Paschen. “Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics.” J Proteome Res 11, no. 2 (February 3, 2012): 1108–17. https://doi.org/10.1021/pr200834f.
       Full Text  Open Access Copy  Link to Item
    • Datwyler, Anna Lena, Gisela Lättig-Tünnemann, Wei Yang, Wulf Paschen, Sabrina Lin Lin Lee, Ulrich Dirnagl, Matthias Endres, and Christoph Harms. “SUMO2/3 conjugation is an endogenous neuroprotective mechanism.” J Cereb Blood Flow Metab 31, no. 11 (November 2011): 2152–59. https://doi.org/10.1038/jcbfm.2011.112.
       Full Text  Link to Item
    • Wang, Zhengfeng, Wei Yang, Gavin W. Britz, Frederick W. Lombard, David S. Warner, and Huaxin Sheng. “Development of a simplified spinal cord ischemia model in mice.” J Neurosci Methods 189, no. 2 (June 15, 2010): 246–51. https://doi.org/10.1016/j.jneumeth.2010.04.003.
       Full Text  Open Access Copy  Link to Item
    • Yang, Wei, and Wulf Paschen. “The endoplasmic reticulum and neurological diseases.” Exp Neurol 219, no. 2 (October 2009): 376–81. https://doi.org/10.1016/j.expneurol.2009.07.009.
       Full Text  Link to Item
    • Sheng, Huaxin, Wei Yang, Shiro Fukuda, Hubert M. Tse, Wulf Paschen, Kwame Johnson, Ines Batinic-Haberle, et al. “Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat.” Free Radic Biol Med 47, no. 7 (October 1, 2009): 917–23. https://doi.org/10.1016/j.freeradbiomed.2009.05.039.
       Full Text  Link to Item
    • Yang, Wei, Qing Ma, G Burkhard Mackensen, and Wulf Paschen. “Deep hypothermia markedly activates the small ubiquitin-like modifier conjugation pathway; implications for the fate of cells exposed to transient deep hypothermic cardiopulmonary bypass.” J Cereb Blood Flow Metab 29, no. 5 (May 2009): 886–90. https://doi.org/10.1038/jcbfm.2009.16.
       Full Text  Link to Item
    • Yang, Wei, and Wulf Paschen. “Gene expression and cell growth are modified by silencing SUMO2 and SUMO3 expression.” Biochem Biophys Res Commun 382, no. 1 (April 24, 2009): 215–18. https://doi.org/10.1016/j.bbrc.2009.03.013.
       Full Text  Link to Item
    • Günther, Juliane, Dirk Koczan, Wei Yang, Gerd Nürnberg, Dirk Repsilber, Hans-Joachim Schuberth, Zaneta Park, Nauman Maqbool, Adrian Molenaar, and Hans-Martin Seyfert. “Assessment of the immune capacity of mammary epithelial cells: comparison with mammary tissue after challenge with Escherichia coli.” Vet Res 40, no. 4 (2009): 31. https://doi.org/10.1051/vetres/2009014.
       Full Text  Link to Item
    • Yang, Wei, Huaxin Sheng, H Mayumi Homi, David S. Warner, and Wulf Paschen. “Cerebral ischemia/stroke and small ubiquitin-like modifier (SUMO) conjugation--a new target for therapeutic intervention?” J Neurochem 106, no. 3 (August 2008): 989–99. https://doi.org/10.1111/j.1471-4159.2008.05404.x.
       Full Text  Link to Item
    • Yang, Wei, Huaxin Sheng, David S. Warner, and Wulf Paschen. “Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation.” J Cereb Blood Flow Metab 28, no. 5 (May 2008): 892–96. https://doi.org/10.1038/sj.jcbfm.9600601.
       Full Text  Link to Item
    • Yang, Wei, Holm Zerbe, Wolfram Petzl, Ronald Marco Brunner, Juliane Günther, Christian Draing, Sonja von Aulock, Hans-Joachim Schuberth, and Hans-Martin Seyfert. “Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli, but S. aureus fails to both activate NF-kappaB in mammary epithelial cells and to quickly induce TNFalpha and interleukin-8 (CXCL8) expression in the udder.” Mol Immunol 45, no. 5 (March 2008): 1385–97. https://doi.org/10.1016/j.molimm.2007.09.004.
       Full Text  Link to Item
    • Yang, Wei, Huaxin Sheng, David S. Warner, and Wulf Paschen. “Transient global cerebral ischemia induces a massive increase in protein sumoylation.” J Cereb Blood Flow Metab 28, no. 2 (February 2008): 269–79. https://doi.org/10.1038/sj.jcbfm.9600523.
       Full Text  Link to Item
    • Yang, Wei, and Wulf Paschen. “Conditional gene silencing in mammalian cells mediated by a stress-inducible promoter.” Biochem Biophys Res Commun 365, no. 3 (January 18, 2008): 521–27. https://doi.org/10.1016/j.bbrc.2007.11.011.
       Full Text  Link to Item
    • Petzl, Wolfram, Holm Zerbe, Juliane Günther, Wei Yang, Hans-Martin Seyfert, Gerd Nürnberg, and Hans-Joachim Schuberth. “Escherichia coli, but not Staphylococcus aureus triggers an early increased expression of factors contributing to the innate immune defense in the udder of the cow.” Vet Res 39, no. 2 (2008): 18. https://doi.org/10.1051/vetres:2007057.
       Full Text  Link to Item
    • Bánhegyi, Gábor, Peter Baumeister, Angelo Benedetti, Dezheng Dong, Yong Fu, Amy S. Lee, Jianze Li, et al. “Endoplasmic reticulum stress.” Ann N Y Acad Sci 1113 (October 2007): 58–71. https://doi.org/10.1196/annals.1391.007.
       Full Text  Link to Item
    • Jaffrézic, Florence, Dirk-Jan de Koning, Paul J. Boettcher, Agnès Bonnet, Bart Buitenhuis, Rodrigue Closset, Sébastien Déjean, et al. “Analysis of the real EADGENE data set: comparison of methods and guidelines for data normalisation and selection of differentially expressed genes (open access publication).” Genet Sel Evol 39, no. 6 (2007): 633–50. https://doi.org/10.1186/1297-9686-39-6-633.
       Full Text  Link to Item
    • Sørensen, Peter, Agnès Bonnet, Bart Buitenhuis, Rodrigue Closset, Sébastien Déjean, Céline Delmas, Mylène Duval, et al. “Analysis of the real EADGENE data set: multivariate approaches and post analysis (open access publication).” Genet Sel Evol 39, no. 6 (2007): 651–68. https://doi.org/10.1186/1297-9686-39-6-651.
       Full Text  Link to Item
    • Vanselow, Jens, Wei Yang, Jens Herrmann, Holm Zerbe, Hans-Joachim Schuberth, Wolfram Petzl, Wolfgang Tomek, and Hans-Martin Seyfert. “DNA-remethylation around a STAT5-binding enhancer in the alphaS1-casein promoter is associated with abrupt shutdown of alphaS1-casein synthesis during acute mastitis.” J Mol Endocrinol 37, no. 3 (December 2006): 463–77. https://doi.org/10.1677/jme.1.02131.
       Full Text  Link to Item
    • Yang, Wei, Adrian Molenaar, Bianka Kurts-Ebert, and Hans-Martin Seyfert. “NF-kappaB factors are essential, but not the switch, for pathogen-related induction of the bovine beta-defensin 5-encoding gene in mammary epithelial cells.” Mol Immunol 43, no. 3 (February 2006): 210–25. https://doi.org/10.1016/j.molimm.2005.02.003.
       Full Text  Link to Item

