Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Universitat Rostock (Germany) 2005
  • M.S., Chinese Academy of Sciences (China) 2002
• 

  Duke Appointment History

  • Assistant Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 2009 - 2017
• Research
• 

  Selected Grants

  • The Unfolded Protein Response and Neuroprotection in Stroke awarded by National Institutes of Health 2016 - 2021
  • Cognitive Effects of Body Temperature During Hypothermic Circulatory Arrest awarded by National Institutes of Health 2016 - 2021
  • Effect of Aging on Brain Ischemia/Stroke Outcome; Pathways, Mechanisms, and Rescue awarded by National Institutes of Health 2016 - 2019
  • Role of SUMO Conjugation in Ischemia: Significance, Mechanisms and Pathways awarded by National Institutes of Health 2012 - 2017
  • Restoration of Endoplasmic Reticulum Function in Experimental Stroke awarded by National Institutes of Health 2012 - 2015
  • SUMO Conjugation and Deep Hypothermia-Induced Organ Protection awarded by National Institutes of Health 2010 - 2014
  • Shutdown of Translation and Ischemia/Stroke-Induced Cell Death awarded by National Institutes of Health 2008 - 2010
  • Conditional Gene Silencing in Ischemia/Stroke Research awarded by National Institutes of Health 2008 - 2010
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Wang, Z, and Yang, W. "Impaired capacity to restore proteostasis in the aged brain after ischemia: Implications for translational brain ischemia research." Neurochemistry International (December 29, 2018). (Review)  Full Text
    • Shen, Y, Yan, B, Zhao, Q, Wang, Z, Wu, J, Ren, J, Wang, W, Yu, S, Sheng, H, Crowley, SD, Ding, F, Paschen, W, and Yang, W. "Aging Is Associated With Impaired Activation of Protein Homeostasis-Related Pathways After Cardiac Arrest in Mice." Journal of the American Heart Association 7, no. 17 (September 2018): e009634-null.  Full Text
    • Karhausen, J, Bernstock, JD, Johnson, KR, Sheng, H, Ma, Q, Shen, Y, Yang, W, Hallenbeck, JM, and Paschen, W. "Ubc9 overexpression and SUMO1 deficiency blunt inflammation after intestinal ischemia/reperfusion." Laboratory Investigation; a Journal of Technical Methods and Pathology 98, no. 6 (June 2018): 799-813.  Full Text
    • Bernstock, JD, Ye, D, Smith, JA, Lee, Y-J, Gessler, FA, Yasgar, A, Kouznetsova, J, Jadhav, A, Wang, Z, Pluchino, S, Zheng, W, Simeonov, A, Hallenbeck, JM, and Yang, W. "Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2." Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology 32, no. 3 (March 2018): 1677-1691.  Full Text
    • Liu, H, Yu, Z, Li, Y, Xu, B, Yan, B, Paschen, W, Warner, DS, Yang, W, and Sheng, H. "Novel Modification of Potassium Chloride Induced Cardiac Arrest Model for Aged Mice." Aging and Disease 9, no. 1 (February 2018): 31-39.  Full Text
    • Bernstock, JD, Yang, W, Ye, DG, Shen, Y, Pluchino, S, Lee, Y-J, Hallenbeck, JM, and Paschen, W. "SUMOylation in brain ischemia: Patterns, targets, and translational implications." Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism 38, no. 1 (January 2018): 5-16. (Review)  Full Text
    • Yang, W, and Paschen, W. "Is age a key factor contributing to the disparity between success of neuroprotective strategies in young animals and limited success in elderly stroke patients? Focus on protein homeostasis." Journal of Cerebral Blood Flow & Metabolism 37, no. 10 (October 2017): 3318-3324. (Review)  Full Text
    • Bernstock, JD, Ye, D, Gessler, FA, Lee, Y-J, Peruzzotti-Jametti, L, Baumgarten, P, Johnson, KR, Maric, D, Yang, W, Kögel, D, Pluchino, S, and Hallenbeck, JM. "Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming." Scientific reports 7, no. 1 (August 7, 2017): 7425-.  Full Text
