Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2.

Published

Journal Article

The development of novel neuroprotective treatments for acute stroke has been fraught with failures, which supports the view of ischemic brain damage as a highly complex multifactorial process. Post-translational modifications such as small ubiquitin-like modifier (SUMO)ylation have emerged as critical molecular regulatory mechanisms in states of both homeostasis and ischemic stress, as evidenced by our previous work. Accordingly, the clinical significance of the selective control of the global SUMOylation process has become apparent in studies of ischemic pathobiology and pathophysiology. Herein, we describe a process capable of identifying and characterizing small molecules with the potential of targeting the SUMO system through inhibition of SUMO deconjugation in an effort to develop novel stroke therapies.-Bernstock, J. D., Ye, D., Smith, J. A., Lee, Y.-J., Gessler, F. A., Yasgar, A., Kouznetsova, J., Jadhav, A., Wang, Z., Pluchino, S., Zheng, W., Simeonov, A., Hallenbeck, J. M., Yang, W. Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO-conjugation via the inhibition of SUMO-specific protease (SENP)2.

Full Text

Duke Authors

Cited Authors

  • Bernstock, JD; Ye, D; Smith, JA; Lee, Y-J; Gessler, FA; Yasgar, A; Kouznetsova, J; Jadhav, A; Wang, Z; Pluchino, S; Zheng, W; Simeonov, A; Hallenbeck, JM; Yang, W

Published Date

  • March 2018

Published In

Volume / Issue

  • 32 / 3

Start / End Page

  • 1677 - 1691

PubMed ID

  • 29146736

Pubmed Central ID

  • 29146736

Electronic International Standard Serial Number (EISSN)

  • 1530-6860

Digital Object Identifier (DOI)

  • 10.1096/fj.201700711R

Language

  • eng

Conference Location

  • United States