  • Book Sections

    • Yang, W., R. Li, X. Li, and D. A. Turner. “Linking proteostasis, aging, and brain ischemia.” In Factors Affecting Neurological Aging: Genetics, Neurology, Behavior, and Diet, 313–24, 2021. https://doi.org/10.1016/B978-0-12-817990-1.00028-7.
       Full Text
    • Thompson, J. W., M. Jiang, and W. Yang. “Proteomic analysis of SUMOylation in the post-ischemic brain.” In Neuromethods, 127:207–24, 2017. https://doi.org/10.1007/978-1-4939-7119-0_13.
       Full Text

  • Conference Papers

    • Wang, Zhuoran, Xuan Li, Ulrike Hoffmann, Huaxin Sheng, and Wei Yang. “Aging-Related Impairment in Post-Ischemic O-GlcNAcylation Activation Critically Contributes to Stroke Outcome.” In Stroke, Vol. 51, 2020.
       Link to Item
    • Shen, Yuntian, Qiang Zhao, Jiangbo Wu, Zhuoran Wang, and Wei Yang. “Cardiac Arrest and Resuscitation Causes Immunodeficiency That Involves the Hypothalamic-Pituitary-Adrenal Axis.” In Circulation, Vol. 138. LIPPINCOTT WILLIAMS & WILKINS, 2018.
       Link to Item
    • Zheng, Liuying, Huaxin Sheng, Xinping Du, Guoxing Zuo, Kuan Wang, Wulf Paschen, and Wei Yang. “Loss of Small Ubiquitin-Like Modifier 1 Protects the Heart From Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction in Mice.” In Circulation, Vol. 134. LIPPINCOTT WILLIAMS & WILKINS, 2016.
       Link to Item
    • Zheng, Liuying, Huaxin Sheng, Xinping Du, Guoxing Zuo, Kuan Wang, Wulf Paschen, and Wei Yang. “Loss of Small Ubiquitin- Like Modifier 1 Protects the Heart From Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction in Mice.” In Circulation, Vol. 134. LIPPINCOTT WILLIAMS & WILKINS, 2016.
       Link to Item

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.