    • Jiang, M, Yu, S, Yu, Z, Sheng, H, Li, Y, Liu, S, Warner, DS, Paschen, W, and Yang, W. "XBP1 (X-Box-Binding Protein-1)-Dependent O-GlcNAcylation Is Neuroprotective in Ischemic Stroke in Young Mice and Its Impairment in Aged Mice Is Rescued by Thiamet-G." Stroke 48, no. 6 (June 2017): 1646-1654.  Full Text
    • Yu, Z, Sheng, H, Liu, S, Zhao, S, Glembotski, CC, Warner, DS, Paschen, W, and Yang, W. "Activation of the ATF6 branch of the unfolded protein response in neurons improves stroke outcome." Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism 37, no. 3 (March 2017): 1069-1079.  Full Text
    • Zhang, L, Liu, X, Sheng, H, Liu, S, Li, Y, Zhao, JQ, Warner, DS, Paschen, W, and Yang, W. "Neuron-specific SUMO knockdown suppresses global gene expression response and worsens functional outcome after transient forebrain ischemia in mice." Neuroscience 343 (February 2017): 190-212.  Full Text
    • Yang, W, and Paschen, W. "Unfolded protein response in brain ischemia: A timely update." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 36, no. 12 (December 2016): 2044-2050. (Review)  Full Text
    • Yang, W, Sheng, H, and Wang, H. "Targeting the SUMO pathway for neuroprotection in brain ischaemia." Stroke and Vascular Neurology 1, no. 3 (September 2016): 101-107. (Review)  Full Text
    • Liu, S, Sheng, H, Yu, Z, Paschen, W, and Yang, W. "O-linked β-N-acetylglucosamine modification of proteins is activated in post-ischemic brains of young but not aged mice: Implications for impaired functional recovery from ischemic stress." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 36, no. 2 (February 2016): 393-398.  Full Text
    • Yang, W, and Paschen, W. "SUMO proteomics to decipher the SUMO-modified proteome regulated by various diseases." Proteomics 15, no. 5-6 (March 2015): 1181-1191. (Review)  Full Text
    • Wang, L, Wansleeben, C, Zhao, S, Miao, P, Paschen, W, and Yang, W. "SUMO2 is essential while SUMO3 is dispensable for mouse embryonic development." Embo Reports 15, no. 8 (August 2014): 878-885.  Full Text
    • Wang, L, Rodriguiz, RM, Wetsel, WC, Sheng, H, Zhao, S, Liu, X, Paschen, W, and Yang, W. "Neuron-specific Sumo1-3 knockdown in mice impairs episodic and fear memories." Journal of Psychiatry & Neuroscience : Jpn 39, no. 4 (July 2014): 259-266.  Full Text
    • Iwabuchi, M, Sheng, H, Thompson, J, Wang, L, Dubois, LG, Gooden, D, Moseley, M, Paschen, W, and Yang, W. "Characterization of the ubiquitin-modified proteome regulated by transient forebrain ischemia." Journal of Cerebral Blood Flow and Metabolism 34, no. 3 (March 1, 2014): 425-432.  Full Text
    • Iwabuchi, M, Sheng, H, Thompson, JW, Wang, L, Dubois, LG, Gooden, D, Moseley, M, Paschen, W, and Yang, W. "Characterization of the ubiquitin-modified proteome regulated by transient forebrain ischemia." Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism 34, no. 3 (March 2014): 425-432.  Full Text
    • Brietzke, A, Goldammer, T, Rebl, H, Korytář, T, Köllner, B, Yang, W, Rebl, A, and Seyfert, HM. "Characterization of the interleukin 1 receptor-associated kinase 4 (IRAK4)-encoding gene in salmonid fish: The functional copy is rearranged in Oncorhynchus mykiss and that factor can impair TLR signaling in mammalian cells." Fish and Shellfish Immunology 36, no. 1 (January 1, 2014): 206-214.  Full Text
    • Yang, W, Sheng, H, Thompson, JW, Zhao, S, Wang, L, Miao, P, Liu, X, Moseley, MA, and Paschen, W. "Small ubiquitin-like modifier 3-modified proteome regulated by brain ischemia in novel small ubiquitin-like modifier transgenic mice: Putative protective proteins/pathways." Stroke 45, no. 4 (January 1, 2014): 1115-1122.  Full Text
    • Yang, W, Wang, L, and Paschen, W. "Development of a high-throughput screening assay for inhibitors of small ubiquitin-like modifier proteases." Journal of Biomolecular Screening 18, no. 5 (June 2013): 621-628.  Full Text
    • Wang, Z, Wang, R, Sheng, H, Sheng, SP, Paschen, W, and Yang, W. "Transient ischemia induces massive nuclear accumulation of SUMO2/3-conjugated proteins in spinal cord neurons." Spinal Cord 51, no. 2 (February 2013): 139-143.  Full Text  Link to Item
    • Brietzke, A, Goldammer, T, Rebl, H, Korytář, T, Köllner, B, Yang, W, Rebl, A, and Seyfert, H-M. "Characterization of the interleukin 1 receptor-associated kinase 4 (IRAK4)-encoding gene in salmonid fish: The functional copy is rearranged in Oncorhynchus mykiss and that factor can impair TLR signaling in mammalian cells." Fish and Shellfish Immunology (2013).
    • Yang, W, Wang, L, Roehn, G, Pearlstein, RD, Ali-Osman, F, Pan, H, Goldbrunner, R, Krantz, M, Harms, C, and Paschen, W. "Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival." Cancer Science 104, no. 1 (January 2013): 70-77.  Full Text
    • Yang, W, Wang, L, Roehn, G, Pearlstein, RD, Ali-Osman, F, Pan, H, Goldbrunner, R, Krantz, M, Harms, C, and Paschen, W. "Small ubiquitin-like modifier 1-3 is activated in human astrocytic brain tumors and is required for glioblastoma cell survival." Cancer Science 104, no. 1 (2013): 70-77.  Full Text
    • Wang, L, Ma, Q, Yang, W, Mackensen, GB, and Paschen, W. "Moderate hypothermia induces marked increase in levels and nuclear accumulation of SUMO2/3-conjugated proteins in neurons." Journal of Neurochemistry 123, no. 3 (November 2012): 349-359.  Full Text
    • Yang, W, Thompson, JW, Wang, Z, Wang, L, Sheng, H, Foster, MW, Moseley, MA, and Paschen, W. "Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics." Journal of Proteome Research 11, no. 2 (February 2012): 1108-1117.  Full Text
    • Datwyler, AL, Lättig-Tünnemann, G, Yang, W, Paschen, W, Lee, SLL, Dirnagl, U, Endres, M, and Harms, C. "SUMO2/3 conjugation is an endogenous neuroprotective mechanism." Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism 31, no. 11 (November 2011): 2152-2159. (Letter)  Full Text
    • Wang, Z, Yang, W, Britz, GW, Lombard, FW, Warner, DS, and Sheng, H. "Development of a simplified spinal cord ischemia model in mice." Journal of Neuroscience Methods 189, no. 2 (June 2010): 246-251.  Full Text
    • Sheng, H, Yang, W, Fukuda, S, Tse, HM, Paschen, W, Johnson, K, Batinic-Haberle, I, Crapo, JD, Pearlstein, RD, Piganelli, J, and Warner, DS. "Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat." Free Radic Biol Med 47, no. 7 (October 1, 2009): 917-923.  Full Text  Link to Item
    • Yang, W, and Paschen, W. "The endoplasmic reticulum and neurological diseases." Exp Neurol 219, no. 2 (October 2009): 376-381.  Full Text  Link to Item
    • Günther, J, Koczan, D, Yang, W, Nürnberg, G, Repsilber, D, Schuberth, HJ, Park, Z, Maqbool, N, Molenaar, A, and Seyfert, HM. "Assessment of the immune capacity of mammary epithelial cells: Comparison with mammary tissue after challenge with Escherichia coli." Veterinary Research 40, no. 4 (July 1, 2009).  Full Text
    • Yang, W, Ma, Q, Mackensen, GB, and Paschen, W. "Deep hypothermia markedly activates the small ubiquitin-like modifier conjugation pathway; implications for the fate of cells exposed to transient deep hypothermic cardiopulmonary bypass." J Cereb Blood Flow Metab 29, no. 5 (May 2009): 886-890.  Full Text  Link to Item
    • Yang, W, and Paschen, W. "Gene expression and cell growth are modified by silencing SUMO2 and SUMO3 expression." Biochem Biophys Res Commun 382, no. 1 (April 24, 2009): 215-218.  Full Text  Link to Item
    • Yang, W, Sheng, H, Homi, HM, Warner, DS, and Paschen, W. "Cerebral ischemia/stroke and small ubiquitin-like modifier (SUMO) conjugation--a new target for therapeutic intervention?." J Neurochem 106, no. 3 (August 2008): 989-999. (Review)  Full Text  Link to Item
    • Yang, W, Sheng, H, Warner, DS, and Paschen, W. "Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation." J Cereb Blood Flow Metab 28, no. 5 (May 2008): 892-896.  Full Text  Link to Item
    • Petzl, W, Zerbe, H, Günther, J, Yang, W, Seyfert, HM, Nürnberg, G, and Schuberth, HJ. "Escherichia coli, but not Staphylococcus aureus triggers an early increased expression of factors contributing to the innate immune defense in the udder of the cow." Veterinary Research 39, no. 2 (March 1, 2008).  Full Text
    • Yang, W, Zerbe, H, Petzl, W, Brunner, RM, Günther, J, Draing, C, von Aulock, S, Schuberth, H-J, and Seyfert, H-M. "Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli, but S. aureus fails to both activate NF-kappaB in mammary epithelial cells and to quickly induce TNFalpha and interleukin-8 (CXCL8) expression in the udder." Molecular Immunology 45, no. 5 (March 2008): 1385-1397.  Full Text
    • Yang, W, Sheng, H, Warner, DS, and Paschen, W. "Transient global cerebral ischemia induces a massive increase in protein sumoylation." J Cereb Blood Flow Metab 28, no. 2 (February 2008): 269-279.  Full Text  Link to Item
    • Yang, W, and Paschen, W. "Conditional gene silencing in mammalian cells mediated by a stress-inducible promoter." Biochem Biophys Res Commun 365, no. 3 (January 18, 2008): 521-527.  Full Text  Link to Item
    • Jaffrézic, F, de Koning, D-J, Boettcher, PJ, Bonnet, A, Buitenhuis, B, Closset, R, Déjean, S, Delmas, C, Detilleux, JC, Dovc, P, Duval, M, Foulley, J-L, Hedegaard, J, Hornshøj, H, Hulsegge, I, Janss, L, Jensen, K, Jiang, L, Lavric, M, Lê Cao, K-A, Lund, MS, Malinverni, R, Marot, G, Nie, H, Petzl, W, Pool, MH, Robert-Granié, C, San Cristobal, M, van Schothorst, EM, Schuberth, H-J, Sørensen, P, Stella, A, Tosser-Klopp, G, Waddington, D, Watson, M, Yang, W, Zerbe, H, and Seyfert, H-M. "Analysis of the real EADGENE data set: comparison of methods and guidelines for data normalisation and selection of differentially expressed genes (open access publication)." Genetics, Selection, Evolution : Gse 39, no. 6 (November 2007): 633-650.  Full Text
    • Sørensen, P, Bonnet, A, Buitenhuis, B, Closset, R, Déjean, S, Delmas, C, Duval, M, Glass, L, Hedegaard, J, Hornshøj, H, Hulsegge, I, Jaffrézic, F, Jensen, K, Jiang, L, de Koning, D-J, Lê Cao, K-A, Nie, H, Petzl, W, Pool, MH, Robert-Granié, C, San Cristobal, M, Lund, MS, van Schothorst, EM, Schuberth, H-J, Seyfert, H-M, Tosser-Klopp, G, Waddington, D, Watson, M, Yang, W, and Zerbe, H. "Analysis of the real EADGENE data set: multivariate approaches and post analysis (open access publication)." Genetics, Selection, Evolution : Gse 39, no. 6 (November 2007): 651-668.  Full Text
    • Bánhegyi, G, Baumeister, P, Benedetti, A, Dong, D, Fu, Y, Lee, AS, Li, J, Mao, C, Margittai, E, Ni, M, Paschen, W, Piccirella, S, Senesi, S, Sitia, R, Wang, M, and Yang, W. "Endoplasmic reticulum stress." Ann N Y Acad Sci 1113 (October 2007): 58-71. (Review)  Full Text  Link to Item
    • Vanselow, J, Yang, W, Herrmann, J, Zerbe, H, Schuberth, H-J, Petzl, W, Tomek, W, and Seyfert, H-M. "DNA-remethylation around a STAT5-binding enhancer in the alphaS1-casein promoter is associated with abrupt shutdown of alphaS1-casein synthesis during acute mastitis." Journal of molecular endocrinology 37, no. 3 (December 2006): 463-477.  Full Text
    • Yang, W, Molenaar, A, Kurts-Ebert, B, and Seyfert, H-M. "NF-kappaB factors are essential, but not the switch, for pathogen-related induction of the bovine beta-defensin 5-encoding gene in mammary epithelial cells." Molecular immunology 43, no. 3 (February 2006): 210-225.  Full Text

  • Book Sections

    • Thompson, JW, Jiang, M, and Yang, W. "Proteomic analysis of SUMOylation in the post-ischemic brain." In Neuromethods, 207-224. January 1, 2017.  Full Text

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